Deep Collagen Silk Peptide Ampoule
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Sungboon Editor Deep Collagen Silk Peptide AmpouleIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.
BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.
It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
It's a type of glycol that - according to the manufacturer - is an extremely good replacement for other glycols like propylene or butylene glycol. Its main job is to be a solvent, but it has also very good antimicrobial properties and acts as a true preservative booster. Also helps with skin hydration without stickiness or tacky feel.
A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives.
- A multi-functional skincare superstar with several proven benefits for the skin
- Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
- Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
- Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
- Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
We don't have description for this ingredient yet.
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula. It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.
It's a little helper ingredient that helps to set the pH of the products to be right. It has an alkaline pH and can neutralize acidic ingredients.
We don't have description for this ingredient yet.
Propanediol is a natural alternative for the often used and often bad-mouthed propylene glycol. It's produced sustainably from corn sugar and it's Ecocert approved.
It's quite a multi-tasker: can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula.
The chemically chopped up version of the big protein molecule, collagen. It is often derived from fish or bovine sources and works as a nice moisturizer and humectant that helps the skin to hold onto water.
To understand a bit more what Hydrolyzed Collagen is, you have to know that proteins are large chains of amino acids connected with so-called peptide bonds. These bonds can be broken up when a water molecule is added and the resulting thing is a mix of shorter length amino acids, also called peptides. So Hydrolyzed Collagen is not really collagen, it is rather an undefined and varying mix of largish peptides. Based on a manufacturer's data, the whole, soluble collagen has an average molecular weight of 300 000 Da, while this chopped up mixture has an average MW of 12 000 Da (still pretty big).
The main thing of these largish peptides is to act as water-binding agents, and to make the skin nice and smooth (aka emollient). Hydrolyzed Collagen is also often used in cleansers as it can make harsh surfactants milder and in hair conditioners as it improves the flexibility and manageability of hair.
If you wanna know more about collagen in cosmetics, we have a shiny explanation about soluble collagen here >>
Adenosine is an important little compound in our body that has a vital cell-signalling role. Research on smearing it on our face is also promising and shows so far a couple of things:
- It can help with wound healing
- It’s a good anti-inflammatory agent
- It might even help with skin’s own collagen production and improve skin firmness and elasticity
- It helps with barrier repair and protection
- It might be even useful for the hair helping with hair thickness and hair growth
We don't have description for this ingredient yet.
A nice little helper ingredient that can thicken up cosmetic products and create beautiful gel formulas. It's derived from cellulose, the major component of the cell wall of green plants. It is compatible with most co-ingredients and gives a very good slip to the formulas.
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.
It is typically used in tiny amounts, around 0.1% or less.
Though its long name does not reveal it, this polymer molecule (big molecule from repeated subunits or monomers) is a relative to the super common, water-loving thickener, Carbomer. Both of them are big molecules that contain acrylic acid units, but Acrylates/C10-30 Alkyl Acrylate Crosspolymer also contains some other monomers that are hydrophobic, i.e. water-hating.
This means that our molecule is part water- and part oil-loving, so it not only works as a thickener but also as an emulsion stabilizer. It is very common in gel-type formulas that also contain an oil-phase as well as in cleansers as it also works with most cleansing agents (unlike a lot of other thickeners).
Synthetic Fluorphlogopite is the synthetic version of the super commonly used mineral, Mica. The advantage of being synthetic is that it has a more consistent quality, fewer impurities and an even lower heavy metal content than Mica (not that Mica's heavy metal content is high). It is also more transparent and has improved light reflection.
The two main use cases for Synthetic Fluorphlogopite is being used neat as a superior "filler" or skin tone enhancer or it can also serve as a base for multi-layered, composite pigments such as pearl effect pigments where it is coated with one or more layers of metal oxide, most commonly titanium dioxide.
A sugar beet-derived amino acid derivative with nice skin protection and moisturization properties. Betaine's special thing is being an osmolyte, a molecule that helps to control cell-water balance. It is also a natural osmoprotectant, meaning that it attracts water away from the protein surface and thus protects them from denaturation and increases their thermodynamic stability.
It also gives sensorial benefits to the formula and when used in cleansers, it helps to make them milder and gentler.
An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid).
Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier.
Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.
Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation.
If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.
As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily.
We don't have description for this ingredient yet.
Titanium Dioxide is one of the two members of the elite sunscreen group called physical sunscreens (or inorganic sunscreens if you’re a science geek and want to be precise).
