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Eighth Day Regenerative Serum

Regenerative Serum

A supercharged serum formulated with a proprietary blend of peptides, growth factors, and immunostimulants that mimic the molecules found in human skin cells.
Uploaded by: jessicaabroad on

Skim through

Ingredient name what-it-does irr., com. ID-Rating
Aqua/Water/Eau solvent
Pentylene Glycol solvent, moisturizer/​humectant
Peptide-Rich Plasma®
[SH-Oligopeptide-2 cell-communicating ingredient
SH-Polypeptide-1 cell-communicating ingredient
SH-Polypeptide-9 cell-communicating ingredient
SH-Polypeptide-11 cell-communicating ingredient
Acetyl Hexapeptide-8 cell-communicating ingredient, moisturizer/​humectant goodie
SH-Oligopeptide-1 cell-communicating ingredient
Palmitoyl Tripeptide-5 cell-communicating ingredient goodie
Palmitoyl Tetrapeptide-7 cell-communicating ingredient goodie
Acetyl Glutamine
Sodium Hyaluronate skin-identical ingredient, moisturizer/​humectant 0, 0 goodie
Lysine Hcl
Alanine skin-identical ingredient goodie
Histidine Hcl
Arginine skin-identical ingredient goodie
Serine skin-identical ingredient goodie
Proline skin-identical ingredient goodie
Glutamic Acid moisturizer/​humectant
Threonine skin-identical ingredient goodie
Valine skin-identical ingredient goodie
Leucine
Glycine skin-identical ingredient goodie
Isoleucine skin-identical ingredient goodie
Phenylalanine skin-identical ingredient goodie
Taurine] buffering
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar
Hedychium Coronarium Root Extract
Tripeptide-1 cell-communicating ingredient goodie
Polygonum Aviculare Extract antioxidant, emollient goodie
Honey soothing, moisturizer/​humectant, antimicrobial/​antibacterial goodie
Nonapeptide-1
Acetyl Heptapeptide-4 moisturizer/​humectant
Phytosphingosine skin-identical ingredient, cell-communicating ingredient, anti-acne, antimicrobial/​antibacterial goodie
Sea Whip Extract
Niacinamide cell-communicating ingredient, skin brightening, anti-acne, moisturizer/​humectant superstar
Hydrolyzed Hyaluronic Acid moisturizer/​humectant goodie
Aminobutyric Acid
Adenosine cell-communicating ingredient goodie
Thioctic Acid antioxidant goodie
Glycolic Acid exfoliant, buffering superstar
Bacillus/Soybean/Folic Acid Ferment Extract
Polysorbate 20 emulsifying, surfactant/​cleansing 0, 0
Allantoin soothing 0, 0 goodie
Caprylyl Glycol moisturizer/​humectant, emollient
Lecithin emollient, emulsifying goodie
Butylene Glycol moisturizer/​humectant, solvent 0, 1
1,2-Hexanediol solvent
Dextran viscosity controlling
Phenoxyethanol preservative
Ethylhexylglycerin preservative
Xanthan Gum viscosity controlling

Eighth Day Regenerative Serum
Ingredients explained

Also-called: Aqua;Water | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product feel great on the skin. It works synergistically with preservatives and helps to improve water-resistance of sunscreens. 

This ingredient name is not according to the INCI-standard. :( What, why?!

Also-called: Insulin-like growth factor 1, IGF-1, rh-Oligopeptide-2;SH-Oligopeptide-2 | What-it-does: cell-communicating ingredient

Sh-Oligopeptide-2 is also called Insulin-like growth factor 1 and it belongs to the same group of ingredients (Growth Factors) as its better-known sister, Epidermal Growth Factor or Sh-Oligopeptide-1. This guy consists of 70 amino acids and, similar to EGF, it is also claimed to stimulate cell proliferation and wound healing. There is also a study that indicates EGF and IGF1 work in synergy to promote keratinocyte (skin cell) proliferation. 

The topic of Growth Factors in skincare is complex and controversial. If you are new to it, read our shiny explanation on EGF to get a (hopefully) balanced impression about the pros and cons.

