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Palmitoyl Pentapeptide-4

Also-called-like-this: Matrixyl, Pal-KTTKS, Formerly Palmitoyl Pentapeptide-3

Official CosIng Information


A pretty famous and better-researched peptide consisting of five amino acids (the building blocks of all proteins). It was created in a joint effort by the French ingredient supplier, Sederma and the cosmetics industry big shot, Procter&Gamble.

The amino acid sequence of the peptide is lysine–threonine–threonine–lysine–serine (KTTKS). Sometimes, it's also called collagen pentapeptide, as it's a subfragment of skin-structure-giving type I collagen. The KTTKS amino sequence is then attached for better oil solubility and skin penetration to palmitic acid and BOOM; we get Palmitoyl Pentapeptide-4. 

Though most research is manufacturer sponsored, the clinical studies about Palmitoyl Pentapeptide-4 are promising.  In short, it can reduce fine lines, wrinkles and improve skin texture significantly (and at crazy low concentrations, the studies were done with just 3 ppm that is 0.0003%).

There are also studies comparing Palmitoyl Pentapeptide-4 with anti-aging gold standard, retinol. One of them compared 3ppm Pal-KTTKS with 700 ppm (0.07%) retinol and found that they showed similar wrinkle improving ability with the peptide showing better skin tolerability.

Bottom line, if you are into peptides, this is a good one to try.

Show me some proof

  • International Journal of Cosmetic Science, Dec 1, 2011, Topically applied KTTKS: a review

Products with Palmitoyl Pentapeptide-4

NCN PRO SKINCARE Multi-Active Peptide Matrixyl Serum 25% NutriBiotic Ultra-Hydrating, Peptide Face Creme Le Mieux Bio Cell Rejuvenating Cream Le Mieux Bio Cell Rejuvenating Cream Le Mieux Essence Moisturizer Le Mieux Moisture Infusion Mask Le Mieux Tgf-B Eye Firming Mask Reviva Labs Nasolabial Fold+ Multi-Peptide Comp Dr Sebagh Serum Repair Isomers All-In-One Mesmer-Eyez Tightening Eye Formula Le Mieux Collagen Peptide Serum Le Mieux Collagen Peptide Serum Le Mieux Eye Wrinkle Corrector LeMieux Eye Wrinkle Corrector MD Skinical Clear Resveratrol NCN PRO SKINCARE Multi-Active Accelerator Isomers Matrixyl-4 Pur Collagen Peptide Serum Le Mieux Eye And Lip Cream Olay Deep Hydrating Eye Gel For Tired Dehydrated Skin Olay Professional Prox Hydra Firming Anti-Aging Face Cream Moisturizer Olay Wrinkle Correction Serum ECLADO Cell Magic Skin Lotion Olay Professional Prox Wrinkle Smoothing Cream Anti-Aging Moisturizer Olay Regenerist Retinol 24 Night Facial Serum Olaz Regenerist Retinol24 Serum (EU) Proud Mary Peptide Ampoule Simple Beauty Fine Line Eye Serum Umoua Advanced Extraction Liposome Tech Peptide Renewal Cream Ddf Wrinkle Resist Plus Pore Minimizer Moisturizing Serum Olay Golden Aura Youth Essence Philosophy When Hope Is Not Enough Serum Pixi Plump Collagen Boost Sheet Mask Mineral Fusion Intense Hydration Face Cream Natio Ageless Brightening Eye Cream Olay Deep Hydrating Eye Gel Olay Golden Aura Melting Soufflé Moisturizer Air Finish Olay Regenerist Fragrance-Free Regenerating Face Serum Olay Regenerist Regenerating Serum (2016 Version) Olay Regenerist Retinol 24 Olaz Regenerist Retinol24 Cream (Eu) TIA'M My Signature Vita B5 Toner Zeroid Dermanewal Revitalizing Ampoule Erin’s Faces Peptide Spf 30 - Uva/Uvb Image Vital C Hydrating Anti-Aging Serum Isomers All-In-One Nutri-Gym Body Toning Moisturizer Joelle Ciocco Eyelisse/Eye Lip Contour Cream Olay Eyes Ultimate Eye Cream Olay Regenerating Serum Olay Regenerist 3-Point Super Serum Olay Regenerist Advanced Anti-Ageing 3 Point Firming Serum