Traditionally, UV-filters are categorized as either chemical or physical. The big difference is supposed to be that chemical agents absorb UV-light while physical agents reflect it like a bunch of mini umbrellas on top of the skin. While this categorization is easy and logical it turns out it's not true. A recent, 2016 study shows that inorganic sunscreens work mostly by absorption, just like chemical filters, and only a little bit by reflection (they do reflect the light in the visible spectrum, but mostly absorb in the UV spectrum).
Anyway, it doesn't matter if it reflects or absorbs, Titanium Dioxide is a pretty awesome sunscreen agent for two main reasons: it gives a nice broad spectrum coverage and it's highly stable. Its protection is very good between 290 - 350 nm (UVB and UVA II range), and less good at 350-400 nm (UVA I) range. Regular sized Titanium Dioxide also has a great safety profile, it's non-irritating and is pretty much free from any health concerns (like estrogenic effect worries with some chemical filters).
The disadvantage of Titanium Dioxide is that it's not cosmetically elegant, meaning it's a white, "unspreadable" mess. Sunscreens containing Titanium Dioxide are often hard to spread on the skin and they leave a disturbing whitish tint. The cosmetic industry is, of course, really trying to solve this problem and the best solution so far is using nanoparticles. The itsy-bitsy Nano-sized particles improve both spreadability and reduce the whitish tint a lot, but unfortunately, it also introduces new health concerns.
The main concern with nanoparticles is that they are so tiny that they are absorbed into the skin more than we want them (ideally sunscreen should remain on the surface of the skin). Once absorbed they might form unwanted complexes with proteins and they might promote the formation of evil free radicals. But do not panic, these are concerns under investigation. A 2009 review article about the safety of nanoparticles summarizes this, "to date, in-vivo and in-vitro studies have not demonstrated percutaneous penetration of nanosized particles in titanium dioxide and zinc oxide sunscreens". The English translation is, so far it looks like sunscreens with nanoparticles do stay on the surface of the skin where they should be.
All in all, Titanium Dioxide is a famous sunscreen agent and for good reason, it gives broad spectrum UV protection (best at UVB and UVA II), it's highly stable, and it has a good safety profile. It's definitely one of the best UV-filter agents we have today, especially in the US where new-generation Tinosorb filters are not (yet) approved.
A bit of a sloppy ingredient name as it covers not one but three pigments: red, yellow and black iron oxide.
The trio is invaluable for "skin-colored" makeup products (think your foundation and pressed powder) as blending these three shades carefully can produce almost any shade of natural-looking flesh tones.
A super versatile and common mineral powder that comes in different particle sizes. It is a multi-tasker used to improve skin feel, increase product slip, give the product light-reflecting properties, enhance skin adhesion or serve as an anti-caking agent.
It is also the most commonly used "base" material for layered composite pigments such as pearl-effect pigments. In this case, mica is coated with one or more metal oxides (most commonly titanium dioxide) to achieve pearl effect via the physical phenomenon known as interference.
A form of skincare superstar, Vitamin C. If you do not know, what the big deal about Vitamin C is, click here and read all about it, we will wait here for you.
So now you know that pure vitamin C (aka ascorbic acid, AA) is really unstable and hard to formulate so the cosmetics industry is coming up with a bunch of derivatives to solve the problem and Magnesium Ascorbyl Phosphate (or MAP) is one of them.
MAP does solve the stability problem: it's stable up to pH 7, so far so good. What is not so good is that, as the great review study about vitamin C derivatives in the Journal of Cosmetic Dermatology writes, MAP is "at very best, poorly absorbed in comparison to AA."
Moreover, derivatives not only have to be absorbed into the skin, they also have to be converted into pure AA. The good news is that in-vitro data shows that MAP does convert, but the bad news is we do not really know if the same is true on real, living human skin. Even if it does, we don't know how good the conversion rate is (but to be fair the same is true for all other derivatives).
Regarding the three magic abilities of pure vitamin C (antioxidant, collagen booster, skin brightener), there is no published data about MAP's antioxidant or photoprotection capabilities. We have better news about the other two things: in-vitro data shows that MAP can boost collagen synthesis similar to AA (though in the case of AA it's proven in-vivo) and even better, MAP is proven to work as a skin brightener in-vivo (on real people).
Bottom line: when it comes to vitamin C derivatives, MAP is definitely an option. We especially recommend it if you are after skin brightening as this seems to be the strongest point of MAP.
