Follow us on our new Insta page »
Centellian24 Madeca Derma Mask 3 Intensive Formula

Madeca Derma Mask 3 Intensive Formula

A mask that is formulated with teca essence from centella asiatica and rh-oligopeptide-1, which add a natural layer of protective barrier to your skin. It soothes damaged pelts due to uv rays, helps heal scarring and marks and enhances moisture levels as it reduces moisture loss. It improves rough texture as it removes dead skin cells, works to increase skin density and minimize the look of deep wrinkles, freckles, and pigmentation.
Uploaded by: dianat on

Highlights

Other Ingredients

Skim through

Ingredient name what-it-does irr., com. ID-Rating
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar
Honey Extract moisturizer/​humectant goodie
Niacinamide cell-communicating ingredient, skin brightening, anti-acne, moisturizer/​humectant superstar
Rosa Damascena Flower Oil antioxidant, perfuming, antimicrobial/​antibacterial icky
Dimethiconol emollient, moisturizer/​humectant
Disodium EDTA chelating, viscosity controlling
Dipropylene Glycol solvent, perfuming, viscosity controlling
Lavandula Angustifolia (Lavender) Oil antimicrobial/​antibacterial, perfuming icky
Madecassic Acid goodie
Citrus Aurantium Bergamia (Bergamot) Fruit Oil perfuming icky
Alcohol Denat antimicrobial/​antibacterial, solvent, viscosity controlling icky
Butylene Glycol moisturizer/​humectant, solvent, viscosity controlling 0, 1
Cyclopentasiloxane emollient, solvent
Cyclohexasiloxane emollient, solvent
Cetearyl Alcohol emollient, viscosity controlling, emulsifying, surfactant/​cleansing 1, 2
Pelargonium Graveolens Flower Oil perfuming icky
Artemisia Absinthium Extract
Adenosine cell-communicating ingredient goodie
Asiaticoside antioxidant, perfuming goodie
Asiatic Acid goodie
Cedrus Atlantica Bark Oil perfuming
Plukenetia Volubilis Seed Oil antioxidant, emollient, moisturizer/​humectant goodie
Allantoin soothing 0, 0 goodie
Ethylhexylglycerin preservative
Citrus Aurantium Dulcis (Orange) Oil perfuming icky
Olea Europaea (Olive) Fruit Oil antioxidant, emollient, perfuming 0, 0-2 goodie
Citrus Grandis (Grapefruit) Peel Oil perfuming icky
Agave Americana Stem Extract
Cananga Odorata Flower Oil perfuming icky
Xanthan Gum viscosity controlling
Rose Flower Oil
Jasminum Officinale (Jasmine) Oil soothing, moisturizer/​humectant, perfuming
Althaea Rosea Flower Extract
Water solvent
Caffeine antioxidant, perfuming goodie
Caprylic/Capric Triglyceride emollient
Caprylyl Glycol moisturizer/​humectant, emollient
Copaifera Officinalis (Balsam Copaiba) Resin
Tromethamine buffering
Phenoxyethanol preservative
Propolis Extract
Helianthus Annuus (Sunflower) Seed Oil emollient 0, 0 goodie
1,2-Hexanediol solvent
rh-Oligopeptide-1 cell-communicating ingredient
Ferula Galbaniflua (Galbanum) Resin Oil antimicrobial/​antibacterial, perfuming
Tuber Aestivum Extract
Glyceryl Stearate emollient, emulsifying 0, 1-2
Thuja Occidentalis Leaf Oil perfuming
Hydroxyacetophenone antioxidant
Acrylates/C10-30 Alkyl Acrylate Crosspolymer viscosity controlling

Centellian24 Madeca Derma Mask 3 Intensive Formula
Ingredients explained

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

Honey Extract - goodie
What-it-does: moisturizer/humectant

Usually, a glycerin or glycol based extract of honey that has similar properties to pure honey, i.e. moisturizing, soothing and antibacterial magic properties.

