SkinMedica Tns Ceramide Treatment Cream
SkinMedica

Tns Ceramide Treatment Cream

A ceramide and HFCM cream for dry or post procedure skin
Uploaded by: ashglows on 21/10/2018

Ingredients overview

Water/Aqua/Eau
what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
,
Cetyl Ethylhexanoate
what‑it‑does emollient
An odorless and colorless emollient ester that gives a velvety and silky feel to the skin. [more]
,
Cetearyl Alcohol
what‑it‑does emollient | emulsifying | viscosity controlling | surfactant/cleansing
irritancy, com. 1 2
A common multitasker ingredient that gives your skin a nice soft feel (emollient). It also helps water and oil to blend (emulsifier) and to thicken up products. [more]
,
Hydroxypropyl Bispalmitamide Mea
what‑it‑does skin-identical ingredient | emollient
A molecule created in a lab to mimic the properties of natural skin-barrier building ceramides. It is claimed to be similarly effective as ceramide 3 at moisturizing the skin and helping the barrier function. [more]
,
Human Fibroblast Conditioned Media
what‑it‑does cell-communicating ingredient
Human Fibroblast Conditioned Media (HFCM) essentially means a "Growth Factor Cocktail" for your skin. We have written more about the most common GF used in skincare, the Epidermal Growth Factor here, so if you are new to the topic head over there to catch up. [more]
,
Dimethicone
what‑it‑does emollient
irritancy, com. 0 1
A very common silicone that gives both skin and hair a silky smooth feel. It also forms a protective barrier on the skin and fills in fine lines. Also used for scar treatment. [more]
,
Olea Europaea Fruit Oil
what‑it‑does antioxidant | emollient
Olive oil - an oleic acid-rich (55-83%) emollient plant oil that can moisturize dry skin. Also, it contains antioxidant polyphenols and vitamin E. [more]
,
Glycine Soja Oil
what‑it‑does emollient
The emollient plant oil coming from the soybean. It is rich in barrier repairing linoleic acid (48-59%) and is generally a good moisturizing oil. [more]
,
Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
, [more]
Cetearyl Glucoside
what‑it‑does emulsifying | surfactant/cleansing
A sugar based emulsifier that's especially great for low viscosity lotions or even sprays. [more]
,
Palmitoyl Tripeptide-1
what‑it‑does cell-communicating ingredient
A three amino acid peptide that is part of famous peptide duo, Matrixyl 3000. It's a type I collagen fragment that might be able to trick the skin to think that collagen broke down and it's time to create some new one. [more]
,
Palmitoyl Tetrapeptide-7
what‑it‑does cell-communicating ingredient
The pal of Palmitoyl Tripeptide-1 in Matrixyl 3000. A four amino acid peptide that works by reducing the production of the signal molecule, inteleukin-6 (IL-6) that promotes inflammation in the skin. [more]
,
Tetrahexyldecyl Ascorbate
what‑it‑does antioxidant | skin brightening
A stable, oil-soluble form of Vitamin C, that might have (in-vitro results) all the magic abilities of pure vitamin C (antioxidant, collagen booster, skin brightener). [more]
,
Avena Sativa Kernel Extract
what‑it‑does antioxidant | abrasive/scrub | emollient
,
Glycine Soja Sterols
what‑it‑does emollient
,
Retinyl Palmitate
what‑it‑does cell-communicating ingredient
An ester form of vitamin A (retinol + palmitic acid) that is pretty much the least effective member of the retinoid family. Its anti-aging effects are quite questionable as well as its behavior in the presence of UVA light. (Use it at night if possible!) [more]
,
Tocopheryl Acetate
what‑it‑does antioxidant
irritancy, com. 0 0
A form of vitamin E that works as an antioxidant. Compared to the pure form it's more stable, has longer shelf life, but it's also more poorly absorbed by the skin. [more]
,
Sodium Carboxymethyl Beta-Glucan
what‑it‑does surfactant/cleansing | viscosity controlling
,
Squalane
what‑it‑does skin-identical ingredient | emollient
irritancy, com. 0 1
An emollient and natural moisturizer that can be found also in the sebum (oily stuff our skin produces). It leaves a nice non-greasy, non-heavy feeling on the skin. [more]
,
Allantoin
what‑it‑does soothing
irritancy, com. 0 0
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. It's not only soothing but it' [more]
,
Bisabolol
what‑it‑does soothing
One of the active parts of Chamomile that is used in skincare as a nice anti-inflammatory and soothing ingredient. [more]
,
Panthenol
what‑it‑does soothing | moisturizer/humectant
irritancy, com. 0 0
Pro-Vitamin B5 is a goodie that moisturises the skin, has anti-inflammatory, skin protecting and wound healing properties. [more]
,
Sodium Hyaluronate
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
,
Xanthan Gum
what‑it‑does viscosity controlling
A super commonly used thickener and emulsion stabilizer. [more]
,
Glyceryl Stearate
what‑it‑does emollient | emulsifying
Waxy, white, solid stuff that helps water and oil to mix together and leaves the skin feeling soft and smooth. [more]
,
Peg-100 Stearate
what‑it‑does surfactant/cleansing | emulsifying
irritancy, com. 0 1
A commonly used water-soluble surfactant and emulsifier. [more]
,
Isoceteth-20
what‑it‑does emulsifying | surfactant/cleansing
A handy helper ingredient that works as an emulsifier or solubilizer to include oil-loving ingredients (such as fragrance) into water-based products. 
,
Butylene Glycol
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
,
Ethoxydiglycol
what‑it‑does solvent
A nice odorless liquid used mainly as a superior solubilizer and efficacy booster for cosmetic active ingredients such as vitamin C or benzoyl peroxide. [more]
,
Carbomer
what‑it‑does viscosity controlling
A handy white powder that magically converts a liquid into a nice gel formula. [more]
,
Disodium Edta
what‑it‑does chelating
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. [more]
,
Ethylhexylglycerin
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]
,
Phenoxyethanol
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
,
Caprylyl Glycol
what‑it‑does moisturizer/humectant | emollient
A handy multi-tasking ingredient that gives the skin a nice, soft feel and also boosts the effectiveness of other preservatives. [more]
,
Caprylhydroxamic Acid
what‑it‑does chelating
A so-called chelating agent that helps to preserve cosmetic products by neutralizing the metal ions (especially iron) in the formula (that usually get into there from water). [more]
,
Potassium Sorbate
what‑it‑does preservative
A not so strong preservative that doesn’t really work against bacteria, but more against mold and yeast. [more]
[less]
Water/Aqua/Eau, Cetyl Ethylhexanoate, Cetearyl Alcohol, Hydroxypropyl Bispalmitamide MEA, Human Fibroblast Conditioned Media, Dimethicone, Olea Europaea Fruit Oil, Glycine Soja Oil, Glycerin, Cetearyl Glucoside, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Tetrahexyldecyl Ascorbate, Avena Sativa Kernel Extract, Glycine Soja Sterols, Retinyl Palmitate, Tocopheryl Acetate, Sodium Carboxymethyl Beta-Glucan, Squalane, Allantoin, Bisabolol, Panthenol, Sodium Hyaluronate, Xanthan Gum, Glyceryl Stearate, PEG-100 Stearate, Isoceteth-20, Butylene Glycol, Ethoxydiglycol, Carbomer, Disodium EDTA, Ethylhexylglycerin, Phenoxyethanol, Caprylyl Glycol, Caprylhydroxamic Acid, Potassium Sorbate

