High Potency Retinol Recovery Overnight Moisturizer
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Perricone MD High Potency Retinol Recovery Overnight MoisturizerIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, is super well tolerated by every skin type and easy to formulate with. No wonder it’s popular.
An often used emollient with a light and silky feel. It's very mild to both skin and eyes and spreads nicely and easily. It's often used in sunscreens as it's also an excellent solvent for sunscreen agents.
Propanediol is a natural alternative for the often used and often bad-mouthed propylene glycol. It's produced sustainably from corn sugar and it's Ecocert approved.
It's quite a multi-tasker: can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula.
An "eco-designed" emollient ester coming from shea butter. While pure shea butter is a rich emollient that might feel greasy on the skin, this one is designed for its light, silky-soft feeling.
The manufacturer claims that it has a great sustainability profile, long lasting stability and a unique, light and silky feel that's ideal as a base for modern, eco-friendly body lotions and facial care products.
A clear, colorless, almost odorless oil that spreads nicely and easily and gives a velvet dry skin feel. It is good friends with sunscreen agents and helps to solubilize them. Also, it makes sunscreens feel lighter and spread easier.
An extremely common multitasker ingredient that gives your skin a nice soft feel (emollient) and gives body to creams and lotions. It also helps to stabilize oil-water mixes (emulsions), though it does not function as an emulsifier in itself. Its typical use level in most cream type formulas is 2-3%.
It’s a so-called fatty alcohol, a mix of cetyl and stearyl alcohol, other two emollient fatty alcohols. Though chemically speaking, it is alcohol (as in, it has an -OH group in its molecule), its properties are totally different from the properties of low molecular weight or drying alcohols such as denat. alcohol. Fatty alcohols have a long oil-soluble (and thus emollient) tail part that makes them absolutely non-drying and non-irritating and are totally ok for the skin.
Probably the most common silicone of all. It is a polymer (created from repeating subunits) molecule and has different molecular weight and thus different viscosity versions from water-light to thick liquid.
As for skincare, it makes the skin silky smooth, creates a subtle gloss and forms a protective barrier (aka occlusive). Also, works well to fill in fine lines and wrinkles and give skin a plump look (of course that is only temporary, but still, it's nice). There are also scar treatment gels out there using dimethicone as their base ingredient. It helps to soften scars and increase their elasticity.
As for hair care, it is a non-volatile silicone meaning that it stays on the hair rather than evaporates from it and smoothes the hair like no other thing. Depending on your hair type, it can be a bit difficult to wash out and might cause some build-up (btw, this is not true to all silicones, only the non-volatile types).
It seems to us that squalane is in fashion and there is a reason for it. Chemically speaking, it is a saturated (no double bonds) hydrocarbon (a molecule consisting only of carbon and hydrogen), meaning that it's a nice and stable oily liquid with a long shelf life.
It occurs naturally in certain fish and plant oils (e.g. olive), and in the sebum (the oily stuff our skin produces) of the human skin. As f.c. puts it in his awesome blog post, squalane's main things are "emolliency, surface occlusion, and TEWL prevention all with extreme cosmetic elegance". In other words, it's a superb moisturizer that makes your skin nice and smooth, without being heavy or greasy.
Another advantage of squalane is that it is pretty much compatible with all skin types and skin conditions. It is excellent for acne-prone skin and safe to use even if you have fungi-related skin issues, like seborrhea or fungal acne.
The unsaturated (with double bonds) and hence less stable version of Squalane is Squalene, you can read about it here >>
A fatty alcohol (the non-drying type with a long oil loving chain of 22 carbon atoms) that is used to increase the viscosity of the formula and it also helps the oily and the watery parts to stay nicely mixed together (called emulsion stabilizing).
We don't have description for this ingredient yet.
A naturally derived (Ecocert approved) colorless to yellowish oily liquid that's touted as a natural silicone alternative. It's claimed to have great sensorial properties: light but caring, velvety, silky and non-sticky.
It's also great at dissolving UV-filters in sunscreens or dispersing pigments in makeup products. You can also bump into Isoamyl Laurate in hair care products as a hair conditioner that makes combing easier without build up.
