Follow us on our new Insta page »

Zinc Gluconate

What-it-does: anti-acne, soothing, deodorant

Official CosIng Information


If you are fighting acne and have looked into oral supplements, chances are that zinc gluconate sounds familiar to you. It is a zinc salt that has research proving it to be effective against inflammatory acne, though not quite as effective as the antibiotic minocycline (31.2% vs. 63.4% success rate). However, zinc supplements are easily available, have little-to-no side effects, so supplementing them with a 30mg per day dose can still be a good idea.

As for smearing zinc gluconate all over your face, it is also not a bad idea. Zinc has multiple magic abilities: it is antibacterial (including evil, acne-causing P. acnes) and sebum-regulating (5α-reductase inhibitor), great for acne-prone skin types. It also stimulates antioxidant enzyme systems (mainly superoxide dismutase) and has nice wound healing abilities acting mainly in the first, proliferation phase. So great for skin types in need of healing and soothing.

What about the gluconate part? It is there to promote the absorption and bioavailability of zinc and also plays a role in cellular regeneration (involved in the synthesis of ribose sugars, structural components of DNA and RNA).

Show me some proof

  • Dreno, B., et al. "Low doses of zinc gluconate for inflammatory acne." Acta Derm Venereol 69.6 (1989): 541-3.
  • Dreno, Brigitte, et al. "Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris." Dermatology 203.2 (2001): 135-140.
  • Tenaud, I., et al. "In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese." British Journal of Dermatology 140.1 (1999): 26-34.

Products with Zinc Gluconate

Bioderma Sebium Micellar Water ME+ Niacinamide & Zinc Booster Skindinavia The Post-Makeup Recovery Spray Bioderma Sébium Sensitive Soothing Anti-Blemish Care Biotherm Biopur Matifying Astringent Lotion Hello Body Rose Divine Daily Face Cleansig Serum Malibu C Perfection C Serum Perricone MD No:Rinse Intensive Pore Minimizing Toner Versed Just Breathe Clarifying Serum Ziaja Manuka Tree Face Toner Cetaphil Pro Dermacontrol Oil Removing Foam Wash Crystal Body Deodorant Mineral Deodorant Stick, Unscented Garnier Gesichtswasser Hautklar Anti-Pickel Marcelle Micellar Water (Oily Skin) Nip+Fab Dragon’s Blood Fix Essence Mist Perricone MD Neuropeptide Face Activator SVR Hydraliane Essence The Chemist Look Booster Vit-B3/Zn Wardah Acnederm Pore Refining Toner Yves Rocher Sebo Vegetal Rebalancing + Antioxidant Essence Bliss What A Melon Replenishing Watermelon Toner Emina Ms Pimple Face Wash Eximia Hyalu Fillet Complex 3D Lierac Mesolift Serum MD Skinical Olive Essence Topicrem AC Purifying Cleansing Gel Avene Cleanance Mat Mattifying Emulsion Elizabeth Grant Caviar Cellular Recharge Super Body Cream Erha Acne Care Lab Acne Spot Gel Florence by Mills Magic Micellar Cleansing Gel Gerovital Stop Acnee Crema Ultra-Activa Gerovital h3 derma Mattifying Moisturizing Emulsion Neutrogena Hydro Boost Micellar Water Nigy laboratories AC Soin Actif Topicrem Rohto Hada Labo Kiwamizu Mineral Amino Lotion Saint Gervais Purifying Cleansing Gel Vichy Normaderm Phytosolution Purifying Cleansing Gel ZIIP Crystal Conductive Gel e.l.f. Matte Blotting Mist Beauty Counter Countercontrol SOS Acne Spot Treatment Bioderma Sebium Lotion Bioderma Sébium Global Bioderma Sébium Global Cover Fluid Dermalogica Overnight Clearing Gel Eau Thermale Avène Cleanance Mat Mattifying Emulsion Lierac Sebologie Blemish Correction Spots Novexpert Purifying Gel Olay Luminous Whip Cream Perricone MD High Potency Classics Nutritive Cleanser e.l.f. Cosmetics Supertone Toner