Highlights

Key Ingredients

Antioxidant: Olea Europaea Fruit Oil
what‑it‑does antioxidant | emollient
Olive oil - an oleic acid-rich (55-83%) emollient plant oil that can moisturize dry skin. Also, it contains antioxidant polyphenols and vitamin E. [more]
,
Tetrahexyldecyl Ascorbate
what‑it‑does antioxidant | skin brightening
A stable, oil-soluble form of Vitamin C, that might have (in-vitro results) all the magic abilities of pure vitamin C (antioxidant, collagen booster, skin brightener). [more]
,
Avena Sativa Kernel Extract
what‑it‑does antioxidant | abrasive/scrub | emollient
,
Tocopheryl Acetate
what‑it‑does antioxidant
irritancy, com. 0 0
A form of vitamin E that works as an antioxidant. Compared to the pure form it's more stable, has longer shelf life, but it's also more poorly absorbed by the skin. [more]
Cell-communicating ingredient: Human Fibroblast Conditioned Media
what‑it‑does cell-communicating ingredient
Human Fibroblast Conditioned Media (HFCM) essentially means a "Growth Factor Cocktail" for your skin. We have written more about the most common GF used in skincare, the Epidermal Growth Factor here, so if you are new to the topic head over there to catch up. [more]
,
Palmitoyl Tripeptide-1
what‑it‑does cell-communicating ingredient
A three amino acid peptide that is part of famous peptide duo, Matrixyl 3000. It's a type I collagen fragment that might be able to trick the skin to think that collagen broke down and it's time to create some new one. [more]
,
Palmitoyl Tetrapeptide-7
what‑it‑does cell-communicating ingredient
The pal of Palmitoyl Tripeptide-1 in Matrixyl 3000. A four amino acid peptide that works by reducing the production of the signal molecule, inteleukin-6 (IL-6) that promotes inflammation in the skin. [more]
,
Retinyl Palmitate
what‑it‑does cell-communicating ingredient
An ester form of vitamin A (retinol + palmitic acid) that is pretty much the least effective member of the retinoid family. Its anti-aging effects are quite questionable as well as its behavior in the presence of UVA light. (Use it at night if possible!) [more]
Skin brightening: Tetrahexyldecyl Ascorbate
what‑it‑does antioxidant | skin brightening
A stable, oil-soluble form of Vitamin C, that might have (in-vitro results) all the magic abilities of pure vitamin C (antioxidant, collagen booster, skin brightener). [more]
Skin-identical ingredient: Hydroxypropyl Bispalmitamide Mea
what‑it‑does skin-identical ingredient | emollient
A molecule created in a lab to mimic the properties of natural skin-barrier building ceramides. It is claimed to be similarly effective as ceramide 3 at moisturizing the skin and helping the barrier function. [more]
,
Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
,
Squalane
what‑it‑does skin-identical ingredient | emollient
irritancy, com. 0 1
An emollient and natural moisturizer that can be found also in the sebum (oily stuff our skin produces). It leaves a nice non-greasy, non-heavy feeling on the skin. [more]
,
Sodium Hyaluronate
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
Soothing: Allantoin
what‑it‑does soothing
irritancy, com. 0 0
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. It's not only soothing but it' [more]
,
Bisabolol
what‑it‑does soothing
One of the active parts of Chamomile that is used in skincare as a nice anti-inflammatory and soothing ingredient. [more]
,
Panthenol
what‑it‑does soothing | moisturizer/humectant
irritancy, com. 0 0
Pro-Vitamin B5 is a goodie that moisturises the skin, has anti-inflammatory, skin protecting and wound healing properties. [more]

