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iS Clinical Youth Intensive Creme

Youth Intensive Creme

A hydrating face cream with intensive anti-aging ingredients.
Uploaded by: ab2859 on

Highlights

#alcohol-free
Alcohol Free

Show all ingredients by function

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Ingredient name what-it-does irr., com. ID-Rating
Water/Aqua/Eau solvent
Hyaluronic Acid skin-identical ingredient, moisturizer/​humectant goodie
Caprylic/Capric Triglyceride emollient
Vaccinium Myrtillus Fruit/Leaf Extract
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar
Urea skin-identical ingredient, moisturizer/​humectant goodie
Glucose moisturizer/​humectant goodie
Guanidine Hcl buffering
Tripeptide-1 cell-communicating ingredient goodie
Saccharum Officinarum (Sugar Cane) Extract\Extrait De Canne À Sucre moisturizer/​humectant goodie
Salix Alba (Willow) Bark Extract soothing goodie
Glyceryl Dilaurate emollient, emulsifying
Tetrahexyldecyl Ascorbate antioxidant, skin brightening goodie
Dimethicone emollient 0, 1
Cetyl Alcohol emollient, emulsifying, viscosity controlling, surfactant/​cleansing 2, 2
Dipalmitoyl Hydroxyproline
Superoxide Dismutase antioxidant goodie
Ormenis Multicaulis Oil
Citrus Aurantium Dulcis (Orange) Peel Oil perfuming icky
Phospholipids skin-identical ingredient, emollient goodie
Retinyl Palmitate cell-communicating ingredient 1-3, 1-3
Tocopheryl Acetate antioxidant 0, 0
Pantothenic Acid
Acer Saccharum (Sugar Maple) Extract
Citrus Aurantium Dulcis (Orange) Fruit Extract
Citrus Medica Limonum (Lemon) Fruit Extract
Asiaticoside antioxidant, perfuming goodie
Asiatic Acid goodie
Madecassic Acid goodie
Ascorbyl Palmitate antioxidant 0, 2 icky
PEG-8/Smdi Copolymer
Dipotassium Glycyrrhizate soothing, moisturizer/​humectant goodie
Soy Isoflavones antioxidant goodie
Ethylbisiminomethylguaiacol Manganese Chloride antioxidant goodie
Hexylene Glycol solvent, emulsifying, perfuming, surfactant/​cleansing 0-1, 0-2
Ethylhexyl Palmitate emollient, perfuming 0, 2-4
Silica Dimethyl Silylate emollient, viscosity controlling
Butylene Glycol moisturizer/​humectant, solvent, viscosity controlling 0, 1
Cetearyl Alcohol emollient, viscosity controlling, emulsifying, surfactant/​cleansing 1, 2
Ceteareth-20 emulsifying, surfactant/​cleansing 3, 2
Glyceryl Stearate emollient, emulsifying 0, 1-2
PEG-100 Stearate surfactant/​cleansing, emulsifying 0, 0
Carbomer viscosity controlling 0, 1
Xanthan Gum viscosity controlling, emulsifying, surfactant/​cleansing
PVP viscosity controlling 0, 0
Panthenol soothing, moisturizer/​humectant 0, 0 goodie
Triethanolamine buffering 0, 2
Disodium EDTA chelating, viscosity controlling
Caprylyl Glycol moisturizer/​humectant, emollient
Methylglucoside Phosphate cell-communicating ingredient goodie
Copper Lysinate/Prolinate cell-communicating ingredient goodie
1,2-Hexanediol solvent

iS Clinical Youth Intensive Creme
Ingredients explained

Also-called: Aqua;Water | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

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Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

  • It’s naturally in our skin and behaves there like a sponge
  • It can bind up to 1000 times its own weight in water
  • It is a big molecule from repeated subunits (polymer) so different molecular weight versions exist (unfortunately there is no way to determine MW from INCI list only)
  • High-molecular-weight-HA (>500 kDa) is an excellent surface hydrator, skin protectant and can act as an osmotic pump helping water-soluble actives to penetrate deeper into the skin
  • Low-molecular-weight-HA (< 500 kDa) can hydrate the skin somewhat deeper though it is still a big molecule and works mainly in the epidermis (outer layer of the skin)
  • Low-molecular-weight-HA might also help the skin to repair itself by increasing its self-defense (~ 200kDa used in the study)
  • Ultra-low-molecular-weight-HA (<50kDa) is a controversial ingredient and might work as a pro-inflammatory signal molecule
Read all the geeky details about Hyaluronic Acid here >>

What-it-does: emollient

A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, is super well tolerated by every skin type and easy to formulate with. No wonder it’s popular. 

What-it-does: astringent

We don't have description for this ingredient yet.

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

Urea - goodie
Also-called: Carbamide | What-it-does: skin-identical ingredient, moisturizer/humectant

Yes, it's the thing that can be found naturally in pee. And in the skin. It is an awesome natural moisturizing factor, aka NMF.  NMFs are important components that help the skin to hold onto water and keep it plump, elastic and hydrated. Urea makes up about 7% of NMFs next to other things such as amino acids (40%), PCA (12%) or Lactate (12%).