Also-called: Basic Fibroblast Growth Factor, FGF2, rh-Polypeptide-1 | What-it-does: cell-communicating ingredient

Sh-Polypeptide-1 is a cell signaling protein also called Basic Fibroblast Growth Factor and is twin sister to Acidic Fibroblast Growth Factor. We can write here pretty much the same things as we did on aFGF: it is a mitogenic (= stimulates cell proliferation) ingredient that stimulates fibroblast cell growth and proliferation. According to manufacturer info, it also stimulates the synthesis of collagen and other extracellular-matrix (the gooey stuff between cells) components. 

Growth Factors and skincare is a big, complicated and controversial topic, so if you wanna know more, we have a more detailed explanation on Epidermal Growth Factor, the most common one used in skincare.

Also-called: Vascular Endothelial Growth Factor, VEGF, rh-Polypeptide-9, part of BIO-Placenta | What-it-does: cell-communicating ingredient

Sh-Polypeptide-9 is a cell signaling protein also called Vascular Endothelial Growth Factor. As its name suggests, its main function is to stimulate the formation of blood vessels. As to what it does in cosmetic products, we found manufacturers info claiming that it plays a role in supplying fibroblast cells (VIP skin cells that make collagen) with nutrients, in the growth and migration of cells and in wound healing

It usually comes to the formula as part of a Growth Factor mix trade named BIO-Placenta, that combines EGF, IGF-1, FGF1, FGF2 and this guy to form a synergistic growth factor cocktail. BIO Placenta is claimed to do pretty much everything you would want from an anti-aging active including anti-wrinkle, skin rejuvenation, elasticity enhancement, moisturizing and cell vitalization properties. 

Also-called: Acidic Fibroblast growth factor, FGF1, rh-Polypeptide-11 | What-it-does: cell-communicating ingredient

Sh-Polypeptide-11 is a medium sized cell signaling molecule also called Acidic Fibroblast Growth Factor. It belongs to the same group of ingredients (Growth Factors) as its better-known sister, Epidermal Growth Factor or Sh-Oligopeptide-1. As its name suggests, FGF can stimulate the growth and proliferation of fibroblast cells (VIP cells that produce among other things collagen). According to manufacturer info, it also stimulates skin regeneration, wound healing and collagen and elastin synthesis. 

As for research, we could find an in-vitro study that proved that "Recombinant FGF-1 strongly stimulated fibroblast and keratinocyte proliferation. However, the transition of this protein through the SC required an appropriate carrier system - lipid spheres." 

Also-called: Argireline, Acetyl Hexapeptide-3 | What-it-does: cell-communicating ingredient, moisturizer/humectant

If you see a cosmetic product that claims that it has "Botox-like effect" then two things are almost certain: one, the product overpromises and two, it contains Argireline. 

So this one is the famous peptide that's marketed by its manufacturer as the "Botox in a jar". The basis for this claim is that it targets the same wrinkle forming mechanism (wrinkles caused by facial muscle movement) as Botox, but the way it works is very different. In addition, the extent to which it can prevent muscles from contracting (and to smooth wrinkles) is very different (otherwise why would anyone use still Botox?). 

Also-called: Epidermal Growth Factor, EGF, rh-Oligopeptide-1 | What-it-does: cell-communicating ingredient

Sh-Oligopeptide-1 is the famous molecule, which is also called Epidermal Growth Factor or EGF. Chemically speaking, Growth Factors are largish peptides or smallish proteins, or to put it in another way, medium-length amino acid sequences (EGF consists of 53 amino acids).  Biologically speaking, Growth Factors are cellular signal molecules that can stimulate cell growth, proliferation, healing and/or differentiation. 

There are lots of Growth Factors and EGF is just one of them. The topic of "Growth Factors and skincare" is a big, confusing and controversial one and we will try our best to summarize the story for you, including the pros and the cons. 

Also-called: Syn-Coll | What-it-does: cell-communicating ingredient

A tripeptide (three amino acids attached to each other: Lys-Val-Lys) that's claimed to protect and boost collagen and improve skin texture.

The manufacturer did an in-vivo (made on real people) study with 45 volunteers and found that used twice daily for 84 days 1% and 2.5% Syn-Coll reduces the appearance of wrinkles by 7 and 12% respectively. In another study (also by the manufacturer) with 33 female Chinese volunteers, 77% of the participants felt that Syn-Coll visibly improved the firmness and elasticity of the skin after 4 weeks. What's more, 60% of the participants also noticed a reduction in the look of the pore size also after 4 weeks of treatment. 

