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Clinique Smart Clinical™ Md Multi-Dimensional Age Transformer Resculpt

Smart Clinical™ Md Multi-Dimensional Age Transformer Resculpt

An instant-tightening gel-cream that visibly rejuvenates facial morphology.
Uploaded by: whishaw on

Ingredients overview

Highlights

#fragrance & essentialoil-free
Fragrance and Essential Oil Free

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Ingredient name what-it-does irr., com. ID-Rating
Water\Aqua\Eau solvent
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar
Caprylyl Methicone emollient
Butylene Glycol moisturizer/​humectant, solvent, viscosity controlling 0, 1
Alcohol Denat antimicrobial/​antibacterial, solvent, viscosity controlling icky
Dimethicone emollient 0, 1
Isododecane emollient, solvent, perfuming
PEG-10 Dimethicone emulsifying
Dipropylene Glycol solvent, perfuming, viscosity controlling
Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract
Cucumis Melo (Melon) Fruit Extract
Persea Gratissima (Avocado) Oil antioxidant, emollient 0, 0-3 goodie
Saccharomyces Lysate Extract moisturizer/​humectant
Acetyl Glucosamine skin-identical ingredient, skin brightening goodie
Porphyridium Cruentum Extract
Dipeptide Diaminobutyroyl Benzylamide Diacetate cell-communicating ingredient goodie
Acetyl Hexapeptide-8 cell-communicating ingredient, moisturizer/​humectant goodie
Palmitoyl Tetrapeptide-7 cell-communicating ingredient goodie
Acetyl Octapeptide-3 cell-communicating ingredient, moisturizer/​humectant goodie
Cholesterol skin-identical ingredient, emollient 0, 0 goodie
Decarboxy Carnosine Hcl
Acetyl Carnitine Hcl
Caffeine antioxidant, perfuming goodie
Creatine
Sigesbeckia Orientalis (St. Paul'S Wort) Extract
Palmitoyl Tripeptide-1 cell-communicating ingredient goodie
Polygonum Cuspidatum Root Extract antioxidant
Centella Asiatica (Hydrocotyl) Extract soothing, antioxidant, moisturizer/​humectant, surfactant/​cleansing goodie
Glycine Soja (Soybean) Protein emulsifying
Ergothioneine antioxidant
Propylene Glycol Dicaprylate emollient, viscosity controlling
PEG-150 moisturizer/​humectant, solvent
Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone emulsifying, surfactant/​cleansing
Jojoba Esters soothing, emollient, moisturizer/​humectant
Whey Protein\Lactis Protein\Protéine Du Petit-Lait cell-communicating ingredient goodie
Adenosine Phosphate
Tocopheryl Acetate antioxidant 0, 0
Lactic Acid exfoliant, moisturizer/​humectant, buffering superstar
Yeast Extract\Faex\Extrait De Levure moisturizer/​humectant goodie
Linoleic Acid skin-identical ingredient, emollient, surfactant/​cleansing goodie
Sodium Hyaluronate skin-identical ingredient, moisturizer/​humectant 0, 0 goodie
Phytantriol moisturizer/​humectant 2, 2
Glycine Soja (Soybean) Seed Extract antioxidant, skin brightening, soothing, emollient goodie
Disteardimonium Hectorite viscosity controlling
Propylene Carbonate solvent, viscosity controlling
Menthanediol
Hydroxypropyl Methylcellulose surfactant/​cleansing, viscosity controlling 0, 1
Pullulan
Polyquaternium-51 moisturizer/​humectant
Sodium Hydroxide buffering
Calcium Chloride viscosity controlling
Carbomer viscosity controlling 0, 1
Sea Whip Extract
Polysorbate 20 emulsifying, surfactant/​cleansing 0, 0
Caprylyl Glycol moisturizer/​humectant, emollient
Tetrahexyldecyl Ascorbate antioxidant, skin brightening goodie
Citric Acid buffering
Potassium Sulfate viscosity controlling
Sodium Hexametaphosphate chelating
Sodium Citrate chelating, buffering
Potassium Sorbate preservative
Sodium Benzoate preservative
Phenoxyethanol preservative

Clinique Smart Clinical™ Md Multi-Dimensional Age Transformer Resculpt
Ingredients explained

Also-called: Aqua;Water | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

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Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

What-it-does: emollient

A clear, colorless, low viscosity, volatile (does not absorb into the skin but rather evaporates from it) silicone fluid that has excellent spreadability and leaves a light, silky and smooth feel on the skin.