What makes urea special, is that it is not only a simple moisturizer, but it is thought to be a "small-molecule regulator of epidermal structure and function" meaning that it has a bunch of extra biological activities. It acts as a mild keratolytic agent (some of its moisturizing action is thought to come from urea's ability to break down bonds in the protein called filaggrin and thus freeing up amino acids in the skin), enhances antimicrobial peptide expression and improves skin barrier function

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Being a mild keratolytic agent and strong moisturizer means that high-percentage (10-40%) urea treatments are found effective in a bunch of skin disorders connected to excessive dryness and malfunctioning skin barrier such as ichthyosis, xerosis, psoriasis, eczema and seborrheic dermatitis.  

Overall, just like glycerin, urea is a real oldie but a goodie, a nice ingredient in any moisturizer.

Glucose - goodie
What-it-does: moisturizer/humectant

A fancy name for sugar. Luckily when you put it on your skin it's good for you not like when you eat it. :) It has water-binding properties, which means that it helps to keep your skin nice and hydrated

What-it-does: buffering

We don't have description for this ingredient yet.

Tripeptide-1 - goodie
Also-called: GHK, Kollaren | What-it-does: cell-communicating ingredient

A small, three amino acid (glycine-histidine-lysine or GHK) peptide that is famous for being a type I collagen fragment. The theory behind collagen-fragment peptides is that when collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen.

Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more. So Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. FYI; Tripeptide-1 is the same peptide that can be found in the famous Matrixyl 3000, but in Matrixyl a palmitic acid is attached to it to increase its oil solubility and thus skin penetration.

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Another reason why Tripeptide-1 is especially famous is that it is not only a signal peptide but also a so-called carrier peptide that helps to stabilize and deliver copper in the skin. It has a high affinity for copper ions and likes to form a complex with them called Copper-Tripeptide-1 or GHK-Cu. GHK-Cu is a famous and well-researched peptide that does a bunch of things in the skin and we have a shiny explanation about it here

As for Tripeptide-1 in and of itself, without a palmitic acid or copper attached to it, it goes by the trade name Kollaren and according to the manufacturer, it not only stimulates collagen but also other essential skin proteins such as fibronectin, elastin, and laminin. Kollaren is also claimed to be beneficial for acne-prone skin as it can boost tissue repair and thus help acne scars to heal faster. 

Also-called: Sugar Cane Extract;Saccharum Officinarum Extract | What-it-does: moisturizer/humectant

Also known as Sugarcane, Saccharum Officinarum is a handy moisturizing ingredient mostly used as a humectant. This means that it can help the skin to attract water and then to hold onto it. 
 
It bears a close relationship to AHA superstar, Glycolic Acid that can be derived from it, so it's often claimed that Sugarcane Extract itself also exfoliates and brightens the skin. We could not find any research studies to back this up, but Saccharum Officinarum very often comes to the formula combined with other acid containing plant extracts trade named ACB Fruit Mix. According to manufacturer data, 5% of the fruit mix increases cellular renewal by 24%, while 4% pure Glycolic did the same by 33%. So maybe, a tiny bit of exfoliation, but if you want proven efficacy, stick to pure acids. 

Also-called: White Willow Bark Extract | What-it-does: soothing, astringent

The extract coming from the bark of the White Willow, a big (25 m/80 ft.) tree that likes to live on riverbanks. It's famous for containing anti-inflammatory natural salicylates (this powder, for example, is standardized to contain 53-65%), a close chemical relative to famous exfoliant salicylic acid.

Thanks to its salicin content, willow bark is often touted as a natural alternative to salicylic acid, though it's quite questionable how effective it is as a chemical exfoliant in the tiny amounts used in cosmetics. Apart from soothing salicin, it also contains flavonoids and phenolic acids that give willow bark tonic, astringent, and antiseptic properties.

What-it-does: emollient, emulsifying

We don't have description for this ingredient yet.

Also-called: Form of Vitamin C, Ascorbyl Isotetrapalmitate, Ascorbyl Tetraisopalmitate, ATIP | What-it-does: antioxidant, skin brightening

Tetrahexyldecyl Ascorbate is a stable, oil-soluble form of skincare big shot Vitamin C. If you do not know, why Vitamin C is such a big deal in skincare, click here and read all about it. We are massive vitamin C fans and have written about it in excruciating detail.

So now, you know that Vitamin C is great and all, but it's really unstable and gives cosmetics companies many headaches. To solve this problem they came up with vitamin C derivatives, and one of them is Tetrahexyldecyl Ascorbate (let's call it ATIP in short).

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It's a really promising candidate (see below), but while reading all the goodness about it in a minute, do not forget that derivatives not only have to be absorbed into the skin but also have to be converted to pure vitamin C (ascorbic acid or AA) and the efficacy of the conversion is often unknown. In addition, vitamin C's three magic properties (antioxidant, collagen booster, skin brightener) are all properly proven in-vivo (on real people), but for the derivatives, it's mostly in-vitro studies or in the case of ATIP, it's in-vitro and done by an ingredient supplier.

With this context in mind let's see what ATIP might be able to do. First, it is stable (if pH < 5), easy to formulate and a joy to work with for a cosmetic chemist.