Centella Asiatica - or sometimes also called Gotu Kola or Cica - has been used in folk medicine for hundreds of years. It’s traditionally used to improve small wounds, burns and scratches and it’s also a well known anti-inflammatory agent for eczema.
Recently science has taken an interest in Gotu Kola as well and it turns out it really has many active compounds with several benefits. Just for hard-core geeks, the main biologically active compounds are pentacyclic triterpenoid saponins called asiaticoside, madecassoside, asiatic and madecassic acid (also called centellosides).
One of the biological activities of the centellosides is to be able to stimulate GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells), and especially hyaluronic acid synthesis in our skin. This is probably one of the reasons why Centella Asiatica Extract has nice skin moisturizing properties that was confirmed by a 25 people, four weeks study along with Centella's anti-inflammatory effects.
Madecassoside can also help in burn wound healing through increasing antioxidant activity and enhancing collagen synthesis. Asiaticoside was shown to increase antioxidant levels on rats skin when applied at 0.2%.
Centella Asiatica also often shows up in products that try to treat cellulite or striae. Of course, it cannot make a miracle but it might have some effect via regulating microcirculation and normalizing the metabolism in the cells of connective tissues.
Bottom line: Gotu Kola is a great plant ingredient with proven wound healing, anti-inflammatory, and antioxidant properties. Nice to spot on any ingredient list.
Houttuynia cordata is a flowering plant native to Southeast Asia. It is eaten as a leaf vegetable, and also has a long history of use in traditional Chinese medicine, including as an attempted treatment for SARS (it didn’t really work). Regarding cosmetics, however, houttuynia cordata extract has a good bit of potential!
The main active components in the plant are these fancy chemicals called flavonoids. Houttuynia cordata specifically has a good amount of polyphenolic flavonoids, four common ones being quercetin, quercitrin, hyperoside, and rutin. All of these exhibit anti-inflammatory, antioxidant, and antibacterial properties. Quercitrin has also been shown to decrease damage from UVB rays, which is an added bonus. One thing to keep in mind, though, is that the flavonoid content of this extract can depend on if the extract is taken from the roots or the leaves, as well as if it’s a water extraction or an alcohol extraction.
Another thing Houttuynia cordata extract contains are polysaccharides, i.e. big molecules from various sugar units (in this case it is galacturonic acid (29.4%), galactose (24.0%), rhamnose (17.2%), arabinose (13.5%), glucuronic acid (6.8%), glucose (5.3%), xylose (2.1%) and mannose (1.8%) ). Polysaccharides and sugars in skincare are excellent humectants and skin hydrators, meaning they help the skin to hold onto water.
Last but not least, we also found an in-vitro (made in test tubes) study showing that houttuynia cordata extract had strong anti-allergic effects and could be helpful in treating skin allergies such as eczema (atopic dermatitis).
Far from the tin cans you find in the supermarket, Tin Oxide is mostly used when dealing with so-called effect pigments, tricky composite pigments that can do color travel (change color depending on the viewing angle) or give multiple color effect.
It's often found alongside Mica (as a base material) and Titanium Dioxide (as a coating) to give a glossy, pearlescent effect. Together, they make up a trademarked technology called RonaFlair Blanace from the German manufacturer Merck. According to their info, this combination can balance out undesirable tones in the skin, making it a popular choice for brightening products and highlighters.
Other than that, CosIng (the official EU INCI database) lists its uses as being a bulking agent (to increase the volume of products), as well as a physical exfoliant or an opacifying agent, but being part of composite effect pigments is a much more common use case.
If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.
Also, it's an effective deodorant and a medium spreading emollient.
It seems to us that squalane is in fashion and there is a reason for it. Chemically speaking, it is a saturated (no double bonds) hydrocarbon (a molecule consisting only of carbon and hydrogen), meaning that it's a nice and stable oily liquid with a long shelf life.
It occurs naturally in certain fish and plant oils (e.g. olive), and in the sebum (the oily stuff our skin produces) of the human skin. As f.c. puts it in his awesome blog post, squalane's main things are "emolliency, surface occlusion, and TEWL prevention all with extreme cosmetic elegance". In other words, it's a superb moisturizer that makes your skin nice and smooth, without being heavy or greasy.
Another advantage of squalane is that it is pretty much compatible with all skin types and skin conditions. It is excellent for acne-prone skin and safe to use even if you have fungi-related skin issues, like seborrhea or fungal acne.
