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Also-called-like-this: GHK, Kollaren


A small, three amino acid (glycine-histidine-lysine or GHK) peptide that is famous for being a type I collagen fragment. The theory behind collagen-fragment peptides is that when collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen.

Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more. So Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. FYI; Tripeptide-1 is the same peptide that can be found in the famous Matrixyl 3000, but in Matrixyl a palmitic acid is attached to it to increase its oil solubility and thus skin penetration.

Another reason why Tripeptide-1 is especially famous is that it is not only a signal peptide but also a so-called carrier peptide that helps to stabilize and deliver copper in the skin. It has a high affinity for copper ions and likes to form a complex with them called Copper-Tripeptide-1 or GHK-Cu. GHK-Cu is a famous and well-researched peptide that does a bunch of things in the skin and we have a shiny explanation about it here

As for Tripeptide-1 in and of itself, without a palmitic acid or copper attached to it, it goes by the trade name Kollaren and according to the manufacturer, it not only stimulates collagen but also other essential skin proteins such as fibronectin, elastin, and laminin. Kollaren is also claimed to be beneficial for acne-prone skin as it can boost tissue repair and thus help acne scars to heal faster. 

Show me some proof

  • Gorouhi, F., and H. I. Maibach. "Role of topical peptides in preventing or treating aged skin." International journal of cosmetic science 31.5 (2009): 327-345.
  • Maquart, François-Xavier, et al. "An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity: Implication in tumor invasion." Critical reviews in oncology/hematology 49.3 (2004): 199-202.

Products with Tripeptide-1

Neova Pure Copper Mask Reposelle Repair Serum Paula's Choice Peptide Booster Droplette Glycolic Acid Capsule Environ Apres-cit NIOD Copper Amino Isolate Serum 3 1:1 (CAIS 3) WOW skin science Anti Acne Face Serum AlumierMD Matticlear Dr.magic Polypeptide Line Reducing Serum Droplette 10.0% Collagen Capsule Droplette Collagen Capsule Nars Powermatte Lip Pigment Nwno Peptides & Prebiotic Restoring Serum Tan-Luxe Pepta-Glow Peptide 360 Gradual Self-Tan Vivier Grenzcine Eye Vivier Peptide Cr Crème Vivier Peptide Cr Eye Crème Yves Rocher Sensitive Camomille iS Clinical C-Eye Serum Advance+ Ariul My Mood Maker Mask Glam CSI Collagen Nourish Anti-Wrinkle Serum Colorescience Pep Up® Collagen Renewal Face & Neck Treatment DEMAR3 Alpe Di 36 Ampoule Forever Living Infinite By Forever™ Firming Serum Lumin Clarifying Body Wash Quannessence Skincare Renewal Skincare Complex SIRCUIT® Cosmeceuticals Infusion-a The Potions Peptide Ampoule Neogen Surmedic Azulene Soothing Peptide Ampoule iS Clinical Youth Intensive Creme Ecooking Super Serum Forever Living Infinite Firming Serum JKOSMEC Skin Solution Peptide Mask Zelens Power D Treatment Drops Ecooking Moisturizing Serum Look Good Live Well The Super Serum - All-In-One Tri-Peptide Treatment M3 Naturals Stretch Mark Cream Collagen & Stem Cell Infused NCN PRO SKINCARE All-Trans Retinol With Non-Prescription Tretinoin Peter Thomas Roth Un-Wrinkle Turbo Line Smoothing Toning Lotion Skin Drink Extreme Regeneration Hydrating Night Complex Thrive Causemetics Timeless Ambition™ Power 10-peptide Sculpting Serum Bliss Triple Oxygen Instant Energizing Foaming Mask FarmStay Peptide9 Baking Powder Pore Scrub iS Clinical Super Serum Advance+ iS Clinical Youth Eye Complex Catrice Power Full 5 Liquid Lip Balm EVER Skincare Hydralift Oil-Free Moisture Injection Gel With Lsr10® Ecooking Acne Serum Ecooking Day Cream IOMA Generous Eye Contour Cream