Second, because it's oil-soluble, its skin penetration abilities seem to be great. So great in fact, that it surpasses the penetration of pure vitamin C threefold at the same concentration and it penetrates successfully into the deeper layers of the skin (that is usually important to do some anti-aging work). There is also in-vitro data showing that it converts to AA in the skin. 

Third, ATIP seems to have all three magic abilities of pure vitamin C: it gives antioxidant protection from both UVB and UVA rays, it increases collagen synthesis (even more than AA) and it has a skin brightening effect by reducing melanogenesis by more than 80% in human melanoma cell cultures.

So this all sounds really great, but these are only in-vitro results at this point. We could find Tetrahexyldecyl Ascorbate mentioned only in one published in-vivo study that examined the anti-aging properties of a silicone formula containing 10% AA and 7% ATIP. The authors theorized that the 10% AA is released slowly from the silicon delivery system and probably stays in the upper layer of the skin to give antioxidant benefits, while ATIP penetrates more rapidly and deeply and gives some wrinkle-reducing benefits. The study was a small (10 patients), double-blind experiment, and the formula did show some measurable anti-aging results. However, it is hard to know how much pure vitamin C or ATIP can be thanked.

Bottom line: a really promising, but not well-proven vitamin C derivative that can be worth a try especially if you like experimenting (but if you like the tried and true, pure vitamin C will be your best bet).

What-it-does: emollient | Irritancy: 0 | Comedogenicity: 1

Probably the most common silicone of all. It is a polymer (created from repeating subunits) molecule and has different molecular weight and thus different viscosity versions from water-light to thick liquid.

As for skincare, it makes the skin silky smooth, creates a subtle gloss and forms a protective barrier (aka occlusive). Also, works well to fill in fine lines and wrinkles and give skin a plump look (of course that is only temporary, but still, it's nice). There are also scar treatment gels out there using dimethicone as their base ingredient. It helps to soften scars and increase their elasticity. 

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As for hair care, it is a non-volatile silicone meaning that it stays on the hair rather than evaporates from it and smoothes the hair like no other thing. Depending on your hair type, it can be a bit difficult to wash out and might cause some build-up (btw, this is not true to all silicones, only the non-volatile types). 

What-it-does: emollient, emulsifying, viscosity controlling, emulsion stabilising, surfactant/cleansing | Irritancy: 2 | Comedogenicity: 2

A so-called fatty (the good, non-drying kind of) alcohol that does all kinds of things in a skincare product: it makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier). Can be derived from coconut or palm kernel oil.

We don't have description for this ingredient yet.

Also-called: SOD | What-it-does: antioxidant

Superoxide Dismutase - or in short SOD - is the body's smart antioxidant enzyme that protects the cells from highly reactive, cell-damaging superoxide radicals (O2−).

You have probably read the terms "free radicals" and "antioxidants" a thousand times, and you know that free radicals are the evil guys, and antioxidants are the good guys. So superoxide radical is a very common free radical that can cause all kinds of cell damages and superoxide dismutase is an enzyme that catalyzes the conversion of superoxide radicals into molecular oxygen and hydrogen peroxide (btw, this one has to be further converted by other antioxidant enzymes, called catalases).

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The extra nice thing about SOD is that it remains intact during the neutralization process and can continue its magic, while non-enzymatic antioxidants (like vitamin E) are used up during neutralization.

The efficacy studies of topical SOD are promising. In-vitro (made in the lab) tests show that SOD is a more effective antioxidant than vitamin E, green tea extract, and MAP. There is also an in-vivo (made on real people) study that measured how SOD can reduce the redness caused by UV rays and it was much more effective than vitamin E (pure or acetate form) and ascorbyl palmitate

All in all, SOD is a really potent antioxidant and slathering it all over yourself is a great way to give the skin a little extra help in protecting itself from all the bad environmental things out there. 

We don't have description for this ingredient yet.

Also-called: Sweet Orange Peel Oil, Citrus Sinensis Oil | What-it-does: perfuming

The essential oil coming from the rind of the orange (the sweet one). In general, the main component of citrus peel oils is limonene (83-97% for sweet orange peel), a super common fragrant ingredient that makes everything smell nice (but counts as a frequent skin sensitizer).

Other than that, citrus peel also contains the problematic compound called furanocoumarin that makes them mildly phototoxic. Orange peel contains less of it than some other citruses (like bergamot or lime), but still, be careful with it especially if it is in a product for daytime use.  

Phospholipids - goodie

A type of lipid that's the major (about 75%) component of all cell membranes. As for skincare, it works as an emollient and skin-identical ingredient.

It has a water-loving head with two water-hating tails and this structure gives the molecule emulsifying properties. It is also often used to create liposomes, small spheres surrounded by phospholipid bi-layer designed to carry some active ingredient and help its absorption.

Also-called: Form of Retinoids | What-it-does: cell-communicating ingredient | Irritancy: 1-3 | Comedogenicity: 1-3

It's an ester form of vitamin A (retinol + palmitic acid) that belongs to the "retinoid family". The retinoid family is pretty much the royal family of skincare, with the queen being the FDA-approved anti-aging ingredient tretinoin. Retinol is also a very famous member of the family, but it's like Prince William, two steps away from the throne. Retinyl palmitate will be then little Prince George, quite far (3 steps) away from the throne. 