Show all ingredients by function

Other Ingredients

Chelating: Disodium Edta
what‑it‑does chelating
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. [more]
,
Caprylhydroxamic Acid
what‑it‑does chelating
A so-called chelating agent that helps to preserve cosmetic products by neutralizing the metal ions (especially iron) in the formula (that usually get into there from water). [more]
Emollient: Cetyl Ethylhexanoate
what‑it‑does emollient
An odorless and colorless emollient ester that gives a velvety and silky feel to the skin. [more]
,
Cetearyl Alcohol
what‑it‑does emollient | emulsifying | viscosity controlling | surfactant/cleansing
irritancy, com. 1 2
A common multitasker ingredient that gives your skin a nice soft feel (emollient). It also helps water and oil to blend (emulsifier) and to thicken up products. [more]
,
Hydroxypropyl Bispalmitamide Mea
what‑it‑does skin-identical ingredient | emollient
A molecule created in a lab to mimic the properties of natural skin-barrier building ceramides. It is claimed to be similarly effective as ceramide 3 at moisturizing the skin and helping the barrier function. [more]
,
Dimethicone
what‑it‑does emollient
irritancy, com. 0 1
A very common silicone that gives both skin and hair a silky smooth feel. It also forms a protective barrier on the skin and fills in fine lines. Also used for scar treatment. [more]
,
Olea Europaea Fruit Oil
what‑it‑does antioxidant | emollient
Olive oil - an oleic acid-rich (55-83%) emollient plant oil that can moisturize dry skin. Also, it contains antioxidant polyphenols and vitamin E. [more]
,
Glycine Soja Oil
what‑it‑does emollient
The emollient plant oil coming from the soybean. It is rich in barrier repairing linoleic acid (48-59%) and is generally a good moisturizing oil. [more]
,
Avena Sativa Kernel Extract
what‑it‑does antioxidant | abrasive/scrub | emollient
,
Glycine Soja Sterols
what‑it‑does emollient
,
Squalane
what‑it‑does skin-identical ingredient | emollient
irritancy, com. 0 1
An emollient and natural moisturizer that can be found also in the sebum (oily stuff our skin produces). It leaves a nice non-greasy, non-heavy feeling on the skin. [more]
,
Glyceryl Stearate
what‑it‑does emollient | emulsifying
Waxy, white, solid stuff that helps water and oil to mix together and leaves the skin feeling soft and smooth. [more]
,
Caprylyl Glycol
what‑it‑does moisturizer/humectant | emollient
A handy multi-tasking ingredient that gives the skin a nice, soft feel and also boosts the effectiveness of other preservatives. [more]
Emulsifying: Cetearyl Alcohol
what‑it‑does emollient | emulsifying | viscosity controlling | surfactant/cleansing
irritancy, com. 1 2
A common multitasker ingredient that gives your skin a nice soft feel (emollient). It also helps water and oil to blend (emulsifier) and to thicken up products. [more]
,
Cetearyl Glucoside
what‑it‑does emulsifying | surfactant/cleansing
A sugar based emulsifier that's especially great for low viscosity lotions or even sprays. [more]
,
Glyceryl Stearate
what‑it‑does emollient | emulsifying
Waxy, white, solid stuff that helps water and oil to mix together and leaves the skin feeling soft and smooth. [more]
,
Peg-100 Stearate
what‑it‑does surfactant/cleansing | emulsifying
irritancy, com. 0 1
A commonly used water-soluble surfactant and emulsifier. [more]
,
Isoceteth-20
what‑it‑does emulsifying | surfactant/cleansing
A handy helper ingredient that works as an emulsifier or solubilizer to include oil-loving ingredients (such as fragrance) into water-based products. 
Moisturizer/humectant: Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
,
Panthenol
what‑it‑does soothing | moisturizer/humectant
irritancy, com. 0 0
Pro-Vitamin B5 is a goodie that moisturises the skin, has anti-inflammatory, skin protecting and wound healing properties. [more]
,
Sodium Hyaluronate
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
,
Butylene Glycol
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
,
Caprylyl Glycol
what‑it‑does moisturizer/humectant | emollient
