Palmitoyl Pentapeptide-4

Also-called-like-this: Matrixyl, Pal-KTTKS, Formerly Palmitoyl Pentapeptide-3


A pretty famous and better-researched peptide consisting of five amino acids (the building blocks of all proteins). It was created in a joint effort by the French ingredient supplier, Sederma and the cosmetics industry big shot, Procter&Gamble.

The amino acid sequence of the peptide is lysine–threonine–threonine–lysine–serine (KTTKS). Sometimes, it's also called collagen pentapeptide, as it's a subfragment of skin-structure-giving type I collagen. The KTTKS amino sequence is then attached for better oil solubility and skin penetration to palmitic acid and BOOM; we get Palmitoyl Pentapeptide-4. 

Though most research is manufacturer sponsored, the clinical studies about Palmitoyl Pentapeptide-4 are promising.  In short, it can reduce fine lines, wrinkles and improve skin texture significantly (and at crazy low concentrations, the studies were done with just 3 ppm that is 0.0003%).

There are also studies comparing Palmitoyl Pentapeptide-4 with anti-aging gold standard, retinol. One of them compared 3ppm Pal-KTTKS with 700 ppm (0.07%) retinol and found that they showed similar wrinkle improving ability with the peptide showing better skin tolerability.

Bottom line, if you are into peptides, this is a good one to try.

Show me some proof

  • International Journal of Cosmetic Science, Dec 1, 2011, Topically applied KTTKS: a review

Products with Palmitoyl Pentapeptide-4

Reviva Labs Nasolabial Fold+ Multi-Peptide Comp Dr Sebagh Serum Repair ECLADO Cell Magic Skin Lotion Philosophy When Hope Is Not Enough Serum Isomers All-In-One Nutri-Gym Body Toning Moisturizer Joelle Ciocco Eyelisse/Eye Lip Contour Cream Olay Regenerist 3-Point Super Serum Mizon Peptide 500 Olay Olay Regenerist Micro-Sculpting Cream With Sunscreen Broad Spectrum Spf 30 Olay Regenerist 3 Point Day Cream Spf 30 Olay Regenerist 3-Point Treatment Cream Olay Regenerist Night Recovery Cream Olay Luminous Brightening & Protecting Lotion With Sunscreen Broad Spectrum Spf 30 Olay Regenerist Micro-Sculpting Cream Simple Beauty Retinol Cream Mizon Snail Repair Intensive Ampoule Fancl Active Conditioning Ex Emulsion Olay Olay Pro-Retinol Eye Treatment Nuface Optimizing Mist Dr. Jart+ Multi Action Eye Balm Dark Spot Corrector Holika Holika One Solution Anti-Wrinkle Ampoule Dr Sebagh Deep Exfoliating Mask Mizon Mizon Snail Repair Eye Cream it Cosmetics Bye Bye Under Eye Eye Cream Olaz Regenerist 3-Zonen Straffende Nachtcreme Manyo Factory Bifidalacto Eye Cream Dermalogica Age Smart Power Rich IOPE Whitegen Eye Serum Mizon Snail Repair Eye Cream Dr Sebagh Deep Exfoliating Mask Sensitive Skin Mizon Snail Recovery Gel Cream JM Solution Derma Care Centella Madeca Capsule Mask Eyenlip Hydrogel Eye Patch Salmon Oil & Peptide Eyenlip Salmon Oil Nutrition Serum Holika Holika One Solution Super Energy Anti-Wrinkle Ampoule Koh Gen Do Macro Vintage Royal Massage Milk Skin Actives Vitamin A Cream Mizon All-In-One Snail Repair Cream Nature Republic Collagen Dream 90 Skin Booster SK-II R.N.A.Power Essence DrGL Moisturiser Anti-Aging Eyenlip Salmon Oil Nutrition Eye Cream Panacea The Aegis Daily Facial Moisturizer Nature Republic Collagen Dream 70 Cream Missha Aqua Peptide Custom Skin Care Toner Nature Republic Collagen Dream 70 Eye Cream Thank You Farmer True Water Deep Serum Too Cool For School Rules Of Mastic Ix Enhancer Earth's Recipe Moisture Bound Cream Thank You Farmer Miracle Age Repair Toner