By steps, we mean metabolic steps. Tretinoin, aka retinoic acid, is the active ingredient our skin cells can understand and retinyl palmitate (RP) has to be converted by our metabolic machinery to actually do something. The conversion is a 3 step one and looks like this:

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retinyl palmitate --> retinol -- > retinaldehyde --> all-trans-retinoic acid

As we wrote in our lengthy retinol description the problem is that the conversion is not terribly effective. The evidence that RP is still an effective anti-aging ingredient is not very strong, in fact, it's weak. Dr. Leslie Baumann in her fantastic Cosmetic Dermatology book writes that RP is topically ineffective

What's more, the anti-aging effectiveness is not the only questionable thing about RP. It also exibits questionable behaviour in the presence of UV light and was the center of a debate between the non-profit group, EWG (whose intentions are no doubt good, but its credibility is often questioned by scientists) and a group of scientists and dermatologists lead by Steven Q. Wang, MD,  director of dermatologic surgery at Memorial-Sloan Kettering Cancer Centre. 

Dr. Leslie Baumann wrote a great review of the debate and summarized the research available about retinyl palmitate here.  It seems that there is a study showing RP being photo protective against UVB rays but there is also a study showing RP causing DNA damage and cytotoxicity in association with UVA. 

We think that the truth lies somewhere in the middle, and we agree with Dr. Baumann's conclusion: "sufficient evidence to establish a causal link between RP and skin cancer has not been produced. Nor, I’m afraid, are there any good reasons to recommend the use of RP". We would add especially during the day!

Bottom line: If you wanna get serious about retinoids, RP is not your ingredient (retinol or tretinoin is!). However, if you use a product that you like and it also contains RP, there is no reason to throw it away. If possible use it at night, just to be on the safe side.

Also-called: Vitamin E Acetate | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 0

It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version. 

According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E. 

We don't have description for this ingredient yet.

Also-called: Sugar Maple Extract

The extract coming from the Sugar Maple tree, the one whose leaf is on the Canadian flag and gives us maple syrup.

The main reason it is used in skin care is that it contains natural AHA acids, namely Malic and Tartaric, and hence why it supposedly helps slough off dead skin cells in combination with other acid-containing fruit extracts as part of the trade name ACB Fruit Mix. The manufacturer claims that both malic and tartaric increase elasticity in the skin, but from our research, the only confirmed uses of these acids are as pH adjusters, especially in the tiny amounts they can be found in the Fruit Mix (less than 1%).  

Also-called: Orange Fruit Extract

We have to start by writing that there are about 900 citrus species in the world, and plenty of them are used to make different kinds of extracts used in cosmetics. This particular one, Citrus Aurantium Dulcis Fruit Extract is a very common ingredient, however, the species "Citrus Aurantium Dulcis" seem to exist only on ingredient lists and the real world calls this guy Citrus Sinensis or, you know, orange. 

To complicate matters further, there are lots of varieties and lots of extraction methods, so it is a bit hard to know what you are getting with this one, but we will try our best to summarize the possibilities. 

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A very common scenario is that  Citrus Aurantium Dulcis Fruit Extract is on the ingredient list for its mild, natural exfoliant properties. It contains mainly citric acid and some malic acid, AHA exfoliants known for their skin renewing properties. If that's the case, it is usually combined with other AHA containing fruits such as bilberry, sugar cane, lemon, and sugar maple in a super popular ingredient mix trade named ACB Fruit Mix.

But orange fruit is loaded with lots of other active compounds with a wide variety of possible effects. A well-known one is the antioxidant vitamin C, aka ascorbic acid, but the dosage will vary based on the extraction method, and it’s possible that some of the ascorbic acid content will degrade before extraction process even takes place. If you want vitamin C in your skincare, that is smart, but do not rely on orange fruit extract for it.

Flavonoids (hesperidin, naringin, luteolin, and ferulic acid) are also nice active compounds with possible antioxidant, anti-inflammatory, and vasoprotective effects. Some of them (namely hesperidin and luteolin) might even have skin brightening activity by inhibiting tyrosinase, the famous enzyme needed for melanin production.

The orange extract also contains carbohydrates, aka sugars (mostly glucose, fructose, and sucrose, but also some bigger polysaccharides such as pectin) giving the ingredient some moisturizing properties.

Some essential oil content is usually also present in citrus fruit extracts, which means a nice scent and antibacterial properties, but also some questionable compounds such as fragrance allergen limonene or phototoxic compound bergaptene. If the amount is big enough to worry about is questionable, probably not, however, the same question applies to all the nice beneficial compounds. 

Overall, we think that the orange fruit extract is a very complex ingredient with lots of potentially good things in it, but we could not find proper in-vivo (made on real people) studies made with standardized extracts to validate what it really does or does not under real-world use cases. 

We don't have description for this ingredient yet.

Asiaticoside - goodie
What-it-does: antioxidant, perfuming

One of the main biologically active components of the famous medicinal plant, Centella Asiatica, aka Gotu Kola. It has well established wound healing and antioxidant activities.  

In-vitro (made in the lab) studies also show that Asiaticoside stimulates GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells) production as well as collagen I synthesis.  Read more at Gotu Kola >>

Asiatic Acid - goodie

One of the biologically active components of Gotu Kola. It's a bit less prominent than its sister component, Asiaticoside, but in-vitro (made in the lab) studies show that Asiatic Acid also stimulates GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells) production as well as collagen I synthesis.

