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Palmitoyl Pentapeptide-4

Also-called-like-this: Matrixyl, Pal-KTTKS, Formerly Palmitoyl Pentapeptide-3


A pretty famous and better-researched peptide consisting of five amino acids (the building blocks of all proteins). It was created in a joint effort by the French ingredient supplier, Sederma and the cosmetics industry big shot, Procter&Gamble.

The amino acid sequence of the peptide is lysine–threonine–threonine–lysine–serine (KTTKS). Sometimes, it's also called collagen pentapeptide, as it's a subfragment of skin-structure-giving type I collagen. The KTTKS amino sequence is then attached for better oil solubility and skin penetration to palmitic acid and BOOM; we get Palmitoyl Pentapeptide-4. 

Though most research is manufacturer sponsored, the clinical studies about Palmitoyl Pentapeptide-4 are promising.  In short, it can reduce fine lines, wrinkles and improve skin texture significantly (and at crazy low concentrations, the studies were done with just 3 ppm that is 0.0003%).

There are also studies comparing Palmitoyl Pentapeptide-4 with anti-aging gold standard, retinol. One of them compared 3ppm Pal-KTTKS with 700 ppm (0.07%) retinol and found that they showed similar wrinkle improving ability with the peptide showing better skin tolerability.

Bottom line, if you are into peptides, this is a good one to try.

Show me some proof

  • International Journal of Cosmetic Science, Dec 1, 2011, Topically applied KTTKS: a review

Products with Palmitoyl Pentapeptide-4

NCN PRO SKINCARE Multi-Active Peptide Matrixyl Serum 25% The Ordinary Matrixyl 10% + Ha Kalahari Vita-Gel Mask NutriBiotic Ultra-Hydrating, Peptide Face Creme Dermadoctor Wrinkle Revenge Rescue And Protect Eye Balm Image Skincare Vital C Hydrating Eye Recovery Gel Makeup Artist Choice Transforming Anti Aging Serum - Loaded With Multi-Actives Suiphar Peptix CELLBONE Collagen Peptide Xc CELLBONE Hyper Peptides Cara Skin Care Amicelle Anti-Line Serum Joli Brightening Serum Joli Sculpting & Firming Serum Lanbena Grape Seed Cream Moisturizer Le Mieux Bio Cell Rejuvenating Cream Le Mieux Bio Cell Rejuvenating Cream Le Mieux Bio Cell Rejuvenating Cream Le Mieux Essence Moisturizer Le Mieux Moisture Infusion Mask Le Mieux Tgf-B Eye Firming Mask Nayelle Revitalizing Serum Nayelle Vitamin C Luminous Serum Olay Winkle And Pore Filler Olay Regenerist Wrinkle & Pore Vanisher Reviva Labs Nasolabial Fold+ Multi-Peptide Comp Skoah. Skin Boost Serum Circadia Myo-Cyte Plus Anti Wrinkle Serum Derma Geek Smoothing Facial Serum 0.3% Retinoid Dermaroller Intensive Hyaluronic Moisturizer Mask Isomers All-In-One Mesmer-Eyez Tightening Eye Formula Le Mieux Collagen Peptide Serum Le Mieux Collagen Peptide Serum Le Mieux Eye Wrinkle Corrector LeMieux Eye Wrinkle Corrector MD Skinical Clear Resveratrol Makeup Artist's Choice Peptide Serum with Botanicals NCN PRO SKINCARE Multi-Active Accelerator Optaderm Profound Facial Serum Revoderm Illuminous Antioxidant Serum SkinPep Super C15 Serum Trish McEvoy Trish McEvoy Beauty Booster Serum Aaron Carre Re:Turn Peptide Serum Isomers Matrixyl-4 Pur Collagen Peptide Serum Joli Wrinkle Defence Serum Le Mieux Eye And Lip Cream Le Mieux Retinol Serum Le Mieux Retinol Serum Olay Deep Hydrating Eye Gel For Tired Dehydrated Skin Olay Magnemasks Advanced Anti Wrinkle Sheet Mask Olay Professional Prox Hydra Firming Anti-Aging Face Cream Moisturizer