If you wanna know more about honey in cosmetics, we have a shiny explanation here >>

Niacinamide - superstar
Also-called: vitamin B3, nicotinamide | What-it-does: cell-communicating ingredient, skin brightening, anti-acne, moisturizer/humectant
  • A multi-functional skincare superstar with several proven benefits for the skin
  • Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
  • Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
  • Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
  • Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
Read all the geeky details about Niacinamide here >>

Also-called: Damask Rose Flower Oil | What-it-does: antioxidant, perfuming, antimicrobial/antibacterial

We are big fans of all kinds of roses as ornamental plants but when it comes to skincare, it is a mixed bag. Before we list out the good and the not so good, here is an interesting thing. 

The oil content in rose is very, very low so distilling rose essential oil requires huge amounts of rose flowers. It has such a wonderful scent that there are no comparable synthetic alternatives. You can probably guess that this means rose essential oil is expensive.... very very expensive

So the good things: thanks to its wonderful scent the high-end perfume industry loves rose oil. Also, we (humans :)) love rose oil. We love its scent so much that it can heal headaches, depression, stress, and even grief. 

Rose oil contains more than 95 compounds, among them flavonoids, anthocyanins, vitamin C, and quercetin that are all known for their medicinal properties and great antioxidant effects. Similar to many other essential oils, it has antimicrobial properties too. 

Now, the not-so-good thing? Out of the 95 compounds, the major ones are citronellol and geraniolfragrant components that might irritate sensitive skin.

 

A thick, high molecular weight silicone that is usually diluted in another, lighter silicone fluid (like dimethicone or cyclopentasiloxane). The dimethiconol containing silicone blends leave a silky smooth, non-greasy film on the skin.

Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.

It is typically used in tiny amounts, around 0.1% or less.

A clear, colorless liquid that works as a solvent and viscosity decreasing ingredient. It also has great skin-moisturizing abilities. 

Also-called: Lavender Essential Oil | What-it-does: antimicrobial/antibacterial, perfuming

We have to start by writing how fascinated we are by the amazing lavender fields of Provance and we do love pretty much everything about lavender: its look, its color, its scent.... but, when it comes to skincare, lavender is a questionable ingredient that you probably do not want in your skincare products.

First, let us start with the pros: it has a lovely scent, so no wonder that it is popular as a fragrance ingredient in natural products wanting to be free from synthetic fragrances but still wanting to smell nice. The scent of lavender is famous for having calming and relaxing properties and some smallish scientific studies do support that. Inhaled volatile compounds seem to have a soothing effect on the central nervous system and studies have shown that lavender aromatherapy can improve patient's anxiety and experience in hospitals.   

Another pro is that lavender oil has some nice antimicrobial and antibacterial properties. It also has some local pain relieving and muscle relaxing magical powers. Lavender oil is also often claimed to have anti-inflammatory properties. We have found a study confirming this but it was the essential oil of the leaves and not the much more commonly used flowers and the two differ in their main chemical compounds very much. (The main components of the flower essential oil are linalyl acetate and linalool [around 80% the two together] while it is 1,8-Cineole [around 65%] in the essential oil of the leaves.)

Now, let us look at the cons: similar to a bunch of other essential oils, the main components of lavender oil are potentially irritating fragrant components. The two main components are linalyl acetate (about 50%) and linalool (about 35%) and both autoxidise on exposure to the air forming strong contact allergens. To make things even worse, lavender oil seems to be cytotoxic from concentrations as low as 0.25% (concentration up to 0.125% were ok). 

There is also an often cited Japanese study that made patch tests with lavender oil for 9 years and found a huge increase in lavender oil sensitivity in 1997 (from 1.1% in 1990 to 8.7% in 1997 and 13.9% in 1998). This was the year when using dried lavender flowers in pillows, wardrobes, and elsewhere became fashionable in Japan, so it seems that increased exposure to lavender results in increased risk of sensitivity.

Overall, it makes us sad to write bad things about such a lovely plant, but when it comes to skincare, you will be better off without lavender. 