Also-called: Part of Matrixyl 3000, Pal-GQPR, Previously Palmitoyl Tetrapeptide-3 | What-it-does: cell-communicating ingredient

A four amino acid peptide with the amino sequence of glycine-glutamine-proline-arginine. It is attached to palmitic acid (a fatty acid)  to increase oil solubility and skin penetration. 

It works by reducing the production of the signal moleculeinterleukin-6 (IL-6) which promotes inflammation in the skin and less inflammation means slower degradation of important things (like collagen) that results in younger looking skin for a longer time. 

We don't have description for this ingredient yet.

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It’s the - sodium form - cousin of the famous NMFhyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

We don't have description for this ingredient yet.

Alanine - goodie

A non-essential amino acid (a building block of skin proteins like collagen or elastin) that hydrates the skin.

We don't have description for this ingredient yet.

Arginine - goodie

A semi-essential (infants cannot synthesize it, but adults can) amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor, a skin hydrator and might also help to speed up wound healing

Arginine usually has a positive charge (cationic) that makes it substantive to skin and hair (those are more negatively charged surfaces) and an excellent film former.  Thanks to the positive charge, it also creates a complex with AHAs (AHAs like to lose a hydrogen ion and be negatively charged, so the positive and the negative ions attract each other) that causes a "time-release AHA effect" and reduces the irritation associated with AHAs

Serine - goodie

Serine is an amino acid that most often comes to the formula as part of a moisturizing complex. It's a non-essential amino acid (meaning that our body can synthesize it) and serves as a water-binding ingredient.

In general, amino acids are great skincare ingredients that play an important role in proper skin hydration but there is not much info out there about what specifically serine can do for the skin.

Proline - goodie

A non-essential amino acid (meaning that our body can produce it) that's also one of the major building blocks of collagen. According to the Futurederm blog, it might be able to improve wrinkles when combined with other amino acids, glycine and leucine

What-it-does: moisturizer/humectant

Glutamic acid is a little molecule and non-essential (our body can synthesize it) amino acid with the important job of being a neurotransmitter in the human body meaning that it helps your nervous system work correctly. 

As for what it's doing in cosmetics, Glutamic acids' main thing (similar to other amino acids) is being a humectant moisturizer and skin-conditioning agent (sidenote: if you attach lots of glutamic acid molecules, you get polyglutamic acid that is claimed to be a better than hyaluronic acid humectant). It also seems to affect skin barrier repair, however, it is not clear-cut in which direction.

Threonine - goodie

An essential amino acid that's also a key building block of collagen and elastin. When taken orally, it helps the digestive and intestinal tracts function more smoothly and also helps the absorption of nutrients. As for skincare, it is not clear what it does other than being a skin hydrator

Valine - goodie

An essential amino acid (a building block of skin proteins like collagen) that our body cannot produce itself but has to take from external sources, like diet. 

It's a branched chain amino acid that is claimed to enhance energy, increase endurance and aid in muscle tissue recovery and repair when taken as a supplement. It's not clear what valine does when you put it on the skin, but as all amino acids, it must be at least a great skin hydrator.

We don't have description for this ingredient yet.

Glycine - goodie

A non-essential amino acid (the building blocks of skin proteins, like collagen or elastin), that the body can produce itself, but its production decreases with age. When you put it all over your face, it works as a moisturizer and maybe more. 

According to great skincare blog Futurederm, glycine might help with wound healing and tissue repair and when used together with other amino acids, leucine and proline it might improve wrinkles

Isoleucine - goodie

A branch-chained, essential amino acid that can be found in things like almond, cashew or soy protein. When taken orally it may promote protein synthesis. As for skincare - like all the amino acids - it's a skin-identical ingredient and moisturizer. It also seems to be useful as a barrier repair ingredient.  

Phenylalanine - goodie

An essential amino acid that the body cannot produce itself but has to take from the diet. Combined with UVA exposure, phenylalanine is used in the treatment of vitiligo (a pigmentation disorder where patches of the skin lose the pigment).

