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Hydrolyzed Hyaluronic Acid

Hydrolyzed Hyaluronic Acid

What-it-does: moisturizer/humectant


Hydrolyzed Hyaluronic Acid is a low molecular weight, chemically chopped up version of the naturally big molecule and current IT-moisturizer, Hyaluronic Acid (HA). The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to retain water, making it plump and elastic. As HA is a polymer, the subunits can be repeated many times (as a high-molecular-weight version), or just a few times (as a low-molecular-weight version).

We wrote in detail at HA about how different molecular weight versions do different things both as a component of the skin and as a skincare ingredient, so click here and read about all the details. Hydrolyzed Hyaluronic Acid can also come in different molecular-weight versions with different properties:

  • 100-300 kDa version: apart from moisturizing, this size might also help the skin to repair itself by increasing its self-defense. It is also claimed to boost the wound healing process and is especially helpful for sensitive skin types (acne, rosacea, inflammation-related skin diseases). 
  • 50k Da version: this is the size that is claimed to be able to absorb into the skin and plump up wrinkles, so it is used mainly as an "anti-aging ingredient" 
  • below 50k, around 10k Da version: there is a Japanese version trade named Hyalo-Oligo that has only a 10k molecular weight and is claimed to penetrate the skin very well, have a unique touch and give deep and long-lasting moisturization. Based on the Evonik-research and the natural role of LMW-HA in the body working as a pro-inflammatory signal molecule, this ultra-low molecular weight version is a controversial ingredient

If you wanna become a real HA-and-the-skin expert, you can read much more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

Show me some proof

  • Journal of immunology, 2008 Aug 1, Low Molecular Weight Hyaluronic Acid Increases the Self-Defense of Skin Epithelium by Induction of β-Defensin 2 via TLR2 and TLR4
  • SOFW Journal, 11-2008, M. Farwick, P. Lersch, G. Strutz (Evonik), Low Molecular Weight Hyaluronic Acid: Its Effects on Epidermal Gene Expression and Skin Ageing
  • ournal of drugs in dermatology : JDD., June 2013 | Volume 12 | Issue 6, Efficacy and Tolerability of Low Molecular Weight Hyaluronic Acid Sodium Salt 0.2% Cream in Rosacea

Products with Hydrolyzed Hyaluronic Acid

Dēpology Deepcare+ Serum-infused Micro Dart Patches Easydew Fill Up Volume Essence Freeman beauty Micro-Darts Pro Fine Line Patches Freeman beauty Micro-Darts Pro Under Eye Patches HAS Imicro Patch Heimish Aqua Tone Up Cream Trulux 5-HA Serum Wellage Real Hyaluronic Blue 100 Toner Pad Wellage Real Hyaluronic Cream 100 feelxo How Was It? Hyaluronic Serum Hada Labo Shirojyun Premium Lotion (2022 Formula) Isntree Hyaluronic Acid Deep Moisture Water Mask Manilla Hyaluronic Acid Serum 3% with Vitamins B5 & C The Saem Power Ampoule Hydra A'pieu Hyaluthione Soonsoo Cream A'pieu Hyaluthione Soonsoo Emulsion A'pieu Hyaluthione Soonsoo Essence Toner Gh Esencia Triple H Gratitude Bar Bright Drops Alpha Arbutin Hyaluronic Acid Vitamin B3 Brightening Serum Hada Labo Advanced Nourish Supreme Lotion Hada Labo Gokujun Hyaluronic Lotion Moist Hada Labo Gokujyun Premium Oil Jelly Hada Labo Shirojyun Premium Whitening Jelly Essence Korika Korean Heritage 8 Types Of Hyaluronic Acid Missha Glow Tension Cushion Nuface Conductive Gel Nuface Hydrating Leave-On Gel Primer Platinum Skincare Hyaluronic Nano Grape Stem Serum Rael Microcrystal Spot Cover Rael Beauty Microcrystal Spot Cover Rohto Mentholatum Hada Labo Shirojyun Arbutin Whitening Lotion Rohto Mentholatum Hada Labo Shirojyun Whitening Cream Rohto Mentholatum Hada Labo Facial Moisturizer Gokujyun Aging Milk SKIO Vb Wrinkle Clear Serum SoS Sōs Hyaluron X3 Concentrate Serum Stayve Booster Serum – Hyaluronic Acid Ampoule TRESemmé Scalp Detox Conditioner Youth To The People Polypeptide 121 Future Cream Youth To The People Polypeptide-121 Future Cream With Peptides And Ceramides dermaceutical gmbh Capilarine nomel Low-maintenance Active Essence Balance Me Hyaluronic Plumping Mist Balance Me Tri-Molecular Hyaluronic Serum Boost Lab About Skin Advisor Blog Faq Best Seller 2d-hyaluronic Hydro Boost Serum Collistar Pure Active Hyaluronic Acid Cosmetic Plant Good Skin – Hydra Boost Gel-cream Cu Acid Hialuronic, Minerale Și Aloe Vera D'Care Face Up Double S Anti-Aging Serum For Beloved One Hyaluronic Acid GHK-Cu Moisturizing Bio-Cellulose Mask Found 24K Gold Primer Frank Body Hydrating Hyaluronic Acid Serum