One of the biologically active components of Gotu Kola that is thought to contribute to the plant extract's well-documented skin regenerating, wound healing, and moisturizing properties

If you are into Gotu Kola we have some more info at Centella Asiatica Extract and its other biologically active components MadecassosideAsiaticoside and Asiatic Acid.

Also-called: Bergamot Fruit Oil | What-it-does: perfuming

The essential oil coming from the fruit (probably the rind) of the bergamot orange.  It's a common top note in perfumes and contains (among others) fragrant compounds limonene (37%), linalyl acetate (30%) and linalool (8.8%). 

A well-known issue with bergamot oil (apart from the fragrance allergens) is that it contains phototoxic compounds called furanocoumarins, but more and more commonly furanocoumarin-free versions are used in cosmetic products. Still, if you have sensitive skin and prefer fragrance-free products, bergamot oil is not for you.

  • It's a super common and super debated skincare ingredient
  • It has several benefits: great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent and antimicrobial
  • It can be very drying if it's in the first few ingredients on an ingredient list
  • Some experts even think that regular exposure to alcohol damages skin barrier and causes inflammation though it's a debated opinion (read more in geeky details tab)
Read all the geeky details about Alcohol Denat. here >>

What-it-does: moisturizer/humectant, solvent, viscosity controlling | Irritancy: 0 | Comedogenicity: 1

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive. 

What-it-does: emollient, solvent

A super commonly used 5 unit long, cyclic structured silicone that is water-thin and does not stay on the skin but evaporates from it (called volatile silicone). Similar to other silicones, it gives skin and hair a silky, smooth feel

It's often combined with the non-volatile (i.e. stays on the skin) dimethicone as the two together form a water-resistant, breathable protective barrier on the skin without a negative tacky feel.

What-it-does: emollient, solvent

A light-feeling, volatile (meaning it does not absorb into the skin but evaporates from it) silicone that gives skin a unique, silky and non-greasy feel. It has excellent spreading properties and leaves no oily residue or build-up. 

What-it-does: emollient, viscosity controlling, emulsifying, emulsion stabilising, surfactant/cleansing | Irritancy: 1 | Comedogenicity: 2

An extremely common multitasker ingredient that gives your skin a nice soft feel (emollient) and gives body to creams and lotions. It also helps to stabilize oil-water mixes (emulsions), though it does not function as an emulsifier in itself. Its typical use level in most cream type formulas is 2-3%.  

It’s a so-called fatty alcohol, a mix of cetyl and stearyl alcohol, other two emollient fatty alcohols.  Though chemically speaking, it is alcohol (as in, it has an -OH group in its molecule), its properties are totally different from the properties of low molecular weight or drying alcohols such as denat. alcohol. Fatty alcohols have a long oil-soluble (and thus emollient) tail part that makes them absolutely non-drying and non-irritating and are totally ok for the skin.

Also-called: Rose Geranium Flower Essential Oil | What-it-does: perfuming

The fragrant essential oil coming from the flowers of Rose Geranium. Like most essential oils, it contains antioxidant and antimicrobial components, but the main ones are fragrant constituents (like citronellol and geraniol). Be careful with it, if your skin is sensitive. 

We don't have description for this ingredient yet.

Adenosine - goodie

Adenosine is an important little compound in our body that has a vital cell-signalling role. Research on smearing it on our face is also promising and shows so far a couple of things:

  • It can help with wound healing
  • It’s a good anti-inflammatory agent
  • It might even help with skin’s own collagen production and improve skin firmness and elasticity
  • It helps with barrier repair and protection
  • It might be even useful for the hair helping with hair thickness and hair growth
Asiaticoside - goodie
What-it-does: antioxidant, perfuming

One of the main biologically active components of the famous medicinal plant, Centella Asiatica, aka Gotu Kola. It has well established wound healing and antioxidant activities.  

In-vitro (made in the lab) studies also show that Asiaticoside stimulates GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells) production as well as collagen I synthesis.  Read more at Gotu Kola >>

Asiatic Acid - goodie

One of the biologically active components of Gotu Kola. It's a bit less prominent than its sister component, Asiaticoside, but in-vitro (made in the lab) studies show that Asiatic Acid also stimulates GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells) production as well as collagen I synthesis.

