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Zinc Gluconate

What-it-does: anti-acne, soothing


If you are fighting acne and have looked into oral supplements, chances are that zinc gluconate sounds familiar to you. It is a zinc salt that has research proving it to be effective against inflammatory acne, though not quite as effective as the antibiotic minocycline (31.2% vs. 63.4% success rate). However, zinc supplements are easily available, have little-to-no side effects, so supplementing them with a 30mg per day dose can still be a good idea.

As for smearing zinc gluconate all over your face, it is also not a bad idea. Zinc has multiple magic abilities: it is antibacterial (including evil, acne-causing P. acnes) and sebum-regulating (5α-reductase inhibitor), great for acne-prone skin types. It also stimulates antioxidant enzyme systems (mainly superoxide dismutase) and has nice wound healing abilities acting mainly in the first, proliferation phase. So great for skin types in need of healing and soothing.

What about the gluconate part? It is there to promote the absorption and bioavailability of zinc and also plays a role in cellular regeneration (involved in the synthesis of ribose sugars, structural components of DNA and RNA).

Show me some proof

  • Dreno, B., et al. "Low doses of zinc gluconate for inflammatory acne." Acta Derm Venereol 69.6 (1989): 541-3.
  • Dreno, Brigitte, et al. "Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris." Dermatology 203.2 (2001): 135-140.
  • Tenaud, I., et al. "In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese." British Journal of Dermatology 140.1 (1999): 26-34.

Products with Zinc Gluconate

Bioderma Sebium Micellar Water ME+ Niacinamide & Zinc Booster Bioderma Sébium Sensitive Malibu C Perfection C Serum Ziaja Manuka Tree Face Toner Cetaphil Pro Oil Removing Foam Wash Nip+Fab Dragon’s Blood Fix Essence Mist Perricone MD Neuropeptide Face Activator SVR Hydraliane Essence Yves Rocher Sebo Vegetal Rebalancing + Antioxidant Essence Bliss What A Melon Replenishing Watermelon Toner Avene Cleanance Mat Mattifying Emulsion Neutrogena Hydro Boost Micellar Water Rohto Hada Labo Kiwamizu Mineral Amino Lotion elf Matte Blotting Mist Bioderma Sebium Lotion Bioderma Sébium Global Bioderma Sébium Global Cover Fluid Dermalogica Overnight Clearing Gel E.L.F. Cosmetics Supertone Toner Eau Thermale Avène Cleanance Mat Mattifying Emulsion E.L.F. Cosmetics Oil Control Liquid Lotion La Roche-Posay Cicaplast Gel B5 Pro-Recovery Skincare La Roche-Posay Cicaplast Pro-Recovery Skincare Codage Paris Concentrated Body Milk Skin Recovery Deliplus Gel Facial Limpiador Purificante (Pieles Grasas) Marcelle Soothing Toner Ren Clearcalm 3 Clarifying Clay Cleanser Vichy Dermablend Covermatte Powder Foundation Ziaja Manuka Tree Purifying Night Cream Andalou Naturals Cannacell D.Tox Mask Atopalm Real Barrier Control-T Toner Bioderma Atoderm Intensive Baume Grow Gorgeous Scalp Stimulating Masque La Roche-Posay Cicaplast Baume B5 La Roche-Posay Cicaplast Baume B5 Mixa Micellar Water Anti-Imperfection REN Skincare Clearcalm 3 Clarity Restoring Mask Sebamed Clear Face Mattifying Cream Ph 5.5 Sebamed Unreine Haut - Creme Mattierend Sephora Gel Mask Hydrating &Quenching Uriage Bariéderm Drying Repairing Cica-Spray Vichy Normaderm 3 In 1 Exfoliant + Cleanser + Mask Avene Oil-Free Gel Cleanser Biotherm Aquasource Hydration Gel Cetaphil Gentle Cleansing Cloths Neutrogena Hydro Boost Sleeping Cream Perricone MD No:Rinse Exfoliating Peel Proactive+ Complexion Perfecting Hydrator Sesderma Salises Facial Moisturizing Gel Cream