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Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-1

Also-called-like-this: Part of Matrixyl 3000, Pal-GHK, Formerly also Palmitoyl Oligopeptide


A really famous peptide that is part of Matrixyl 3000, the most sold peptide complex in the word. Before we go and find out what the big deal with Matrixyl 3000 is, let's just focus on Palmitoyl Tripeptide-1 itself for a bit.

It's a small three amino acid (they are the building blocks of all proteins) peptide with the amino sequence of glycine-histidine-lysine, or GHK. GHK is attached to palmitic acid (a fatty acid) to increase oil solubility and skin penetration. 

The GHK part is the important one as it's a type I collagen fragment. When collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen. Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more.

Therefore, Palmitoyl Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. 

In Matrixyl 3000, Palmitoyl Tripeptide-1 is coupled with Palmitoyl Tetrapeptide-7  and the duo works in synergy to reduce wrinkles and give younger looking skin. According to the manufacturer's in-vivo (made on real people) test, applying 3% Matrixyl 3000 twice a day for 2 months resulted in all of the following things:

  • 39.4% reduction in surface occupied by deep wrinkles
  • 32.9% reduction in main wrinkle density
  • 19.9% reduction in main wrinkle average depth
  • 16% improvement in roughness
  • 16.2% in lifting effect
  • 5.5% improvement in elasticity
  • 15.5% improvement in skin tone

Manufacturer results, of course, always have to be taken with a pinch of salt, but if you like peptides, the Matryxil 3000 duo is one of the best-proven and most well-known ones and it's something that is worth trying.

Show me some proof

  • Pai, Varadraj Vasant, Prasana Bhandari, and Pankaj Shukla. "Topical peptides as cosmeceuticals." Indian Journal of Dermatology, Venereology, and Leprology 83.1 (2017): 9.
  • Schagen, Silke Karin. "Topical peptide treatments with effective anti-aging results." Cosmetics 4.2 (2017): 16.
  • Gorouhi, F., and H. I. Maibach. "Role of topical peptides in preventing or treating aged skin." International journal of cosmetic science 31.5 (2009): 327-345.

Products with Palmitoyl Tripeptide-1

HSBCC Neck Firming Cream Iris&Romeo Power Peptide Lip Balm 1STLY Skincare Peptide Eye Lifting Serum Conscious Chemist The Defender™️ - Multi Peptide Retinol Night Cream Thrive Co Youth Renewal Starter Retinal Serum Trutuyu Willow Dream 4-in-1 Aqua Cream ISOMERS Skincare Copper P Concentrate Serum Le Mieux Collagen Peptide Serum Le Mieux Stemcell EGF Revuele Cys Reconstructors - Peptides Umoua Advanced Extraction Liposome Tech Peptide Serum Vitali Skin Cell Restorative Serum Be Minimalist Multi-Peptide Serum (7% Matrixyl 3000 + 3% Bio-Placenta) Cos De BAHA Peptide Serum Dermastir Ampoules – Egf Oligopeptide-1 Face Reality Antioxidant Peptide Eye Gel Helia-D Cell Concept Botox Effect Serum ISOMERS Skincare Matrixyl® 20% + Ha High Strength Peptide Body Serum Interostem Stem Cell Eye Serum Jaina Face Real Peptide Complex Serum Le Mieux Eye And Lip Cream Peter Thomas Roth Un-Wrinkle Turbo Line Smoothing Toning Lotion The Ordinary Matrixyl 10% + HA The Ordinary Matrixyl 10% + Ha The Ordinary Matrixyl 10% + Ha High Strength Peptide Formulation Vou Pre Serum minimalist Multi-peptides 10% nelly DEVUYST Lifting Peptides Serum Arcona Eye Serum Bassa Hydrin Hyaluronic Eye Serum Dark Circles BlissPro 11.8% AHA | BHA | PHA Liquid Exfoliant BlissPro Multi-peptide Youth Serum Cos De BAHA M.A Peptide Serum GOA Oil-Free Protein Moisturizer Glow Lab Pro Collagen Plumping Facial Serum Image Skincare Ageless Total Retinol-A Crème Mary Kay Timewise Night Solution Medik8 Liquid Peptides Merle Norman Gentle Solutions Toner Olival Proffesional Peptide Serum Paula's Choice Peptide Booster Philosophy When Hope Is Not Enough Hydrating Anti-Oxidant Serum Pure Sciences Neck Firming Cream Reviva Labs Under Eye Dark Circle Serum Revox Just Peptides 10% Revuele Polypeptide Face & Neck Serum Skincall Daily Triple Serum VI DERM Intense Hydration Serum schaf Age Repair Cream schaf Moisturizer