Kintsugi Peptides & Ceramide Skin Barrier Repair Cream
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Zakka Naturals Kintsugi Peptides & Ceramide Skin Barrier Repair CreamIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
Propanediol is a natural alternative for the often used and often bad-mouthed propylene glycol. It's produced sustainably from corn sugar and it's Ecocert approved.
It's quite a multi-tasker: can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula.
A naturally derived (Ecocert approved) colorless to yellowish oily liquid that's touted as a natural silicone alternative. It's claimed to have great sensorial properties: light but caring, velvety, silky and non-sticky.
It's also great at dissolving UV-filters in sunscreens or dispersing pigments in makeup products. You can also bump into Isoamyl Laurate in hair care products as a hair conditioner that makes combing easier without build up.
A nice-feeling, light emollient that makes the skin soft and smooth. It gives a fresh and gliding sensation with a powdery or soft after-feel depending on the exact grade used. It is a popular alternative to replace silicones.
Chemically speaking, it is an alkane (stable, non-reacting hydrocarbon) that used to be produced from petrochemicals, but today's versions are typically vegetable based. It is readily biodegradable.
It seems to us that squalane is in fashion and there is a reason for it. Chemically speaking, it is a saturated (no double bonds) hydrocarbon (a molecule consisting only of carbon and hydrogen), meaning that it's a nice and stable oily liquid with a long shelf life.
It occurs naturally in certain fish and plant oils (e.g. olive), and in the sebum (the oily stuff our skin produces) of the human skin. As f.c. puts it in his awesome blog post, squalane's main things are "emolliency, surface occlusion, and TEWL prevention all with extreme cosmetic elegance". In other words, it's a superb moisturizer that makes your skin nice and smooth, without being heavy or greasy.
Another advantage of squalane is that it is pretty much compatible with all skin types and skin conditions. It is excellent for acne-prone skin and safe to use even if you have fungi-related skin issues, like seborrhea or fungal acne.
The unsaturated (with double bonds) and hence less stable version of Squalane is Squalene, you can read about it here >>
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.
BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.
It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive.
An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid).
Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier.
Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.
Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation.
If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.
As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily.
A skin protecting ingredient obtained by enzymatic synthesis from natural sugars (sucrose and maltose). It's claimed to be a bio-selective substrate that protects and stimulates the beneficial microbial skin flora without doing the same with pathogens and undesirable flora. It also stimulates the antimicrobial peptide release by keratinocytes (skin cells).
A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, is super well tolerated by every skin type and easy to formulate with. No wonder it’s popular.
A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives.
We don't have description for this ingredient yet.
The famous omega-6 fatty acid, the mother of all ω-6 fatty acids in our body. It is a so-called polyunsaturated fatty acid meaning it has more than one (in this case two) double bonds and a somewhat kinky structure that makes LA and LA-rich oils a thin liquid.
It is also an essential fatty acid meaning our body cannot synthesize it and has to take it from food. This is not hard at all as plenty of nuts (such as flax, poppy or sesame seeds) and vegetable oils (such as sunflower or safflower) are rich in LA. The hard thing seems to be eating enough omega-3-s, more specifically eating a healthy ratio of omega-6 to omega-3, but that is a topic for a what-is-good-to-eat-site and not for us.
As for linoleic acid and the skin, LA is a really important little guy found naturally in our skin. It is the most abundant fatty acid in the epidermis and it serves as a structural precursor for important skin lipids called ceramides. Knowing this, it will not come as a surprise that Linoleic acid has a central role in the structure and function of stratum corneum permeability, aka healthy skin barrier. LA deficiency leads to an impaired more permeable skin barrier and the topical application of LA-rich sunflower oil can fix this issue rapidly (while oleic-rich olive oil did not have the same barrier repairing effect).
LA is not only important for dry, barrier damaged skin types but also for acne-prone skin. Research shows that problem skin has lower levels of linoleic acid (and higher levels of oleic acid) than normal skin. So LA-deficiency in the skin seems to be connected not only to an impaired skin barrier but also to acne and smearing LA all over your face might help with your problem skin. A double-blind study using a 2.5% LA gel for 4 weeks found a 25% reduction in the size of microcomedones, the tiny blocked pores that can later lead to acne.
If that was not enough, we have one more thing to report about LA. It lightens hyperpigmentation (aka UVB caused sun spots) both by blocking the melanin production of melanocytes (the skin cells that make the pigment melanin) and by enhancing the desquamation of melanin pigment from the upper layers of the skin.
Overall, linoleic acid is a multi-functional skin goodie with barrier repairing, acne-reducing, and skin-lightening magic abilities. It's a nice one to spot on the ingredient list pretty much for any skin type.