The unsaturated (with double bonds) and hence less stable version of Squalane is Squalene, you can read about it here >>
A very common ingredient that can be found in all cell membranes. In cosmetics it's quite the multi-tasker: it's an emollient and water-binding ingredient but it's also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes.
We don't have description for this ingredient yet.
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol.
The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.
It's the chemically chopped up version of normal lecithin. Most often it's used to create liposomes and to coat and stabilize other ingredients.
A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, is super well tolerated by every skin type and easy to formulate with. No wonder it’s popular.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
- Primary fat-soluble antioxidant in our skin
- Significant photoprotection against UVB rays
- Vit C + Vit E work in synergy and provide great photoprotection
- Has emollient properties
- Easy to formulate, stable and relatively inexpensive
It's a special "cross-linked" from of IT-moisturizer, hyaluronic acid (HA). Cross-linked means that "normal" HA pieces (1-2 million Da molecular weight) are chemically bound togeather to create a big, "infinite" mesh.
The special HA mesh has a remarkable water-binding capacity, 5 times more than the already crazy water-binding capacity of "normal" HA. This water filled crosslinked HA gel forms a smooth film on the skin and continuously delivers the bound water, so it gives long-term moisturizing benefits.
Btw, crosslinking HA was developed for dermal fillers (as crosslinking helps their longevity), and this guy is the topical version of FDA approved dermal filler called Hylan B gel. Smearing crosslinked version all over ourselves is a newish thing, and incoming evidence so far suggests that it's a great idea, even better than normal HA.
A very recent, 2016 research article compared the topical moisturizing effect of crosslinked HA (not Hylan B gel specifically, but something called Resilient HA or RHA), HMW-HA and LMW-HA and found that "TEWL (that is trans-epidermal water loss, the water that evaporates from the skin) was reduced by 27.8% with RHA, and by 15.6% with HMW HA, but increased by 55.5% with LMW HA." (You can read much more about HMW and LMW HA here in the geeky details section.)
All in all, we think Sodium Hyaluronate Crosspolymer is an awesome version of HA, probably superior to traditional versions, so be happy to spot it on the ingredient list.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
Hydrolyzed Hyaluronic Acid is a low molecular weight, chemically chopped up version of the naturally big molecule and current IT-moisturizer, Hyaluronic Acid (HA). The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to retain water, making it plump and elastic. As HA is a polymer, the subunits can be repeated many times (as a high-molecular-weight version), or just a few times (as a low-molecular-weight version).
We wrote in detail at HA about how different molecular weight versions do different things both as a component of the skin and as a skincare ingredient, so click here and read about all the details. Hydrolyzed Hyaluronic Acid can also come in different molecular-weight versions with different properties:
- 100-300 kDa version: apart from moisturizing, this size might also help the skin to repair itself by increasing its self-defense. It is also claimed to boost the wound healing process and is especially helpful for sensitive skin types (acne, rosacea, inflammation-related skin diseases).
- 50k Da version: this is the size that is claimed to be able to absorb into the skin and plump up wrinkles, so it is used mainly as an "anti-aging ingredient"
- below 50k, around 10k Da version: there is a Japanese version trade named Hyalo-Oligo that has only a 10k molecular weight and is claimed to penetrate the skin very well, have a unique touch and give deep and long-lasting moisturization. Based on the Evonik-research and the natural role of LMW-HA in the body working as a pro-inflammatory signal molecule, this ultra-low molecular weight version is a controversial ingredient.
If you wanna become a real HA-and-the-skin expert, you can read much more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
The big and important protein molecule that usually comes from animal skin such as fish or bovine. The gist of the "collagen in topical skincare" subject is to know that collagen in a jar has nothing to do with wrinkles but everything to do with skin hydration. We have a shiny explanation about this at soluble collagen, so click here to read more >>
We don't have description for this ingredient yet.
An Ecocert-approved, natural preservative that counts as gentle and non-irritating to the skin. Usually, it comes to the formula as part of a preservative blend as it's not enough on its own.
A helper ingredient that helps to make the products stay nice longer, aka preservative. It works mainly against fungi.
It’s pH dependent and works best at acidic pH levels (3-5). It’s not strong enough to be used in itself so it’s always combined with something else, often with potassium sorbate.
We don't have description for this ingredient yet.
