Exo Rejuva Ultra Lifting Cream
Ingredients overview
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VENDERMA Exo Rejuva Ultra Lifting CreamIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.
BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.
It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive.
A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, is super well tolerated by every skin type and easy to formulate with. No wonder it’s popular.
We don't have description for this ingredient yet.
A hydrocarbon-based emollient that can come in different viscosities from silky-light through satiny-smooth to luxurious, rich. It forms a non-occlusive film on the surface of the skin and brings gloss without greasiness to the formula. It's a very pure and hypoallergenic emollient that's also ideal for baby care products.
- A multi-functional skincare superstar with several proven benefits for the skin
- Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
- Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
- Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
- Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid).
Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier.
Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.
Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation.
If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.
As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily.
A vegetable-based emulsifier that helps the oily and watery parts of the formula to mix nicely together. It is compatible with a bunch of cosmetic oils as well as active ingredients and its specialty is creating emulsions with super high heat and freeze stability (from -25 °C and +50 °C).
Jojoba is a drought resistant evergreen shrub native to South-western North America. It's known and grown for jojoba oil, the golden yellow liquid coming from the seeds (about 50% of the weight of the seeds will be oil).
At first glance, it seems like your average emollient plant oil: it looks like an oil and it's nourishing and moisturizing to the skin but if we dig a bit deeper, it turns out that jojoba oil is really special and unique: technically - or rather chemically - it's not an oil but a wax ester (and calling it an oil is kind of sloppy).
So what the heck is a wax ester and why is that important anyway? Well, to understand what a wax ester is, you first have to know that oils are chemically triglycerides: one glycerin + three fatty acids attached to it. The fatty acids attached to the glycerin vary and thus we have many kinds of oils, but they are all triglycerides. Mother Nature created triglycerides to be easily hydrolyzed (be broken down to a glycerin + 3 fatty acid molecules) and oxidized (the fatty acid is broken down into small parts) - this happens basically when we eat fats or oils and our body generates energy from it.
Mother Nature also created wax esters but for a totally different purpose. Chemically, a wax ester is a fatty acid + a fatty alcohol, one long molecule. Wax esters are on the outer surface of several plant leaves to give them environmental protection. 25-30% of human sebum is also wax esters to give us people environmental protection.
So being a wax ester results in a couple of unique properties: First, jojoba oil is extremely stable. Like crazy stable. Even if you heat it to 370 C (698 F) for 96 hours, it does not budge. (Many plant oils tend to go off pretty quickly). If you have some pure jojoba oil at home, you should be fine using it for years.
Second, jojoba oil is the most similar to human sebum (both being wax esters), and the two are completely miscible. Acne.org has this not fully proven theory that thanks to this, jojoba might be able to "trick" the skin into thinking it has already produced enough sebum, so it might have "skin balancing" properties for oily skin.
Third, jojoba oil moisturizes the skin through a unique dual action: on the one hand, it mixes with sebum and forms a thin, non-greasy, semi-occlusive layer; on the other hand, it absorbs into the skin through pores and hair follicles then diffuses into the intercellular spaces of the outer layer of the skin to make it soft and supple.
On balance, the point is this: in contrast to real plant oils, wax esters were designed by Mother Nature to stay on the surface and form a protective, moisturizing barrier and jojoba oil being a wax ester is uniquely excellent at doing that.
We don't have description for this ingredient yet.
An ester that comes from Cetearyl alcohol and the fatty acids of olive oil. It often comes to the formula coupled with Sorbitan Olivate as the two together form the well-known, natural emulsifier trade named Olivem 1000.
Other than helping oil and water to blend, the main thing of Olivem 1000 is generating liquid crystal structures that are similar to the lipid structures of the stratum corneum (the outermost layer of the skin). Thanks to this, Olivem 1000 doubles as an active ingredient with significant moisturizing, barrier-repairing and soothing properties.
It also helps to deliver water-soluble actives such as caffeine more effectively, and can even boost SPF in sunscreen formulas. Its typical use level is 1-5% and has wide compatibility with other actives and oils.
Overall, a real multi-tasker with nice sensorial properties. No wonder it is so popular.
We don't have description for this ingredient yet.
An ester coming from sorbitol and the fatty acids of olive oil. It is part of the popular emulsifier trade named Olivem 1000 that is well-known for generating biomimetic liquid crystal structures. We have more info on Olivem 1000 at Cetearyl Olivate >>
Though its long name does not reveal it, this polymer molecule (big molecule from repeated subunits or monomers) is a relative to the super common, water-loving thickener, Carbomer. Both of them are big molecules that contain acrylic acid units, but Acrylates/C10-30 Alkyl Acrylate Crosspolymer also contains some other monomers that are hydrophobic, i.e. water-hating.
This means that our molecule is part water- and part oil-loving, so it not only works as a thickener but also as an emulsion stabilizer. It is very common in gel-type formulas that also contain an oil-phase as well as in cleansers as it also works with most cleansing agents (unlike a lot of other thickeners).