A handy multi-tasking ingredient that gives the skin a nice, soft feel and also boosts the effectiveness of other preservatives. [more]
Preservative: Ethylhexylglycerin
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]
,
Phenoxyethanol
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
,
Potassium Sorbate
what‑it‑does preservative
A not so strong preservative that doesn’t really work against bacteria, but more against mold and yeast. [more]
Solvent: Water/Aqua/Eau
what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
,
Butylene Glycol
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
,
Ethoxydiglycol
what‑it‑does solvent
A nice odorless liquid used mainly as a superior solubilizer and efficacy booster for cosmetic active ingredients such as vitamin C or benzoyl peroxide. [more]
Surfactant/cleansing: Cetearyl Alcohol
what‑it‑does emollient | emulsifying | viscosity controlling | surfactant/cleansing
irritancy, com. 1 2
A common multitasker ingredient that gives your skin a nice soft feel (emollient). It also helps water and oil to blend (emulsifier) and to thicken up products. [more]
,
Cetearyl Glucoside
what‑it‑does emulsifying | surfactant/cleansing
A sugar based emulsifier that's especially great for low viscosity lotions or even sprays. [more]
,
Sodium Carboxymethyl Beta-Glucan
what‑it‑does surfactant/cleansing | viscosity controlling
,
Peg-100 Stearate
what‑it‑does surfactant/cleansing | emulsifying
irritancy, com. 0 1
A commonly used water-soluble surfactant and emulsifier. [more]
,
Isoceteth-20
what‑it‑does emulsifying | surfactant/cleansing
A handy helper ingredient that works as an emulsifier or solubilizer to include oil-loving ingredients (such as fragrance) into water-based products. 
Viscosity controlling: Cetearyl Alcohol
what‑it‑does emollient | emulsifying | viscosity controlling | surfactant/cleansing
irritancy, com. 1 2
A common multitasker ingredient that gives your skin a nice soft feel (emollient). It also helps water and oil to blend (emulsifier) and to thicken up products. [more]
,
Sodium Carboxymethyl Beta-Glucan
what‑it‑does surfactant/cleansing | viscosity controlling
,
Xanthan Gum
what‑it‑does viscosity controlling
A super commonly used thickener and emulsion stabilizer. [more]
,
Carbomer
what‑it‑does viscosity controlling
A handy white powder that magically converts a liquid into a nice gel formula. [more]

Skim through

Ingredient name what-it-does irr., com. ID-Rating
Water/Aqua/Eau solvent
Cetyl Ethylhexanoate emollient
Cetearyl Alcohol emollient, emulsifying, viscosity controlling, surfactant/​cleansing 1, 2
Hydroxypropyl Bispalmitamide Mea skin-identical ingredient, emollient goodie
Human Fibroblast Conditioned Media cell-communicating ingredient
Dimethicone emollient 0, 1
Olea Europaea Fruit Oil antioxidant, emollient goodie
Glycine Soja Oil emollient goodie
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 goodie
Cetearyl Glucoside emulsifying, surfactant/​cleansing
Palmitoyl Tripeptide-1 cell-communicating ingredient goodie
Palmitoyl Tetrapeptide-7 cell-communicating ingredient goodie
Tetrahexyldecyl Ascorbate antioxidant, skin brightening goodie
Avena Sativa Kernel Extract antioxidant, abrasive/​scrub, emollient goodie
Glycine Soja Sterols emollient
Retinyl Palmitate cell-communicating ingredient
Tocopheryl Acetate antioxidant 0, 0
Sodium Carboxymethyl Beta-Glucan surfactant/​cleansing, viscosity controlling
Squalane skin-identical ingredient, emollient 0, 1 goodie
Allantoin soothing 0, 0 goodie
Bisabolol soothing goodie
Panthenol soothing, moisturizer/​humectant 0, 0 goodie
Sodium Hyaluronate skin-identical ingredient, moisturizer/​humectant 0, 0 goodie
Xanthan Gum viscosity controlling
Glyceryl Stearate emollient, emulsifying
Peg-100 Stearate surfactant/​cleansing, emulsifying 0, 1
Isoceteth-20 emulsifying, surfactant/​cleansing
Butylene Glycol moisturizer/​humectant, solvent 0, 1
Ethoxydiglycol solvent
Carbomer viscosity controlling
Disodium Edta chelating
Ethylhexylglycerin preservative
Phenoxyethanol preservative
Caprylyl Glycol moisturizer/​humectant, emollient
Caprylhydroxamic Acid chelating
Potassium Sorbate preservative