The famous omega-3 fatty acid, the mother of all ω-3 fatty acids in our body. Next to linoleic acid, it is the other essential fatty acid that our body cannot synthesize and we have to ingest it from our food. It is also a PUFA, aka polyunsaturated fatty acid with three double bonds, a kinky chemical structure and thus a liquid consistency.
While linoleic acid is abundant in the skin, this is not the case with alpha-linolenic acid (ALA). It is not entirely clear if it is meant to be like that or if this is a consequence of not eating enough Omega-3 with the typical Western diet.
Leafy green vegetables, walnuts, flax seeds and fish oils are rich sources of ALA and if you are not eating a lot from these, supplementing with fish oil is a pretty good idea backed by research. It is a good idea both in terms of general health benefits as well as potentially improving inflammation-related skin issues such as atopic dermatitis or acne.
As for using ALA topically, we have to say that its role and effects seem to be less direct than with LA. ALA's main role in the skin appears to be modulating the immune response of the epidermis. This is probably helpful for inflammatory skin diseases but most studies examine ALA as an oral supplement and not when applied topically. One exception, we could find, is a study that found that topically applied ALA has nice spot-fading abilities.
To be honest, it seems to us that oral supplementation of ALA is more important than smearing it all over your face. However, that is not to say that topical ALA is a bad thing, it is a good thing. It is a skin-identical ingredient, it is probably moisturizing and anti-inflammatory but its topical effects are less established than that of fellow omega fatty acid, linoleic acid.
We don't have description for this ingredient yet.
An extremely common multitasker ingredient that gives your skin a nice soft feel (emollient) and gives body to creams and lotions. It also helps to stabilize oil-water mixes (emulsions), though it does not function as an emulsifier in itself. Its typical use level in most cream type formulas is 2-3%.
It’s a so-called fatty alcohol, a mix of cetyl and stearyl alcohol, other two emollient fatty alcohols. Though chemically speaking, it is alcohol (as in, it has an -OH group in its molecule), its properties are totally different from the properties of low molecular weight or drying alcohols such as denat. alcohol. Fatty alcohols have a long oil-soluble (and thus emollient) tail part that makes them absolutely non-drying and non-irritating and are totally ok for the skin.
An oily kind of ingredient that can magically blend with water all by itself. This is called self-emulsifying and SE in its name stands for that.
The difference between "normal" Glyceryl Stearate and this guy is that the SE grade contains a small amount of water-loving soap molecules, such as sodium stearate. This increases Glyceryl Stearate's affinity for water and gives it stronger emulsifying abilities.
Other than that, it’s a nice emollient that gives a smooth and soft appearance to the skin.
You can read some more at Glyceryl Stearate >>
A glycerin-derived gentle cleansing agent that is described as being skin and eye-friendly, and not leaving the skin dry or tight. It's also used as a co-emulsifier or solubilizer that helps to blend small amounts of oily things into water-based products.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
One of the many types of ceramides that can be found naturally in the upper layer of the skin. Ceramides make up about 50% of the goopy stuff that's between our skin cells and play a super important role in having a healthy skin barrier and keeping the skin hydrated. It works even better when combined with its pal, Ceramide 1.
We wrote way more about ceramides at ceramide 1, so click here to know more.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
A common functional ingredient that helps to keep the oil-loving and water-loving ingredients together (emulsifier), stabilizes and thickens the products.
Chemically speaking, it is ethoxylated Cetearyl alcohol, meaning that some ethylene oxide is added to the fatty alcohol to increase the water-soluble part in the molecule. The result is that the mainly oil soluble, emollient fatty alcohol is converted to an emulsifier molecule that keeps oil and water mixed in creams. The number in the name of Ceteareth emulsifiers refers to the average number of ethylene oxide molecules added and 20 makes a good emulsifier.
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically.
It's not only soothing but it' also skin-softening and protecting and can promote wound healing.
Centella Asiatica - or sometimes also called Gotu Kola or Cica - has been used in folk medicine for hundreds of years. It’s traditionally used to improve small wounds, burns and scratches and it’s also a well known anti-inflammatory agent for eczema.
Recently science has taken an interest in Gotu Kola as well and it turns out it really has many active compounds with several benefits. Just for hard-core geeks, the main biologically active compounds are pentacyclic triterpenoid saponins called asiaticoside, madecassoside, asiatic and madecassic acid (also called centellosides).
