Acetyl Hexapeptide-8

Acetyl Hexapeptide-8

Also-called-like-this: Argireline, Acetyl Hexapeptide-3


If you see a cosmetic product that claims that it has "Botox-like effect" then two things are almost certain: one, the product overpromises and two, it contains Argireline. 

So this one is the famous peptide that's marketed by its manufacturer as the "Botox in a jar". The basis for this claim is that it targets the same wrinkle forming mechanism (wrinkles caused by facial muscle movement) as Botox, but the way it works is very different. In addition, the extent to which it can prevent muscles from contracting (and to smooth wrinkles) is very different (otherwise why would anyone use still Botox?). 

The manufacturer did several studies to prove that Argireline really works and it does (just not as well as Botox). In-vivo (made on real people) tests showed that using 10% Argireline solution around the eyes for 15 days decreased wrinkles depth by 17%. A Spanish University also did some research and found that Argireline increased the level of skin moisturization and decreased both the depth and width of wrinkles "significantly". 

This means, Acetyl Hexapeptide-8 does have some ability to smooth wrinkles (but not as well as Botox - sorry, if we sound like a broken record). Also, we have to agree with TruthInAging, that it's not a collagen builder and not a preventer of structural aging (think vitamin C, AHAs or retinol); it's just a quick fix. If you are looking for one, this could be your thing. If you are more of a "let's treat this aging thing properly" type, then it's probably not your thing.

Show me some proof

  • Ruiz, M. A., et al. "Evaluation of the anti-wrinkle efficacy of cosmetic formulations with an anti-aging peptide (Argireline┬«)." Ars pharm 50.4 (2010): 168-176.
  • Wang, Yuan, et al. "The Anti-Wrinkle Efficacy of Argireline, a Synthetic Hexapeptide, in Chinese Subjects." American journal of clinical dermatology 14.2 (2013): 147-153.

Products with Acetyl Hexapeptide-8

Scinic Peptide Ampoule 95 NuGene Eye Serum Isomers All-In-One Complete Face Firming Serum Peter Thomas Roth Mega Rich Intense Anti-Ageing Cellular Cream The Ordinary Argireline Solution 10% Sidmool 'Min Jung Gi' Bio-Nano Egf Serum The Ordinary Buffet Pacifica Dreamy Youth Moisturizer The Ordinary Buffet + Copper Peptides 1% Jaina Face Real Peptide Complex Serum Jordan Samuel Skin The Performance Cream Cos De BAHA M.A Peptide Serum Manyo Factory Lactobacillus Bifida Mist Dr. Jart+ Water Drop Hydrating Moisturiser Estee Lauder Micro Essence Skin Activating Treatment Lotion NIOD Fractionated Eye Contour Concentrate Neogen Pink Cactus Liftmax Knit Mask Pacifica Crystal Youth Gem Infused Face Lotion BIOSSANCE Squalane + Peptide Eye Gel Tula Multi-Spectrum Eye Renewal Serum Manyo Factory Bifidalacto Complex Perricone MD Cold Plasma Face Serum Concentrate Perricone MD Neuropeptide Firming Moisturizer Mizon Peptide 500 Peter Thomas Roth Mega Rich Anti Cellular Eye Cream Dr. Troub Bio Repair Powder Cleanser Clinique Fresh Pressed Daily Booster With Pure Vitamin C 10% First Aid Beauty Fab Skin Lab Retinol Serum 0.25% Pure Concentrate First Aid Beauty Fab Skin Lab Retinol Serum 0.25% Pure Concentrate Peter Thomas Roth Un-Wrinkle Night Peter Thomas Roth Un-Wrinkle Turbo Line Smoothing Toning Lotion Azelique Age Refining Night Cream Kiss My Face Face Factor Spf30 Sunscreen Peter Thomas Roth Un-Wrinkle Turbo Face Serum it Cosmetics Bye Bye Under Eye Eye Cream Clinique Pep-Start Hydroblur Moisturizer Scinic Snail Aio Ampoule Dr. Jart+ Multi Action Eye Balm Dark Spot Corrector Erasa Xep-30 Smashbox Camera Ready Bb Cream Spf 35 ECO YOUR SKIN O2 Melting Serum Clinique Smart Custom-Repair Serum Hanacure Facial Peel Manyo Factory 4Gf Eye Cream Atopalm Real Barrier Aqua Soothing Toner Manyo Factory Bifidalacto Eye Cream Eyenlip Salmon Oil Nutrition Serum Koh Gen Do Macro Vintage Royal Massage Milk STARSKIN Eye Catcher Smoothing Bio Cellulose Second Skin Eye Masks Neogen White Truffle Laycure Oil Stick