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Thioctic Acid

Also-called-like-this: Alpha-Lipoic Acid
What-it-does: antioxidant


Alpha-Lipoic Acid (ALA) is a great antioxidant that's also part of the body's natural antioxidant system. It's soluble both in water-rich and lipid-rich environments so it's versatile and can interact with many types of evil oxidants as well as other nice antioxidants. 

ALA seems to be a great choice for topical use as studies show it can penetrate the skin rapidly where it's converted to DHLA (dihydrolipoic acid), an even more potent antioxidant molecule.  A nicely designed (we mean double-blind, placebo-controlled) 12-week study from 2003 confirmed that 5% ALA cream can decrease skin roughness and improve general signs of photoaging statistically significantly.  A slight catch, though, is that burning and warmth in the skin was quite a common side effect, especially in the first 4 weeks. 

All in all, ALA is definitely a research-proven, great antioxidant but if your skin is sensitive higher concentrations might not be for you.

Show me some proof

  • Beitner, Harry. "Randomized, placebo‐controlled, double blind study on the clinical efficacy of a cream containing 5% α‐lipoic acid related to photoageing of facial skin." British Journal of Dermatology 149.4 (2003): 841-849.
  • Podda, Maurizio, et al. "Activity of alpha-lipoic acid in the protection against oxidative stress in skin." Oxidants and antioxidants in cutaneous biology. Vol. 29. Karger Publishers, 2001. 43-51.

Products with Thioctic Acid

ClearChoice Sport Shield Ruruberry Alpha Lipoic Acid The Ordinary Alpha Lipoic Acid 5% ClearChoice Sport Shield SPF 45 My Dermatician Sun Drops SPF 35 Nirmal skin Luminova Perricone MD High Potency Classics Face Firming Serum about-face essentials Resqoil laborest Tiobec Crema Advanced Rejuvenating Concepts Rapid Renewal Serum DrGL Skin Repair La Clinica 30% Vitamin C Anhydrous Humectant Serum Make Happy Skin Super Antioxidant Serum Vis Plantis Secret Garden Brightening Oil Serum Vitamin injections Vitamin E Everything Moisturiser verabella MoistureScreen ClearChoice Anti-Wrinkle Retinox Herbal Glo See Younger Looking Skin Facial Masque Jabushe Original Cream Kalahari Alpha Lipoic Complex With Astaxanthin LuvrePro Gel Concentrado Antiage Descongestivo Naeli Face Moisturizer Skoah. Lip Dip Trader Joe's Nourish Antioxidant Facial Serum face doctor Facesurgeon ATACHE Biological Triple Antioxidant Night Protector Add Actives C20 Tetraforce Activator Banish Ceramide + Retinol Serum ClearChoice Hydrating Cleanser ClearChoice Hydrating Masque + Night Therapy Derma E Firming Dmae Moisturizer Derma E Firming Dmae Toner FARMEC Gerovital Equilibrium Multivitamin Vials Missha Firming Gel Eye Patch Results RNA Acs 200 Silver Gel Extra Strength Spa Pharma by Arganicare Hydractive Moisturizing Cream Aloe Vera Theraderm OPC Reparative Serum Zine Solución Dmae Cosmedix Radiance Age Restorative Serum Derma E Ester C Cleanser EXEL Gel Cream Renovador Glimmer goddess Organic Resveratrol Life Choice Dmae Restorative Cream Majestic Pure Vitamin C Serum With Vegan Collagen Medik8 Pore Minimising Tonic Perricone MD High Potency Classics Nutritive Cleanser Perricone MD Skin Perfecting Serum Reviva Labs Alpha Lipoic Acid Vitamin C Ester Dmae Créme SkinResourceMD Total Antioxidant - Vitamin C Facial Serum artnaturals Vitamin C Toner