English translation equals that it probably contributes to the well-established moisturizing and wound healing abilities of Gotu Kola

What-it-does: perfuming

We don't have description for this ingredient yet.

Also-called: Sacha Inchi Seed Oil | What-it-does: antioxidant, emollient, moisturizer/humectant

An emollient plant oil coming from the Sacha Inchi plant from the Colombian Amazon.

Similar to other plant oils, it's loaded with nourishing and moisturizing fatty acids: it's especially rich in α-Linolenic acid (42-49%) and linoleic acid (32-38%) and contains less oleic acid (9-14%). It also contains a decent amount of antioxidant vitamin E (200 mg/kg).

Allantoin - goodie
What-it-does: soothing | Irritancy: 0 | Comedogenicity: 0

Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. 

It's not only soothing but it' also skin-softening and protecting and can promote wound healing.

What-it-does: preservative, deodorant

If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.

Also, it's an effective deodorant and a medium spreading emollient

Also-called: Orange Oil | What-it-does: perfuming

The essential oil coming from the sweet orange. In the case of orange (and citruses in general), the essential oil is mainly in the peel of the fruit, so it's pretty much the same as the orange peel oil (also has the same CAS number - a unique ID assigned to chemicals).

Its main component is limonene (up to 97%), a super common fragrant ingredient that makes everything smell nice (but counts as a frequent skin sensitizer). 

Also-called: Olive Fruit Oil | What-it-does: antioxidant, emollient, perfuming | Irritancy: 0 | Comedogenicity: 0-2

You probably know olive oil from the kitchen as a great and healthy option for salad dressing but it's also a great and healthy option to moisturize and nourish the skin, especially if it's on the dry side. 

Similar to other emollient plant oils, it's loaded with nourishing fatty acids: oleic is the main component (55-83%), and also contains linoleic (3.5-20%) and palmitic acids (7-20%). It also contains antioxidant polyphenols, tocopherols (types of vitamin E) and carotenoids and it's one of the best plant sources of skin-identical emollient, Squalene

Overall, a great option for dry skin but less so for acne-prone or damaged skin.

Also-called: Grapefruit Peel Oil | What-it-does: perfuming

The essential oil coming from the rind of the grapefruit. In general, the main component of citrus peel oils is limonene (86-95% for grapefruit peel), a super common fragrant ingredient that makes everything smell nice (but counts as a frequent skin sensitizer).

Other than that, citrus peel also contains the problematic compound called furanocoumarin that makes them mildly phototoxic. In general, the more sour-bitter the fruit, the more problematic it is regarding phototoxicity: orange and clementine peel contain less of it while lemon, grapefruit, and bergamot contain some more. Be careful with it if it is in a product for daytime use.  

We don't have description for this ingredient yet.

Also-called: Ylang Ylang Essential Oil | What-it-does: perfuming

Sweet, exotic and floral, it’ no surprise that Ylang Ylang is a popular essential oil. It is coming from the yellow, fragrant flowers of the Cananga tree native to tropical Asia and, similar to other essential oils, it is a chemically complex mixture with several pros and cons. 

Unfortunately, these are a bit tricky to pin down as the composition varies largely depending on where it is sourced, how the oil is extracted and the grade of it that is used in the product, but we’ll do our best!

Let’s start with the easy stuff.  The main components are fragrant molecules, including super common linalool (1-19%), benzyl benzoate (2-10%) and several others adding up to a max amount of 37.6% of EU sensitizers. The most expensive Extra grade is the most fragrant (has more benzyl acetate and cresyl methyl ether) and is used in high-end perfumes, while the First and Second grades are less fragrant, and used mainly in cosmetics.   

Other than smelling nice and making cosmetic formulas also smell nice, Ylang Ylang might have some antimicrobial and antioxidant benefits and also works as an insect repellent. Its nice smell is also commonly known as being relaxing and calming (also backed up by a few recent studies), but it is an aromatherapy use case (when inhaled) so this probably does not count much skincare-wise. 