English translation equals that it probably contributes to the well-established moisturizing and wound healing abilities of Gotu Kola

One of the biologically active components of Gotu Kola that is thought to contribute to the plant extract's well-documented skin regenerating, wound healing, and moisturizing properties

If you are into Gotu Kola we have some more info at Centella Asiatica Extract and its other biologically active components MadecassosideAsiaticoside and Asiatic Acid.

Also-called: Form of Vitamin C | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 2

A form of skincare superstar, vitamin C. Even though we are massive vitamin C fans,  Ascorbyl Palmitate  (AP) is our least favorite. (Btw, if you do not know what the big deal with vitamin C is then you are missing out. You must go and read our geeky details about it.) 

So, AP is one of the attempts by the cosmetics industry to solve the stability issues with vitamin C while preserving its benefits,  but it seems to fall short on several things.

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What's the problem?

Firstly, it's stability is only similar to that of pure ascorbic acid (AA), which means it is not really stable. A great study in the Journal of Cosmetic Dermatology compared a bunch of vitamin C derivatives and this derivative was the only one where the study said in terms of stability that it's "similar to AA". Not really that good.

Second, a study that examined the skin absorption of vitamin C found that ascorbyl palmitate did not increase the skin levels of AA. This does not mean that ascorbyl palmitate cannot penetrate the skin (because it can, it's oil soluble and the skin likes to absorb oil soluble things) but this means that it's questionable if ascorbyl palmitate can be converted into pure Vit C in the skin. Even if it can be converted, the palmitate part of the molecule is more than the half of it, so the efficacy will not be good and we have never seen a serum that contains a decent (and proudly disclosed) amount of AP.  We are highly skeptical what effect a tiny amount of AP has in a formula.

Third, another study that wanted to examine the antioxidant properties of AP was surprised to find that even though AP does have nice antioxidant properties; following UVB radiation (the same one that comes from the sun) it also promotes lipid peroxidation and cytotoxicity. It was only an in-vitro study meaning that it was done on cell cultures and not on real people, but still, this also does not support the use of AP too much. 

The only good thing we can write about Ascorbyl Palmitate is that there is an in-vitro (made in the lab, not on real people) study showing that it might be able to boost collagen production.

Regarding the skin-brightening properties of pure vitamin C, this is another magic property AP does not have, or at least there is no data, not even in-vitro, about it.

Overall, Ascorbyl Palmitate is our least favorite vitamin C derivative. It is there in lots of products in tiny amounts (honestly, we do not really understand why), however, we do not know about any vitamin C serum featuring AP in high amounts. That is probably no coincidence. If you are into vitamin C, you can take a look at more promising derivatives here

We don't have description for this ingredient yet.

Also-called: Licorice | What-it-does: soothing, moisturizer/humectant

The salt form of one of the main anti-inflammatory ingredients in the licorice plant, monoammonium glycyrrhizinate. It’s a yellowish powder with a nice sweet smell. 

It’s used mainly for its soothing and anti-inflammatory properties, but according to manufacturer info, it’s also sebum regulating so it's a perfect ingredient for problem skin products. 

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Read more about licorice and why it's a skincare superstar here. 

What-it-does: antioxidant

The biologically active, phytoestrogenic parts of the soybean. The most well-known one is genistein, a potent antioxidant that is proven to inhibit UV-induced redness in human skin. 

Soy isoflavones are also thought to be useful for situations when natural estrogen levels are low, such as during and after menopause. Low estrogen levels can cause skin thinning and collagen loss and soy isoflavones might be able to help with that. 

Also-called: EUK-134 | What-it-does: antioxidant

An interesting synthetic molecule that mimics two antioxidant skin enzymes superoxide dismutase (SOD) and catalase

If you are wondering what the heck SOD and catalase are, here is a little background: they are two smart enzymes found in our bodies that speed up the conversion of the evil, cell damaging free radicals (such as superoxide radicals) into friendly and harmless things such as water and oxygen. We wrote some more about SOD here.

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So this unpronounceable guy is actually a nice molecule that mimics the behavior of the natural enzymes in our skin. Estee Lauder likes this ingredient, uses it and has done some studies to prove that Ethylbisiminomethylguaiacol Manganese Chloride, aka EUK-134, can nicely protect the cells from UVB damage. They hypothesize that "EUK-134, via direct protection of the membrane from UVB-induced oxidative damage, reduces oxidative stress induced MAPK signaling and consequently lowers the level of p53 induction. The protection conferred by EUK-134 results in a significant increase in cell survival following UVB irradiation."

Another study (also by Estee Lauder) found that EUK-134 lowers hydroperoxide levels at the surface of UVA-exposed skin in vivo and concluded that this salen–manganese compound is a "unique cosmetic tool to protect the skin surface from accumulating oxidative damage". 