A five amino acid peptide (Lys-Leu-Ala-Lys-Lys) attached to the oil-soluble fatty acid, myristic acid for better bioavailability. It is known to significantly stimulate keratin genes, i. e. it can convince the cells to produce more keratin, the super important structural protein in hair, nails and the outermost layer of the skin.
Most often you will meet Myristoyl Pentapeptide-17 combined with Myristoyl Hexapeptide-16 in eyelash growth products, as the two together can visibly increase eyelash length after two weeks.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
A relatively new, four amino acid peptide that promises to help combat hair loss alongside red clover extract as part of the trademarked technology Capixyl.
The main thing of Acetyl Tetrapeptide-3 is to stimulate the synthesis of key Extra Cellular Matrix (aka ECM, the gooey stuff between cells that make up the framework of our skin) components in the scalp. According to the manufacturer’s lab studies, the expression of type III collagen increased by 65% and the expression of laminins (anchoring proteins found in the ECM) was up a massive 285%, resulting in a stronger ECM bed for hair anchoring.
Together with red clover extract, the duo has a synergistic action and works to combat hair loss thanks to a neat multi-faceted approach: it not only stimulates important ECM components but also inhibits the DHT-causing 5-a-reductase enzyme (DHT is the annoying hormone largely responsible for male pattern baldness) and reduces micro-inflammation around hair follicles. The manufacturer’s study over 4 months showed the total impact of Capixyl was an increased anagen (growth phase)/telogen (resting phase) ratio of +46%, resulting in significantly denser hair.
All in all, Acetyl Tetrapeptide-3 is a promising ingredient in the fight against hair loss, but as the only results we could find were from the manufacturer, take these claims with a pinch of salt until more research is done.
We don't have description for this ingredient yet.
- GHK-Cu is a copper-peptide complex found naturally in yucky bodily fluids (plasma, saliva, and urine)
- It has unique wound healing properties by stimulating the breakdown of unhealthy, too large collagen in scar tissue and stimulating nice and healthy collagen production afterwards
- It stimulates the production of several important skin-identical ingredients (e.g. collagen, elastin, and glycosaminoglycans)
- It has significant anti-inflammatory and antioxidant effect
- There are a few promising studies showing GHK-Cu can improve skin elasticity, clarity, firmness and reduce lines and wrinkles
- It can improve hair growth by enlarging hair follicles (and bigger follicles produce longer, thicker hair)
- There are some urban legends about possible overdosing or facial hair problems (read more in geeky details)
A pretty famous and better-researched peptide consisting of five amino acids (the building blocks of all proteins). It was created in a joint effort by the French ingredient supplier, Sederma and the cosmetics industry big shot, Procter&Gamble.
The amino acid sequence of the peptide is lysine–threonine–threonine–lysine–serine (KTTKS). Sometimes, it's also called collagen pentapeptide, as it's a subfragment of skin-structure-giving type I collagen. The KTTKS amino sequence is then attached for better oil solubility and skin penetration to palmitic acid and BOOM; we get Palmitoyl Pentapeptide-4.
Though most research is manufacturer sponsored, the clinical studies about Palmitoyl Pentapeptide-4 are promising. In short, it can reduce fine lines, wrinkles and improve skin texture significantly (and at crazy low concentrations, the studies were done with just 3 ppm that is 0.0003%).
There are also studies comparing Palmitoyl Pentapeptide-4 with anti-aging gold standard, retinol. One of them compared 3ppm Pal-KTTKS with 700 ppm (0.07%) retinol and found that they showed similar wrinkle improving ability with the peptide showing better skin tolerability.
Bottom line, if you are into peptides, this is a good one to try.
If you see a cosmetic product that claims that it has "Botox-like effect" then two things are almost certain: one, the product overpromises and two, it contains Argireline.
So this one is the famous peptide that's marketed by its manufacturer as the "Botox in a jar". The basis for this claim is that it targets the same wrinkle forming mechanism (wrinkles caused by facial muscle movement) as Botox, but the way it works is very different. In addition, the extent to which it can prevent muscles from contracting (and to smooth wrinkles) is very different (otherwise why would anyone use still Botox?).
The manufacturer did several studies to prove that Argireline really works and it does (just not as well as Botox). In-vivo (made on real people) tests showed that using 10% Argireline solution around the eyes for 15 days decreased wrinkles depth by 17%, while a 5% Argireline formula applied for 28 days did almost the same with a decrease in wrinkle depth by 16.26%. A Spanish University also did some research and found that Argireline increased the level of skin moisturization and decreased both the depth and width of wrinkles "significantly".
