Dr. Different

Vitalift: Renew Youth Retinal Night Cream

It seems to us that squalane is in fashion and there is a reason for it. Chemically speaking, it is a saturated  (no double bonds) hydrocarbon (a molecule consisting only of carbon and hydrogen), meaning that it's a nice and stable oily liquid with a long shelf life. 

It occurs naturally in certain fish and plant oils (e.g. olive), and in the sebum (the oily stuff our skin produces) of the human skin. As f.c. puts it in his awesome blog post, squalane's main things are "emolliency, surface occlusion, and TEWL prevention all with extreme cosmetic elegance". In other words, it's a superb moisturizer that makes your skin nice and smooth, without being heavy or greasy.

Expand to read more

The oil coming from the seeds of the yellow flowered safflower plant. Similar to other plant oils, it's loaded with nourishing and moisturizing fatty acids: it's a high linoleic acid oil (70%) and has only smaller amounts of oleic acid (11%) (this might be great for acne-prone skin). It also contains antioxidant vitamin E (44mg/100g alpha-tocopherol).

• A multi-functional skincare superstar with several proven benefits for the skin
• Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
• Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
• Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
• Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis

Unless you live under a rock you must have heard about shea butter. It's probably the most hyped up natural butter in skincare today. It comes from the seeds of African Shea or Karite Trees and used as a magic moisturizer and emollient.

But it's not only a simple emollient, it regenerates and soothes the skin, protects it from external factors (such as UV rays or wind) and is also rich in antioxidants (among others vitamin A, E, F, quercetin and epigallocatechin gallate). If you are looking for rich emollient benefits + more, shea is hard to beat. 

We don't have description for this ingredient yet.

It's one of the important lipids that can be found naturally in the outer layer of the skin. About 25% of the goopy stuff between our skin cells consists of cholesterol. Together with ceramides and fatty acids, they play a vital role in having a healthy skin barrier and keeping the skin hydrated. 

Apart from being an important skin-identical ingredient, it's also an emollient and stabilizer. 

We don't have description for this ingredient yet.

A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives. 

We don't have description for this ingredient yet.

The sodium salt form of skincare superstar, vitamin C. If you do not know what the big fuss about vitamin C is, you are missing out and you have to click here and read all the geeky details about it.

Pure vitamin C (aka ascorbic acid, AA) is great and all, but its lack of stability is a big challenge for the cosmetics industry. One solution is to create stable derivatives that can be absorbed into the skin, convert there to AA and do all the magic AA is proven to do (which is being an antioxidant, a collagen booster, and a skin brightener).

Expand to read more

• GHK-Cu is a copper-peptide complex found naturally in yucky bodily fluids (plasma, saliva, and urine)
• It has unique wound healing properties by stimulating the breakdown of unhealthy, too large collagen in scar tissue and stimulating nice and healthy collagen production afterwards
• It stimulates the production of several important skin-identical ingredients (e.g. collagen, elastin, and glycosaminoglycans)
• It has significant anti-inflammatory and antioxidant effect
• There are a few promising studies showing GHK-Cu can improve skin elasticity, clarity, firmness and reduce lines and wrinkles
• It can improve hair growth by enlarging hair follicles (and bigger follicles produce longer, thicker hair)
• There are some urban legends about possible overdosing or facial hair problems (read more in geeky details)

The oil-soluble extract coming from the edible, orange part of the carrot. It is created by macerating the carrot root in a carrier oil such as sunflower or olive oil, and the resulting thing (base oil + carrot root extract) is often called carrot oil or carrot root oil. (Not to be confused with carrot seed oil, that can be fixed or essential and comes from the seeds.)

The root extract is known for containing the orange pigment beta-carotene, aka provitamin A. It is a famous molecule for being a potent antioxidant, suntan accelerator and having skin-regenerative abilities. Carrot oil also contains vitamin E and some fatty acids that give the oil further antioxidant and barrier repairing properties. 

It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

Expand to read more

It's the chemically chopped up version of normal lecithin. Most often it's used to create liposomes and to coat and stabilize other ingredients. 

A natural high-molecular weight amino acid polymer (big molecule from repeated subunits) that is claimed to have awesome, better than IT-moisturizer HA, skin hydrating properties. It is a film-forming polymer that improves both the moisture binding and retention properties of the skin.

One of the many types of ceramides that can be found naturally in the upper layer of the skin. Ceramides make up about 50% of the goopy stuff that's between our skin cells and play a super important role in having a healthy skin barrier and keeping the skin hydrated. It works even better when combined with its pal, Ceramide 1.

We wrote way more about ceramides at ceramide 1, so click here to know more.

A common multi-tasker fatty acid. It makes your skin feel nice and smooth (emollient), gives body to cream type products and helps to stabilize water and oil mixes (aka emulsions).