According to manufacturer info, its big advantage is that it's compatible both with other silicones and with natural plant oils, so it's a great ingredient to formulate products with good-sounding, consumer-pleasing vegetable oils but still maintain a cosmetically elegant, non-greasy and non-tacky feel.

What-it-does: moisturizer/humectant, solvent, viscosity controlling | Irritancy: 0 | Comedogenicity: 1

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

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It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive. 

  • It's a super common and super debated skincare ingredient
  • It has several benefits: great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent and antimicrobial
  • It can be very drying if it's in the first few ingredients on an ingredient list
  • Some experts even think that regular exposure to alcohol damages skin barrier and causes inflammation though it's a debated opinion (read more in geeky details tab)
Read all the geeky details about Alcohol Denat. here >>

What-it-does: emollient | Irritancy: 0 | Comedogenicity: 1

Probably the most common silicone of all. It is a polymer (created from repeating subunits) molecule and has different molecular weight and thus different viscosity versions from water-light to thick liquid.

As for skincare, it makes the skin silky smooth, creates a subtle gloss and forms a protective barrier (aka occlusive). Also, works well to fill in fine lines and wrinkles and give skin a plump look (of course that is only temporary, but still, it's nice). There are also scar treatment gels out there using dimethicone as their base ingredient. It helps to soften scars and increase their elasticity. 

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As for hair care, it is a non-volatile silicone meaning that it stays on the hair rather than evaporates from it and smoothes the hair like no other thing. Depending on your hair type, it can be a bit difficult to wash out and might cause some build-up (btw, this is not true to all silicones, only the non-volatile types). 

What-it-does: emollient, solvent, perfuming

A  clear, colorless and odorless, highly volatile (meaning it does not absorb into the skin but evaporates from it) liquid that's used as an emollient. It gives a nice non-oily light skin feel and it can improve the slip of the formula without leaving a tacky residue behind.

It's also popular in make-up products as its volatility makes mascaras and foundations last longer. If that would not be enough, it's also an excellent solvent, and it's a regular not only on the ingredients lists of make-ups but also on makeup removers.  

What-it-does: emulsifying

A silicone emulsifier that helps water and silicone oils to mix nicely together. It can also be used together with plant oil + silicone oil mixtures. 

A clear, colorless liquid that works as a solvent and viscosity decreasing ingredient. It also has great skin-moisturizing abilities. 

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Also-called: Avocado Oil, Persea Americana Oil | What-it-does: antioxidant, emollient | Irritancy: 0 | Comedogenicity: 0-3

The oil coming from the pulp of one of the most nutritious fruits in the world, the avocado. It's loaded with the nourishing and moisturizing fatty acid, oleic (70%) and contains some others including palmitic (10%) and linoleic acid (8%). It also contains a bunch of minerals and vitamins A, E and D

Avocado oil has extraordinary skin penetration abilities and can nourish different skin layers. It's a very rich, highly moisturizing emollient oil that makes the skin smooth and nourished. Thanks to its vitamin E content it also has some antioxidant properties. As a high-oleic plant oil, it is recommended for dry skin

What-it-does: moisturizer/humectant

We don't have description for this ingredient yet.

An amino acid sugar that can be found in the skin and does there good and important things. One of them is that it's a precursor for the biosynthesis of superstar moisturizer, hyaluronic acid. So acetyl glucosamine itself is also an important skin-identical ingredient and natural moisturizing factor.

But that is not all, acetyl glucosamine has two other great properties proved by double-blind clinical trials. First, it's a promising ingredient against wrinkles:  2% can improve wrinkles, particularly in the eye area.

