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Zinc Gluconate

What-it-does: anti-acne, soothing, deodorant


If you are fighting acne and have looked into oral supplements, chances are that zinc gluconate sounds familiar to you. It is a zinc salt that has research proving it to be effective against inflammatory acne, though not quite as effective as the antibiotic minocycline (31.2% vs. 63.4% success rate). However, zinc supplements are easily available, have little-to-no side effects, so supplementing them with a 30mg per day dose can still be a good idea.

As for smearing zinc gluconate all over your face, it is also not a bad idea. Zinc has multiple magic abilities: it is antibacterial (including evil, acne-causing P. acnes) and sebum-regulating (5α-reductase inhibitor), great for acne-prone skin types. It also stimulates antioxidant enzyme systems (mainly superoxide dismutase) and has nice wound healing abilities acting mainly in the first, proliferation phase. So great for skin types in need of healing and soothing.

What about the gluconate part? It is there to promote the absorption and bioavailability of zinc and also plays a role in cellular regeneration (involved in the synthesis of ribose sugars, structural components of DNA and RNA).

Show me some proof

  • Dreno, B., et al. "Low doses of zinc gluconate for inflammatory acne." Acta Derm Venereol 69.6 (1989): 541-3.
  • Dreno, Brigitte, et al. "Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris." Dermatology 203.2 (2001): 135-140.
  • Tenaud, I., et al. "In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese." British Journal of Dermatology 140.1 (1999): 26-34.

Products with Zinc Gluconate

Glowderma Sebonac Gel Kerastase Fondant Chromatique Conditioner Novexpert Trio-Zinc Mist Eximia Aqua Mat Micelar Typology Sensitive Skin Serum 5 Mineral Complex Acneed Acne Control Lotion Bioderma Sebium Micellar Water Derma-ceutix Hydrating Vitamin Mist Eau Thermale Avène Cleanance MAT Mattifying Toner Erhair Scalperfect Allantoin & Silk Protein Scalp Soothing Serum Fundamentals Skincare Rejuvinating Masque ME+ Niacinamide & Zinc Booster Oxynergy Power Infuse Toning Mist Skindinavia The Post-Makeup Recovery Spray bioearth Zinc + Niacinamide 11% Bioderma Sebium Gel Moussant Actif Bioderma Sébium Gel Moussant Actif Bioderma Sébium Sensitive Soothing Anti-Blemish Care Biotherm Biopur Matifying Astringent Lotion Derma-ceutix Hyaluronic Anti-oxidant Mask Dermaceutic Oxybiome Cleansing Micellar Water Eximia Hyalu- B Concentré GRAVICH Oily Sebum Reducer First Care Toner Hello Body Rose Divine Daily Face Cleansig Serum Le Mieux Essence Toner Lierac Sebologie Deep-Cleansing Scrub Mask Lierac Sebologie Double Concentrate Malibu C Perfection C Serum Ofra West End Vitamin C Micellar Water Perricone MD No:Rinse Intensive Pore Minimizing Toner Rodial Dragon'S Blood Essence Mist Skinfuse Rescue Calming Complex Versed Just Breathe Clarifying Serum Ziaja Manuka Tree Face Toner facetheory Elaquate Serum S11 CRYSTAL Mineral Deodorant Stick, Unscented Cetaphil Pro Dermacontrol Oil Removing Foam Wash Emina Ms. Pimple Toner Emina Witch Power Face Toner Garnier Gesichtswasser Hautklar Anti-Pickel Ives rocher Purity Shampoo Marcelle Micellar Water (Oily Skin) Nip+Fab Dragon’s Blood Fix Essence Mist Perricone MD Neuropeptide Face Activator Rodial Dragon'S Blood Hyaluronic Tonic SVR Hydraliane Essence SVR Sebiaclear Sebiaclear Micro-Peel Sesderma Sesretinal Young Skin Moisturizing Gel The Chemist Look Booster Vit-B3/Zn Typology Purifying Toner 1% Salicylic Acid