Other than that, we found a study that examined a serum to manage skin redness in sensitive, pale skin types and contained EUK-134 along with a bunch of other ingredients. The formula examined did reduce facial redness so EUK-134 seems to be tolerated well even by redness-prone, sensitive skin types

What-it-does: solvent, emulsifying, perfuming, surfactant/cleansing | Irritancy: 0-1 | Comedogenicity: 0-2

Similar to other glycols, it's a helper ingredient used as a solvent, or to thin out thick formulas and make them more nicely spreadable. 

Hexylene Glycol is also part a preservative blend named Lexgard® HPO, where it helps the effectiveness of current IT-preservative, phenoxyethanol

What-it-does: emollient, perfuming | Irritancy: 0 | Comedogenicity: 2-4

A super common, medium-spreading emollient ester that gives richness to the formula and a mild feel during rubout. It can be a replacement for mineral oil and is often combined with other emollients to achieve different sensorial properties.

It's a water-hating, fumed silica that works as a thickener for oils and it can also suspend particles in oils.

Also, increases the gloss of castor oil that can be useful for makeup products.

What-it-does: moisturizer/humectant, solvent, viscosity controlling | Irritancy: 0 | Comedogenicity: 1

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

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It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive. 

What-it-does: emollient, viscosity controlling, emulsifying, emulsion stabilising, surfactant/cleansing | Irritancy: 1 | Comedogenicity: 2

An extremely common multitasker ingredient that gives your skin a nice soft feel (emollient) and gives body to creams and lotions. It also helps to stabilize oil-water mixes (emulsions), though it does not function as an emulsifier in itself. Its typical use level in most cream type formulas is 2-3%.  

It’s a so-called fatty alcohol, a mix of cetyl and stearyl alcohol, other two emollient fatty alcohols.  Though chemically speaking, it is alcohol (as in, it has an -OH group in its molecule), its properties are totally different from the properties of low molecular weight or drying alcohols such as denat. alcohol. Fatty alcohols have a long oil-soluble (and thus emollient) tail part that makes them absolutely non-drying and non-irritating and are totally ok for the skin.

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 3 | Comedogenicity: 2

A common functional ingredient that helps to keep the oil-loving and water-loving ingredients together (emulsifier), stabilizes and thickens the products. 

Chemically speaking, it is ethoxylated Cetearyl alcohol, meaning that some ethylene oxide is added to the fatty alcohol to increase the water-soluble part in the molecule. The result is that the mainly oil soluble, emollient fatty alcohol is converted to an emulsifier molecule that keeps oil and water mixed in creams. The number in the name of Ceteareth emulsifiers refers to the average number of ethylene oxide molecules added and 20 makes a good emulsifier.

What-it-does: emollient, emulsifying | Irritancy: 0 | Comedogenicity: 1-2

A super common, waxy, white, solid stuff that helps water and oil to mix together, gives body to creams and leaves the skin feeling soft and smooth.

Chemically speaking, it is the attachment of a glycerin molecule to the fatty acid called stearic acid. It can be produced from most vegetable oils (in oils three fatty acid molecules are attached to glycerin instead of just one like here) in a pretty simple, "green" process that is similar to soap making. It's readily biodegradable.

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It also occurs naturally in our body and is used as a food additive. As cosmetic chemist Colins writes it, "its safety really is beyond any doubt".

What-it-does: surfactant/cleansing, emulsifying | Irritancy: 0 | Comedogenicity: 0

A very common water-loving surfactant and emulsifier that helps to keep water and oil mixed nicely together. 

It's often paired with glyceryl stearate - the two together form a super effective emulsifier duo that's salt and acid tolerant and works over a wide pH range. It also gives a "pleasing product aesthetics", so no wonder it's popular.

What-it-does: viscosity controlling, emulsion stabilising | Irritancy: 0 | Comedogenicity: 1

A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula.  It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient.

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range. 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

Also-called: Poly Vinyl Pyrollidone | What-it-does: viscosity controlling, emulsion stabilising | Irritancy: 0 | Comedogenicity: 0

These three letters stand for Poly Vinyl Pyrollidone, a big molecule created from repeated units of Vinyl Pyrrolidone, aka VP. Its main thing is being an important film former. It was the first synthetic polymer introduced as a hair fixative in the 1950s instead of insect-derived Shellac. 

So PVP likes to attach itself to surfaces such as the hair and the skin and forms a nice, thin, even film there. The film is useful for holding a hairstyle or extending the wear of color cosmetics and sunscreens. The disadvantage of PVP is that the film is a bit brittle and that PVP loves water (hygroscopic) that tends to destroy the film. This is the reason why hair styled with a PVP based product loses its style in high humidity. To fix this problem, there are now several versions of VP containing film formers that are less sensitive to humidity, for example, the molecule called VP/VA Copolymer

Panthenol - goodie
Also-called: Pro-Vitamin B5 | What-it-does: soothing, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid). 

Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier. 

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Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.

Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation. 

If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.

As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily. 

What-it-does: buffering | Irritancy: 0 | Comedogenicity: 2

It’s a little helper ingredient that helps to set the pH of a cosmetic formulation to be just right. It’s very alkaline (you know the opposite of being very acidic): a 1% solution has a pH of around 10.

It does not have the very best safety reputation but in general, you do not have to worry about it. 