One of the biological activities of the centellosides is to be able to stimulate GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells), and especially hyaluronic acid synthesis in our skin. This is probably one of the reasons why Centella Asiatica Extract has nice skin moisturizing properties that was confirmed by a 25 people, four weeks study along with Centella's anti-inflammatory effects.
Madecassoside can also help in burn wound healing through increasing antioxidant activity and enhancing collagen synthesis. Asiaticoside was shown to increase antioxidant levels on rats skin when applied at 0.2%.
Centella Asiatica also often shows up in products that try to treat cellulite or striae. Of course, it cannot make a miracle but it might have some effect via regulating microcirculation and normalizing the metabolism in the cells of connective tissues.
Bottom line: Gotu Kola is a great plant ingredient with proven wound healing, anti-inflammatory, and antioxidant properties. Nice to spot on any ingredient list.
The extract coming from the lovely herb, rosemary. It contains lots of chemicals, including flavonoids, phenolic acids, and diterpenes. Its main active is rosmarinic acid, a potent antioxidant, and anti-inflammatory. It has also anti-bacterial, astringent and toning properties.
The leaves contain a small amount of essential oil (1-2%) with fragrant components, so if you are allergic to fragrance, it might be better to avoid it.
We don't have description for this ingredient yet.
A handy multifunctional ingredient that works as a preservative booster, as well as an antioxidant and soothing agent.
A non-essential amino acid (the building blocks of skin proteins, like collagen or elastin), that the body can produce itself, but its production decreases with age. When you put it all over your face, it works as a moisturizer and maybe more.
According to great skincare blog Futurederm, glycine might help with wound healing and tissue repair and when used together with other amino acids, leucine and proline it might improve wrinkles.
BTW, it's also a building block of a bunch of important and famous peptides, including copper-tripeptide-1, palmitoyl tripeptide-1 or palmitoyl hexapeptide-12.
Glutamic acid is a little molecule and non-essential (our body can synthesize it) amino acid with the important job of being a neurotransmitter in the human body meaning that it helps your nervous system work correctly.
As for what it's doing in cosmetics, Glutamic acids' main thing (similar to other amino acids) is being a humectant moisturizer and skin-conditioning agent (sidenote: if you attach lots of glutamic acid molecules, you get polyglutamic acid that is claimed to be a better than hyaluronic acid humectant). It also seems to affect skin barrier repair, however, it is not clear-cut in which direction.
The complication is that glutamic acid has two distinct forms, L-glutamic acid and D-glutamic acid, that are the mirror images of each other (think of it like your left and right hand). Studies show that a topical application of L-glutamic acid on damaged skin delayed skin repair, while D-glutamic acid application sped up skin repair. As both forms are used by the industry, it is a bit uncertain what you are getting with just glutamic acid on the ingredient list (but if it is a Shiseido group product, it is probably the goodie D-form :)).
Other than that, Glutamic acid can also be used as a pH adjuster and can be processed via biological pathways into pyrrolidone carboxylic acid, the sodium salt of which is a goodie and one of your skin’s natural moisturizing factors.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
A traditional Chinese herbal medicine loaded with potent antioxidant and anti-inflammatory flavonoids such as baicalin, baicalein, and wogonin.
If that would not be enough, Skullcap Root is also claimed to have antimicrobial and antifungal properties (also against P.acnes and Malassezia furfur) as well as some skin-brightening activity. A multi-functional skin-goodie.
Chamomile probably needs no introduction as it's one of the most widely used medicinal herbs. You probably drink it regularly as a nice, calming cup of tea and it's also a regular on skincare ingredient lists.
Cosmetic companies use it mainly for its anti-inflammatory properties. It contains the terpenoids chamazulene and bisabolol both of which show great anti-inflammatory action in animal studies. On top of that chamomile also has some antioxidant activity (thanks to some other active ingredients called matricine, apigenin and luteolin).
Though chamomile is usually a goodie for the skin, it's also not uncommon to have an allergic reaction to it.
It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range.
Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415).
- Green tea is one of the most researched natural ingredients
- The active parts are called polyphenols, or more precisely catechins (EGCG being the most abundant and most active catechin)
- There can be huge quality differences between green tea extracts. The good ones contain 50-90% catechins (and often make the product brown and give it a distinctive smell)
- Green tea is proven to be a great antioxidant, UV protectant, anti-inflammatory, anticarcinogenic and antimicrobial
- Because of these awesome properties green tea is a great choice for anti-aging and also for skin diseases including rosacea, acne and atopic dermatitis
Sh-Oligopeptide-1 is the famous molecule, which is also called Epidermal Growth Factor or EGF. Chemically speaking, Growth Factors are largish peptides or smallish proteins, or to put it in another way, medium-length amino acid sequences (EGF consists of 53 amino acids). Biologically speaking, Growth Factors are cellular signal molecules that can stimulate cell growth, proliferation, healing and/or differentiation.