A semi-essential (infants cannot synthesize it, but adults can) amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor, a skin hydrator and might also help to speed up wound healing.
Arginine usually has a positive charge (cationic) that makes it substantive to skin and hair (those are more negatively charged surfaces) and an excellent film former. Thanks to the positive charge, it also creates a complex with AHAs (AHAs like to lose a hydrogen ion and be negatively charged, so the positive and the negative ions attract each other) that causes a "time-release AHA effect" and reduces the irritation associated with AHAs.
A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives.
A handy multifunctional ingredient that works as a preservative booster, as well as an antioxidant and soothing agent.
A sugar beet-derived amino acid derivative with nice skin protection and moisturization properties. Betaine's special thing is being an osmolyte, a molecule that helps to control cell-water balance. It is also a natural osmoprotectant, meaning that it attracts water away from the protein surface and thus protects them from denaturation and increases their thermodynamic stability.
It also gives sensorial benefits to the formula and when used in cleansers, it helps to make them milder and gentler.
A superabsorbent polymer (big molecule from repeated subunits) that has crazy water binding abilities. Sometimes its referred to as "waterlock" and can absorb 100 to 1000 times its mass in water.
As for its use in cosmetic products, it is a handy multi-tasker that thickens up water-based formulas and also has some emulsifying and emulsion stabilizing properties.
A famous water-like, yeast-derived ingredient that the whole SKII brand is built on. As legend has it, SKII scientists in the 1970's discovered by chance that aged Japanese sake brewers have amazingly soft and youthful hands in contrast to their aged and wrinkled faces. They concluded that the secret must lie in the yeast that the brewers’ hands were in constant contact with during the sake fermentation process.
So Pitera - obtained by a fermentation process of a certain yeast belonging to the genus Galactomyces - was discovered as an anti-aging, skin-nourishing magic liquid. The company claims that the clear, water-like liquid is loaded with good-for-the-skin stuff and is rich in vitamins, amino acids, minerals and organic acids.
As for the science behind Pitera, SKII parent company P&G did an in-vitro (made in the lab) study that confirmed that Pitera-containing moisturizers do indeed help to protect the skin against damage. More specifically, they found that Pitera has antioxidant effects and increases hyaluronan production in epidermal cells. And more hyaluronic acid in the skin means better hydrated, plumper, healthier skin.
If that would not be enough, there is also a 2014 study showing that Pitera might be able to help with skin pigmentation and a 2015 study finding that Galactomyces Ferment Filtrate can activate aryl hydrocarbon receptor (AhR) that's important in epidermal homeostasis by upregulating epidermal barrier proteins. English translation equals: Pitera might be able to help with a healthy skin barrier.
All in all, both anecdotal and scientific evidence show that Pitera is a skin goodie so if you are into essences and yeast-derived fermentations, it's definitely worth a try.
A clear, almost colorless (or slightly yellowish) oily liquid (an ester to be precise) that's used as a medium spreading emollient. It gives skin a nice and smooth after-feel and it's very good at reducing oiliness or greasiness coming from other heavier oils in the formula.
If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.
Also, it's an effective deodorant and a medium spreading emollient.
Adenosine is an important little compound in our body that has a vital cell-signalling role. Research on smearing it on our face is also promising and shows so far a couple of things:
- It can help with wound healing
- It’s a good anti-inflammatory agent
- It might even help with skin’s own collagen production and improve skin firmness and elasticity
- It helps with barrier repair and protection
- It might be even useful for the hair helping with hair thickness and hair growth
A big sugar molecule (polysaccharide) that is used as a natural thickening and gelling agent. It is similar to more commonly used Xanthan Gum, and the two are also often combined to create gel formulas or to stabilize emulsions.
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
We don't have description for this ingredient yet.
- Green tea is one of the most researched natural ingredients
- The active parts are called polyphenols, or more precisely catechins (EGCG being the most abundant and most active catechin)
- There can be huge quality differences between green tea extracts. The good ones contain 50-90% catechins (and often make the product brown and give it a distinctive smell)
- Green tea is proven to be a great antioxidant, UV protectant, anti-inflammatory, anticarcinogenic and antimicrobial
- Because of these awesome properties green tea is a great choice for anti-aging and also for skin diseases including rosacea, acne and atopic dermatitis
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.
It is typically used in tiny amounts, around 0.1% or less.
We don't have description for this ingredient yet.
It's the chemically chopped up version of normal lecithin. Most often it's used to create liposomes and to coat and stabilize other ingredients.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We have to start by writing how fascinated we are by the amazing lavender fields of Provance and we do love pretty much everything about lavender: its look, its color, its scent.... but, when it comes to skincare, lavender is a questionable ingredient that you probably do not want in your skincare products.
First, let us start with the pros: it has a lovely scent, so no wonder that it is popular as a fragrance ingredient in natural products wanting to be free from synthetic fragrances but still wanting to smell nice. The scent of lavender is famous for having calming and relaxing properties and some smallish scientific studies do support that. Inhaled volatile compounds seem to have a soothing effect on the central nervous system and studies have shown that lavender aromatherapy can improve patient's anxiety and experience in hospitals.
