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What-it-does: antioxidant, soothing


One of the main biologically active components of the famous medicinal plant, Centella Asiatica, aka Gotu Kola. It has well established wound healing, skin-soothing and antioxidant activities.

There is also a study by La Roche Posay (belongs to L'Oreal) that examined the anti-aging effects of 5% Vitamin C combined with 0.1% Madecassoside. They mention that " Madecassoside is known to induce collagen expression and ⁄ or to modulate inflammatory mediators thus might  prevent and correct some signs of aging." The surprisingly long, 6-month study observed "significant improvement of the clinical score for deep and superficial wrinkles, suppleness, firmness, roughness, and skin hydration", but Vitamin C in itself is already an anti-aging superstar, so it is hard to know how much Madecassoside did. 

Another promising property of Madecassoside is that it seems to inhibit UV-induced melanin synthesis (test formula with 0.05% MA, used twice a day on 23 volunteers for 8 weeks), making it a great active for hyperpigmentation-prone skin.  

If that would not be enough, the French manufacturer (Seppic) also has encouraging in-vivo studies on the molecule. Used at 0.2%, Madecassoside reduces redness and peeling in skin with light atopic dermatitis as well as itching in psoriasis-prone skin. 

If you are into Gotu Kola, read more here >> 

Show me some proof

  • Shen, Xueqing, et al. "Propionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from Centella asiatica." Bioscience, biotechnology, and biochemistry 83.3 (2019): 561-568.
  • Jung, Eunsun, et al. "Madecassoside inhibits melanin synthesis by blocking ultraviolet-induced inflammation." Molecules 18.12 (2013): 15724-15736.
  • Liu, Mei, et al. "Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice." Planta medica 74.08 (2008): 809-815.
  • Haftek, Marek, et al. "Clinical, biometric and structural evaluation of the long‐term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin." Experimental dermatology 17.11 (2008): 946-952.
  • Sasmita, Andrew Octavian, et al. "Madecassoside activates anti‑neuroinflammatory mechanisms by inhibiting lipopolysaccharide‑induced microglial inflammation." International journal of molecular medicine 41.5 (2018): 3033-3040.

Products with a known amount of Madecassoside

Other products with Madecassoside

BiteCoCo Redness Neutralizing Color Correcting Cream Caolion P-Tox® Recovery Essence Torriden Cellmazing Centellareal Lotion MEDI-PEEL Phyto Cica-Nol B5 Spot Patch Skin&Lab Medicica Comfort Cleanser innisfree Aloe Revital Skin Mist innisfree Aloe Revital Soothing Gel Dr. Jart+ Cicapair Facial Calming Mist MEDI-PEEL Phyto Cica-Nol B5 AHA + BHA + Vitamin Calming Micellar Cleansing Water PATCH PRO Micro Eye Patch Sidmool Galatokside 100 Premium Functional Ampoule URANG Cica Soothing Ampoule Vice Reversa Micro-Needling Pimple Patches innisfree The Minimum Ampoule Essence For Sensitive Skin 2Sol Elixir Propolis Serum 82°E Gotu Kola Dew COSRX Pure Fit Cica Powder CURESYS Trouble Clear Needle Patch Clemence Organics Brightening Eye + Skin Serum Crazyskin Centella Tica Ampule Esthemax Sulfur Face Mask 604 Etude House Soon Jung Panthensoside Sheet Mask Etude House Soon Jung Ph 5.5 Relief Toner Fresh Skinlab Calamine Anti Blemish Calming Foam Wash Fresh Skinlab Calamine Anti Blemish Calming Spot Cream Fresh Skinlab Calamine Anti Blemish Toner Fresh Skinlab Calamine Calming Gel Moisturizer Fresh Skinlab Fresh Fresh Skinlab Calamine Anti Blemish Gel Moisturizer JUMISO Waterfull Hyaluronic Acid Toner JUMISO Waterfull Hyaluronic Toner Kerastase Anti-Hair Loss Cure Anti-Chute Spécifique LOOKS & MEII Centella Relaxation Calming Mask Orjena Centella Toner PACKage Don't Worry Healing Mask True Story Hydracushion Gentle-exfoliating Essence Toner Zeroid Dermanewal Revitalizing Ampoule meebak Cica Mask Soak+ Soothe A'pieu Madecassoside Ampoule 2x Beausta CICARECIPE TONER Biodroga Intense Moisture Basic Moist Fluid Duvaderm Acne Shot Duvaderm Glow C Serum Dēpology Deepcare+ Serum-infused Micro Dart Patches Etude House Soon Jung 5-Panthensoside Cica Balm Etude House Soon Jung 5-panthensoside Cica Balm Etude House Soon Jung Ph5.5 Relief Toner Farm Stay Cica Farm Recovery Ampoule Jin Jung Sung Soothing Moisture Skin Essence Joseristine Centellae Herba & Lactococcus Ferment Lysate Recovery Mask Box Set Luxe Organix Cica Rescue Calming Toner