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Second, the same amount can also fade - always stubborn - brown spots. (Do not expect magic, though - the photos from the study show the difference after 8 weeks of daily use. The difference is visible, but not that big. It's always good to have realistic expectations. :))  Combined with skincare superstar niacinamide the duo is synergistic and is more effective at improving hyperpigmentation, so if you are after the skin-lightening benefit look out for products that contain both. 

We don't have description for this ingredient yet.

Also-called: Syn-Ake | What-it-does: cell-communicating ingredient

This awfully long named ingredient is, in fact, a pretty small molecule. It's a tripeptide (a three amino acid peptide)  with molecular weight less than 500 Da, meaning that it's small enough to penetrate nicely and easily into the skin.

It belongs to the "Botox in a jar" type of peptides (similar to Argireline or Leuphasyl) targeting wrinkles caused by facial movements, like laughter lines or crow’s feet. According to the manufacturer's in-vivo (made on real people) studies, 4% Syn-Ake used for 28 days resulted in 21% smoother and 15-20% less wrinkled skin with max values up to 52%. The smoothing effect was measurable on 80% of the volunteers, while the wrinkle reduction effect was evident on 73%.

Also-called: Argireline, Acetyl Hexapeptide-3 | What-it-does: cell-communicating ingredient, moisturizer/humectant

If you see a cosmetic product that claims that it has "Botox-like effect" then two things are almost certain: one, the product overpromises and two, it contains Argireline. 

So this one is the famous peptide that's marketed by its manufacturer as the "Botox in a jar". The basis for this claim is that it targets the same wrinkle forming mechanism (wrinkles caused by facial muscle movement) as Botox, but the way it works is very different. In addition, the extent to which it can prevent muscles from contracting (and to smooth wrinkles) is very different (otherwise why would anyone use still Botox?). 

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The manufacturer did several studies to prove that Argireline really works and it does (just not as well as Botox). In-vivo (made on real people) tests showed that using 10% Argireline solution around the eyes for 15 days decreased wrinkles depth by 17%. A Spanish University also did some research and found that Argireline increased the level of skin moisturization and decreased both the depth and width of wrinkles "significantly". 

This means, Acetyl Hexapeptide-8 does have some ability to smooth wrinkles (but not as well as Botox - sorry, if we sound like a broken record). Also, we have to agree with TruthInAging, that it's not a collagen builder and not a preventer of structural aging (think vitamin C, AHAs or retinol); it's just a quick fix. If you are looking for one, this could be your thing. If you are more of a "let's treat this aging thing properly" type, then it's probably not your thing.

Also-called: Part of Matrixyl 3000, Pal-GQPR, Previously Palmitoyl Tetrapeptide-3 | What-it-does: cell-communicating ingredient

A four amino acid peptide with the amino sequence of glycine-glutamine-proline-arginine. It is attached to palmitic acid (a fatty acid)  to increase oil solubility and skin penetration. 

It works by reducing the production of the signal moleculeinteleukin-6 (IL-6) which promotes inflammation in the skin and less inflammation means slower degradation of important things (like collagen) that results in younger looking skin for a longer time. 

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It works in synergy with its pal, Palmitoyl Tripeptide-1 in the famous Matrixyl 3000 complex. You can read some more about the famous duo here.

Also-called: SNAP-8, Acetyl Glutamyl Heptapeptide-1 | What-it-does: cell-communicating ingredient, moisturizer/humectant

A newer and, molecule-wise, somewhat bigger version of the famous "Botox-like" peptide called Acetyl Hexapeptide-8 or Argireline. Just like Argireline, Acetyl Octapeptide-3 is also claimed to influence the muscle contraction process that results in a more relaxed and line-free face, especially around the forehead and the eyes.  

While Argireline counts as a pretty well-proven peptide, with multiple studies confirming its anti-wrinkle efficacy, we cannot say the same for Acetyl Octapeptide-3. What we have is the manufacturer's claim that comparing 10% Argireline with 10% SNAP-8 solution (that means 0.005% pure peptide powder) the SNAP-8 peptide did a bit better as it reduced wrinkles by 34.98% vs 27.05% reduction for Argireline (twice a day use for 28 days on 17 women). 