• Primary fat-soluble antioxidant in our skin
• Significant photoprotection against UVB rays
• Vit C + Vit E work in synergy and provide great photoprotection
• Has emollient properties
• Easy to formulate, stable and relatively inexpensive

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

Expand to read more

A common fatty acid that can be found in lots of plant oils. Its name, "oleic", means derived from olive oil, a plant oil rich in oleic acid, but avocado, macadamia and marula oils, just to name a few, are also oleic rich.

Its chemical structure is monounsaturated, meaning it has one double bond (cis-9) that makes it less kinky than polyunsaturated fatty acids with multiple double bonds. Less kinkiness means that oleic acid and OA-rich oils are a bit thicker and heavier than their LA-rich siblings.

Expand to read more

Adenosine is an important little compound in our body that has a vital cell-signalling role. Research on smearing it on our face is also promising and shows so far a couple of things:

• It can help with wound healing
• It’s a good anti-inflammatory agent
• It might even help with skin’s own collagen production and improve skin firmness and elasticity
• It helps with barrier repair and protection
• It might be even useful for the hair helping with hair thickness and hair growth

If you are reading here, we are pretty sure the words retinoids and retinol ring a bell, but if not, you are seriously missing out, please click here immediately to catch up.  The TL;DR version is that retinoids are the royal family of skincare with tretinoin being the king, the only FDA-approved ingredient to treat the signs of photoaging. Retinol is like a grandkid, it has to be converted (through two steps) in the skin to become retinoic acid. The conversion means retinol is both less effective and less harsh on the skin. 

So where does our current molecule, Retinal, aka Retinaldehyde fit into the family (btw, here is a nice visual family tree about who is who)?  Remember that retinol needed two conversion steps to become retinoic acid? Yes, you are right, Retinal is the intermediate step between retinoic acid and retinol, meaning it needs only one conversion step to become active in the skin. If we go with our royal family analogy, Retinal is Prince William, directly next in line to the throne. 

Expand to read more

We don't have description for this ingredient yet.

Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.

It is typically used in tiny amounts, around 0.1% or less.

A small, three-amino acid peptide (Glycine-Proline-Hydroxyproline) found naturally in our collagen structure.

The theory behind Tripeptide-29 is the following: Collagen is a long sequence of amino acids and breaking it down produces short amino acid sequences, aka peptides. These peptides "signal" to the skin that collagen was lost and that new collagen should be produced. So putting collagen-fragment-identical peptides on the skin might trick it into thinking that new collagen is needed. 

Expand to read more

A small, three amino acid (glycine-histidine-lysine or GHK) peptide that is famous for being a type I collagen fragment. The theory behind collagen-fragment peptides is that when collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen.

Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more. So Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. FYI; Tripeptide-1 is the same peptide that can be found in the famous Matrixyl 3000, but in Matrixyl a palmitic acid is attached to it to increase its oil solubility and thus skin penetration.

Expand to read more

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

A really famous peptide that is part of Matrixyl 3000, the most sold peptide complex in the word. Before we go and find out what the big deal with Matrixyl 3000 is, let's just focus on Palmitoyl Tripeptide-1 itself for a bit.

It's a small three amino acid (they are the building blocks of all proteins) peptide with the amino sequence of glycine-histidine-lysine, or GHK. GHK is attached to palmitic acid (a fatty acid) to increase oil solubility and skin penetration. 

Expand to read more

If you see a cosmetic product that claims that it has "Botox-like effect" then two things are almost certain: one, the product overpromises and two, it contains Argireline. 

So this one is the famous peptide that's marketed by its manufacturer as the "Botox in a jar". The basis for this claim is that it targets the same wrinkle forming mechanism (wrinkles caused by facial muscle movement) as Botox, but the way it works is very different. In addition, the extent to which it can prevent muscles from contracting (and to smooth wrinkles) is very different (otherwise why would anyone use still Botox?). 

Expand to read more

A pretty famous and better-researched peptide consisting of five amino acids (the building blocks of all proteins). It was created in a joint effort by the French ingredient supplier, Sederma and the cosmetics industry big shot, Procter&Gamble.

The amino acid sequence of the peptide is lysine–threonine–threonine–lysine–serine (KTTKS). Sometimes, it's also called collagen pentapeptide, as it's a subfragment of skin-structure-giving type I collagen. The KTTKS amino sequence is then attached for better oil solubility and skin penetration to palmitic acid and BOOM; we get Palmitoyl Pentapeptide-4. 

Expand to read more

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

A four amino acid peptide with the amino sequence of glycine-glutamine-proline-arginine. It is attached to palmitic acid (a fatty acid)  to increase oil solubility and skin penetration. 

It works by reducing the production of the signal molecule, interleukin-6 (IL-6) which promotes inflammation in the skin and less inflammation means slower degradation of important things (like collagen) that results in younger looking skin for a longer time. 

Expand to read more

An anti-aging peptide that can visibly reduce the length and depth of wrinkles, at least according to its manufacturer. In vitro (meaning it was done in the lab, not on real people) studies show that it enhances epidermal regeneration, collagen type I and III synthesis as well as the synthesis of other important skin proteins.