What-it-does: buffering

We don't have description for this ingredient yet.

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

We don't have description for this ingredient yet.

Tripeptide-1 - goodie
Also-called: GHK, Kollaren | What-it-does: cell-communicating ingredient

A small, three amino acid (glycine-histidine-lysine or GHK) peptide that is famous for being a type I collagen fragment. The theory behind collagen-fragment peptides is that when collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen.

Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more. So Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. FYI; Tripeptide-1 is the same peptide that can be found in the famous Matrixyl 3000, but in Matrixyl a palmitic acid is attached to it to increase its oil solubility and thus skin penetration.

Also-called: Knotgrass Extract, Elix-IR | What-it-does: antioxidant, emollient

A flavonoid-rich plant extract coming from knotgrass that is claimed to protect the skin from both UV and Infrared damage.  By now it's pretty well-known that UV-light is the number one external skin-aging factor, however, *sigh* it looks like UV is not the only kind of light that causes bad things to happen to the skin.

Infrared light (760 nm to 1 mm) is the spectral band above visible light and there is some research concluding that it can accelerate skin aging via multiple mechanisms, one of them being the stimulation of the production of evil collagen-destroying enzymes called matrix metalloproteinases (MMP).

Honey - goodie
Also-called: Mel | What-it-does: soothing, moisturizer/humectant, antimicrobial/antibacterial

We all know honey as the sweet, gooey stuff that is lovely to sweeten a good cup of tea and we have good news about putting honey all over our skin. It is just as lovely on the skin as it is in the tea. 

The great review article about honey in the Journal of Cosmetic Dermatology writes that it is arguably the oldest skincare ingredient and evidence from around 4500 BC mentions honey in some eye cream recipes. Chemically speaking, it is a bee-derived, supersaturated sugar solution.  About 95% of honey dry weight is sugar and the other 5% consists of a great number of other minor components including proteins, amino acids, vitamins, enzymes, and minerals

We don't have description for this ingredient yet.

What-it-does: moisturizer/humectant

We don't have description for this ingredient yet.

It's a type of lipid, a so-called sphingoid base that can be found naturally in the upper layer of the skin. It's found both in "free-form" and as part of famous skin lipids, ceramides.

There is emerging research about Phytosphingosine that shows that it has antimicrobial and cell-communicating properties and is considered part of the skin's natural defense system.

We don't have description for this ingredient yet.

Niacinamide - superstar
Also-called: vitamin B3, nicotinamide | What-it-does: cell-communicating ingredient, skin brightening, anti-acne, moisturizer/humectant
  • A multi-functional skincare superstar with several proven benefits for the skin
  • Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
  • Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
  • Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
  • Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
Read all the geeky details about Niacinamide here >>

What-it-does: moisturizer/humectant

Hydrolyzed Hyaluronic Acid is a low molecular weight, chemically chopped up version of the naturally big molecule and current IT-moisturizer, Hyaluronic Acid (HA). The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to retain water, making it plump and elastic. As HA is a polymer, the subunits can be repeated many times (as a high-molecular-weight version), or just a few times (as a low-molecular-weight version).

We wrote in detail at HA about how different molecular weight versions do different things both as a component of the skin and as a skincare ingredient, so click here and read about all the details. Hydrolyzed Hyaluronic Acid can also come in different molecular-weight versions with different properties:

We don't have description for this ingredient yet.

Adenosine - goodie

Adenosine is an important little compound in our body that has a vital cell-signalling role. Research on smearing it on our face is also promising and shows so far a couple of things:

  • It can help with wound healing
  • It’s a good anti-inflammatory agent
  • It might even help with skin’s own collagen production and improve skin firmness and elasticity
  • It helps with barrier repair and protection
  • It might be even useful for the hair helping with hair thickness and hair growth
Thioctic Acid - goodie
Also-called: Alpha-Lipoic Acid | What-it-does: antioxidant

Alpha-Lipoic Acid (ALA) is a great antioxidant that's also part of the body's natural antioxidant system. It's soluble both in water-rich and lipid-rich environments so it's versatile and can interact with many types of evil oxidants as well as other nice antioxidants. 