This means, Acetyl Hexapeptide-8 does have some ability to smooth wrinkles (but not as well as Botox - sorry, if we sound like a broken record). Also, we have to agree with TruthInAging, that it's not a collagen builder and not a preventer of structural aging (think vitamin C, AHAs or retinol); it's just a quick fix. If you are looking for one, this could be your thing. If you are more of a "let's treat this aging thing properly" type, then it's probably not your thing.
- It’s naturally in our skin and behaves there like a sponge
- It can bind up to 1000 times its own weight in water
- It is a big molecule from repeated subunits (polymer) so different molecular weight versions exist (unfortunately there is no way to determine MW from INCI list only)
- High-molecular-weight-HA (>500 kDa) is an excellent surface hydrator, skin protectant and can act as an osmotic pump helping water-soluble actives to penetrate deeper into the skin
- Low-molecular-weight-HA (< 500 kDa) can hydrate the skin somewhat deeper though it is still a big molecule and works mainly in the epidermis (outer layer of the skin)
- Low-molecular-weight-HA might also help the skin to repair itself by increasing its self-defense (~ 200kDa used in the study)
- Ultra-low-molecular-weight-HA (<50kDa) is a controversial ingredient and might work as a pro-inflammatory signal molecule
A four amino acid peptide with the amino sequence of glycine-glutamine-proline-arginine. It is attached to palmitic acid (a fatty acid) to increase oil solubility and skin penetration.
It works by reducing the production of the signal molecule, interleukin-6 (IL-6) which promotes inflammation in the skin and less inflammation means slower degradation of important things (like collagen) that results in younger looking skin for a longer time.
It works in synergy with its pal, Palmitoyl Tripeptide-1 in the famous Matrixyl 3000 complex. You can read some more about the famous duo here.
A high-tech, South-Korean peptide that's made synthetically to be identical to the protein called Met-Enkephalin. It's a 10 amino acid neuropeptide that helps the body to regulate how it responds to harmful things (like heat, cold, cutting or irritation).
In general, neuropeptides are believed to be important in wound-healing and the manufacturer claims that Sh-Decapeptide-7 is effective for anti-aging and would-healing skincare.
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| what‑it‑does | solvent |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 1 |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | solvent |
| what‑it‑does | solvent |
| what‑it‑does | cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant |
| what‑it‑does | solvent |
| what‑it‑does | viscosity controlling |
| irritancy, com. | 0, 1 |
| what‑it‑does | buffering |
| what‑it‑does | emulsifying | surfactant/cleansing |
| what‑it‑does | solvent | moisturizer/humectant |
| what‑it‑does | emollient | moisturizer/humectant |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | abrasive/scrub |
| what‑it‑does | viscosity controlling |
| what‑it‑does | viscosity controlling |
| what‑it‑does | chelating |
| what‑it‑does | viscosity controlling |
| what‑it‑does | viscosity controlling |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | soothing | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | sunscreen | colorant |
| what‑it‑does | colorant |
| irritancy, com. | 0, 0 |
| what‑it‑does | colorant |
| what‑it‑does | viscosity controlling |
| what‑it‑does | skin brightening | antioxidant |
| what‑it‑does | soothing | antioxidant | moisturizer/humectant |
| what‑it‑does | antioxidant | soothing |
| what‑it‑does | colorant | abrasive/scrub | viscosity controlling |
| what‑it‑does | preservative |
| what‑it‑does | skin-identical ingredient | emollient |
| irritancy, com. | 0, 1 |
| what‑it‑does | solvent |
| what‑it‑does | emollient | emulsifying |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | moisturizer/humectant | emollient |
| what‑it‑does | emollient | emulsifying |
| what‑it‑does | emollient |
| what‑it‑does | surfactant/cleansing |
| what‑it‑does | antioxidant |
| irritancy, com. | 0-3, 0-3 |
| what‑it‑does | skin-identical ingredient | antioxidant | moisturizer/humectant |
| what‑it‑does | antimicrobial/antibacterial | antioxidant |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | colorant |
| what‑it‑does | buffering |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | viscosity controlling |
| what‑it‑does | preservative |
| what‑it‑does | preservative |
| what‑it‑does | moisturizer/humectant | emollient |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | cell-communicating ingredient | soothing | antioxidant |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | cell-communicating ingredient | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | cell-communicating ingredient | antioxidant | buffering | chelating |