Having such a cool name and coming from Hawaii how could this oil be not good? Well, it is good. It's absorbed excellently by the skin and is used traditionally by the Hawaiians to soothe sunburn and other inflammations.
Research confirms this: it's shown to have anti-inflammatory, pain reducing, and wound healing properties. It's also a particularly rich source of moisturizing essential fatty acids linoleic and linolenic (about 42 and 32%) and it's not so rich in oleic acid - around 15% - that can be good even for acne prone skin.
A super common, waxy, white, solid stuff that helps water and oil to mix together, gives body to creams and leaves the skin feeling soft and smooth.
Chemically speaking, it is the attachment of a glycerin molecule to the fatty acid called stearic acid. It can be produced from most vegetable oils (in oils three fatty acid molecules are attached to glycerin instead of just one like here) in a pretty simple, "green" process that is similar to soap making. It's readily biodegradable.
It also occurs naturally in our body and is used as a food additive. As cosmetic chemist Colins writes it, "its safety really is beyond any doubt".
A very common water-loving surfactant and emulsifier that helps to keep water and oil mixed nicely together.
It's often paired with glyceryl stearate - the two together form a super effective emulsifier duo that's salt and acid tolerant and works over a wide pH range. It also gives a "pleasing product aesthetics", so no wonder it's popular.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
A common functional ingredient that helps to keep the oil-loving and water-loving ingredients together (emulsifier), stabilizes and thickens the products.
Chemically speaking, it is ethoxylated Cetearyl alcohol, meaning that some ethylene oxide is added to the fatty alcohol to increase the water-soluble part in the molecule. The result is that the mainly oil soluble, emollient fatty alcohol is converted to an emulsifier molecule that keeps oil and water mixed in creams. The number in the name of Ceteareth emulsifiers refers to the average number of ethylene oxide molecules added and 20 makes a good emulsifier.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic.
Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10).
It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.
A type of silicone elastomer (rubber-like material with both viscosity and elasticity) whose major function is forming a nice film on the skin.
It is also cosmetically very elegant with a non-tacky, non-oily and smooth skin feel. It also works as a stable delivery system of active materials, has sebum absorption and control properties and upon application, it transforms into a matte appearance with a powdery after feel.
An amino acid-based emulsifier that helps water and oil to mix and stay that way. It is considered as natural, environmentally friendly, and hypoallergenic.
We don't have description for this ingredient yet.
Citric acid comes from citrus fruits and is an AHA. If these magic three letters don’t tell you anything, click here and read our detailed description on glycolic acid, the most famous AHA.
So citric acid is an exfoliant, that can - just like other AHAs - gently lift off the dead skin cells of your skin and make it more smooth and fresh.
There is also some research showing that citric acid with regular use (think three months and 20% concentration) can help sun-damaged skin, increase skin thickness and some nice hydrating things called glycosaminoglycans in the skin.
But according to a comparative study done in 1995, citric acid has less skin improving magic properties than glycolic or lactic acid. Probably that’s why citric acid is usually not used as an exfoliant but more as a helper ingredient in small amounts to adjust the pH of a formulation.
We don't have description for this ingredient yet.
The famous Vaseline or Petroleum Jelly. Just like mineral oil, it is also a by-product of refining crude oil, aka petroleum, and it is also a mixture of hydrocarbons but with bigger (C18-90+) carbon chain length.
The unique thing about petrolatum is that it is the most effective occlusive agent known today. While the occlusivity of mineral oil is in the same league as the occlusivity of plant oils, petrolatum is in a league of its own. It sits on top of the skin and hinders so-called transepidermal water loss (TEWL) like nothing else.
This comes in handy healing cracked lips or severely dry skin patches, though overdoing it (i.e. reducing TEWL by more than 40%) is not good as it can create a nice moist place for fungi and bacteria to grow.
As for petrolatum and safety, we can write here pretty much the exact same thing as we have written at mineral oil. There is no evidence whatsoever that cosmetic, USP grade petrolatum is carcinogenic. It also does not absorb into the skin but sits on top of it and that in itself greatly minimises health risks. It also has a long history of safe use, as it was first used as a skincare product more than 100 years ago, in 1872 to be precise.
