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Acetyl Hexapeptide-8

Acetyl Hexapeptide-8

Also-called-like-this: Argireline, Acetyl Hexapeptide-3

Official CosIng Information


If you see a cosmetic product that claims that it has "Botox-like effect" then two things are almost certain: one, the product overpromises and two, it contains Argireline. 

So this one is the famous peptide that's marketed by its manufacturer as the "Botox in a jar". The basis for this claim is that it targets the same wrinkle forming mechanism (wrinkles caused by facial muscle movement) as Botox, but the way it works is very different. In addition, the extent to which it can prevent muscles from contracting (and to smooth wrinkles) is very different (otherwise why would anyone use still Botox?). 

The manufacturer did several studies to prove that Argireline really works and it does (just not as well as Botox). In-vivo (made on real people) tests showed that using 10% Argireline solution around the eyes for 15 days decreased wrinkles depth by 17%. A Spanish University also did some research and found that Argireline increased the level of skin moisturization and decreased both the depth and width of wrinkles "significantly". 

This means, Acetyl Hexapeptide-8 does have some ability to smooth wrinkles (but not as well as Botox - sorry, if we sound like a broken record). Also, we have to agree with TruthInAging, that it's not a collagen builder and not a preventer of structural aging (think vitamin C, AHAs or retinol); it's just a quick fix. If you are looking for one, this could be your thing. If you are more of a "let's treat this aging thing properly" type, then it's probably not your thing.

Show me some proof

  • Ruiz, M. A., et al. "Evaluation of the anti-wrinkle efficacy of cosmetic formulations with an anti-aging peptide (Argireline®)." Ars pharm 50.4 (2010): 168-176.
  • Wang, Yuan, et al. "The Anti-Wrinkle Efficacy of Argireline, a Synthetic Hexapeptide, in Chinese Subjects." American journal of clinical dermatology 14.2 (2013): 147-153.

Products with Acetyl Hexapeptide-8

Scinic Peptide Ampoule 95 Borghese Insta Form Platinum Hyalogic Episilk, Facial Relax Face Serum Le Mieux Bio Cell Rejuvenating Cream Le Mieux Bio Cell Rejuvenating Cream Le Mieux Essence Moisturizer NuGene Eye Serum Umoua Advanced Extraction Liposome Tech Peptide Renewal Cream iQ Natural Line Reducing - Argireline Serum Ecooking Day Cream Isomers All-In-One Complete Face Firming Serum Le Mieux Eye Wrinkle Corrector Le Mieux Moisture Infusion Mask Le Mieux Tgf-B Eye Firming Mask LeMieux Eye Wrinkle Corrector NuGene Clinical Premier Universal Serum Peter Thomas Roth Mega Rich Intense Anti-Ageing Cellular Cream Pure Anada Awake Eye Gel Revision Skincare Revox 7 Serum The Ordinary Argireline Solution 10% UniLipo Peptide Packed Eye Serum VIJUVE 45% Vitamin C Serum With Double Hyaluronic Acid And Collagen Peptides For Face, Eyes, Neck And Chest Isomers Wrinkle Viper Expression Line Treatment Nuvo Elixir Snail Serum Sidmool 'Min Jung Gi' Bio-Nano Egf Serum The Ordinary Buffet Tiege Hanley Pm—Bedtime Facial Moisturizer Tiege Hanley Super Serum Dr.magic Polypeptide Line Reducing Serum Good Molecules Super Peptide Serum Le Mieux Eye And Lip Cream MD Skinical Soothing Hydropeptide Serum NutriBiotic Ultra-Hydrating, Peptide Face Creme Pacifica Dreamy Youth Moisturizer The Ordinary Buffet + Copper Peptides 1% Vine Vera Resveratrol Shiraz Instentic Non-Surgical Syringe YOU Skincare Essential Hydration Serum 111SKIN Space Defence Bright Eye Lift Gel BLACK TRUFFLE Instant Repair Syringe Elta MD Renew Eye Gel Jaina Face Real Peptide Complex Serum Jordan Samuel Skin The Performance Cream MD Skinical Eye Petide Gel MUKTI Age Defiance Eye Serum Malibu C Perfection C Serum Miamo Peptide Functonal Complex Serum Nezeni Contorno Ojos Open Formula Peptide Face Mask (10% Peptides) Sidmool Speedy Valley Spread Ampoule Tiege Hanley Eyes—Am/Pm Eye Cream