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Also-called-like-this: GHK, Kollaren


A small, three amino acid (glycine-histidine-lysine or GHK) peptide that is famous for being a type I collagen fragment. The theory behind collagen-fragment peptides is that when collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen.

Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more. So Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. FYI; Tripeptide-1 is the same peptide that can be found in the famous Matrixyl 3000, but in Matrixyl a palmitic acid is attached to it to increase its oil solubility and thus skin penetration.

Another reason why Tripeptide-1 is especially famous is that it is not only a signal peptide but also a so-called carrier peptide that helps to stabilize and deliver copper in the skin. It has a high affinity for copper ions and likes to form a complex with them called Copper-Tripeptide-1 or GHK-Cu. GHK-Cu is a famous and well-researched peptide that does a bunch of things in the skin and we have a shiny explanation about it here

As for Tripeptide-1 in and of itself, without a palmitic acid or copper attached to it, it goes by the trade name Kollaren and according to the manufacturer, it not only stimulates collagen but also other essential skin proteins such as fibronectin, elastin, and laminin. Kollaren is also claimed to be beneficial for acne-prone skin as it can boost tissue repair and thus help acne scars to heal faster. 

Show me some proof

  • Gorouhi, F., and H. I. Maibach. "Role of topical peptides in preventing or treating aged skin." International journal of cosmetic science 31.5 (2009): 327-345.
  • Maquart, François-Xavier, et al. "An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity: Implication in tumor invasion." Critical reviews in oncology/hematology 49.3 (2004): 199-202.

Products with Tripeptide-1

Paula's Choice Peptide Booster Dr.magic Polypeptide Line Reducing Serum Colorescience Pep Up® Collagen Renewal Face & Neck Treatment iS Clinical Super Serum Advance+ NIOD Copper Amino Isolate Serum 2:1 NCN PRO SKINCARE All-Trans Retinol With Non-Prescription Tretinoin Peter Thomas Roth Un-Wrinkle Turbo Line Smoothing Toning Lotion Bliss Triple Oxygen Instant Energizing Foaming Mask iS Clinical Youth Eye Complex Ecooking Acne Serum iS Clinical Youth Serum Natura Bissé The Cure Pure Serum Cover fx Dewy Skin Primer Peter Thomas Roth Un-Wrinkle Turbo Face Serum Solal C-Serum dr. denese Wrinkle Rx 76% Peptide Solution Concentrate IDC Profil Cellélite + Peter Thomas Roth Peptide 21 Wrinkle Resist Serum iS Clinical Reparative Moisture Emulsion Verso Lip Serum By Verso CeraVe Skin Renewing Night Cream Burberry Liquid Lip Velvet Grown Alchemist Age Repair Moisturiser Zelens Intense Defence Antioxidant Serum Ciate London Dewy Stix Peter Thomas Roth Peptide 21 Lift & Firm Moisturizer Serious Skincare Pure Pep Creme Riche ISKIN New York Lipaddict Dr Sebagh Supreme Maintenance Youth Serum D'Care Face Up Double S Anti-Aging Serum Leaders Daily Wonders What Happened Last Night? Mask Missha Time Revolution Night Repair New Science Activator Ampoule Mask JMsolution Water Luminous Black Jelly Pack Missha Time Revolution Vitality Toner Mecca Cosmetica Lip De-Luscious Treatment STARSKIN Vip The Diamond Illuminating Luxury Bio Cellulose Second Skin Face Mask Missha Aqua Peptide Custom Skin Care Toner JMsolution Water Luminous White Jelly Pack Missha Time Revolution Vitality Lotion Mesoestetic Fast Skin Repair Missha Time Revolution Vitality Eye Cream Missha Time Revolution Immortal Youth Cream Missha Time Revolution Night Repair Borabit Ampoule Missha Time Revolution Night Repair Science Activator Ampoule Dr. Jart+ Peptidin™ Radiance Serum With Energy Peptides Dr. Jart+ Peptidin™ Firming Serum With Energy Peptides AHC Ageless Real Eye Cream For Face