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Acetyl Hexapeptide-8

Acetyl Hexapeptide-8

Also-called-like-this: Argireline, Acetyl Hexapeptide-3

Official CosIng Information


If you see a cosmetic product that claims that it has "Botox-like effect" then two things are almost certain: one, the product overpromises and two, it contains Argireline. 

So this one is the famous peptide that's marketed by its manufacturer as the "Botox in a jar". The basis for this claim is that it targets the same wrinkle forming mechanism (wrinkles caused by facial muscle movement) as Botox, but the way it works is very different. In addition, the extent to which it can prevent muscles from contracting (and to smooth wrinkles) is very different (otherwise why would anyone use still Botox?). 

The manufacturer did several studies to prove that Argireline really works and it does (just not as well as Botox). In-vivo (made on real people) tests showed that using 10% Argireline solution around the eyes for 15 days decreased wrinkles depth by 17%. A Spanish University also did some research and found that Argireline increased the level of skin moisturization and decreased both the depth and width of wrinkles "significantly". 

This means, Acetyl Hexapeptide-8 does have some ability to smooth wrinkles (but not as well as Botox - sorry, if we sound like a broken record). Also, we have to agree with TruthInAging, that it's not a collagen builder and not a preventer of structural aging (think vitamin C, AHAs or retinol); it's just a quick fix. If you are looking for one, this could be your thing. If you are more of a "let's treat this aging thing properly" type, then it's probably not your thing.

Show me some proof

  • Ruiz, M. A., et al. "Evaluation of the anti-wrinkle efficacy of cosmetic formulations with an anti-aging peptide (Argireline®)." Ars pharm 50.4 (2010): 168-176.
  • Wang, Yuan, et al. "The Anti-Wrinkle Efficacy of Argireline, a Synthetic Hexapeptide, in Chinese Subjects." American journal of clinical dermatology 14.2 (2013): 147-153.

Products with Acetyl Hexapeptide-8

Dew and Dew Luxury Cell Collagen Peptide Ampoule Scinic Peptide Ampoule 95 Sidmool Min Jung Gi Efi Eye Cream Borghese Insta Form Platinum DMK Eye Tone Dr's Secret Eye Cream Hyalogic Episilk, Facial Relax Face Serum Image Skincare The Max™ Stem Cell Serum Le Mieux Bio Cell Rejuvenating Cream Le Mieux Bio Cell Rejuvenating Cream Le Mieux Bio Cell Rejuvenating Cream Le Mieux Essence Moisturizer NuGene Eye Serum Recover Antiaging Antiarrugas Intensivo Skin1765 Repair Suiphar Peptix Trish McEvoy Instant Solutions Triangle Of Light Eye Mask Trish McEvoy Trish McEvoy Beauty Booster Serum Umoua Advanced Extraction Liposome Tech Peptide Renewal Cream V Magic Magic V Pre-Serum (V-Serum) iQ Natural Line Reducing - Argireline Serum Bellirium Serum Botox-Like Complex Ecooking Day Cream HomeFacialPro 寡肽原液 Isomers All-In-One Complete Face Firming Serum Le Mieux Eye Wrinkle Corrector Le Mieux Moisture Infusion Mask Le Mieux Tgf-B Eye Firming Mask LeMieux Eye Wrinkle Corrector NuGene Clinical Premier Universal Serum Peter Thomas Roth Mega Rich Intense Anti-Ageing Cellular Cream Pure Anada Awake Eye Gel Revision Skincare Revox 7 Serum The Ordinary Argireline Solution 10% UniLipo Peptide Packed Eye Serum V Magic Magic White Serum VIJUVE 45% Vitamin C Serum With Double Hyaluronic Acid And Collagen Peptides For Face, Eyes, Neck And Chest Vivier Ulimage Airnderm Aesthetic Retinol Serum Derma E Advanced Peptides & Collagen Serum Hema Ultra Hydrate Skin Booster Isomers Wrinkle Viper Expression Line Treatment Monat 30 Second Miracle™ Instant Perfector Nuvo Elixir Snail Serum Organys Anti-Wrinkle Face & Eye Serum Sidmool 'Min Jung Gi' Bio-Nano Egf Serum The Ordinary Buffet Tiege Hanley Pm—Bedtime Facial Moisturizer Tiege Hanley Super Serum ALLEGRO NATURA Siero Viso Anti Age B-Like