Ingredients explained

Also-called: Aqua | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

Expand to read more

Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

What-it-does: emollient

An odorless and colorless emollient ester (cetyl alcohol + ethylhexanoic acid) that gives a velvety and silky feel to the skin. It has geat spreadability and a non-oily feel. It's a popular ingredient in makeup removers.

What-it-does: emollient, emulsifying, viscosity controlling, surfactant/cleansing | Irritancy: 1 | Comedogenicity: 2

A super common multitasker ingredient that gives your skin a nice soft feel (emollient). It also helps water and oil to blend (emulsifier) and to thicken up products

It’s a so-called fatty alcohol (a mix of cetyl and stearyl alcohol - other two emollient fatty alcohols).  Though alcohol is in its name, its properties are totally different from the properties of “normal” alcohol, or denat. alcohol. It’s not drying and not irritating and totally ok for the skin.

Also-called: Synthetic Ceramide Analog | What-it-does: skin-identical ingredient, emollient

A molecule created in a lab to mimic the properties of natural skin-barrier building ceramides. It is claimed to be similarly effective as ceramide 3 at moisturizing the skin and helping the barrier function. We have more about ceramides here

The advantages of Hydroxypropyl Bispalmitamide MEA are claimed to be lower melting point and hence easier formulation and better price point than real ceramides. 

Human Fibroblast Conditioned Media (HFCM) essentially means a "Growth Factor Cocktail" for your skin. We have written more about the most common GF used in skincare, the Epidermal Growth Factor here, so if you are new to the topic head over there to catch up. The TL;DR version is that a Growth Factor is a medium long amino acid sequence (= small protein = big peptide) that works as a cell signaling molecule to stimulate cell growth, proliferation, healing and/or differentiation

Ingredients called "Conditioned Media" cover not one but a mix of Growth Factors derived from some cells grown in a lab. In the EU, human cell-derived ingredients are illegal, so GF products available in the EU usually use a plant source (e.g. barley). In the US, human-derived GFs are all OK, and Human Fibroblast Conditioned Media is derived, as its name suggests, from human fibroblast cells (VIP skin cells for collagen production). 

Expand to read more

The company Skinmedica was a pioneer in using GFs in cosmeceutical skincare, and their version of HFCM contains a "proprietary mixture of growth factors, cytokines, and soluble matrix proteins secreted by cultured neonatal human dermal fibroblasts during the production of extracellular matrix (ECM)". It is claimed to be a physiologically balanced mix of GFs that are ideal for skin cells to regenerate themselves. More specifically, it contains growth factors that can promote angiogenesis (VEGF and hepatocyte growth factor), modulate inflammation (IL-6 and IL-8), and enhance ECM deposition (TGF-β1 and platelet-derived growth factor-A). 

Skinmedica has pretty convincing research showing that their products containing GFs (TNS line) work and have great anti-aging benefits. Multiple clinical studies show that the TNS Recovery Complex improves the appearance of fine lines, wrinkles, skin tone and texture. The benefits are even greater when GFs are combined with tried and true anti-aging actives such as antioxidants and retinol.

This all sounds really good, however, GFs in skincare are somewhat controversial. As potent mitogenic (= stimulates cell proliferation) molecules, you should not use them if you have any of the skin cancer risk factors high or if you have psoriasis. We have written more about the concerns at EGF

Overall, Growth Factors have increasing evidence (both proper clinical studies as well as some GF products with a cult following) showing that they have great anti-aging benefits. Whether you are comfortable with using human-derived ingredients or not or if you feel like the cons outweigh the pros or not, is up to you. If you are a better safe than sorry type, daily SPF + retinol is still the golden standard of anti-aging.

