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Also-called-like-this: GHK, Kollaren


A small, three amino acid (glycine-histidine-lysine or GHK) peptide that is famous for being a type I collagen fragment. The theory behind collagen-fragment peptides is that when collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen.

Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more. So Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. FYI; Tripeptide-1 is the same peptide that can be found in the famous Matrixyl 3000, but in Matrixyl a palmitic acid is attached to it to increase its oil solubility and thus skin penetration.

Another reason why Tripeptide-1 is especially famous is that it is not only a signal peptide but also a so-called carrier peptide that helps to stabilize and deliver copper in the skin. It has a high affinity for copper ions and likes to form a complex with them called Copper-Tripeptide-1 or GHK-Cu. GHK-Cu is a famous and well-researched peptide that does a bunch of things in the skin and we have a shiny explanation about it here

As for Tripeptide-1 in and of itself, without a palmitic acid or copper attached to it, it goes by the trade name Kollaren and according to the manufacturer, it not only stimulates collagen but also other essential skin proteins such as fibronectin, elastin, and laminin. Kollaren is also claimed to be beneficial for acne-prone skin as it can boost tissue repair and thus help acne scars to heal faster. 

Show me some proof

  • Gorouhi, F., and H. I. Maibach. "Role of topical peptides in preventing or treating aged skin." International journal of cosmetic science 31.5 (2009): 327-345.
  • Maquart, François-Xavier, et al. "An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity: Implication in tumor invasion." Critical reviews in oncology/hematology 49.3 (2004): 199-202.

Products with Tripeptide-1

Paula's Choice Peptide Booster Droplette Glycolic Acid Capsule NIOD Copper Amino Isolate Serum 3 1:1 (CAIS 3) WOW skin science Anti Acne Face Serum AlumierMD Matticlear Dr.magic Polypeptide Line Reducing Serum Nars Powermatte Lip Pigment Tan-Luxe Pepta-Glow Peptide 360 Gradual Self-Tan Vivier Grenzcine Eye Vivier Peptide Cr Crème Vivier Peptide Cr Eye Crème Yves Rocher Sensitive Camomille iS Clinical C-Eye Serum Advance+ Ariul My Mood Maker Mask Glam CSI Collagen Nourish Anti-Wrinkle Serum Colorescience Pep Up® Collagen Renewal Face & Neck Treatment DEMAR3 Alpe Di 36 Ampoule Forever Living Infinite By Forever™ Firming Serum Lumin Clarifying Body Wash Quannessence Skincare Renewal Skincare Complex The Potions Peptide Ampoule Neogen Surmedic Azulene Soothing Peptide Ampoule iS Clinical Youth Intensive Creme Ecooking Super Serum Forever Living Infinite Firming Serum JKOSMEC Skin Solution Peptide Mask Zelens Power D Treatment Drops Ecooking Moisturizing Serum Look Good Live Well The Super Serum - All-In-One Tri-Peptide Treatment NCN PRO SKINCARE All-Trans Retinol With Non-Prescription Tretinoin Peter Thomas Roth Un-Wrinkle Turbo Line Smoothing Toning Lotion Skin Drink Extreme Regeneration Hydrating Night Complex Bliss Triple Oxygen Instant Energizing Foaming Mask iS Clinical Super Serum Advance+ iS Clinical Youth Eye Complex EVER Skincare Hydralift Oil-Free Moisture Injection Gel With Lsr10® Ecooking Acne Serum Ecooking Day Cream Isntree Ceramide Deep Moisture Cream Mask NCN PRO SKINCARE Skin Tight Lifting Elixir Postquam Age Control Facial Serum Postquam Age Control Facial Serum "Naturage Age Control" iS Clinical Youth Serum Derm Institute Cellular Rejuvenating Eye Contour Masque Single Pack Derm Institute Youth Alchemy Eye Cream Ecooking Night Cream LACURA Q10 Renew Day Cream Mary Kay Timewise Repair Crema De Noche Natura Bissé The Cure Pure Serum Nella Watery Cream