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Other than that, we can write here pretty much the same as at Argireline. Obviously, no peptide works as effectively as real Botox, and the Botox-inspired peptides are quick fixes rather than being collagen builders or real preventers of structural aging. They are nice additions to an anti-aging skincare routine but not the real superstars (think vitamin CAHAs or retinol).

Cholesterol - goodie
What-it-does: skin-identical ingredient, emollient | Irritancy: 0 | Comedogenicity: 0

It's one of the important lipids that can be found naturally in the outer layer of the skin. About 25% of the goopy stuff between our skin cells consists of cholesterol. Together with ceramides and fatty acids, they play a vital role in having a healthy skin barrier and keeping the skin hydrated. 

Apart from being an important skin-identical ingredient, it's also an emollient and stabilizer

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Caffeine - goodie
What-it-does: antioxidant, perfuming

Hello, our favorite molecule that helps us wake up in the morning and then keeps us going through the day. As a super well-known stimulant from coffee, tea and plenty of other soft drinks, Caffeine needs no introduction. So we will skip right to the part where we talk about what the hell it does in so-so many cosmetic products.

Looking at the research, we were surprised to find how versatile Caffeine is. It is a small, water-loving molecule with pretty good skin penetration abilties. Once in the skin, it has nice antioxidant properties, meaning that it reduces the formation of evil free radicals and it might even be useful in preventing UV-induced skin cancers. 

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A well-known thing about Caffeine is that it improves the microcirculation of the blood vessels. Though conventional wisdom and anecdotal evidence says that this property is helpful for dark under-eye circles and puffy eyes, we have to mention that the double-blind research we have found about a 3% caffeine gel concluded that "the overall efficacy of the selected caffeine gel in reducing puffy eyes was not significantly different from that of its gel base."  But you know, the proof is in the pudding.

Another thing Caffeine is used for in body care products is its anti-cellulite effects. In theory, it can speed up the lipolysis process (the "fat burning"  by our cells) and stimulate the draining lymph system that might lead to the improvement of cellulite. But here again, the evidence that it actually makes a measurable, let alone visible,  improvement on actual human beings is limited (we could find only some animal skin studies or caffeine being combined with other actives). 

Last, but not least, we have to write about caffeine and hair growth. The theory is that it can inhibit the activity of the 5-α-reductase enzyme that plays an important role in hair loss and allows a renewed growth phase of the hair. We have found some recent and promising research to back this up. A 2017 study compared a 0.2% caffeine liquid with a 5% Minoxidil  (an FDA approved active to treat baldness) solution and found that  "a caffeine-based topical liquid should be considered as not inferior to minoxidil 5% solution in men with androgenetic alopecia", or English translation means that the caffeine liquid was pretty much as good as the FDA-approved Minoxidil stuff. Not bad!

Overall, we think that caffeine is a very versatile and biologically active ingredient. Even though some of its effects are more hyped up than backed up, it is still a nice to have on many ingredient lists. 

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Also-called: Part of Matrixyl 3000, Pal-GHK, Formerly also Palmitoyl Oligopeptide | What-it-does: cell-communicating ingredient

A really famous peptide that is part of Matrixyl 3000, the most sold peptide complex in the word. Before we go and find out what the big deal with Matrixyl 3000 is, let's just focus on Palmitoyl Tripeptide-1 itself for a bit.

It's a small three amino acid (they are the building blocks of all proteins) peptide with the amino sequence of glycine-histidine-lysine, or GHK. GHK is attached to palmitic acid (a fatty acid) to increase oil solubility and skin penetration. 

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The GHK part is the important one as it's a type I collagen fragment. When collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen. Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more.

Therefore, Palmitoyl Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. 