 

What-it-does: emollient | Irritancy: 0 | Comedogenicity: 1

Probably the cheapest and most common silicone of all. It is a polymer (created from repeating subunits) molecule and has different molecular weight and thus different viscosity versions from water-light to thick liquid.

As for skincare, it makes the skin silky smooth, creates a subtle gloss and forms a protective barrier. Also, works well to fill in fine lines and wrinkles and give skin a plump look (of course that is only temporary, but still, it's nice). There are also scar treatment gels out there using dimethicone as their base ingredient. It helps to soften scars and increase their elasticity. 

Expand to read more

As for hair care, it is a non-volatile silicone meaning that it stays on the hair rather than evaporates from it and smoothes the hair like no other thing. Depending on your hair type, it can be a bit difficult to wash out and might cause some build-up (btw, this is not true to all silicones, only the non-volatile types). 

Also-called: Olive Fruit Oil | What-it-does: antioxidant, emollient

You probably know olive oil from the kitchen as a great and healthy option for salad dressing but it's also a great and healthy option to moisturize and nourish the skin, especially if it's on the dry side. 

Similar to other emollient plant oils, it's loaded with nourishing fatty acids: oleic is the main component (55-83%), and also contains linoleic (3.5-20%) and palmitic acids (7-20%). It also contains antioxidant polyphenols, tocopherols (types of vitamin E) and carotenoids and it's one of the best plant sources of skin-identical emollient, Squalene

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Overall, a great option for dry skin but less so for acne-prone or damaged skin.

Glycine Soja Oil - goodie
Also-called: Soybean Oil | What-it-does: emollient

The emollient plant oil coming from the soybean. It is considered to be a nice, cost-effective base oil with moisturizing properties. As for its fatty acid profile, it contains 48-59% barrier-repairing linoleic acid, 17-30% nourishing oleic acid and also some (4.5-11%) potentially anti-inflammatory linolenic acid

Glycerin - goodie
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • Super common, used for more than 50 years
  • Not only a simple moisturizer but plays an important role in keeping the stuff between our skin cells healthy
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

A sugar based emulsifier that's especially great for low viscosity lotions or even sprays. It's effective in small amounts, only 1-1.5% is needed to form an emulsion. The resulting cream or lotion has great cosmetic properties with good spreadability and an enhanced soft skin feel. 

Also-called: Part of Matrixyl 3000, Pal-GHK, Formerly also Palmitoyl Oligopeptide | What-it-does: cell-communicating ingredient

A really famous peptide that is part of Matrixyl 3000, the most sold peptide complex in the word. Before we go and find out what the big deal with Matrixyl 3000 is, let's just focus on Palmitoyl Tripeptide-1 itself for a bit.

It's a small three amino acid (they are the building blocks of all proteins) peptide with the amino sequence of glycine-histidine-lysine, or GHK. GHK is attached to palmitic acid (a fatty acid) to increase oil solubility and skin penetration. 

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The GHK part is the important one as it's a type I collagen fragment. When collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen. Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more.

Therefore, Palmitoyl Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. 

In Matrixyl 3000, Palmitoyl Tripeptide-1 is coupled with Palmitoyl Tetrapeptide-7  and the duo works in synergy to reduce wrinkles and give younger looking skin. According to the manufacturer's in-vivo (made on real people) test, applying 3% Matrixyl 3000 twice a day for 2 months resulted in all of the following things:

  • 39.4% reduction in surface occupied by deep wrinkles
  • 32.9% reduction in main wrinkle density
  • 19.9% reduction in main wrinkle average depth
  • 16% improvement in roughness
  • 16.2% in lifting effect
  • 5.5% improvement in elasticity
  • 15.5% improvement in skin tone

Manufacturer results, of course, always have to be taken with a pinch of salt, but if you like peptides, the Matryxil 3000 duo is one of the best-proven and most well-known ones and it's something that is worth trying.

Also-called: Part of Matrixyl 3000, Pal-GQPR, Previously Palmitoyl Tetrapeptide-3 | What-it-does: cell-communicating ingredient

A four amino acid peptide with the amino sequence of glycine-glutamine-proline-arginine. It is attached to palmitic acid (a fatty acid)  to increase oil solubility and skin penetration. 

It works by reducing the production of the signal moleculeinteleukin-6 (IL-6) which promotes inflammation in the skin and less inflammation means slower degradation of important things (like collagen) that results in younger looking skin for a longer time. 

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It works in synergy with its pal, Palmitoyl Tripeptide-1 in the famous Matrixyl 3000 complex. You can read some more about the famous duo here.

Also-called: Form of Vitamin C, Ascorbyl Isotetrapalmitate, Ascorbyl Tetraisopalmitate, ATIP | What-it-does: antioxidant, skin brightening

Tetrahexyldecyl Ascorbate is a stable, oil-soluble form of skincare big shot Vitamin C. If you do not know, why Vitamin C is such a big deal in skincare, click here and read all about it. We are massive vitamin C fans and have written about it in excruciating detail.

