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Palmitoyl Pentapeptide-4

Also-called-like-this: Matrixyl, Pal-KTTKS, Formerly Palmitoyl Pentapeptide-3


A pretty famous and better-researched peptide consisting of five amino acids (the building blocks of all proteins). It was created in a joint effort by the French ingredient supplier, Sederma and the cosmetics industry big shot, Procter&Gamble.

The amino acid sequence of the peptide is lysine–threonine–threonine–lysine–serine (KTTKS). Sometimes, it's also called collagen pentapeptide, as it's a subfragment of skin-structure-giving type I collagen. The KTTKS amino sequence is then attached for better oil solubility and skin penetration to palmitic acid and BOOM; we get Palmitoyl Pentapeptide-4. 

Though most research is manufacturer sponsored, the clinical studies about Palmitoyl Pentapeptide-4 are promising.  In short, it can reduce fine lines, wrinkles and improve skin texture significantly (and at crazy low concentrations, the studies were done with just 3 ppm that is 0.0003%).

There are also studies comparing Palmitoyl Pentapeptide-4 with anti-aging gold standard, retinol. One of them compared 3ppm Pal-KTTKS with 700 ppm (0.07%) retinol and found that they showed similar wrinkle improving ability with the peptide showing better skin tolerability.

Bottom line, if you are into peptides, this is a good one to try.

Show me some proof

  • International Journal of Cosmetic Science, Dec 1, 2011, Topically applied KTTKS: a review

Products with Palmitoyl Pentapeptide-4

Crystolite Melona-F NCN PRO SKINCARE Multi-Active Peptide Matrixyl Serum 25% The Ordinary Matrixyl 10% + Ha Kalahari Vita-Gel Mask NutriBiotic Ultra-Hydrating, Peptide Face Creme Olay Pro Advanced Regenerist Complex Clear SkinCare Tighten Serum Dermadoctor Wrinkle Revenge Rescue And Protect Eye Balm Image Skincare Vital C Hydrating Eye Recovery Gel Innertrue Focus Penta Hyaluronic + Peptide Ampoule Makeup Artist Choice Transforming Anti Aging Serum - Loaded With Multi-Actives Skin Actives Scientific Palmitoyl Pentapeptide-3 Suiphar Peptix CELLBONE Collagen Peptide Xc CELLBONE Hyper Peptides Cara Skin Care Amicelle Anti-Line Serum Joli Brightening Serum Joli Sculpting & Firming Serum Lanbena Grape Seed Cream Moisturizer Lanbena Grape Seed Eye Cream Le Mieux Bio Cell Rejuvenating Cream Le Mieux Bio Cell Rejuvenating Cream Le Mieux Bio Cell Rejuvenating Cream Le Mieux Essence Moisturizer Le Mieux Moisture Infusion Mask Le Mieux Tgf-B Eye Firming Mask Nayelle Revitalizing Serum Nayelle Vitamin C Luminous Serum Olay Advanced Brightening Sheet Mask Olay Winkle And Pore Filler Olay Regenerist Wrinkle & Pore Vanisher Reviva Labs Nasolabial Fold+ Multi-Peptide Comp Skoah. Skin Boost Serum Tree of Life Pro Collagen Triple Peptide Serum Circadia Myo-Cyte Plus Anti Wrinkle Serum Derma Geek Smoothing Facial Serum 0.3% Retinoid Dermaroller Intensive Hyaluronic Moisturizer Mask Isomers All-In-One Mesmer-Eyez Tightening Eye Formula Le Mieux Collagen Peptide Serum Le Mieux Eye Wrinkle Corrector LeMieux Eye Wrinkle Corrector MD Skinical Clear Resveratrol Makeup Artist's Choice Peptide Serum with Botanicals NCN PRO SKINCARE Multi-Active Accelerator Olay Collagen Peptide 24 Max Optaderm Profound Facial Serum REPLENIX Growth Factor Restorative Serum Revoderm Illuminous Antioxidant Serum SkinPep Collagen Renew Growth Factor Night Cream SkinPep Super C15 Serum