ALA seems to be a great choice for topical use as studies show it can penetrate the skin rapidly where it's converted to DHLA (dihydrolipoic acid), an even more potent antioxidant molecule.  A nicely designed (we mean double-blind, placebo-controlled) 12-week study from 2003 confirmed that 5% ALA cream can decrease skin roughness and improve general signs of photoaging statistically significantly.  A slight catch, though, is that burning and warmth in the skin was quite a common side effect, especially in the first 4 weeks. 

Glycolic Acid - superstar
What-it-does: exfoliant, buffering
  • It’s the most researched AHA with the most proven skin benefits
  • It gently lifts off dead skin cells to reveal newer, fresher, smoother skin
  • It can help skin’s own collagen production that results in firmer, younger skin
  • It can fade brown spots caused by sun damage or PIH
  • Choose a product where you know the concentration and pH value because these two greatly influence effectiveness
  • Don’t forget to use your sunscreen (in any case but especially so next to an AHA product)
  • Slight stinging or burning with a stronger AHA product is normal
  • If your skin is very sensitive, rosacea prone choose rather a BHA or PHA product
Read all the geeky details about Glycolic Acid here >>

We don't have description for this ingredient yet.

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 0 | Comedogenicity: 0

It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 

Allantoin - goodie
What-it-does: soothing | Irritancy: 0 | Comedogenicity: 0

Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. 

It's not only soothing but it' also skin-softening and protecting and can promote wound healing.

It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol

The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.

Lecithin - goodie
What-it-does: emollient, emulsifying

A very common ingredient that can be found in all cell membranes. In cosmetics it's quite the multi-tasker: it's an emollient and water-binding ingredient but it's also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes

What-it-does: moisturizer/humectant, solvent | Irritancy: 0 | Comedogenicity: 1

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

What-it-does: solvent

A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives

What-it-does: viscosity controlling

We don't have description for this ingredient yet.

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

What-it-does: preservative, deodorant

If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.

Also, it's an effective deodorant and a medium spreading emollient

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range. 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

You may also want to take a look at...