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What is true is that if a product contains so-called N-nitrogenating agents (e.g.: preservatives like 2-Bromo-2-Nitropropane-1,3-Diol, 5-Bromo-5-Nitro- 1,3-Dioxane or sodium nitrate - so look out for things with nitro, nitra in the name) that together with TEA can form some not nice carcinogenic stuff (that is called nitrosamines). But with proper formulation that does not happen, TEA in itself is not a bad guy. 

But let’s assume a bad combination of ingredients were used and the nitrosamines formed. :( Even in that case you are probably fine because as far as we know it cannot penetrate the skin. 

But to be on the safe side, if you see Triethanolamine in an INCI and also something with nitra, nitro in the name of it just skip the product, that cannot hurt.

Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.

It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol

The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.

It's a pretty new anti-aging ingredient that is a "safe and pre-activated source of energy to feed aging skin cells".  

It's part of an anti-aging complex trade named Neodermyl, where methylglucoside phosphate is combined with the essential amino acids proline, lysine and also copper. This complex is claimed to be able to increase the collagen I and III production of skin and even more surprisingly, also the elastin production. Both slow down with age and beeing able to boost the skin's own production of these super important proteins results in improved skin firmness and elasticity.

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This is a very big deal, especially the elastin part, as there is not yet a clinically proven active ingredient that is able to boost the skin's own elastin production. There are also very few ones (think vitamin C, glycolic acid, and retinol) that are proven to boost collagen.  The claims about Neodermyl are not yet confirmed in independent studies but the manufacturer did do some very convincing testing that showed a visible reduction of wrinkle depth and volume in just 15 days. If you are into anti-aging, this is a new active that might be worth a try. 

An essential amino acid - mineral complex that is part of the pretty new anti-aging complex called Neodermyl. The manufacturer claims that the complex is able to boost skin's own collagen I and III as well as elastin production. Read more details at methylglucoside phosphate.

What-it-does: solvent

A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives

You may also want to take a look at...

