Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-1

Also-called-like-this: Part of Matrixyl 3000, Pal-GHK, Formerly also Palmitoyl Oligopeptide


A really famous peptide that is part of Matrixyl 3000, the most sold peptide complex in the word. Before we go and find out what the big deal with Matrixyl 3000 is, let's just focus on Palmitoyl Tripeptide-1 itself for a bit.

It's a small three amino acid (they are the building blocks of all proteins) peptide with the amino sequence of glycine-histidine-lysine, or GHK. GHK is attached to palmitic acid (a fatty acid) to increase oil solubility and skin penetration. 

The GHK part is the important one as it's a type I collagen fragment. When collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen. Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more.

Therefore, Palmitoyl Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. 

In Matrixyl 3000, Palmitoyl Tripeptide-1 is coupled with Palmitoyl Tetrapeptide-7  and the duo works in synergy to reduce wrinkles and give younger looking skin. According to the manufacturer's in-vivo (made on real people) test, applying 3% Matrixyl 3000 twice a day for 2 months resulted in all of the following things:

  • 39.4% reduction in surface occupied by deep wrinkles
  • 32.9% reduction in main wrinkle density
  • 19.9% reduction in main wrinkle average depth
  • 16% improvement in roughness
  • 16.2% in lifting effect
  • 5.5% improvement in elasticity
  • 15.5% improvement in skin tone

Manufacturer results, of course, always have to be taken with a pinch of salt, but if you like peptides, the Matryxil 3000 duo is one of the best-proven and most well-known ones and it's something that is worth trying.

Show me some proof

  • Pai, Varadraj Vasant, Prasana Bhandari, and Pankaj Shukla. "Topical peptides as cosmeceuticals." Indian Journal of Dermatology, Venereology, and Leprology 83.1 (2017): 9.
  • Schagen, Silke Karin. "Topical peptide treatments with effective anti-aging results." Cosmetics 4.2 (2017): 16.
  • Gorouhi, F., and H. I. Maibach. "Role of topical peptides in preventing or treating aged skin." International journal of cosmetic science 31.5 (2009): 327-345.

Products with Palmitoyl Tripeptide-1

Jaina Face Real Peptide Complex Serum Peter Thomas Roth Un-Wrinkle Turbo Line Smoothing Toning Lotion The Ordinary Matrixyl 10% + Ha Cos De BAHA M.A Peptide Serum Mary Kay Timewise Night Solution Paula's Choice Peptide Booster 2Sol Elixir Propolis Serum The Ordinary Buffet The Ordinary Buffet + Copper Peptides 1% Isomers All-In-One Complete Face Firming Serum Isomers All-In-One Nutri-Gym Body Toning Moisturizer Isomers All-In-One The Cream Bliss Eye Do All Things Paula's Choice Resist Advanced Smoothing Treatment 10% Aha Dr Macrene High Performance Anti-Aging Cream Paula's Choice Resist Weightless Advanced Repairing Toner Sebamed Anti-Ageing Augencreme Allies of Skin Molecular Saviour Mist Manyo Factory Lactobacillus Bifida Mist Paula's Choice Resist Barrier Repair Moisturizer SkinMedica Tns Ceramide Treatment Cream Sugar Baby Vita+Skin Crème De La Crème Daily Moisture Cream 2Sol Facial Recovery Booster Perricone MD Cold Plasma Face Serum Concentrate The Inkey List Hyaluronic Acid Serum Allies of Skin 1A Overnight Mask Diadermine Lift+ Super Filler Hyaluron Anti-Age Nachtcreme Paula's Choice Resist 1% Retinol Booster Paula's Choice Resist Brightening Essence Treatment Revolution Skincare Wrinkle & Fine Line Reducing Serum - 10% Matrixyl Dmk Beta Gel Dr Dennis Gross Triple C Firming Peptide Oil Drunk Elephant Shaba Complex Eye Serum Revolution Skincare Multi Targeting & Firming Serum - Multi Peptide Serum NIOD Lip Bio-Lipid Concentrate Paula's Choice Skin Recovery Replenishing Moisturizer Algenist Genius Liquid Collagen MIss Spa 24K Gold Crème Mask Drunk Elephant C-Tango Multivitamin Eye Cream Drunk Elephant Protini™ Polypeptide Cream No7 Line Correcting Booster Serum Purito Centella Green Level Eye Cream VENeffect Anti-Aging Moisturizer Spf 15 Clinique Fresh Pressed Daily Booster With Pure Vitamin C 10% Paula's Choice Resist Intensive Repair Cream Hanskin Super Light Touch Bb Drunk Elephant Lippe Balm Allies of Skin Bright Future Overnight Facial Manyo Factory Bifidalacto Eye Cream Caudalie Premier Cru The Rich Cream