In Matrixyl 3000, Palmitoyl Tripeptide-1 is coupled with Palmitoyl Tetrapeptide-7  and the duo works in synergy to reduce wrinkles and give younger looking skin. According to the manufacturer's in-vivo (made on real people) test, applying 3% Matrixyl 3000 twice a day for 2 months resulted in all of the following things:

  • 39.4% reduction in surface occupied by deep wrinkles
  • 32.9% reduction in main wrinkle density
  • 19.9% reduction in main wrinkle average depth
  • 16% improvement in roughness
  • 16.2% in lifting effect
  • 5.5% improvement in elasticity
  • 15.5% improvement in skin tone

Manufacturer results, of course, always have to be taken with a pinch of salt, but if you like peptides, the Matryxil 3000 duo is one of the best-proven and most well-known ones and it's something that is worth trying.

What-it-does: antioxidant

We don't have description for this ingredient yet.

Also-called: Gotu Kola, Tiger Grass | What-it-does: soothing, antioxidant, moisturizer/humectant, surfactant/cleansing

Centella Asiatica - or gotu kola as normal people call it  - has been used in folk medicine for hundreds of years. It’s traditionally used to improve small wounds, burns and scratches and it’s also a well known anti-inflammatory agent for eczema.

Recently science has taken an interest in Gotu Kola as well and it turns out it really has many active compounds with several benefits. Just for hard-core geeks, the main biologically active compounds are pentacyclic triterpenoid saponins called asiaticoside, madecassoside, asiatic and madecassic acid (also called centellosides).

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One of the biological activities of the centellosides is to be able to stimulate GAGs  (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells), and especially hyaluronic acid synthesis in our skin. This is probably one of the reasons why Centella Asiatica Extract has nice skin moisturizing properties that was confirmed by a 25 people, four weeks study along with Centella's anti-inflammatory effects.

Madecassoside can also help in burn wound healing through increasing antioxidant activity and enhancing collagen synthesis. Asiaticoside was shown to increase antioxidant levels on rats skin when applied at 0.2%. 

Centella Asiatica also often shows up in products that try to treat cellulite or striae. Of course, it cannot make a miracle but it might have some effect via regulating microcirculation and normalizing the metabolism in the cells of connective tissues. 

Bottom line: Gotu Kola is a great plant ingredient with proven wound healing, anti-inflammatory, and antioxidant properties. Nice to spot on any ingredient list.  

What-it-does: emulsifying

We don't have description for this ingredient yet.

What-it-does: antioxidant

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

The snappily named Lauryl Peg-9 Polydimethylsiloxyethyl Dimethicone is a silicone emulsifier fluid whose main thing is being a good dispersant for powders such as mineral UV filters or color pigments. 

According to the manufacturer Kobo, this partly water- and partly oily soluble form of dimethicone helps filters like Titanium Dioxide and Zinc Oxide disperse more evenly and thus provide better UV protection while also minimizing any white-cast that often comes hand-in-hand with mineral filters.

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This is why it can also be found in makeup products like eyeshadows and concealers, as it helps disperse color pigments in the same way.

Jojoba-derived emollient wax esters (fatty acid + fatty alcohol) that make your skin feel nice and smooth. Chemically speaking, pure jojoba oil is also a wax ester (read our shiny explanation here), however, the ingredients called jojoba esters on the ingredient lists are made from jojoba oil and/or hydrogenated jojoba oil via interesterification. 

They have multiple versions with variable fatty acid chain length and the ingredient can have a liquid, a creamy, a soft or firm paste, or even a hard wax consistency. The common thing between all versions is, that unlike most normal triglyceride oils, jojoba esters have superior stability, provide non-greasy emolliency and are readily absorbed into the skin

Also-called: Milk Peptide Complex;Whey Protein | What-it-does: cell-communicating ingredient

Protein fragments, aka peptides and growth factors derived from milk (whey). It is claimed to boost the production of important extracellular matrix components (the gooey stuff between the skin cells) such as hyaluronic acid, collagen I and fibronectin. The in-vivo (made on people) tests showed reduced wrinkles and improved firmness within two weeks by using 0.5% of Whey Protein.

We don't have description for this ingredient yet.

Also-called: Vitamin E Acetate | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 0

It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version. 

