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Also-called-like-this: GHK, Kollaren


A small, three amino acid (glycine-histidine-lysine or GHK) peptide that is famous for being a type I collagen fragment. The theory behind collagen-fragment peptides is that when collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen.

Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more. So Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. FYI; Tripeptide-1 is the same peptide that can be found in the famous Matrixyl 3000, but in Matrixyl a palmitic acid is attached to it to increase its oil solubility and thus skin penetration.

Another reason why Tripeptide-1 is especially famous is that it is not only a signal peptide but also a so-called carrier peptide that helps to stabilize and deliver copper in the skin. It has a high affinity for copper ions and likes to form a complex with them called Copper-Tripeptide-1 or GHK-Cu. GHK-Cu is a famous and well-researched peptide that does a bunch of things in the skin and we have a shiny explanation about it here

As for Tripeptide-1 in and of itself, without a palmitic acid or copper attached to it, it goes by the trade name Kollaren and according to the manufacturer, it not only stimulates collagen but also other essential skin proteins such as fibronectin, elastin, and laminin. Kollaren is also claimed to be beneficial for acne-prone skin as it can boost tissue repair and thus help acne scars to heal faster. 

Show me some proof

  • Gorouhi, F., and H. I. Maibach. "Role of topical peptides in preventing or treating aged skin." International journal of cosmetic science 31.5 (2009): 327-345.
  • Maquart, François-Xavier, et al. "An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity: Implication in tumor invasion." Critical reviews in oncology/hematology 49.3 (2004): 199-202.

Products with Tripeptide-1

Paula's Choice Peptide Booster Droplette Glycolic Acid Capsule NIOD Copper Amino Isolate Serum 2:1 AlumierMD Matticlear Dr.magic Polypeptide Line Reducing Serum Yves Rocher Sensitive Camomille iS Clinical C-Eye Serum Advance+ CSI Collagen Nourish Anti-Wrinkle Serum Colorescience Pep Up® Collagen Renewal Face & Neck Treatment DEMAR3 Alpe Di 36 Ampoule Forever Living Infinite By Forever™ Firming Serum The Potions Peptide Ampoule NIOD Copper Amino Isolate Serum 2:1 Neogen Surmedic Azulene Soothing Peptide Ampoule iS Clinical Youth Intensive Creme Ecooking Super Serum Ecooking Moisturizing Serum NCN PRO SKINCARE All-Trans Retinol With Non-Prescription Tretinoin Peter Thomas Roth Un-Wrinkle Turbo Line Smoothing Toning Lotion Bliss Triple Oxygen Instant Energizing Foaming Mask iS Clinical Super Serum Advance+ iS Clinical Youth Eye Complex Ecooking Acne Serum Ecooking Day Cream Isntree Ceramide Deep Moisture Cream Mask NCN PRO SKINCARE Skin Tight Lifting Elixir Postquam Age Control Facial Serum Postquam Age Control Facial Serum "Naturage Age Control" iS Clinical Youth Serum Ecooking Night Cream LACURA Q10 Renew Day Cream Natura Bissé The Cure Pure Serum Nella Watery Cream Postquam Moisturizing Facial Olive Oil Postquam R+ Cell to Cell Essence Gel Crème Cien Caviar Serum Cover fx Dewy Skin Primer Grown Alchemist Detox Night Cream Peter Thomas Roth Un-Wrinkle Turbo Face Serum Solal C-Serum dr. denese Wrinkle Rx 76% Peptide Solution Concentrate Derma Elravie Botalinum Timeless Tension Ampoule Ecooking DAY CREAM Fragrance Free Environ Youth + Tri-Peptide Complex + Avance Elixir Gerovital H3 Evolution Anti-Wrinkle Concentrated Cream With Hyaluronic Acid IDC Profil Cellélite + Mary Kay Timewise Repair® Volu-Firm™ Day Cream With Spf 30 Reino Sérum Multi-Corrector gatineau Age Benefit Integral Regenerating Eye Cream Grown Alchemist Regenerating Night Cream: Peptide-30 & Violet Leaf Extract