It is also non-comedogenic, though its pure form is very heavy and greasy so combination and oily skin types might want to avoid it anyway.
Overall, it is the gold-standard occlusive agent known today and a tub of Vaseline comes in handy in any household to heal cracked lips or other severely dry skin patches.
We don't have description for this ingredient yet.
If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.
Also, it's an effective deodorant and a medium spreading emollient.
- Retinol (pure Vitamin A) is probably the most proven anti-aging ingredient available OTC
- It has to be converted in the skin to retinoic acid to work its magic
- Once converted, it has the same effect as all-trans-retinoic acid, aka tretinoin
- A generally accepted ballpark number is that retinol is 10-to-20 times less potent than retinoic acid
- It makes skin less wrinkled, smoother, firmer and tighter
- It might also be helpful for acne prone skin as it normalizes keratinization and makes the pores produce less sebum
- Possible side effects and irritation are also much less than with retinoic acid
- Do not use whilst pregnant
We don't have description for this ingredient yet.
It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range.
Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415).
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula.
Exactly what it sounds: nice smelling stuff put into cosmetic products so that the end product also smells nice. Fragrance in the US and parfum in the EU is a generic term on the ingredient list that is made up of 30 to 50 chemicals on average (but it can have as much as 200 components!).
If you are someone who likes to know what you put on your face then fragrance is not your best friend - there's no way to know what’s really in it.
Also, if your skin is sensitive, fragrance is again not your best friend. It’s the number one cause of contact allergy to cosmetics. It’s definitely a smart thing to avoid with sensitive skin (and fragrance of any type - natural is just as allergic as synthetic, if not worse!).
We don't have description for this ingredient yet.
Sunflower does not need a big intro as you probably use it in the kitchen as cooking oil, or you munch on the seeds as a healthy snack or you adore its big, beautiful yellow flower during the summer - or you do all of these and probably even more. And by even more we mean putting it all over your face as sunflower oil is one of the most commonly used plant oils in skincare.
It’s a real oldie: expressed directly from the seeds, the oil is used not for hundreds but thousands of years. According to The National Sunflower Association, there is evidence that both the plant and its oil were used by American Indians in the area of Arizona and New Mexico about 3000 BC. Do the math: it's more than 5000 years – definitely an oldie.
Our intro did get pretty big after all (sorry for that), so let's get to the point finally: sunflower oil - similar to other plant oils - is a great emollient that makes the skin smooth and nice and helps to keep it hydrated. It also protects the surface of the skin and enhances the damaged or irritated skin barrier. Leslie Bauman notes in Cosmetic Dermatology that one application of sunflower oil significantly speeds up the recovery of the skin barrier within an hour and sustains the results 5 hours after using it.
It's also loaded with fatty acids (mostly linoleic (50-74%) and oleic (14-35%)). The unrefined version (be sure to use that on your skin!) is especially high in linoleic acid that is great even for acne-prone skin. Its comedogen index is 0, meaning that it's pretty much an all skin-type oil.
Truth be told, there are many great plant oils and sunflower oil is definitely one of them.
We don't have description for this ingredient yet.
It's a little helper ingredient coming from corn, rice or potato starch that can help to keep skin mat (absorbent), to stabilise emulsions, and to keep the product together (binding).
A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product feel great on the skin. It works synergistically with preservatives and helps to improve water-resistance of sunscreens.
A white, waxy emollient that gives "body" to skincare formulas. Comes from coconut or palm kernel oil.
A white waxy solid that helps water and oil to mix nicely together (emulsifier). It is derived from the fatty alcohol lauryl alcohol by ethoxylating it and thus making the molecule a lot more water-soluble. In fact, Laureth-23 is mostly water-soluble acting as a solubilizer for dissolving small amounts of oily things into water-based formulas.
It's a "bioengineered" from of skin building block N-acetylglucosamine-6-phosphate (NAG6P) that is used by the skin to synthesize important skin-identical humectants like GAGs and hyaluronan.