According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E. 

Lactic Acid - superstar
  • It’s the second most researched AHA after glycolic acid
  • It gently lifts off dead skin cells to reveal newer, fresher, smoother skin
  • It also has amazing skin hydrating properties
  • In higher concentration (10% and up) it improves skin firmness, thickness and wrinkles
  • Choose a product where you know the concentration and pH value because these two greatly influence effectiveness
  • Don’t forget to use your sunscreen (in any case but especially so next to an AHA product)
Read all the geeky details about Lactic Acid here >>

What-it-does: moisturizer/humectant

You probably know yeast from the kitchen where you put it into milk with a little sugar and then after a couple of minutes brownish bubbles form. That is the fungi fermenting the sugar

As for skin care, yeast contains beta-glucan that is a great soothing ingredient and also a mild antioxidant.  The yeast extract itself is a silky clear liquid that has some great moisturizing, skin protecting and film-forming properties on the skin. 

Linoleic Acid - goodie
Also-called: LA, omega-6 fatty acid, 18:2 cis-9,12, Form of Vitamin F | What-it-does: skin-identical ingredient, emollient, surfactant/cleansing

The famous omega-6 fatty acid, the mother of all ω-6 fatty acids in our body. It is a so-called polyunsaturated fatty acid meaning it has more than one (in this case two) double bonds and a somewhat kinky structure that makes LA and LA-rich oils a thin liquid.

It is also an essential fatty acid meaning our body cannot synthesize it and has to take it from food. This is not hard at all as plenty of nuts (such as flax, poppy or sesame seeds) and vegetable oils (such as sunflower or safflower) are rich in LA. The hard thing seems to be eating enough omega-3-s, more specifically eating a healthy ratio of omega-6 to omega-3, but that is a topic for a what-is-good-to-eat-site and not for us. 

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As for linoleic acid and the skin, LA is a really important little guy found naturally in our skin. It is the most abundant fatty acid in the epidermis and it serves as a structural precursor for important skin lipids called ceramides. Knowing this, it will not come as a surprise that Linoleic acid has a central role in the structure and function of stratum corneum permeability, aka healthy skin barrier.  LA deficiency leads to an impaired more permeable skin barrier and the topical application of LA-rich sunflower oil can fix this issue rapidly (while oleic-rich olive oil did not have the same barrier repairing effect).

LA is not only important for dry, barrier damaged skin types but also for acne-prone skin. Research shows that problem skin has lower levels of linoleic acid (and higher levels of oleic acid) than normal skin. So LA-deficiency in the skin seems to be connected not only to an impaired skin barrier but also to acne and smearing LA all over your face might help with your problem skin. A double-blind study using a 2.5% LA gel for 4 weeks found a 25% reduction in the size of microcomedones, the tiny blocked pores that can later lead to acne.

If that was not enough, we have one more thing to report about LA.  It lightens hyperpigmentation (aka UVB caused sun spots) both by blocking the melanin production of melanocytes (the skin cells that make the pigment melanin) and by enhancing the desquamation of melanin pigment from the upper layers of the skin.

Overall, linoleic acid is a multi-functional skin goodie with barrier repairing, acne-reducing, and skin-lightening magic abilities. It's a nice one to spot on the ingredient list pretty much for any skin type. 

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It’s the - sodium form - cousin of the famous NMFhyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

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In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).

What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists. 

If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

What-it-does: moisturizer/humectant | Irritancy: 2 | Comedogenicity: 2

We don't have description for this ingredient yet.

Also-called: Soybean Extract | What-it-does: antioxidant, skin brightening, soothing, emollient

When you hear the word Soy, you probably associate it with soy sauce or tofu, not skincare. But as it turns out, the soybean has a bunch of useful active components and soybean extract is an interesting cosmetic ingredient with a wide range of possible effects. 

Its main active components are antioxidant phenolic acids and flavonoids as well as small and large soy proteins. The large proteins give soybean extract nice skin smoothing and softening properties, while the small proteins (soybean trypsin inhibitor (STI) and Bowman-Birk inhibitor (BBI)) are thought to inhibit skin pigmentation and delay hair regrowth.   