There are lots of Growth Factors and EGF is just one of them. The topic of "Growth Factors and skincare" is a big, confusing and controversial one and we will try our best to summarize the story for you, including the pros and the cons.
EGF is a special snowflake when it comes to skincare as it was the first Growth Factor that made its way into cosmetic products and it is also the most common one. The American biochemist, Stanley Cohen discovered EGF and was awarded a Noble prize in 1986 for it. As the Noble prize may signify, the molecule is significant and powerful and directly stimulates the proliferation of epidermal cells.
When it comes to Sh-Oligopeptide-1 in a cosmetic product, it has pretty well-established wound healing and skin renewal properties. It might even do more than that. According to a 2012 study on a serum containing barley bioengineered epidermal growth factor, "clinical evaluations showed statistically significant improvement in the appearance of fine lines and rhytids, skin texture, pore size, and various dyschromatic conditions apparent within the first month of use, and continuing improvement trends for the duration of the study" (which was 3 months).
This all sounds amazing, "give me some EGF Serum", we can hear you say! But as we wrote in the intro, the topic is complex and controversial so here are some of the questions that keep coming up around slathering EGF all over our face.
The first and biggest concern is that if EGF is so good at stimulating cell proliferation, how does it relate to cancer? Is the definition of cancer not "cells proliferating out of control"? Most experts agree on this answer: EGF is mitogenic (= stimulates cell proliferation) but not mutagenic (= does not alter the cell to make it cancerous). If you do not have cancer, you will not get cancer from EGF. However, if you have cancerous cells, EGF will help them to spread, just like it helps healthy cells. So if you have a lot of moles, excessive UV exposure in the past, or if you have any of the skin cancer risk factors, we suggest you should think twice about using EGF products. The same is true if you have psoriasis, a skin disease related to the abnormal growth of epidermal skin cells. You do not want to add fuel to the fire with EGF.
Other (less serious) concerns are if EGF can properly penetrate the skin (as it is a medium-sized, polar molecule, so a special delivery system is probably needed), if it can affect collagen synthesis (or just works on the surface plumping up only the upmost layers of the skin) and if it has beneficial effects at all when used in isolation versus when used in a "conditioned media" that contains lots of growth factors resembling the synergistic balance found in the skin.
Overall, our impression is that EGF is definitely a potent molecule. Some EGF products have a cult-like following adding anecdotal evidence to the clinical studies showing EGF has a beneficial effect on the skin. If you like experimenting, by all means, go ahead (unless you have psoriasis or high skin cancer risk factors), but if you are a better safe than sorry type, stick to daily SPF + a good retinoid product. This duo is still the golden standard of anti-aging.
Are you interested in Growth Factors and skincare? We have some more here:
- Human Fibroblast Conditioned Media - a growth factor cocktail used in some cosmetic products
- Insulin-like growth factor 1, aka sh-Oligopeptide -2 - a pal of EGF composed of 70 amino acids
- Vascular Endothelial Growth Factor, aka Sh-Polypeptide-9 - part of a GF cocktail trade named BIO-Placenta
A sugar beet-derived amino acid derivative with nice skin protection and moisturization properties. Betaine's special thing is being an osmolyte, a molecule that helps to control cell-water balance. It is also a natural osmoprotectant, meaning that it attracts water away from the protein surface and thus protects them from denaturation and increases their thermodynamic stability.
It also gives sensorial benefits to the formula and when used in cleansers, it helps to make them milder and gentler.
PCA stands for Pyrrolidone Carboxylic Acid and though it might not sound like it, it is a thing that can be found naturally in our skin. The sodium salt form of PCA is an important skin-identical ingredient and great natural moisturizer that helps the skin to hold onto water and stay nicely hydrated.
The sodium salt of lactic acid. It's a great skin moisturizer and also used to regulate the pH value of the cosmetic formula. It's a natural ingredient approved by both ECOCERT and COSMOS.
A non-essential amino acid (a building block of skin proteins like collagen or elastin) that hydrates the skin.
We don't have description for this ingredient yet.
An essential amino acid that's also a key building block of collagen and elastin. When taken orally, it helps the digestive and intestinal tracts function more smoothly and also helps the absorption of nutrients. As for skincare, it is not clear what it does other than being a skin hydrator.
A semi-essential (infants cannot synthesize it, but adults can) amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor, a skin hydrator and might also help to speed up wound healing.
