Follow us on our new Insta page »

Zinc Gluconate

What-it-does: anti-acne, soothing, deodorant

Official CosIng Information


If you are fighting acne and have looked into oral supplements, chances are that zinc gluconate sounds familiar to you. It is a zinc salt that has research proving it to be effective against inflammatory acne, though not quite as effective as the antibiotic minocycline (31.2% vs. 63.4% success rate). However, zinc supplements are easily available, have little-to-no side effects, so supplementing them with a 30mg per day dose can still be a good idea.

As for smearing zinc gluconate all over your face, it is also not a bad idea. Zinc has multiple magic abilities: it is antibacterial (including evil, acne-causing P. acnes) and sebum-regulating (5α-reductase inhibitor), great for acne-prone skin types. It also stimulates antioxidant enzyme systems (mainly superoxide dismutase) and has nice wound healing abilities acting mainly in the first, proliferation phase. So great for skin types in need of healing and soothing.

What about the gluconate part? It is there to promote the absorption and bioavailability of zinc and also plays a role in cellular regeneration (involved in the synthesis of ribose sugars, structural components of DNA and RNA).

Show me some proof

  • Dreno, B., et al. "Low doses of zinc gluconate for inflammatory acne." Acta Derm Venereol 69.6 (1989): 541-3.
  • Dreno, Brigitte, et al. "Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris." Dermatology 203.2 (2001): 135-140.
  • Tenaud, I., et al. "In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese." British Journal of Dermatology 140.1 (1999): 26-34.

Products with Zinc Gluconate

Bioderma Sebium Micellar Water ME+ Niacinamide & Zinc Booster Bioderma Sébium Sensitive Soothing Anti-Blemish Care Malibu C Perfection C Serum Perricone MD No:Rinse Intensive Pore Minimizing Toner Versed Just Breathe Clarifying Serum Ziaja Manuka Tree Face Toner Cetaphil Pro Oil Removing Foam Wash Nip+Fab Dragon’s Blood Fix Essence Mist Perricone MD Neuropeptide Face Activator SVR Hydraliane Essence Wardah Acnederm Pore Refining Toner Yves Rocher Sebo Vegetal Rebalancing + Antioxidant Essence Bliss What A Melon Replenishing Watermelon Toner Emina Ms Pimple Face Wash MD Skinical Olive Essence Avene Cleanance Mat Mattifying Emulsion Florence by Mills Magic Micellar Cleansing Gel Neutrogena Hydro Boost Micellar Water Nigy laboratories AC Soin Actif Topicrem Rohto Hada Labo Kiwamizu Mineral Amino Lotion Vichy Normaderm Phytosolution Purifying Cleansing Gel e.l.f. Matte Blotting Mist Beauty Counter Countercontrol SOS Acne Spot Treatment Bioderma Sebium Lotion Bioderma Sébium Global Bioderma Sébium Global Cover Fluid Dermalogica Overnight Clearing Gel Eau Thermale Avène Cleanance Mat Mattifying Emulsion Perricone MD High Potency Classics Nutritive Cleanser e.l.f. Cosmetics Supertone Toner La Roche-Posay Cicaplast Gel B5 Pro-Recovery Skincare La Roche-Posay Cicaplast Pro-Recovery Skincare La Roche-Posay Hydraphase Intense Legere Payot Roselift Collagène Concentré Perricone MD Citrus Brightening Cleanser e.l.f. Cosmetics Oil Control Liquid Lotion Codage Paris Concentrated Body Milk Skin Recovery Deliplus Gel Facial Limpiador Purificante (Pieles Grasas) Garnier Anti-Pickel-Stift Laura Mercier Mineral Finishing Powder Marcelle Soothing Toner OsmosisMD Catalyst AC-11- DNA Repair REN Clearcalm 3 Clarifying Clay Cleanser Topicrem Cica Soothing Cream Vichy Dermablend Covermatte Powder Foundation Wardah Acnederm Pure Foaming Cleanser Ziaja Manuka Tree Purifying Night Cream Andalou Naturals Cannacell D.Tox Mask Atopalm Real Barrier Control-T Toner