According to the manufacturer's in-vitro and ex-vivo (made in the lab not on real people) tests, NovHyal can boost GAGs production both in the upper and middle layer of the skin by 84% in 10 days. It can also increase hyaluronic acid synthesis by 282% in just 2 days. Sounds good, though some in-vivo tests (made on real people) would be nice.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
Sodium Acetylated Hyaluronate is a variation of current IT moisturizer, Hyaluronic acid, where some water-loving -OH groups are replaced by amphipathic (partly water-loving and partly water-hating) acetyl groups. The modified molecule is claimed to have even better moisture retention ability than normal HA and better affinity to the skin surface.
The better affinity comes from the acetyl groups that act as tiny "anchors" to attach the HA molecule to the skin. Staying on top of the skin better and longer means longer-lasting surface hydration and improved elasticity. It is also less sticky and more cosmetically elegant than normal HA, so no wonder the nickname of this molecule is super hyaluronic acid.
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
One of the many types of ceramides that can be found naturally in the upper layer of the skin. Ceramides make up about 50% of the goopy stuff that's between our skin cells and play a super important role in having a healthy skin barrier and keeping the skin hydrated. It works even better when combined with its pal, Ceramide 1.
We wrote way more about ceramides at ceramide 1, so click here to know more.
The unfancy name for it is lye. It’s a solid white stuff that’s very alkaline and used in small amounts to adjust the pH of the product and make it just right.
For example, in case of AHA or BHA exfoliants, the right pH is super-duper important, and pH adjusters like sodium hydroxide are needed.
BTW, lye is not something new. It was already used by ancient Egyptians to help oil and fat magically turn into something else. Can you guess what? Yes, it’s soap. It still often shows up in the ingredient list of soaps and other cleansers.
Sodium hydroxide in itself is a potent skin irritant, but once it's reacted (as it is usually in skin care products, like exfoliants) it is totally harmless.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
If you are fighting acne and have looked into oral supplements, chances are that zinc gluconate sounds familiar to you. It is a zinc salt that has research proving it to be effective against inflammatory acne, though not quite as effective as the antibiotic minocycline (31.2% vs. 63.4% success rate). However, zinc supplements are easily available, have little-to-no side effects, so supplementing them with a 30mg per day dose can still be a good idea.
As for smearing zinc gluconate all over your face, it is also not a bad idea. Zinc has multiple magic abilities: it is antibacterial (including evil, acne-causing P. acnes) and sebum-regulating (5α-reductase inhibitor), great for acne-prone skin types. It also stimulates antioxidant enzyme systems (mainly superoxide dismutase) and has nice wound healing abilities acting mainly in the first, proliferation phase. So great for skin types in need of healing and soothing.
What about the gluconate part? It is there to promote the absorption and bioavailability of zinc and also plays a role in cellular regeneration (involved in the synthesis of ribose sugars, structural components of DNA and RNA).
The extract coming from the lovely herb, rosemary. It contains lots of chemicals, including flavonoids, phenolic acids, and diterpenes. Its main active is rosmarinic acid, a potent antioxidant, and anti-inflammatory. It has also anti-bacterial, astringent and toning properties.
The leaves contain a small amount of essential oil (1-2%) with fragrant components, so if you are allergic to fragrance, it might be better to avoid it.
A helper ingredient that is used as a bulking and viscosity controlling agent. It is also an emulsion stabilizer in water-in-oil emulsions, where water droplets are dispersed in the continuous oil phase and not the other way round.
It can also be used as a heat generating agent in water-less formulas as it has an instant heat-generating chemical reaction with water.
It's a special "cross-linked" from of IT-moisturizer, hyaluronic acid (HA). Cross-linked means that "normal" HA pieces (1-2 million Da molecular weight) are chemically bound togeather to create a big, "infinite" mesh.
The special HA mesh has a remarkable water-binding capacity, 5 times more than the already crazy water-binding capacity of "normal" HA. This water filled crosslinked HA gel forms a smooth film on the skin and continuously delivers the bound water, so it gives long-term moisturizing benefits.
Btw, crosslinking HA was developed for dermal fillers (as crosslinking helps their longevity), and this guy is the topical version of FDA approved dermal filler called Hylan B gel. Smearing crosslinked version all over ourselves is a newish thing, and incoming evidence so far suggests that it's a great idea, even better than normal HA.