Arginine usually has a positive charge (cationic) that makes it substantive to skin and hair (those are more negatively charged surfaces) and an excellent film former. Thanks to the positive charge, it also creates a complex with AHAs (AHAs like to lose a hydrogen ion and be negatively charged, so the positive and the negative ions attract each other) that causes a "time-release AHA effect" and reduces the irritation associated with AHAs.
A non-essential amino acid (meaning that our body can produce it) that's also one of the major building blocks of collagen. According to the Futurederm blog, it might be able to improve wrinkles when combined with other amino acids, glycine and leucine
Sh-Oligopeptide-2 is also called Insulin-like growth factor 1 and it belongs to the same group of ingredients (Growth Factors) as its better-known sister, Epidermal Growth Factor or Sh-Oligopeptide-1. This guy consists of 70 amino acids and, similar to EGF, it is also claimed to stimulate cell proliferation and wound healing. There is also a study that indicates EGF and IGF1 work in synergy to promote keratinocyte (skin cell) proliferation.
The topic of Growth Factors in skincare is complex and controversial. If you are new to it, read our shiny explanation on EGF to get a (hopefully) balanced impression about the pros and cons.
You might know licorice as a sweet treat from your childhood, but it's actually a legume that grows around the Mediterranean Sea, the Middle East, central and southern Russia. It's sweet and yellow and not only used for licorice all sorts but it's also a skincare superstar thanks to two magic properties:
Nr. 1 magic property is that it has skin-lightening or to say it another way depigmenting properties. The most active part is called glabridin. The topical application (meaning when you put it on your face) of 0.5% glabridin was shown to inhibit UVB caused pigmentation of guinea pigs. Another study even suggested that licorice is more effective than the gold standard skin-lightening agent hydroquinone. All in all, licorice is considered to be one of the safest skin lightening agents with the fewest side effects.
There is just one catch regarding glabridin and licorice: the amount of glabridin in commercial licorice extracts can vary a lot. We have seen extracts with only 4% glabridin as well as 40% glabridin. The latter one is a very-very expensive ingredient, so if you are after the depigmenting properties try to choose a product that boasts its high-quality licorice extract.
Nr. 2 magic property is that licorice is a potent anti-inflammatory. Glabridin has also some soothing properties but the main active anti-inflammatory component is glycyrrhizin. It’s used to treat several skin diseases that are connected to inflammation including atopic dermatitis, rosacea or eczema.
Oh, and one more thing: glabridin seems to be also an antioxidant, which is just one more reason to be happy about licorice root extract on an ingredient list.
Bottom line: Licorice is a great skincare ingredient with significant depigmenting, anti-inflammatory and even some antioxidant properties. Be happy if it's on the ingredient list. :)
When it comes to grape and skincare, the seed extract and the seed oil steals most of the show. The reason for that is that the seed contains the majority of the skin goodies, the antioxidant superstar polyphenols.
The fruit also contains some, but it's less potent. However - according to manufacturer info - the fruit extract is not only an antioxidant, but it's also a soothing, moisturizing and nourishing agent.
PCA stands for Pyrrolidone Carboxylic Acid and though it might not sound like it, it is a thing that can be found naturally in our skin. In fact, after amino acids, it is the second biggest NMF component of the skin with 12% being PCA of the NMF composition of normal skin. So similar to other NMFs, it's a skin goodie that helps the skin to hold onto water and stay nicely hydrated.
Serine is an amino acid that most often comes to the formula as part of a moisturizing complex. It's a non-essential amino acid (meaning that our body can synthesize it) and serves as a water-binding ingredient.
In general, amino acids are great skincare ingredients that play an important role in proper skin hydration but there is not much info out there about what specifically serine can do for the skin.
The extract coming from ginger, the lovely spice that we all know from the kitchen. It is also a medicinal plant used both in Chinese and Ayurvedic medicine for pretty much everything you can imagine (muscular pain, sore throat, nausea, fever or cramps, just to give a few examples).
As for ginger and skincare, the root extract contains the biologically active component called gingerol that has potent antioxidant and anti-inflammatory properties. Combined with Bisabolol, the duo works synergistically to sooth the skin and take down redness.
Other than that, ginger also contains moisturizing polysaccharides, amino acids, and sugars, and it is also quite well known to increase blood circulation and have a toning effect.
Last but not least, Ginger also has some volatile, essential oil compounds (1-3%). Those are mostly present in ginger oil, but small amounts might be in the extract as well (around 0.5% based on manufacturer info).