On the other hand, the nice smell also means allergen fragrant components and 37.6% of EU sensitizers counts as quite high and the oil is considered to have high skin sensitization potential. It is a good idea to avoid if your skin is sensitive.

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range. 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Also-called: Aqua | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

Caffeine - goodie
What-it-does: antioxidant, perfuming

Hello, our favorite molecule that helps us wake up in the morning and then keeps us going through the day. As a super well-known stimulant from coffee, tea and plenty of other soft drinks, Caffeine needs no introduction. So we will skip right to the part where we talk about what the hell it does in so-so many cosmetic products.

Looking at the research, we were surprised to find how versatile Caffeine is. It is a small, water-loving molecule with pretty good skin penetration abilties. Once in the skin, it has nice antioxidant properties, meaning that it reduces the formation of evil free radicals and it might even be useful in preventing UV-induced skin cancers. 

A well-known thing about Caffeine is that it improves the microcirculation of the blood vessels. Though conventional wisdom and anecdotal evidence says that this property is helpful for dark under-eye circles and puffy eyes, we have to mention that the double-blind research we have found about a 3% caffeine gel concluded that "the overall efficacy of the selected caffeine gel in reducing puffy eyes was not significantly different from that of its gel base."  But you know, the proof is in the pudding.

Another thing Caffeine is used for in body care products is its anti-cellulite effects. In theory, it can speed up the lipolysis process (the "fat burning"  by our cells) and stimulate the draining lymph system that might lead to the improvement of cellulite. But here again, the evidence that it actually makes a measurable, let alone visible,  improvement on actual human beings is limited (we could find only some animal skin studies or caffeine being combined with other actives). 

Last, but not least, we have to write about caffeine and hair growth. The theory is that it can inhibit the activity of the 5-α-reductase enzyme that plays an important role in hair loss and allows a renewed growth phase of the hair. We have found some recent and promising research to back this up. A 2017 study compared a 0.2% caffeine liquid with a 5% Minoxidil  (an FDA approved active to treat baldness) solution and found that  "a caffeine-based topical liquid should be considered as not inferior to minoxidil 5% solution in men with androgenetic alopecia", or English translation means that the caffeine liquid was pretty much as good as the FDA-approved Minoxidil stuff. Not bad!

Overall, we think that caffeine is a very versatile and biologically active ingredient. Even though some of its effects are more hyped up than backed up, it is still a nice to have on many ingredient lists. 

What-it-does: emollient

A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, is super well tolerated by every skin type and easy to formulate with. No wonder it’s popular. 

It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol

The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.

We don't have description for this ingredient yet.

What-it-does: buffering

It's a little helper ingredient that helps to set the pH of the products to be right. It has an alkaline pH and can neutralize acidic ingredients.

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10). 

It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.

We don't have description for this ingredient yet.

Also-called: Sunflower Oil | What-it-does: emollient | Irritancy: 0 | Comedogenicity: 0

Sunflower does not need a big intro as you probably use it in the kitchen as cooking oil, or you munch on the seeds as a healthy snack or you adore its big, beautiful yellow flower during the summer - or you do all of these and probably even more. And by even more  we mean putting it all over your face as sunflower oil is one of the most commonly used plant oils in skincare.

It’s a real oldie: expressed directly from the seeds, the oil is used not for hundreds but thousands of years. According to The National Sunflower Association, there is evidence that both the plant and its oil were used by American Indians in the area of Arizona and New Mexico about 3000 BC. Do the math: it's more than 5000 years – definitely an oldie.

Our intro did get pretty big after all (sorry for that), so let's get to the point finally: sunflower oil - similar to other plant oils - is a great emollient that makes the skin smooth and nice and helps to keep it hydrated. It also protects the surface of the skin and enhances the damaged or irritated skin barrier. Leslie Bauman notes in Cosmetic Dermatology that one application of sunflower oil significantly speeds up the recovery of the skin barrier within an hour and sustains the results 5 hours after using it.

