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Palmitoyl Pentapeptide-4

Also-called-like-this: Matrixyl, Pal-KTTKS, Formerly Palmitoyl Pentapeptide-3


A pretty famous and better-researched peptide consisting of five amino acids (the building blocks of all proteins). It was created in a joint effort by the French ingredient supplier, Sederma and the cosmetics industry big shot, Procter&Gamble.

The amino acid sequence of the peptide is lysine–threonine–threonine–lysine–serine (KTTKS). Sometimes, it's also called collagen pentapeptide, as it's a subfragment of skin-structure-giving type I collagen. The KTTKS amino sequence is then attached for better oil solubility and skin penetration to palmitic acid and BOOM; we get Palmitoyl Pentapeptide-4. 

Though most research is manufacturer sponsored, the clinical studies about Palmitoyl Pentapeptide-4 are promising.  In short, it can reduce fine lines, wrinkles and improve skin texture significantly (and at crazy low concentrations, the studies were done with just 3 ppm that is 0.0003%).

There are also studies comparing Palmitoyl Pentapeptide-4 with anti-aging gold standard, retinol. One of them compared 3ppm Pal-KTTKS with 700 ppm (0.07%) retinol and found that they showed similar wrinkle improving ability with the peptide showing better skin tolerability.

Bottom line, if you are into peptides, this is a good one to try.

Show me some proof

  • International Journal of Cosmetic Science, Dec 1, 2011, Topically applied KTTKS: a review

Products with Palmitoyl Pentapeptide-4

Le Mieux Bio Cell Rejuvenating Cream Le Mieux Essence Moisturizer Reviva Labs Nasolabial Fold+ Multi-Peptide Comp Dr Sebagh Serum Repair Isomers All-In-One Mesmer-Eyez Tightening Eye Formula LeMieux Eye Wrinkle Corrector Isomers Matrixyl-4 Pur Collagen Peptide Serum Olay Deep Hydrating Eye Gel For Tired Dehydrated Skin ECLADO Cell Magic Skin Lotion Simple Beauty Fine Line Eye Serum Olay Golden Aura Youth Essence Philosophy When Hope Is Not Enough Serum Pixi Plump Collagen Boost Sheet Mask Olay Deep Hydrating Eye Gel Olay Golden Aura Melting Soufflé Moisturizer Air Finish TIA'M My Signature Vita B5 Toner Image Vital C Hydrating Anti-Aging Serum Isomers All-In-One Nutri-Gym Body Toning Moisturizer Joelle Ciocco Eyelisse/Eye Lip Contour Cream Olay Regenerating Serum Olay Regenerist 3-Point Super Serum LANCER Lift & Plump Sheet Mask Mizon Peptide 500 Olay Olay Regenerist Micro-Sculpting Cream With Sunscreen Broad Spectrum Spf 30 Olay Regenerist 3 Point Day Cream Spf 30 Olay Regenerist 3-Point Treatment Cream Olay Regenerist Micro-Sculpting Serum Fragrance-Free Olay Regenerist Night Recovery Cream Olay Luminous Brightening & Protecting Lotion With Sunscreen Broad Spectrum Spf 30 Olay Regenerist Micro-Sculpting Cream Olay Unscented Olay Regenerist Micro-Sculpting Cream Face Moisturizer Olay ProX Hydra Firming Cream Simple Beauty Retinol Cream Sidmool Saccharo Ferment Therapy Essence dr. denese Triple Strength Neck Wrinkle Smoother Mizon Snail Repair Intensive Ampoule Fancl Active Conditioning Ex Emulsion Olay Olay Pro-Retinol Eye Treatment Nuface Optimizing Mist Pion-tech Volume Tox Original Peptide Essence Dr. Jart+ Multi Action Eye Balm Dark Spot Corrector Holika Holika One Solution Anti-Wrinkle Ampoule Dr Sebagh Deep Exfoliating Mask Joelle Ciocco Médiateur Oxygénation Mizon Mizon Snail Repair Eye Cream it Cosmetics Bye Bye Under Eye Eye Cream Olaz Regenerist 3-Zonen Straffende Nachtcreme Sesderma C-Vit Glowing Facial Fluid Manyo Factory Bifidalacto Eye Cream Dermalogica Age Smart Power Rich