So now, you know that Vitamin C is great and all but, it's really unstable and gives cosmetics companies many headaches. To solve this problem they came up with vitamin C derivatives, and one of them is Tetrahexyldecyl Ascorbate (let's call it ATIP in short).

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It's a really promising candidate (see below), but while reading all the goodness about it in a minute, do not forget that derivatives not only have to be absorbed into the skin but also have to be converted to pure vitamin C (ascorbic acid or AA) and the efficacy of the conversion is often unknown. In addition, vitamin C's three magic properties (antioxidant, collagen booster, skin brightener) are all properly proven in-vivo (on real people), but for the derivatives, it's mostly in-vitro studies or in the case of ATIP, it's in-vitro and done by an ingredient supplier.

With this context in mind let's see what ATIP might be able to do. First, it is stable (if pH < 5), easy to formulate and a joy to work with for a cosmetic chemist.

Second, because it's oil-soluble, its skin penetration abilities seem to be great. So great in fact, that it surpasses the penetration of pure vitamin C threefold at the same concentration and it penetrates successfully into the deeper layers of the skin (that is usually important to do some anti-aging work). There is also in-vitro data showing that it converts to AA in the skin. 

Third, ATIP seems to have all three magic abilities of pure vitamin C: it gives antioxidant protection from both UVB and UVA rays, it increases collagen synthesis (even more than AA) and it has a skin brightening effect by reducing melanogenesis by more than 80% in human melanoma cell cultures.

So this all sounds really great, but these are only in-vitro results at this point. We could find Tetrahexyldecyl Ascorbate mentioned only in one published in-vivo study that examined the anti-aging properties of a silicone formula containing 10% AA and 7% ATIP. The authors theorized that the 10% AA is released slowly from the silicon delivery system and probably stays in the upper layer of the skin to give antioxidant benefits, while ATIP penetrates more rapidly and deeply and gives some wrinkle-reducing benefits. The study was a small (10 patients), double-blind experiment, and the formula did show some measurable anti-aging results. However, it is hard to know how much pure vitamin C or ATIP can be thanked.

Bottom line: a really promising, but not well-proven vitamin C derivative that can be worth a try especially if you like experimenting (but if you like the tried and true, pure vitamin C will be your best bet).

Also-called: Oat Kernel Extract | What-it-does: antioxidant, abrasive/scrub, emollient

We don't have description for this ingredient yet.

Also-called: Soybean Sterols | What-it-does: emollient

We don't have description for this ingredient yet.

Also-called: Form of Retinoids | What-it-does: cell-communicating ingredient

It's an ester form of vitamin A (retinol + palmitic acid) that belongs to the "retinoid family". The retinoid family is pretty much the royal family of skincare, with the queen being the FDA-approved anti-aging ingredient tretinoin. Retinol is also a very famous member of the family, but it's like Prince William, two steps away from the throne. Retinyl palmitate will be then little Prince George, quite far (3 steps) away from the throne. 

By steps, we mean metabolic steps. Tretinoin, aka retinoic acid, is the active ingredient our skin cells can understand and retinyl palmitate (RP) has to be converted by our metabolic machinery to actually do something. The conversion is a 3 step one and looks like this:

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retinyl palmitate --> retinol -- > retinaldehyde --> all-trans-retinoic acid

As we wrote in our lengthy retinol description the problem is that the conversion is not terribly effective. The evidence that RP is still an effective anti-aging ingredient is not very strong, in fact, it's weak. Dr. Leslie Baumann in her fantastic Cosmetic Dermatology book writes that RP is topically ineffective

What's more, the anti-aging effectiveness is not the only questionable thing about RP. It also exibits questionable behaviour in the presence of UV light and was the center of a debate between the non-profit group, EWG (whose intentions are no doubt good, but its credibility is often questioned by scientists) and a group of scientists and dermatologists lead by Steven Q. Wang, MD,  director of dermatologic surgery at Memorial-Sloan Kettering Cancer Centre. 

Dr. Leslie Baumann wrote a great review of the debate and summarized the research available about retinyl palmitate here.  It seems that there is a study showing RP being photo protective against UVB rays but there is also a study showing RP causing DNA damage and cytotoxicity in association with UVA. 

We think that the truth lies somewhere in the middle, and we agree with Dr. Baumann's conclusion: "sufficient evidence to establish a causal link between RP and skin cancer has not been produced. Nor, I’m afraid, are there any good reasons to recommend the use of RP". We would add especially during the day!