It's also loaded with fatty acids (mostly linoleic (50-74%)  and oleic (14-35%)). The unrefined version (be sure to use that on your skin!) is especially high in linoleic acid that is great even for acne-prone skin. Its comedogen index is 0, meaning that it's pretty much an all skin-type oil

Truth be told, there are many great plant oils and sunflower oil is definitely one of them.

What-it-does: solvent

A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives

Also-called: Epidermal Growth Factor, EGF, rh-Oligopeptide-1;SH-Oligopeptide-1 | What-it-does: cell-communicating ingredient

Sh-Oligopeptide-1 is the famous molecule, which is also called Epidermal Growth Factor or EGF. Chemically speaking, Growth Factors are largish peptides or smallish proteins, or to put it in another way, medium-length amino acid sequences (EGF consists of 53 amino acids).  Biologically speaking, Growth Factors are cellular signal molecules that can stimulate cell growth, proliferation, healing and/or differentiation. 

There are lots of Growth Factors and EGF is just one of them. The topic of "Growth Factors and skincare" is a big, confusing and controversial one and we will try our best to summarize the story for you, including the pros and the cons. 

EGF is a special snowflake when it comes to skincare as it was the first Growth Factor that made its way into cosmetic products and it is also the most common one. The American biochemist, Stanley Cohen discovered EGF and was awarded a Noble prize in 1986 for it. As the Noble prize may signify, the molecule is significant and powerful and directly stimulates the proliferation of epidermal cells. 

When it comes to Sh-Oligopeptide-1 in a cosmetic product, it has pretty well-established wound healing and skin renewal properties. It might even do more than that. According to a 2012 study on a serum containing barley bioengineered epidermal growth factor, "clinical evaluations showed statistically significant improvement in the appearance of fine lines and rhytids, skin texture, pore size, and various dyschromatic conditions apparent within the first month of use, and continuing improvement trends for the duration of the study" (which was 3 months).

This all sounds amazing, "give me some EGF Serum", we can hear you say! But as we wrote in the intro, the topic is complex and controversial so here are some of the questions that keep coming up around slathering EGF all over our face. 

The first and biggest concern is that if EGF is so good at stimulating cell proliferation, how does it relate to cancer? Is the definition of cancer not "cells proliferating out of control"?  Most experts agree on this answer: EGF is mitogenic (= stimulates cell proliferation) but not mutagenic (= does not alter the cell to make it cancerous)If you do not have cancer, you will not get cancer from EGF. However, if you have cancerous cells, EGF will help them to spread, just like it helps healthy cells. So if you have a lot of moles, excessive UV exposure in the past, or if you have any of the skin cancer risk factors, we suggest you should think twice about using EGF products. The same is true if you have psoriasis, a skin disease related to the abnormal growth of epidermal skin cells. You do not want to add fuel to the fire with EGF. 

Other (less serious) concerns are if EGF can properly penetrate the skin (as it is a medium-sized, polar molecule, so a special delivery system is probably needed), if it can affect collagen synthesis (or just works on the surface plumping up only the upmost layers of the skin) and if it has beneficial effects at all when used in isolation versus when used in a "conditioned media" that contains lots of growth factors resembling the synergistic balance found in the skin. 

Overall, our impression is that EGF is definitely a potent molecule. Some EGF products have a cult-like following adding anecdotal evidence to the clinical studies showing EGF has a beneficial effect on the skin. If you like experimenting, by all means, go ahead (unless you have psoriasis or high skin cancer risk factors), but if you are a better safe than sorry type, stick to daily SPF + a good retinoid product. This duo is still the golden standard of anti-aging.

Are you interested in Growth Factors and skincare? We have some more here:

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

What-it-does: emollient, emulsifying | Irritancy: 0 | Comedogenicity: 1-2

A super common, waxy, white, solid stuff that helps water and oil to mix together, gives body to creams and leaves the skin feeling soft and smooth.