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
Sh-Polypeptide-9 is a cell signaling protein also called Vascular Endothelial Growth Factor. As its name suggests, its main function is to stimulate the formation of blood vessels. As to what it does in cosmetic products, we found manufacturers info claiming that it plays a role in supplying fibroblast cells (VIP skin cells that make collagen) with nutrients, in the growth and migration of cells and in wound healing.
It usually comes to the formula as part of a Growth Factor mix trade named BIO-Placenta, that combines EGF, IGF-1, FGF1, FGF2 and this guy to form a synergistic growth factor cocktail. BIO Placenta is claimed to do pretty much everything you would want from an anti-aging active including anti-wrinkle, skin rejuvenation, elasticity enhancement, moisturizing and cell vitalization properties.
This all sounds great and Growth Factors are for sure potent cell signaling molecules, but the use of them in cosmetic products is somewhat controversial, so if you are new to the topic, read our explanation at EGF to get a (hopefully) balanced view.
We don't have description for this ingredient yet.
A natural polymer (big molecules from repeated subunits) that is harvested from the Acacia tree in the sub-Saharan region in Africa. It's a great thickening and binding agent. Often coupled with xanthan gum, as it helps to reduce its unpleasant stickiness.
We don't have description for this ingredient yet.
A 100% natural and plant-derived moisturizer that mimics the natural carbohydrate fraction found in the upper layer of the skin. Its special magic power is to bind to the skin stronger and longer than other moisturizer ingredients do so it can keep the skin hydrated longer than usual.
A pretty famous and better-researched peptide consisting of five amino acids (the building blocks of all proteins). It was created in a joint effort by the French ingredient supplier, Sederma and the cosmetics industry big shot, Procter&Gamble.
The amino acid sequence of the peptide is lysine–threonine–threonine–lysine–serine (KTTKS). Sometimes, it's also called collagen pentapeptide, as it's a subfragment of skin-structure-giving type I collagen. The KTTKS amino sequence is then attached for better oil solubility and skin penetration to palmitic acid and BOOM; we get Palmitoyl Pentapeptide-4.
Though most research is manufacturer sponsored, the clinical studies about Palmitoyl Pentapeptide-4 are promising. In short, it can reduce fine lines, wrinkles and improve skin texture significantly (and at crazy low concentrations, the studies were done with just 3 ppm that is 0.0003%).
There are also studies comparing Palmitoyl Pentapeptide-4 with anti-aging gold standard, retinol. One of them compared 3ppm Pal-KTTKS with 700 ppm (0.07%) retinol and found that they showed similar wrinkle improving ability with the peptide showing better skin tolerability.
Bottom line, if you are into peptides, this is a good one to try.
We don't have description for this ingredient yet.
Citric acid comes from citrus fruits and is an AHA. If these magic three letters don’t tell you anything, click here and read our detailed description on glycolic acid, the most famous AHA.
So citric acid is an exfoliant, that can - just like other AHAs - gently lift off the dead skin cells of your skin and make it more smooth and fresh.
There is also some research showing that citric acid with regular use (think three months and 20% concentration) can help sun-damaged skin, increase skin thickness and some nice hydrating things called glycosaminoglycans in the skin.
But according to a comparative study done in 1995, citric acid has less skin improving magic properties than glycolic or lactic acid. Probably that’s why citric acid is usually not used as an exfoliant but more as a helper ingredient in small amounts to adjust the pH of a formulation.
A little helper ingredient that is used to adjust the pH of the product. It also helps to keep products stay nice longer by neutralizing the metal ions in the formula (they usually come from water).
You probably know yeast from the kitchen where you put it into milk with a little sugar and then after a couple of minutes brownish bubbles form. That is the fungi fermenting the sugar.
As for skin care, yeast contains beta-glucan that is a great soothing ingredient and also a mild antioxidant. The yeast extract itself is a silky clear liquid that has some great moisturizing, skin protecting and film-forming properties on the skin.
It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic.
Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10).
It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.
Biosaccharide Gum-1 is a pretty interesting kind of sugar ingredient that is created from sorbitol via bacterial fermentation.
According to the manufacturer it’s a “S.M.A.R.T.” sugar: it has Soothing, Moisturizing, Anti-aging, Restructuring and Touch properties. Let’s look at them quickly one by one.
Soothing: the manufacturer tested out the soothing effect in vivo (meaning on humans that is always a good thing!) by measuring how 3% Biosaccharide Gum-1 decreased the tingling sensation caused by 10% lactic acid. The result was good: the tingling was decreased by 47%.
Moisturizing: Compared to famous hyaluronic acid, it turns out that the two are great together. HA has a quicker effect and provides more instant hydration (much more hydration was measured after 1h of application), while our nice sugar has a somewhat delayed effect demonstrating stronger hydration after 3h of application. After 8 hours both had similar moisturizing effect.
