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Palmitoyl Pentapeptide-4

Also-called-like-this: Matrixyl, Pal-KTTKS, Formerly Palmitoyl Pentapeptide-3


A pretty famous and better-researched peptide consisting of five amino acids (the building blocks of all proteins). It was created in a joint effort by the French ingredient supplier, Sederma and the cosmetics industry big shot, Procter&Gamble.

The amino acid sequence of the peptide is lysine–threonine–threonine–lysine–serine (KTTKS). Sometimes, it's also called collagen pentapeptide, as it's a subfragment of skin-structure-giving type I collagen. The KTTKS amino sequence is then attached for better oil solubility and skin penetration to palmitic acid and BOOM; we get Palmitoyl Pentapeptide-4. 

Though most research is manufacturer sponsored, the clinical studies about Palmitoyl Pentapeptide-4 are promising.  In short, it can reduce fine lines, wrinkles and improve skin texture significantly (and at crazy low concentrations, the studies were done with just 3 ppm that is 0.0003%).

There are also studies comparing Palmitoyl Pentapeptide-4 with anti-aging gold standard, retinol. One of them compared 3ppm Pal-KTTKS with 700 ppm (0.07%) retinol and found that they showed similar wrinkle improving ability with the peptide showing better skin tolerability.

Bottom line, if you are into peptides, this is a good one to try.

Show me some proof

  • International Journal of Cosmetic Science, Dec 1, 2011, Topically applied KTTKS: a review

Products with Palmitoyl Pentapeptide-4

Le Mieux Bio Cell Rejuvenating Cream Le Mieux Essence Moisturizer Reviva Labs Nasolabial Fold+ Multi-Peptide Comp Dr Sebagh Serum Repair Isomers All-In-One Mesmer-Eyez Tightening Eye Formula LeMieux Eye Wrinkle Corrector NCN PRO SKINCARE Multi-Active Accelerator Isomers Matrixyl-4 Pur Collagen Peptide Serum Olay Deep Hydrating Eye Gel For Tired Dehydrated Skin ECLADO Cell Magic Skin Lotion Simple Beauty Fine Line Eye Serum Umoua Advanced Extraction Liposome Tech Peptide Renewal Cream Olay Golden Aura Youth Essence Philosophy When Hope Is Not Enough Serum Pixi Plump Collagen Boost Sheet Mask Olay Deep Hydrating Eye Gel Olay Golden Aura Melting Soufflé Moisturizer Air Finish Olay Regenerist Fragrance-Free Regenerating Face Serum Olay Regenerist Regenerating Serum (2016 Version) TIA'M My Signature Vita B5 Toner Image Vital C Hydrating Anti-Aging Serum Isomers All-In-One Nutri-Gym Body Toning Moisturizer Joelle Ciocco Eyelisse/Eye Lip Contour Cream Olay Regenerating Serum Olay Regenerist 3-Point Super Serum Osmotics Blue Copper 5 Firming Elasticity Repair Cosme Decorte Liposome Eye Cream LANCER Lift & Plump Sheet Mask Mizon Peptide 500 Olay Olay Regenerist Micro-Sculpting Cream With Sunscreen Broad Spectrum Spf 30 Olay Regenerist 3 Point Day Cream Spf 30 Olay Regenerist 3-Point Treatment Cream Olay Regenerist Micro-Sculpting Serum Fragrance-Free Olay Regenerist Night Recovery Cream Umoua Barrier Repair Essential Emulsion Cosme Decorte Aq Lotion Cosme Decorte Aq Lotion Extra Rich Olay Luminous Brightening & Protecting Lotion With Sunscreen Broad Spectrum Spf 30 Olay Regenerist Micro-Sculpting Cream Olay Unscented Olay Regenerist Micro-Sculpting Cream Face Moisturizer Olay ProX Hydra Firming Cream Simple Beauty Retinol Cream Cosme Decorte Aq Toning Lotion Sidmool Saccharo Ferment Therapy Essence dr. denese Triple Strength Neck Wrinkle Smoother Mizon Snail Repair Intensive Ampoule Olay Eyes Brightening Eye Cream Olay Regenerist Eye Lifting Serum Cosme Decorte Aq Oil Infusion Cosme Decorte Aq Massage Cream