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Hydrolyzed Hyaluronic Acid

Hydrolyzed Hyaluronic Acid

What-it-does: moisturizer/humectant

Official CosIng Information


Hydrolyzed Hyaluronic Acid is a low molecular weight, chemically chopped up version of the naturally big molecule and current IT-moisturizer, Hyaluronic Acid (HA). The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to retain water, making it plump and elastic. As HA is a polymer, the subunits can be repeated many times (as a high-molecular-weight version), or just a few times (as a low-molecular-weight version).

We wrote in detail at HA about how different molecular weight versions do different things both as a component of the skin and as a skincare ingredient, so click here and read about all the details. Hydrolyzed Hyaluronic Acid can also come in different molecular-weight versions with different properties:

  • 100-300 kDa version: apart from moisturizing, this size might also help the skin to repair itself by increasing its self-defense. It is also claimed to boost the wound healing process and is especially helpful for sensitive skin types (acne, rosacea, inflammation-related skin diseases). 
  • 50k Da version: this is the size that is claimed to be able to absorb into the skin and plump up wrinkles, so it is used mainly as an "anti-aging ingredient" 
  • below 50k, around 10k Da version: there is a Japanese version trade named Hyalo-Oligo that has only a 10k molecular weight and is claimed to penetrate the skin very well, have a unique touch and give deep and long-lasting moisturization. Based on the Evonik-research and the natural role of LMW-HA in the body working as a pro-inflammatory signal molecule, this ultra-low molecular weight version is a controversial ingredient

If you wanna become a real HA-and-the-skin expert, you can read much more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

Show me some proof

  • Journal of immunology, 2008 Aug 1, Low Molecular Weight Hyaluronic Acid Increases the Self-Defense of Skin Epithelium by Induction of β-Defensin 2 via TLR2 and TLR4
  • SOFW Journal, 11-2008, M. Farwick, P. Lersch, G. Strutz (Evonik), Low Molecular Weight Hyaluronic Acid: Its Effects on Epidermal Gene Expression and Skin Ageing
  • ournal of drugs in dermatology : JDD., June 2013 | Volume 12 | Issue 6, Efficacy and Tolerability of Low Molecular Weight Hyaluronic Acid Sodium Salt 0.2% Cream in Rosacea

Products with Hydrolyzed Hyaluronic Acid

Eaoron Hyaluronic Acid Collagen Essence V Manilla Hyaluronic Acid Serum 3% with Vitamins B5 & C The Saem Power Ampoule Hydra A'pieu Hyaluthione Soonsoo Cream A'pieu Hyaluthione Soonsoo Essence Toner Missha Glow Tension Cushion Nuface Conductive Gel Nuface Hydrating Leave-On Gel Primer SKIO Vb Wrinkle Clear Serum Balance Me Hyaluronic Plumping Mist Balance Me Tri-Molecular Hyaluronic Serum D'Care Face Up Double S Anti-Aging Serum For Beloved One Hyaluronic Acid GHK-Cu Moisturizing Bio-Cellulose Mask Hada Labo Gokujyun Hyaluron Hydrating Essence Hada Labo Shirojyun Arbutin Whitening Lotion (Rich) Kate Somerville Tight'N Cryogenic Tightening Gel Neogen Code9 Black Volume Cream Nuface 24K Gel Primer Nuface Firm 24K Gold Gel Primer PERDERMA Moisturizing Face Mask With Hyaluronic Acid Sidmool Stellera Chamaejasme 62% Ampoule The Saem Power Ampoule Hydra Zelens Hyaluron Hyaluronic Acid Complex Serum Drops Cosmedix Surge Hyaluronic Acid Booster Hada Labo Gokujyun Hydrating Lotion Hada Labo Shirojyun Premium Whitening Emulsion Hada Labo Shirojyun Premium Whitening Lotion Light Hada Labo Shirojyun Premium Whitening Lotion Rich Hada Labo Tokyo Super Hydrator Lotion Kate Somerville Skincare Wrinkle Warrior Pink Plumping Mask Larenim Hyaluronic Acid Serum Lovemore Pearl & Red Pearl Barley Whitening Mask Sheet Neogen Super Hydra Aqua Capsule Mask Nip+Fab No Needle Fix Eye Mask Olivarrier Dual Moist Toning Lotion SkinMedica Hydrating Complex Venus Hyaluronic Acid 150Mg BONAJOUR Green Tea Water Bomb Toner DR ROEBUCK’S No Worries Hydrating Face Moisturizer FLORENCE ORGANICS C Facial Serum Hada Labo Goku-jyun Light Lotion Hada Labo Koi Gokujyun Hyaluronic Acid Jelly Image Ageless Total Pure Hyaluronic6 Filler Kilig Hydrating Face Mist Lululun Face Mask Precious White OGX Replenishing + Water Cream Hydrating Treatment SVR B3 Hydra Bulb Versed Hydration Station Booster With Hyaluronic Acid Facial Treatment Wonjin Effect Medi Hydro Vial Mask blanc doux The Lab Oligo Hyaluronic Acid 5000 Da Toner