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Regarding skin pigmentation, the soybean extract works by hindering melanosome transfer, meaning it blocks the melanin pigment from traveling up to the surface of the skin and becoming visible there. This is useful for most pigmentation situations but, if you have melasma, soy is not for you as melasma is estrogen-mediated and soy is a well-known phytoestrogen

The most famous and bioactive flavonoids in soybeans are the isoflavones called genistein and diadzein that have potent antioxidant and anti-inflammatory properties. Genistein is also proven to inhibit UV induced redness in human skin. These isoflavones are also the ones that make soy a phytoestrogen, meaning they have a (weak) estrogenic effect. Topical estrogen is known to decrease skin thinning and collagen loss and soy might be able to do the same, especially during and after menopause when natural estrogen levels run low.  

There is also some promising, but as yet not in-vivo (done on real people), research that soybean extract can stimulate both elastin and collagen synthesis and thus lead to healthier, younger-looking skin. 

Overall, soybean extract is a promising and multi-functional active, a nice addition to most ingredient lists.

What-it-does: viscosity controlling

An organic derivative of hectorite clay, Disteardimonium Hectorite is used as a viscosity controller - it thickens up formulations to make them less runny.

It’s most popular use in cosmetics is in sunscreens, under the trademarked name Bentone 38 from Elementis. According to the manufacturer info, it is a real multi-tasker, including the ability to prevent pigments settling during storage, stabilizing a formula for longercreating a light and smooth skin feel and enhancing the water-resistance of sunscreen formulas
 

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

What-it-does: surfactant/cleansing, viscosity controlling, emulsion stabilising | Irritancy: 0 | Comedogenicity: 1

A handy helper ingredient (a polymer, i.e. big molecule from repeated subunits) that is used to stabilize emulsions as well as to thicken up products. It can also stabilize foam in cleansing products. 

If you ever wondered what those little Listerine breath strips were made of, you found your answer! Pullulan is a polysaccharide polymer, which basically means that it’s a big molecule made up of smaller sugar molecule units.

It dissolves in water and can make a thin, elastic, and moisture-absorbing film when spread on the skin that can cause an instant tightening effect. It can also be used as a thickener to get a silicone-like feel and can be used in peel-off masks. Btw, it's made from fungus via fermentation. 

What-it-does: moisturizer/humectant

A biocompatible copolymer (a big molecule that consists of more than one type of building blocks) that has the same structure as important cell membrane ingredient, phospholipid. It's a good skin moisturizer, leaves a silky, smooth feel on the skin and can help to reduce irritation caused by some not-so-nice ingredients (like surfactants).

Also-called: lye | What-it-does: buffering

The unfancy name for it is lye. It’s a solid white stuff that’s very alkaline and used in small amounts to adjust the pH of the product and make it just right. 

For example, in case of AHA or BHA exfoliants, the right pH is super-duper important, and pH adjusters like sodium hydroxide are needed.  

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BTW, lye is not something new. It was already used by ancient Egyptians to help oil and fat magically turn into something else. Can you guess what? Yes, it’s soap. It still often shows up in the ingredient list of soaps and other cleansers.

Sodium hydroxide in itself is a potent skin irritant, but once it's reacted (as it is usually in skin care products, like exfoliants) it is totally harmless.

We don't have description for this ingredient yet.

What-it-does: viscosity controlling, emulsion stabilising | Irritancy: 0 | Comedogenicity: 1

A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula.  It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient.

We don't have description for this ingredient yet.

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 0 | Comedogenicity: 0

It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 

It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol

The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.

Also-called: Form of Vitamin C, Ascorbyl Isotetrapalmitate, Ascorbyl Tetraisopalmitate, ATIP | What-it-does: antioxidant, skin brightening

Tetrahexyldecyl Ascorbate is a stable, oil-soluble form of skincare big shot Vitamin C. If you do not know, why Vitamin C is such a big deal in skincare, click here and read all about it. We are massive vitamin C fans and have written about it in excruciating detail.