Bottom line: If you wanna get serious about retinoids, RP is not your ingredient (retinol or tretinoin is!). However, if you use a product that you like and it also contains RP, there is no reason to throw it away. If possible use it at night, just to be on the safe side.

Also-called: Vitamin E Acetate | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 0

It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version. 

According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E. 

We don't have description for this ingredient yet.

Squalane - goodie
What-it-does: skin-identical ingredient, emollient | Irritancy: 0 | Comedogenicity: 1

It seems to us that squalane is in fashion and there is a reason for it. Chemically speaking, it is a saturated  (no double bonds) hydrocarbon (a molecule consisting only of carbon and hydrogen), meaning that it's a nice and stable oily liquid with a long shelf life. 

It occurs naturally in certain fish and plant oils (e.g. olive), and in the sebum (the oily stuff our skin produces) of the human skin. As f.c. puts it in his awesome blog post, squalane's main things are "emolliency, surface occlusion, and TEWL prevention all with extreme cosmetic elegance". In other words, it's a superb moisturizer that makes your skin nice and smooth, without being heavy or greasy.

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Another advantage of squalane is that it is pretty much compatible with all skin types and skin conditions. It is excellent for acne-prone skin and safe to use even if you have fungi-related skin issues, like seborrhea or fungal acne.

The unsaturated (with double bonds) and hence less stable version of Squalane is Squalene, you can read about it here >> 

Allantoin - goodie
What-it-does: soothing | Irritancy: 0 | Comedogenicity: 0

Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. 

It's not only soothing but it' also skin-softening and protecting and can promote wound healing.

Bisabolol - goodie
Also-called: Alpha-Bisabolol | What-it-does: soothing

It's one of the active parts of Chamomile that contains about 30% of bisabolol. It's a clear oily fluid that is used in skincare as a nice anti-inflammatory and soothing ingredient. 

Panthenol - goodie
Also-called: Pro-Vitamin B5 | What-it-does: soothing, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid). 

Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier. 

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Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.

Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation. 

If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.

As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily. 

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It’s the - sodium form - cousin of the famous NMFhyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

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In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).

What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists. 

If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little of xanthan gum will make it more gel-like.  Used alone, it can make the formula sticky so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

What-it-does: emollient, emulsifying

A super common, waxy, white, solid stuff that helps water and oil to mix together and leaves the skin feeling soft and smooth.

It can be produced from most vegetable oils in a pretty simple, "green" process that is similar to soap making. It's readily biodegradable.

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It also occurs naturally in our body and is used as a food additive. As cosmetic chemist Colins writes it, "its safety really is beyond any doubt".

What-it-does: surfactant/cleansing, emulsifying | Irritancy: 0 | Comedogenicity: 1

A very common water-loving surfactant and emulsifier that helps to keep water and oil mixed nicely together. 

It's often paired with glyceryl stearate - the two together form a super effective emulsifier duo that's salt and acid tolerant and works over a wide pH range. It also gives a "pleasing product aesthetics", so no wonder it's popular.

A handy helper ingredient that works as an emulsifier or solubilizer to include oil-loving ingredients (such as fragrance) into water-based products. 

What-it-does: moisturizer/humectant, solvent | Irritancy: 0 | Comedogenicity: 1

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

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It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive. 

What-it-does: solvent

A nice odorless liquid used mainly as a superior solubilizer and efficacy booster for cosmetic active ingredients such as skincare bigshot vitamin C, self-tanning active DHA or the anti-acne gold standard, benzoyl peroxide

Other than that it can also be used in hair care products where it gives a longer-lasting and more uniform coloring. According to a manufacturer, it might even prevent the formation of split ends.

What-it-does: viscosity controlling

A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula. If you see gel in the name of a moisturizer type thing, chances are carbomer will be in the ingredient list. 

What-it-does: chelating

Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.

What-it-does: preservative

If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.

Also, it's an effective deodorant and a medium spreading emollient

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

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Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10). 

It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.

It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol

The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.

What-it-does: chelating

A so-called chelating agent that helps to preserve cosmetic products by neutralizing the metal ions (especially iron) in the formula (that usually get into there from water). Its special thing is that it also acts as a biostatic and fungistatic agent and remains active even at high pH.

It is often coupled with antimicrobial glycols (such as propanediol) to create a "preservative free preservative system" for cosmetic products.

What-it-does: preservative

It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. It’s not a strong one and doesn’t really work against bacteria, but more against mold and yeast. To do that it has to break down to its active form, sorbic acid. For that to happen, there has to be water in the product and the right pH value (pH 3-4). 

But even if everything is right, it’s not enough on its own. If you see potassium sorbate you should see some other preservative next to it too.

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BTW, it’s also a food preservative and even has an E number, E202.

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