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Also-called-like-this: Insulin-like growth factor 1, IGF-1, rh-Oligopeptide-2

Official CosIng Information


Sh-Oligopeptide-2 is also called Insulin-like growth factor 1 and it belongs to the same group of ingredients (Growth Factors) as its better-known sister, Epidermal Growth Factor or Sh-Oligopeptide-1. This guy consists of 70 amino acids and, similar to EGF, it is also claimed to stimulate cell proliferation and wound healing. There is also a study that indicates EGF and IGF1 work in synergy to promote keratinocyte (skin cell) proliferation. 

The topic of Growth Factors in skincare is complex and controversial. If you are new to it, read our shiny explanation on EGF to get a (hopefully) balanced impression about the pros and cons.

Show me some proof

  • Krane, Jeffrey F., et al. "Synergistic effects of epidermal growth factor (EGF) and insulin-like growth factor I/somatomedin C (IGF-I) on keratinocyte proliferation may be mediated by IGF-I transmodulation of the EGF receptor." Journal of investigative dermatology 96.4 (1991): 419-424.

Products with SH-Oligopeptide-2

Manyo Factory 4Gf Eye Cream Eighth Day Regenerating Serum Catherine Jinn Age Gracefully Acure Radically Rejuvenating Whipped Night Cream Acure Radically Rejuvenating Whipped Night Cream Le Mieux 24 Hour Age Defying Cream Yuri Pibu Cellum Amaid Ampoule Drunk Elephant Protini™ Polypeptide Cream Isntree Egf Repair Cream Isntree Egf Repair Cream Kate Somerville Kx Active Concentrates Bio-Mimicking Peptides Serum Sidmool Min Jung Gi Efi Eye Cream Sidmool Royal Honey Peptide Deep Moisture Sleeping Pack Swanicoco Fermentation Peptine Eye Care Cream Neulii Cicapepta Repair Serum Sidmool Dr. Galatok Real Peptide Barrier Moisture Cream Colibri Cosmetics Hyaluron Konzentrat Murad Nutrient-Charged Water Gel Sidmool Madagascar Ultra Moisture Cream Nurse Jamie EGF Platinum 7 Rejuvenating Facial Cream Sidmool Bulgarian Rose Essential Sidmool Idebenone Elastic Ampoule Dr. Brandt Needles No More No More Baggage Plush Bio Contur Intensiv Ochi - Extract Proaspăt De Tei, Oligopeptide, Placentă MEDI-PEEL Naite Thread Neck Cream SeneGence Advanced Seneplex+® Renewal Serum With Retinol AnteAGE MD Serum AnteAGE Md Serum Saturday Skin Quench Intense Hydration Mask Saturday Skin Spotlight Brightening Mask Caolion Pore Deep Toner Isntree TW-Real Eye Cream Klairs Midnight Blue Calming Cream Klairs Midnight Blue Calming Cream Saturday Skin Balancing Act Skin-Smoothing Lotion dear Klairs Midnight Blue Calming Cream Missha Super Aqua Cell Renew Snail Ampoule Saturday Skin Pore Clarifying Toner 10% Glycolic Acid + Pore Control Complex Saturday Skin Waterfall Glacier Water Cream Sensilis Origin Pro Egf-5 Cream Klairs Freshly Juiced Vitamin C Serum LJH (LEEGEEHAAM) Plc Hope Repair Cream Saturday Skin Rub-A-Dub Refining Peel Gel dear Klairs Freshly Juiced Vitamin Drop DMCK Moisture Cream Saturday Skin Rise + Shine Purifying Cleanser Caolion P-Tox® Neck Recovery Cream Saturday Skin Daily Dew Hydrating Essence Mist Saturday Skin Yuzu Vitamin C Sleep Mask Saturday Skin Wide Awake Brightening Eye Cream