what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does solvent | moisturizer/humectant
A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent, and a broad spectrum antimicrobial. [more]
what‑it‑does cell-communicating ingredient
Sh-Oligopeptide-2 is also called Insulin-like growth factor 1 and it belongs to the same group of ingredients (Growth Factors) as its better-known sister, Epidermal Growth Factor or Sh-Oligopeptide-1. [more]
what‑it‑does cell-communicating ingredient
Sh-Polypeptide-1 is a cell signaling protein also called Basic Fibroblast Growth Factor and is twin sister to Acidic Fibroblast Growth Factor. [more]
what‑it‑does cell-communicating ingredient
Sh-Polypeptide-9 is a cell signaling protein also called Vascular Endothelial Growth Factor. As its name suggests, its main function is to stimulate the formation of blood vessels. [more]
what‑it‑does cell-communicating ingredient
Sh-Polypeptide-11 is a medium sized cell signaling molecule also called Acidic Fibroblast Growth Factor. It belongs to the same group of ingredients (Growth Factors) as its better-known sister, Epidermal Growth Factor or Sh-Oligopeptide-1. [more]
what‑it‑does cell-communicating ingredient | moisturizer/humectant
Argireline - famous peptide that's often referred to as "Botox in a jar". In reality, it's nowhere near that powerful, but it can smooth wrinkles to some extent by preventing facial muscles from contracting. [more]
what‑it‑does cell-communicating ingredient
Epidermal Growth Factor - a smallish protein that works as a potent cell signaling molecule. It stimulates cell proliferation, wound healing and skin renewal. Do not use if you have psoriasis or high skin cancer risk factors. [more]
what‑it‑does cell-communicating ingredient
Syn-Coll - An anti-aging tripeptide that's claimed to protect and boost collagen and improve skin texture. [more]
what‑it‑does cell-communicating ingredient
The pal of Palmitoyl Tripeptide-1 in Matrixyl 3000. A four amino acid peptide that works by reducing the production of the signal molecule, inteleukin-6 (IL-6) that promotes inflammation in the skin. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
what‑it‑does skin-identical ingredient
A non-essential amino acid (a building block of skin proteins like collagen or elastin) that hydrates the skin.
what‑it‑does skin-identical ingredient
An amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor and might also help to speed up wound healing.  [more]
what‑it‑does skin-identical ingredient
Serine is an amino acid that most often comes to the formula as part of a moisturizing complex. It's a non-essential amino acid (meaning that our body can synthesize it) and serves as a water-binding ingredient.In general, amino acids are great skincare ingredients that play an important role in proper skin hydration but there is not much info out there about what specifically serine can d [more]
what‑it‑does skin-identical ingredient
A non-essential amino acid (meaning that our body can produce it) that might be able to improve wrinkles combined with other amino acids, glycine and leucine. [more]
what‑it‑does moisturizer/humectant
Glutamic acid is a little molecule and non-essential (our body can synthesize it) amino acid with the important job of being a neurotransmitter in the human body meaning that it helps your nervous system work correctly.  As for what it's doing in cosmetics, Glutamic acids' main thing (similar to other amino acids) is being a humectant moisturizer and skin-conditioning [more]
what‑it‑does skin-identical ingredient
An essential amino acid (important building block of collagen and elastin) that hydrates the skin. [more]
what‑it‑does skin-identical ingredient
An essential amino acid (a building block of skin proteins like collagen) that is a skin hydrator. [more]
what‑it‑does skin-identical ingredient
An amino acid (the building blocks of skin proteins, like collagen) that hydrates the skin and might help wound healing and improve wrinkles. [more]
what‑it‑does skin-identical ingredient
An essential amino acid that hydrates the skin and might be also a barrier repair ingredient. [more]
what‑it‑does skin-identical ingredient
An essential amino acid that is used in the treatment of vitiligo. [more]
what‑it‑does buffering
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does cell-communicating ingredient
A small, three amino acid (glycine-histidine-lysine or GHK) peptide that is famous for being a type I collagen fragment. The theory behind collagen-fragment peptides is that when collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen. [more]
what‑it‑does antioxidant | emollient
A flavonoid-rich plant extract coming from knotgrass that's claimed to protect the skin both from UV and Infrared damage. [more]
what‑it‑does soothing | moisturizer/humectant | antimicrobial/antibacterial
The sweet, gooey, sugar-laden stuff with skin moisturizing, soothing, antibacterial and some antioxidant properties. [more]
what‑it‑does moisturizer/humectant
what‑it‑does skin-identical ingredient | cell-communicating ingredient | anti-acne | antimicrobial/antibacterial
A type of lipid that can be found naturally in the skin. Has antimicrobial and cell-communicating properties and is considered to be part of the skin's natural defence system. [more]
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
what‑it‑does moisturizer/humectant
Hydrolyzed Hyaluronic Acid is a low molecular weight, chemically chopped up version of the naturally big molecule and current IT-moisturizer, Hyaluronic Acid (HA). The TL; [more]
what‑it‑does cell-communicating ingredient
An important compound in our body that has a vital cell-signalling role. It is wound healing, anti-inflammatory and can help with barrier repair. [more]
what‑it‑does antioxidant
Alpha-Lipoic Acid (ALA) is a great antioxidant that's also part of the body's natural antioxidant system. It's soluble both in water-rich and lipid-rich environments so it's versatile and can interact with many types of evil oxidants as well as other nice antioxidants. ALA seems to be a great choice for topical use as studies show it can penetrate the skin rapidl [more]
what‑it‑does exfoliant | buffering
The most researched and well-known AHA exfoliant. It gently lifts off dead skin cells to reveal newer, fresher, smoother skin. In larger concentration (>10%) it's a proven collagen booster. [more]
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 0, 0
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 
what‑it‑does soothing
irritancy, com. 0, 0
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. It's not only soothing but it' [more]
what‑it‑does moisturizer/humectant | emollient
A handy multi-tasking ingredient that gives the skin a nice, soft feel and also boosts the effectiveness of other preservatives. [more]
what‑it‑does emollient | emulsifying
It's quite the multi-tasker: an emollient and water-binding ingredient but also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes.  [more]
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0, 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
what‑it‑does solvent
A multi-functional helper ingredient that acts as a humectant and emollient. It's also a solvent and can boost the effectiveness of preservatives. [more]
what‑it‑does viscosity controlling
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]
what‑it‑does viscosity controlling
A super commonly used thickener and emulsion stabilizer. [more]