Anti-aging: According to ex-vivo tests (meaning not on humans, so do not trust it too much) Biosaccharide Gum-1 can stimulate a protein in our skin called sirtuin-1. This is supposed to help our skin cells to live longer, and function better.
Resurfacing: The sirtuin-1 stimulation also results in quicker cell renewal - something that happens anyway but slows down as we age. And the quicker cell renewal is good because it helps the regeneration of the barrier function. That is especially nice for fragile, sensitive skin.
Touch: our fermented sugar is not only good to the skin, but it also feels great on the skin. It gives a nice “soft touch” feeling and makes the products pleasant to use.
The bottom line is that the above info is from the manufacturer (and we could not find any relevant independent research) so obviously take it with a grain of salt. But Biosaccharide Gum-1 does look as an interesting and promising ingredient that’s why it earned our goodie rating.
A very common ingredient that can be found in all cell membranes. In cosmetics it's quite the multi-tasker: it's an emollient and water-binding ingredient but it's also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes.
Sh-Polypeptide-1 is a cell signaling protein also called Basic Fibroblast Growth Factor and is twin sister to Acidic Fibroblast Growth Factor. We can write here pretty much the same things as we did on aFGF: it is a mitogenic (= stimulates cell proliferation) ingredient that stimulates fibroblast cell growth and proliferation. According to manufacturer info, it also stimulates the synthesis of collagen and other extracellular-matrix (the gooey stuff between cells) components.
Growth Factors and skincare is a big, complicated and controversial topic, so if you wanna know more, we have a more detailed explanation on Epidermal Growth Factor, the most common one used in skincare.
Sh-Polypeptide-11 is a medium sized cell signaling molecule also called Acidic Fibroblast Growth Factor. It belongs to the same group of ingredients (Growth Factors) as its better-known sister, Epidermal Growth Factor or Sh-Oligopeptide-1. As its name suggests, FGF can stimulate the growth and proliferation of fibroblast cells (VIP cells that produce among other things collagen). According to manufacturer info, it also stimulates skin regeneration, wound healing and collagen and elastin synthesis.
As for research, we could find an in-vitro study that proved that "Recombinant FGF-1 strongly stimulated fibroblast and keratinocyte proliferation. However, the transition of this protein through the SC required an appropriate carrier system - lipid spheres."
It's also good to know that slathering mitogenic (= stimulates cell proliferation) ingredients on yourself is somewhat controversial. If you are new to the "Growth Factors and skincare" topic, we have a more detailed explanation of Epidermal Growth Factor, so click here and read all about it.
It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol.
The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.
It's one of the active parts of Chamomile that contains about 30% of bisabolol. It's a clear oily fluid that is used in skincare as a nice anti-inflammatory and soothing ingredient.
It’s a little helper ingredient that helps to set the pH of a cosmetic formulation to be just right. It’s very alkaline (you know the opposite of being very acidic): a 1% solution has a pH of around 10.
It does not have the very best safety reputation but in general, you do not have to worry about it.
What is true is that if a product contains so-called N-nitrogenating agents (e.g.: preservatives like 2-Bromo-2-Nitropropane-1,3-Diol, 5-Bromo-5-Nitro- 1,3-Dioxane or sodium nitrate - so look out for things with nitro, nitra in the name) that together with TEA can form some not nice carcinogenic stuff (that is called nitrosamines). But with proper formulation that does not happen, TEA in itself is not a bad guy.
But let’s assume a bad combination of ingredients were used and the nitrosamines formed. :( Even in that case you are probably fine because as far as we know it cannot penetrate the skin.
But to be on the safe side, if you see Triethanolamine in an INCI and also something with nitra, nitro in the name of it just skip the product, that cannot hurt.
We are big fans of all kinds of roses as ornamental plants but when it comes to skincare, it is a mixed bag. Before we list out the good and the not so good, here is an interesting thing.
The oil content in rose is very, very low so distilling rose essential oil requires huge amounts of rose flowers. It has such a wonderful scent that there are no comparable synthetic alternatives. You can probably guess that this means rose essential oil is expensive.... very very expensive.
So the good things: thanks to its wonderful scent the high-end perfume industry loves rose oil. Also, we (humans :)) love rose oil. We love its scent so much that it can heal headaches, depression, stress, and even grief.
Rose oil contains more than 95 compounds, among them flavonoids, anthocyanins, vitamin C, and quercetin that are all known for their medicinal properties and great antioxidant effects. Similar to many other essential oils, it has antimicrobial properties too.