Chemically speaking, it is the attachment of a glycerin molecule to the fatty acid called stearic acid. It can be produced from most vegetable oils (in oils three fatty acid molecules are attached to glycerin instead of just one like here) in a pretty simple, "green" process that is similar to soap making. It's readily biodegradable.

It also occurs naturally in our body and is used as a food additive. As cosmetic chemist Colins writes it, "its safety really is beyond any doubt".

What-it-does: perfuming

We don't have description for this ingredient yet.

What-it-does: antioxidant

A handy multifunctional ingredient that works as a preservative booster, as well as an antioxidant and soothing agent

Though its long name does not reveal it, this polymer molecule (big molecule from repeated subunits or monomers) is a relative to the super common, water-loving thickener, Carbomer. Both of them are big molecules that contain acrylic acid units, but Acrylates/C10-30 Alkyl Acrylate Crosspolymer also contains some other monomers that are hydrophobic, i.e. water-hating. 

This means that our molecule is part water- and part oil-loving, so it not only works as a thickener but also as an emulsion stabilizer. It is very common in gel-type formulas that also contain an oil-phase as well as in cleansers as it also works with most cleansing agents (unlike a lot of other thickeners). 

You may also want to take a look at...

what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does moisturizer/humectant
Usually, a glycerin or glycol based extract of honey that has similar properties to pure honey, i.e. moisturizing, soothing and antibacterial magic properties. If you wanna know more about honey in cosmetics, we have a shiny explanation here >> [more]
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
what‑it‑does antioxidant | perfuming | antimicrobial/antibacterial
Rose essential oil - a super expensive oil with a lovely scent. Has also antioxidant and antimicrobial properties. Contains fragrant components that might irritate sensitive skin. [more]
what‑it‑does emollient | moisturizer/humectant
A thick, high molecular weight silicone that is usually diluted in a lighter silicone fluid. The dimethiconol containing silicone blends leave a silky smooth, non-greasy film on the skin. [more]
what‑it‑does chelating | viscosity controlling
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. [more]
what‑it‑does solvent | perfuming | viscosity controlling
A clear, colorless liquid that works as a solvent and viscosity decreasing ingredient. It also has great skin-moisturizing abilities.  [more]
what‑it‑does antimicrobial/antibacterial | perfuming
Lavender - essential oil with a calming scent and antimicrobial properties. Contains fragrant components (linalyl acetate - 50% and linalool - 35%) and might be cytotoxic from 0.25%. [more]
One of the biologically active components of Gotu Kola that is thought to contribute to the plant extract's well-documented skin regenerating, wound healing, and moisturizing properties. If you are into Gotu Kola we have some more info at Centella Asiatica Extract and its other biologically active components  [more]
what‑it‑does perfuming
The essential oil coming from the fruit (probably the rind) of the bergamot orange.  It's a common top note in perfumes and contains (among others) fragrant compounds limonene (37%), linalyl acetate (30%) and linalool (8.8%).  A well-known issue with bergamot oil (apart from the fragrance allergens) is that it contains phototoxic  [more]
what‑it‑does antimicrobial/antibacterial | solvent | viscosity controlling
Alcohol with some additives to make it unconsumable. It is great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent, and antimicrobial. In large amounts, it can be very drying to the skin. [more]
what‑it‑does moisturizer/humectant | solvent | viscosity controlling
irritancy, com. 0, 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
what‑it‑does emollient | solvent
It's a super commonly used water-thin volatile silicone that gives skin and hair a silky, smooth feel.  [more]
what‑it‑does emollient | solvent
A light-feeling, volatile silicone that gives skin a unique, silky and non-greasy feel. It has excellent spreading properties and leaves no oily residue or build-up. 
what‑it‑does emollient | viscosity controlling | emulsifying | surfactant/cleansing
irritancy, com. 1, 2
A super common multitasker ingredient that gives your skin a nice soft feel (emollient) and gives body to creams. [more]
what‑it‑does perfuming
