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Hydrolyzed Hyaluronic Acid

Hydrolyzed Hyaluronic Acid

What-it-does: moisturizer/humectant


Hydrolyzed Hyaluronic Acid is a low molecular weight, chemically chopped up version of the naturally big molecule and current IT-moisturizer, Hyaluronic Acid (HA). The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to retain water, making it plump and elastic. As HA is a polymer, the subunits can be repeated many times (as a high-molecular-weight version), or just a few times (as a low-molecular-weight version).

We wrote in detail at HA about how different molecular weight versions do different things both as a component of the skin and as a skincare ingredient, so click here and read about all the details. Hydrolyzed Hyaluronic Acid can also come in different molecular-weight versions with different properties:

  • 100-300 kDa version: apart from moisturizing, this size might also help the skin to repair itself by increasing its self-defense. It is also claimed to boost the wound healing process and is especially helpful for sensitive skin types (acne, rosacea, inflammation-related skin diseases). 
  • 50k Da version: this is the size that is claimed to be able to absorb into the skin and plump up wrinkles, so it is used mainly as an "anti-aging ingredient" 
  • below 50k, around 10k Da version: there is a Japanese version trade named Hyalo-Oligo that has only a 10k molecular weight and is claimed to penetrate the skin very well, have a unique touch and give deep and long-lasting moisturization. Based on the Evonik-research and the natural role of LMW-HA in the body working as a pro-inflammatory signal molecule, this ultra-low molecular weight version is a controversial ingredient

If you wanna become a real HA-and-the-skin expert, you can read much more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

Show me some proof

  • Journal of immunology, 2008 Aug 1, Low Molecular Weight Hyaluronic Acid Increases the Self-Defense of Skin Epithelium by Induction of β-Defensin 2 via TLR2 and TLR4
  • SOFW Journal, 11-2008, M. Farwick, P. Lersch, G. Strutz (Evonik), Low Molecular Weight Hyaluronic Acid: Its Effects on Epidermal Gene Expression and Skin Ageing
  • ournal of drugs in dermatology : JDD., June 2013 | Volume 12 | Issue 6, Efficacy and Tolerability of Low Molecular Weight Hyaluronic Acid Sodium Salt 0.2% Cream in Rosacea

Products with Hydrolyzed Hyaluronic Acid

Eaoron Hyaluronic Acid Collagen Essence V The Saem Power Ampoule Hydra Nuface Conductive Gel Nuface Hydrating Leave-On Gel Primer Balance Me Hyaluronic Plumping Mist D'Care Face Up Double S Anti-Aging Serum Hada Labo Gokujyun Hyaluron Hydrating Essence Neogen Code9 Black Volume Cream Nuface 24K Gel Primer Nuface Firm 24K Gold Gel Primer PERDERMA Moisturizing Face Mask With Hyaluronic Acid Sidmool Stellera Chamaejasme 62% Ampoule The Saem Power Ampoule Hydra Cosmedix Surge Hyaluronic Acid Booster Hada Labo Gokujyun Hydrating Lotion Hada Labo Shirojyun Premium Whitening Emulsion Hada Labo Shirojyun Premium Whitening Lotion Light Hada Labo Shirojyun Premium Whitening Lotion Rich Hada Labo Tokyo Super Hydrator Lotion Kate Somerville Skincare Wrinkle Warrior Pink Plumping Mask Larenim Hyaluronic Acid Serum Neogen Super Hydra Aqua Capsule Mask Olivarrier Dual Moist Toning Lotion SkinMedica Hydrating Complex Venus Hyaluronic Acid 150Mg DR ROEBUCK’S No Worries Hydrating Face Moisturizer Hada Labo Goku-jyun Light Lotion Lululun Face Mask Precious White SVR B3 Hydra Bulb Versed Hydration Station Booster With Hyaluronic Acid Facial Treatment Wonjin Effect Medi Hydro Vial Mask blanc doux The Lab Oligo Hyaluronic Acid 5000 Da Toner Balance Me Flash Cleanse Micellar Water Cosmetex Roland Biyougeneki Hyaluronic Acid And Astaxanthin Super Moisture Lotion Geek & Gorgeous Ha 5 Light Hyaluronic Acid Serum Geek & Gorgeous Ha 5 Rich Hyaluronic Acid Serum Hada Labo Tokyo Anti-Aging Super Hydrator Lotion IOPE Hyaluronic Serum Moon Juice Beauty Shroom™ Plumping Jelly Serum Neotrogena Hydro Boost Hydrating Cleansing Gel The Face Shop All Clear Cleansing Water Cosme Decorte Vita De Rêve Herbal Vitalizing Lotion Cosme Decorte Vita De Rêve Herbal Vitalizing Lotion Mask DrJart+ Vital Hydra Solution Capsule Ampoule Good Molecules Daily Brightening Serum Hada Labo Goku-Jyun Mist Hada Labo Gokujyun 3D Perfect Face Mask (30 Masks) Hada Labo Gokujyun Premium Hyaluron Milk Emulsion Hada Labo Gokujyun Premium Hyaluronic Acid Lotion Lancôme Visionnaire Skin Solutions 15% Vitamin C Correcting Concentrate