Now, the not-so-good thing? Out of the 95 compounds, the major ones are citronellol and geraniol, fragrant components that might irritate sensitive skin.
We have to start by writing how fascinated we are by the amazing lavender fields of Provance and we do love pretty much everything about lavender: its look, its color, its scent.... but, when it comes to skincare, lavender is a questionable ingredient that you probably do not want in your skincare products.
First, let us start with the pros: it has a lovely scent, so no wonder that it is popular as a fragrance ingredient in natural products wanting to be free from synthetic fragrances but still wanting to smell nice. The scent of lavender is famous for having calming and relaxing properties and some smallish scientific studies do support that. Inhaled volatile compounds seem to have a soothing effect on the central nervous system and studies have shown that lavender aromatherapy can improve patient's anxiety and experience in hospitals.
Another pro is that lavender oil has some nice antimicrobial and antibacterial properties. It also has some local pain relieving and muscle relaxing magical powers. Lavender oil is also often claimed to have anti-inflammatory properties. We have found a study confirming this but it was the essential oil of the leaves and not the much more commonly used flowers and the two differ in their main chemical compounds very much. (The main components of the flower essential oil are linalyl acetate and linalool [around 80% the two together] while it is 1,8-Cineole [around 65%] in the essential oil of the leaves.)
Now, let us look at the cons: similar to a bunch of other essential oils, the main components of lavender oil are potentially irritating fragrant components. The two main components are linalyl acetate (about 50%) and linalool (about 35%) and both autoxidise on exposure to the air forming strong contact allergens. To make things even worse, lavender oil seems to be cytotoxic from concentrations as low as 0.25% (concentration up to 0.125% were ok).
There is also an often cited Japanese study that made patch tests with lavender oil for 9 years and found a huge increase in lavender oil sensitivity in 1997 (from 1.1% in 1990 to 8.7% in 1997 and 13.9% in 1998). This was the year when using dried lavender flowers in pillows, wardrobes, and elsewhere became fashionable in Japan, so it seems that increased exposure to lavender results in increased risk of sensitivity.
Overall, it makes us sad to write bad things about such a lovely plant, but when it comes to skincare, you will be better off without lavender.
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| what‑it‑does | solvent |
| what‑it‑does | solvent | moisturizer/humectant |
| what‑it‑does | emollient |
| what‑it‑does | emollient |
| what‑it‑does | skin-identical ingredient | emollient |
| irritancy, com. | 0, 1 |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 1 |
| what‑it‑does | soothing | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | emollient |
| what‑it‑does | solvent |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient | emollient | surfactant/cleansing |
| what‑it‑does | skin-identical ingredient | emollient | surfactant/cleansing | perfuming |
| what‑it‑does | viscosity controlling |
| what‑it‑does | emollient | viscosity controlling | emulsifying | surfactant/cleansing |
| irritancy, com. | 1, 2 |
| what‑it‑does | emulsifying |
| irritancy, com. | 2, 3 |
| what‑it‑does | surfactant/cleansing | emulsifying |
| what‑it‑does | viscosity controlling | emulsifying |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | emulsifying | surfactant/cleansing |
| what‑it‑does | emulsifying | surfactant/cleansing |
| irritancy, com. | 3, 2 |
| what‑it‑does | soothing |
| irritancy, com. | 0, 0 |
| what‑it‑does | soothing | antioxidant | moisturizer/humectant |
| what‑it‑does | antioxidant | soothing | antimicrobial/antibacterial |
| what‑it‑does | chelating |
| what‑it‑does | antioxidant |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | antioxidant |
| what‑it‑does | soothing | antioxidant | antimicrobial/antibacterial | moisturizer/humectant |
| what‑it‑does | soothing | antioxidant |
| irritancy, com. | 0, 0 |
| what‑it‑does | viscosity controlling |
| what‑it‑does | antioxidant | soothing |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | buffering | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | soothing | skin brightening |
| what‑it‑does | soothing | antioxidant | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | antioxidant | soothing |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | preservative | antimicrobial/antibacterial |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | antimicrobial/antibacterial |
| what‑it‑does | buffering |
| what‑it‑does | chelating | buffering |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | preservative |
| what‑it‑does | soothing | moisturizer/humectant |
| what‑it‑does | emollient | emulsifying |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | moisturizer/humectant | emollient |
| what‑it‑does | soothing |
| what‑it‑does | buffering |
| irritancy, com. | 0, 2 |
| what‑it‑does | antioxidant | perfuming | antimicrobial/antibacterial |
| what‑it‑does | antimicrobial/antibacterial | perfuming |