what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
A famous natural moisturizing factor that can bind up to 1000 times its own weight in water. Works as an excellent surface hydrator in skincare. [more]
what‑it‑does emollient
A very common emollient that makes your skin feel nice and smooth. Comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
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The thing in the pee that is also a natural moisturizing factor (NMF) with mild keratolytic and strong skin moisturizing superpowers. [more]
what‑it‑does moisturizer/humectant
Sugar - as a skincare ingredient it has water-binding properties, which means that it helps to keep your skin nice and hydrated.  [more]
what‑it‑does buffering
what‑it‑does cell-communicating ingredient
A small, three amino acid (glycine-histidine-lysine or GHK) peptide that is famous for being a type I collagen fragment. The theory behind collagen-fragment peptides is that when collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen. [more]
what‑it‑does moisturizer/humectant
Also known as Sugarcane, Saccharum Officinarum is a handy moisturizing ingredient mostly used as a humectant. This means that it can help the skin to attract water and then to hold onto it.  It bears a close relationship to AHA superstar, Glycolic Acid that can be derived from it, so it's often claimed that Sugarcane  [more]
what‑it‑does soothing
White Willow Bark Extract - Famous for containing anti-inflammatory natural salicylates. It also has tonic, astringent, and antiseptic properties. [more]
what‑it‑does emollient | emulsifying
what‑it‑does antioxidant | skin brightening
A stable, oil-soluble form of Vitamin C, that might have (in-vitro results) all the magic abilities of pure vitamin C (antioxidant, collagen booster, skin brightener). [more]
what‑it‑does emollient
irritancy, com. 0, 1
A very common silicone that gives both skin and hair a silky smooth feel. It also forms a protective barrier on the skin and fills in fine lines. Also used for scar treatment. [more]
what‑it‑does emollient | emulsifying | viscosity controlling | surfactant/cleansing
irritancy, com. 2, 2
A fatty (the good, non-drying kind of) alcohol that makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier).
what‑it‑does antioxidant
Superoxide Dismutase - or in short SOD - is the body's smart antioxidant enzyme that protects the cells from highly reactive, cell-damaging superoxide radicals (O2−). You have probably read the terms "free radicals" [more]
what‑it‑does perfuming
The essential oil coming from the rind of the orange. Its main component (83-97%) is limonene, the super common fragrant ingredient. [more]
what‑it‑does skin-identical ingredient | emollient
A type of lipid that's the major component of all cell membranes. As for skincare, it works as an emollient and skin-identical ingredient. It's also often used to create liposomes. [more]
what‑it‑does cell-communicating ingredient
irritancy, com. 1-3, 1-3
An ester form of vitamin A (retinol + palmitic acid) that is pretty much the least effective member of the retinoid family. Its anti-aging effects are quite questionable as well as its behavior in the presence of UVA light. (Use it at night if possible!) [more]
what‑it‑does antioxidant
irritancy, com. 0, 0
A form of vitamin E that works as an antioxidant. Compared to the pure form it's more stable, has longer shelf life, but it's also more poorly absorbed by the skin. [more]
The extract coming from the Sugar Maple tree, the one whose leaf is on the Canadian flag and gives us maple syrup.The main reason it is used in skin care is that it contains natural AHA acids, namely Malic and Tartaric, and hence why it supposedly helps slough off dead skin cells in combination with other acid-containing fruit extracts as part of the trade name ACB Fruit Mix. [more]
We have to start by writing that there are about 900 citrus species in the world, and plenty of them are used to make different kinds of extracts used in cosmetics. This particular one, Citrus Aurantium Dulcis Fruit Extract is a very common ingredient, however, the species "Citrus Aurantium Dulcis" [more]
what‑it‑does antioxidant | perfuming
One of the main biologically active components of the famous medicinal plant, Centella Asiatica, aka Gotu Kola. It has well established wound healing and antioxidant activities.  In-vitro (made in the lab) studies also show that Asiaticoside stimulates GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells) production as well as coll [more]
One of the biologically active components of Gotu Kola. It's a bit less prominent than its sister component, Asiaticoside, but in-vitro (made in the lab) studies show that Asiatic Acid also stimulates GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells) production as well as collagen I synthesis. [more]
One of the biologically active components of Gotu Kola that is thought to contribute to the plant extract's well-documented skin regenerating, wound healing, and moisturizing properties. If you are into Gotu Kola we have some more info at Centella Asiatica Extract and its other biologically active components  [more]
what‑it‑does antioxidant
irritancy, com. 0, 2
An oil soluble vitamin C derivative that has mixed data about its effectiveness. [more]
what‑it‑does soothing | moisturizer/humectant
The salt form of one of the main anti-inflammatory ingredients in the licorice plant, monoammonium glycyrrhizinate. It’s a yellowish powder with a nice sweet smell.  It’s used mainly for its soothing and anti-inflammatory properties, but according to manufacturer info, it’s also sebum regulating so it' [more]
what‑it‑does antioxidant
The biologically active, phytoestrogenic parts of the soybean. The most well-known one is genistein, a potent antioxidant that is proven to inhibit UV-induced redness in human skin. Soy isoflavones are also thought to be useful for situations when natural estrogen levels are low, such as during and after menopause. [more]
what‑it‑does antioxidant
An interesting synthetic molecule that mimics two antioxidant skin enzymes superoxide dismutase (SOD) and catalase.  If you are wondering what the heck SOD and catalase are, here is a little background: [more]
what‑it‑does solvent | emulsifying | perfuming | surfactant/cleansing
irritancy, com. 0-1, 0-2
Similar to other glycols, it's a helper ingredient used as a solvent, or to thin out thick formulas and make them more nicely spreadable.  Hexylene Glycol is also part a preservative blend named Lexgard® [more]
what‑it‑does emollient | perfuming
irritancy, com. 0, 2-4
A super common, medium-spreading emollient ester that gives richness to the formula and a mild feel during rubout. [more]
what‑it‑does emollient | viscosity controlling
It's a water-hating, fumed silica that works as a thickener for oils and it can also suspend particles in oils. [more]
what‑it‑does moisturizer/humectant | solvent | viscosity controlling
irritancy, com. 0, 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
what‑it‑does emollient | viscosity controlling | emulsifying | surfactant/cleansing
irritancy, com. 1, 2
A super common multitasker ingredient that gives your skin a nice soft feel (emollient) and gives body to creams. [more]
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 3, 2
A common functional ingredient that helps to keep the oil-loving and water-loving ingredients together (emulsifier), stabilizes and thickens the products.  [more]
what‑it‑does emollient | emulsifying
irritancy, com. 0, 1-2
Waxy, white, solid stuff that helps water and oil to mix together and leaves the skin feeling soft and smooth. [more]
what‑it‑does surfactant/cleansing | emulsifying
irritancy, com. 0, 0
A commonly used water-soluble surfactant and emulsifier. [more]
what‑it‑does viscosity controlling
irritancy, com. 0, 1
A handy white powder that magically converts a liquid into a nice gel formula. [more]
what‑it‑does viscosity controlling | emulsifying | surfactant/cleansing
A super commonly used thickener and emulsion stabilizer. [more]
what‑it‑does viscosity controlling
irritancy, com. 0, 0
These three letters stand for Poly Vinyl Pyrollidone, a big molecule created from repeated units of Vinyl Pyrrolidone, aka VP. Its main thing is being an important film former. [more]
what‑it‑does soothing | moisturizer/humectant
irritancy, com. 0, 0
Pro-Vitamin B5 is a goodie that moisturises the skin, has anti-inflammatory, skin protecting and wound healing properties. [more]
what‑it‑does buffering
irritancy, com. 0, 2
Helps to set the pH of a cosmetic formulation to be right. It’s very alkaline. [more]
what‑it‑does chelating | viscosity controlling
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. [more]
what‑it‑does moisturizer/humectant | emollient
A handy multi-tasking ingredient that gives the skin a nice, soft feel and also boosts the effectiveness of other preservatives. [more]
what‑it‑does cell-communicating ingredient
A new anti-aging ingredient that combined with essential amino acids proline and lysine and also copper can boost skin's own collagen and elastin production that result in improved skin firmness and elasticity. [more]
what‑it‑does cell-communicating ingredient
An essential amino acid - mineral complex that is part of the pretty new anti-aging complex called Neodermyl. The manufacturer claims that the complex is able to boost skin's own collagen I and III as well as elastin production. [more]
what‑it‑does solvent
A multi-functional helper ingredient that acts as a humectant and emollient. It's also a solvent and can boost the effectiveness of preservatives. [more]