Hydrolyzed Hyaluronic Acid

What-it-does: moisturizer/humectant


It is a low molecular weight (LMW) version of the naturally big molecule and current IT-moisturizer, Hyaluronic Acid (HA). The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to retain water, making it plump and elastic. As HA is a polymer, the subunits can be repeated many times (as a high-molecular-weight version), or just a few times (as a low-molecular-weight version).

We wrote in detail at HA about how different molecular weight versions do different things both as a component of the skin and as a skincare ingredient, so click here and read about all the details. Hydrolyzed Hyaluronic Acid can also come in different molecular-weight versions with different properties:

  • 100-300 kDa version: apart from moisturizing, this size might also help the skin to repair itself by increasing its self-defense. It is also claimed to boost the wound healing process and is especially helpful for sensitive skin types (acne, rosacea, inflammation-related skin diseases). 
  • 50k Da version: this is the size that is claimed to be able to absorb into the skin and plump up wrinkles, so it is used mainly as an "anti-aging ingredient" 
  • below 50k, around 10k Da version: there is a Japanese version trade named Hyalo-Oligo that has only a 10k molecular weight and is claimed to penetrate the skin very well, have a unique touch and give deep and long-lasting moisturization. Based on the Evonik-research and the natural role of LMW-HA in the body working as a pro-inflammatory signal molecule, this ultra-low molecular weight version is a controversial ingredient

If you wanna become a real HA-and-the-skin expert, you can read much more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

Show me some proof

  • Journal of immunology, 2008 Aug 1, Low Molecular Weight Hyaluronic Acid Increases the Self-Defense of Skin Epithelium by Induction of β-Defensin 2 via TLR2 and TLR4
  • SOFW Journal, 11-2008, M. Farwick, P. Lersch, G. Strutz (Evonik), Low Molecular Weight Hyaluronic Acid: Its Effects on Epidermal Gene Expression and Skin Ageing
  • ournal of drugs in dermatology : JDD., June 2013 | Volume 12 | Issue 6, Efficacy and Tolerability of Low Molecular Weight Hyaluronic Acid Sodium Salt 0.2% Cream in Rosacea

Products with Hydrolyzed Hyaluronic Acid

Nuface Hydrating Leave-On Gel Primer Neogen Code9 Black Volume Cream Sidmool Stellera Chamaejasme 62% Ampoule The Saem Power Ampoule Hydra Hada Labo Gokujyun Hydrating Lotion Kate Somerville Skincare Wrinkle Warrior Pink Plumping Mask Rohto Hada Labo Gokujyun Hyaluronic Essence SkinMedica Hydrating Complex DR ROEBUCK’S No Worries Hydrating Face Moisturizer Lululun Face Mask Precious White Wonjin Effect Medi Hydro Vial Mask Balance Me Flash Cleanse Micellar Water Cosmetex Cosmetex Roland Biyougeneki Hyaluronic Acid And Astaxanthin Super Moisture Lotion IOPE Hyaluronic Serum Moon Juice Beauty Shroom™ Plumping Jelly Serum Neotrogena Hydro Boost Hydrating Cleansing Gel Hada Labo Gokujyun Premium Hyaluronic Acid Lotion Neutrogena Hydro Boost Sleeping Cream Atopalm Real Barrier Aqua Soothing Ampoule Farmacy Honey Drop Lightweight Moisturiser Farmacy Honey Drop Lightweight Moisturizer With Echinacea Greenenvy Balea Beauty Effect Tuchmaske Biyougeneki Super Hyaluronic Acid & Astaxanthin Lotion L'oreal Revitalift Derm Intensives 10% Pure Vitamin C Serum SkinMedica Ha5 Rejuvenating Hydrator VENeffect Firming Phyto-Lift Serum Vichy Laboratories Liftactiv Anti-Oxidant And Anti-Fatigue Fresh Shot Cetaphil Rich Hydrating Night Cream Isntree Green Tea Fresh Toner (Old Version) Isntree Green Tea Toner GET IT BEAUTY Secret Aqua Mask Isntree Hyaluronic Acid Aqua Gel Cream MDNA Skin The Serum Natura Bissé The Cure Pure Serum Neogen Real Cica Micellar Cleansing Water Neogen White Truffle Hydramax Knit Mask Peach and Lily Glass Skin Refining Serum Purito Snail Repair Advanced Serum Sunday Riley Tidal Brightening Enzyme Water Cream A'pieu Aqua Sun Gel Spf 50 A'pieu Pure Block Aqua Sun Gel Spf 50+ Pa+++ Atopalm Real Barrier Control-T Toner Beauty Pie Triple Hyaluronic Ha + Peptide Serum Farmacy Invincible First Aid Beauty Fab Skin Lab Retinol Serum 0.25% Pure Concentrate First Aid Beauty Fab Skin Lab Retinol Serum 0.25% Pure Concentrate Hada Labo Gokujyun Uv White Gel Kate Somerville Wrinkle Warrior 2-In-1 Plumping Moisturizer + Serum LEEGEEHAAM Grow Hyal B5 Ampoule La Roche-Posay Hyalu B5 Serum