The essential oil coming from the flowers of Rose Geranium. Like most essential oils, it contains antioxidant and antimicrobial components, but the main ones are fragrant constituents. [more]
what‑it‑does cell-communicating ingredient
An important compound in our body that has a vital cell-signalling role. It is wound healing, anti-inflammatory and can help with barrier repair. [more]
what‑it‑does antioxidant | perfuming
One of the main biologically active components of the famous medicinal plant, Centella Asiatica, aka Gotu Kola. It has well established wound healing and antioxidant activities.  In-vitro (made in the lab) studies also show that Asiaticoside stimulates GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells) production as well as coll [more]
One of the biologically active components of Gotu Kola. It's a bit less prominent than its sister component, Asiaticoside, but in-vitro (made in the lab) studies show that Asiatic Acid also stimulates GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells) production as well as collagen I synthesis. [more]
what‑it‑does perfuming
what‑it‑does antioxidant | emollient | moisturizer/humectant
An emollient plant oil that contains nourishing fatty acids and antioxidant vitamin E. It's especially rich in α-Linolenic acid (42-49%). [more]
what‑it‑does soothing
irritancy, com. 0, 0
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. It's not only soothing but it' [more]
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]
what‑it‑does perfuming
The essential oil coming from the sweet orange. Its main component is limonene (up to 97%), a super common fragrant ingredient that makes everything smell nice. [more]
what‑it‑does antioxidant | emollient | perfuming
irritancy, com. 0, 0-2
Olive oil - an oleic acid-rich (55-83%) emollient plant oil that can moisturize dry skin. Also, it contains antioxidant polyphenols and vitamin E. [more]
what‑it‑does perfuming
The essential oil coming from the rind of the grapefruit. Its main component (86-95%) is limonene, the super common fragrant ingredient. [more]
what‑it‑does perfuming
Sweet, exotic and floral, it’ no surprise that Ylang Ylang is a popular essential oil. It is coming from the yellow, fragrant flowers of the Cananga tree native to tropical Asia and, similar to other essential oils, it is a chemically complex mixture with several pros and cons. Unfortunately, these are a bit tricky to pin down as the composition varies largely depending on where it is so [more]
what‑it‑does viscosity controlling
A super commonly used thickener and emulsion stabilizer. [more]
what‑it‑does soothing | moisturizer/humectant | perfuming
what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does antioxidant | perfuming
The well-known stimulant from coffee. It has nice antioxidant properties and can improve the microcirculation. Might be helpful for dark circles, puffy eyes, as well as cellulite and hair loss. [more]
what‑it‑does emollient
A very common emollient that makes your skin feel nice and smooth. Comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. [more]
what‑it‑does moisturizer/humectant | emollient
A handy multi-tasking ingredient that gives the skin a nice, soft feel and also boosts the effectiveness of other preservatives. [more]
what‑it‑does buffering
It's a little helper ingredient that helps to set the pH of the products to be right. It has an alkaline pH and can neutralize acidic ingredients.
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
what‑it‑does emollient
irritancy, com. 0, 0
Sunflower Oil - it's a great emollient that protects & enhances the skin barrier. [more]
what‑it‑does solvent
A multi-functional helper ingredient that acts as a humectant and emollient. It's also a solvent and can boost the effectiveness of preservatives. [more]
what‑it‑does cell-communicating ingredient
Epidermal Growth Factor - a smallish protein that works as a potent cell signaling molecule. It stimulates cell proliferation, wound healing and skin renewal. Do not use if you have psoriasis or high skin cancer risk factors. [more]
what‑it‑does antimicrobial/antibacterial | perfuming
what‑it‑does emollient | emulsifying
irritancy, com. 0, 1-2
Waxy, white, solid stuff that helps water and oil to mix together and leaves the skin feeling soft and smooth. [more]
what‑it‑does perfuming
what‑it‑does antioxidant
A handy multifunctional ingredient that works as a preservative booster, as well as an antioxidant and soothing agent.
what‑it‑does viscosity controlling
A common helper ingredient that stabilizes emulsions and helps to thicken up products. [more]