So now, you know that Vitamin C is great and all, but it's really unstable and gives cosmetics companies many headaches. To solve this problem they came up with vitamin C derivatives, and one of them is Tetrahexyldecyl Ascorbate (let's call it ATIP in short).

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It's a really promising candidate (see below), but while reading all the goodness about it in a minute, do not forget that derivatives not only have to be absorbed into the skin but also have to be converted to pure vitamin C (ascorbic acid or AA) and the efficacy of the conversion is often unknown. In addition, vitamin C's three magic properties (antioxidant, collagen booster, skin brightener) are all properly proven in-vivo (on real people), but for the derivatives, it's mostly in-vitro studies or in the case of ATIP, it's in-vitro and done by an ingredient supplier.

With this context in mind let's see what ATIP might be able to do. First, it is stable (if pH < 5), easy to formulate and a joy to work with for a cosmetic chemist.

Second, because it's oil-soluble, its skin penetration abilities seem to be great. So great in fact, that it surpasses the penetration of pure vitamin C threefold at the same concentration and it penetrates successfully into the deeper layers of the skin (that is usually important to do some anti-aging work). There is also in-vitro data showing that it converts to AA in the skin. 

Third, ATIP seems to have all three magic abilities of pure vitamin C: it gives antioxidant protection from both UVB and UVA rays, it increases collagen synthesis (even more than AA) and it has a skin brightening effect by reducing melanogenesis by more than 80% in human melanoma cell cultures.

So this all sounds really great, but these are only in-vitro results at this point. We could find Tetrahexyldecyl Ascorbate mentioned only in one published in-vivo study that examined the anti-aging properties of a silicone formula containing 10% AA and 7% ATIP. The authors theorized that the 10% AA is released slowly from the silicon delivery system and probably stays in the upper layer of the skin to give antioxidant benefits, while ATIP penetrates more rapidly and deeply and gives some wrinkle-reducing benefits. The study was a small (10 patients), double-blind experiment, and the formula did show some measurable anti-aging results. However, it is hard to know how much pure vitamin C or ATIP can be thanked.

Bottom line: a really promising, but not well-proven vitamin C derivative that can be worth a try especially if you like experimenting (but if you like the tried and true, pure vitamin C will be your best bet).

What-it-does: buffering

Citric acid comes from citrus fruits and is an AHA. If these magic three letters don’t tell you anything, click here and read our detailed description on glycolic acid, the most famous AHA. 

So citric acid is an exfoliant, that can - just like other AHAs - gently lift off the dead skin cells of your skin and make it more smooth and fresh. 

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There is also some research showing that citric acid with regular use (think three months and 20% concentration) can help sun-damaged skin, increase skin thickness and some nice hydrating things called glycosaminoglycans in the skin. 

But according to a comparative study done in 1995, citric acid has less skin improving magic properties than glycolic or lactic acid. Probably that’s why citric acid is usually not used as an exfoliant but more as a helper ingredient in small amounts to adjust the pH of a formulation. 

What-it-does: viscosity controlling

We don't have description for this ingredient yet.

What-it-does: chelating

We don't have description for this ingredient yet.

What-it-does: chelating, buffering

A little helper ingredient that is used to adjust the pH of the product. It also helps to keep products stay nice longer by neutralizing the metal ions in the formula (they usually come from water). 

What-it-does: preservative

It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. It’s not a strong one and doesn’t really work against bacteria, but more against mold and yeast. To do that it has to break down to its active form, sorbic acid. For that to happen, there has to be water in the product and the right pH value (pH 3-4). 

But even if everything is right, it’s not enough on its own. If you see potassium sorbate you should see some other preservative next to it too.

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BTW, it’s also a food preservative and even has an E number, E202.

What-it-does: preservative

A helper ingredient that helps to make the products stay nice longer, aka preservative. It works mainly against fungi. 

It’s pH dependent and works best at acidic pH levels (3-5). It’s not strong enough to be used in itself so it’s always combined with something else, often with potassium sorbate.

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

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Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10). 

It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.

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