A very recent, 2016 research article compared the topical moisturizing effect of crosslinked HA (not Hylan B gel specifically, but something called Resilient HA or RHA), HMW-HA and LMW-HA and found that "TEWL (that is trans-epidermal water loss, the water that evaporates from the skin) was reduced by 27.8% with RHA, and by 15.6% with HMW HA, but increased by 55.5% with LMW HA." (You can read much more about HMW and LMW HA here in the geeky details section.)
All in all, we think Sodium Hyaluronate Crosspolymer is an awesome version of HA, probably superior to traditional versions, so be happy to spot it on the ingredient list.
- It’s naturally in our skin and behaves there like a sponge
- It can bind up to 1000 times its own weight in water
- It is a big molecule from repeated subunits (polymer) so different molecular weight versions exist (unfortunately there is no way to determine MW from INCI list only)
- High-molecular-weight-HA (>500 kDa) is an excellent surface hydrator, skin protectant and can act as an osmotic pump helping water-soluble actives to penetrate deeper into the skin
- Low-molecular-weight-HA (< 500 kDa) can hydrate the skin somewhat deeper though it is still a big molecule and works mainly in the epidermis (outer layer of the skin)
- Low-molecular-weight-HA might also help the skin to repair itself by increasing its self-defense (~ 200kDa used in the study)
- Ultra-low-molecular-weight-HA (<50kDa) is a controversial ingredient and might work as a pro-inflammatory signal molecule
We don't have description for this ingredient yet.
- Primary fat-soluble antioxidant in our skin
- Significant photoprotection against UVB rays
- Vit C + Vit E work in synergy and provide great photoprotection
- Has emollient properties
- Easy to formulate, stable and relatively inexpensive
A copper salt (copper cation + gluconate anion) probably best known for promoting cellular regeneration and wound healing. It works mainly in the final healing phase that complements nicely with the wound healing abilities of its mineral salt sister, zinc gluconate.
Other than that, copper is also involved in several enzyme systems: it is a cofactor for the antioxidant enzyme, superoxide dismutase and also a cofactor for the melanin stimulating enzyme, tyrosinase. This means that copper has some tan activating properties, though we think you should not be into tanning at all, as UV is so bad for the skin.
The gluconate part is there to promote the bioavailability of copper and it also plays a role in cellular regeneration (involved in the synthesis of ribose sugars, structural components of DNA and RNA).
Citronellol is a very common fragrance ingredient with a nice rose-like odor. In the UK, it’s actually the third most often listed perfume on the ingredient lists.
It can be naturally found in geranium oil (about 30%) or rose oil (about 25%).
As with all fragrance ingredients, citronellol can also cause allergic contact dermatitis and should be avoided if you have perfume allergy. In a 2001 worldwide study with 178 people with known sensitization to fragrances citronellol tested positive in 5.6% of the cases.
There is no known anti-aging or positive skin benefits of the ingredient. It’s in our products to make it smell nice.
Geraniol is a common fragrance ingredient. It smells like rose and can be found in rose oil or in small quantities in geranium, lemon and many other essential oils.
Just like other similar fragrance ingredients (like linalool and limonene) geraniol also oxidises on air exposure and becomes allergenic. Best to avoid if you have sensitive skin.
A common fragrance ingredient that has a sweet scent somewhere between lily and fruity melon. Can be found in essential oils, such as lavender oil, orange flower oil or ylang-ylang.
In cosmetics, it can be used up to 1%. It’s one of the “EU 26 fragrances” that has to be labelled separately (and cannot be simply included in the term “fragrance/perfume” on the label) because of allergen potential. Best to avoid if your skin is sensitive.
A colorless or yellowish oil that's used as a fragrance. It has a spicy scent and can be found for example in basil, clove or cinnamon oil.
A 2006 in-vitro (made in the lab not on real people) study examined if clove oil is cytotoxic and found that not only clove oil but also its main constituent, eugenol is cytotoxic even at very low concentration (0.03%). It’s also one of the “EU 26 fragrances” that has to be labelled separately (and cannot be simply included in the term “fragrance/perfume” on the label) because of allergen potential. Best to avoid at least in leave-on products.
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