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Tripeptide-1

goodie
Also-called-like-this: GHK, Kollaren

Official CosIng Information

Details

A small, three amino acid (glycine-histidine-lysine or GHK) peptide that is famous for being a type I collagen fragment. The theory behind collagen-fragment peptides is that when collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen.

Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more. So Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. FYI; Tripeptide-1 is the same peptide that can be found in the famous Matrixyl 3000, but in Matrixyl a palmitic acid is attached to it to increase its oil solubility and thus skin penetration.

Another reason why Tripeptide-1 is especially famous is that it is not only a signal peptide but also a so-called carrier peptide that helps to stabilize and deliver copper in the skin. It has a high affinity for copper ions and likes to form a complex with them called Copper-Tripeptide-1 or GHK-Cu. GHK-Cu is a famous and well-researched peptide that does a bunch of things in the skin and we have a shiny explanation about it here

As for Tripeptide-1 in and of itself, without a palmitic acid or copper attached to it, it goes by the trade name Kollaren and according to the manufacturer, it not only stimulates collagen but also other essential skin proteins such as fibronectin, elastin, and laminin. Kollaren is also claimed to be beneficial for acne-prone skin as it can boost tissue repair and thus help acne scars to heal faster. 

Show me some proof

  • Gorouhi, F., and H. I. Maibach. "Role of topical peptides in preventing or treating aged skin." International journal of cosmetic science 31.5 (2009): 327-345.
  • Maquart, François-Xavier, et al. "An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity: Implication in tumor invasion." Critical reviews in oncology/hematology 49.3 (2004): 199-202.

Products with Tripeptide-1

NOID Copper Amino Isolate Serum 2:1 Paula's Choice Peptide Booster Dr.magic Polypeptide Line Reducing Serum iS Clinical C-Eye Serum Advance+ Colorescience Pep Up® Collagen Renewal Face & Neck Treatment iS Clinical Super Serum Advance+ NIOD Copper Amino Isolate Serum 2:1 Neogen Surmedic Azulene Soothing Peptide Ampoule Ecooking Super Serum NCN PRO SKINCARE All-Trans Retinol With Non-Prescription Tretinoin Peter Thomas Roth Un-Wrinkle Turbo Line Smoothing Toning Lotion Bliss Triple Oxygen Instant Energizing Foaming Mask iS Clinical Youth Eye Complex Ecooking Acne Serum Ecooking Day Cream NCN PRO SKINCARE Skin Tight Lifting Elixir iS Clinical Youth Serum Natura Bissé The Cure Pure Serum Cover fx Dewy Skin Primer Peter Thomas Roth Un-Wrinkle Turbo Face Serum Solal C-Serum dr. denese Wrinkle Rx 76% Peptide Solution Concentrate Derma Elravie Botalinum Timeless Tension Ampoule IDC Profil Cellélite + One Ocean Beauty Replenishing Deep Sea Moisturizer Peter Thomas Roth Peptide 21 Wrinkle Resist Serum iS Clinical Reparative Moisture Emulsion Verso Lip Serum By Verso CeraVe Skin Renewing Night Cream Frezyderm Active Block Spf 25 Burberry Liquid Lip Velvet Grown Alchemist Age Repair Moisturiser Skin doctors Beelift Zelens Intense Defence Antioxidant Serum Bliss Triple Oxygen Mask Ecooking Moisturising Serum Ciate London Dewy Stix Peter Thomas Roth Peptide 21 Lift & Firm Moisturizer Serious Skincare Pure Pep Creme Riche Skin doctors Antarctilyne Plump³ NCN PRO SKINCARE All-In-One Anti Aging Cream ISKIN New York Lipaddict Dr Sebagh Supreme Maintenance Youth Serum D'Care Face Up Double S Anti-Aging Serum Missha Time Revolution Immortal Youth Blue Essence Missha Time Revolution Night Repair Probio Ampoule Seoulista Beauty Diamond Radiance Instant Facial Leaders Amino Lifting Mask STARSKIN Close-Up™ Firming Bio-Cellulose Second Skin Face Mask Leaders Daily Wonders What Happened Last Night? Mask