Another pro is that lavender oil has some nice antimicrobial and antibacterial properties. It also has some local pain relieving and muscle relaxing magical powers. Lavender oil is also often claimed to have anti-inflammatory properties. We have found a study confirming this but it was the essential oil of the leaves and not the much more commonly used flowers and the two differ in their main chemical compounds very much. (The main components of the flower essential oil are linalyl acetate and linalool [around 80% the two together] while it is 1,8-Cineole [around 65%] in the essential oil of the leaves.)
Now, let us look at the cons: similar to a bunch of other essential oils, the main components of lavender oil are potentially irritating fragrant components. The two main components are linalyl acetate (about 50%) and linalool (about 35%) and both autoxidise on exposure to the air forming strong contact allergens. To make things even worse, lavender oil seems to be cytotoxic from concentrations as low as 0.25% (concentration up to 0.125% were ok).
There is also an often cited Japanese study that made patch tests with lavender oil for 9 years and found a huge increase in lavender oil sensitivity in 1997 (from 1.1% in 1990 to 8.7% in 1997 and 13.9% in 1998). This was the year when using dried lavender flowers in pillows, wardrobes, and elsewhere became fashionable in Japan, so it seems that increased exposure to lavender results in increased risk of sensitivity.
Overall, it makes us sad to write bad things about such a lovely plant, but when it comes to skincare, you will be better off without lavender.
We don't have description for this ingredient yet.
The famous tea tree oil. One of the best known essential oils which comes from Australia where it has been used for almost 100 years for its antiseptic and anti-inflammatory actions. Legend has it that the medicinal benefits of the oil were considered so important that Australian soldiers were supplied with some tea tree oil in their World War II military kit.
Similar to other essential oils, tea tree oil is a very complex chemical mixture consisting of about 100 components, the major ones being terpinen-4-ol (40%), γ-Terpinene (23%) and α-Terpinene (10%). Terpinen-4-ol is considered to be the main active component but as a great article in Clinical Microbiology Reviews states "while some TTO components may be considered less active, none can be considered inactive" and most components contribute to TTO's strong antibacterial, antiviral and antifungal effects.
Regarding skincare and tea tree oil, its most well-known effect is probably being a well established anti-acne ingredient. Multiple studies confirm that TTO is effective against the evil acne-causing bacteria called P. acnes and the effectiveness of 5% TTO gel is comparable to the gold standard anti-acne treatment, 5% Benzoyl Peroxide lotion. You need to be a bit more patient with TTO, though, as its effects come slower but also with fewer side effects.
Regarding TTO and sensitive skin, we say that you should be careful. Even if your skin is not sensitive you should never put undiluted TTO on your skin. Luckily, it contains only very small amounts of the common allergens (such as limonene), but irritant and allergic reactions still happen, especially by oxidation products that occur in older or not properly stored oil. So if you have some pure TTO at home, know that storage matters, keep it in a cool, dry, dark place and use it up in a reasonable amount of time.
Overall, we do not often give a goodie status to essential oils, but we feel that TTO's unique antibacterial and anti-acne properties with its minimal allergen content warrant an exception. If your skin is acne-prone, TTO is something to experiment with.
The essential oil created by steam distilling the leaves of the Eucalyptus tree. It's a colorless, pale yellow oil with a camphoraceous aroma used traditionally in vapor rubs to treat coughs. Its name-giving main component is eucalyptol (also called 1,8-cineole, 80-91%) that has significant antibacterial and expectorant properties.
Among essential oils, Eucalyptus Globulus counts as rather non-sensitising with an EU sensitizer total of 5% (due to limonene). However, if your skin is super-sensitive or you are allergic to fragrances, it is still better to avoid it.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
If you are into perfumes, you must know patchouli as an important essential oil in the perfume industry. It boasts a pleasant woody, earthy and camphoraceous scent and has fixative properties (makes the fragrance long-lasting).
Its composition is pretty unique: it does not contain any of the EU's 26 most common fragrance allergens, but its most important components are patchoulol (30%) and alpha-patchoulene (6%) which are responsible for its aroma and antifungal properties.
Among essential oils, the allergen profile of patchouli counts as pretty good (much better than ylang-ylang or lemongrass oils), but if your skin is sensitive, it's still best to avoid it.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
Hydrolyzed Hyaluronic Acid is a low molecular weight, chemically chopped up version of the naturally big molecule and current IT-moisturizer, Hyaluronic Acid (HA). The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to retain water, making it plump and elastic. As HA is a polymer, the subunits can be repeated many times (as a high-molecular-weight version), or just a few times (as a low-molecular-weight version).
We wrote in detail at HA about how different molecular weight versions do different things both as a component of the skin and as a skincare ingredient, so click here and read about all the details. Hydrolyzed Hyaluronic Acid can also come in different molecular-weight versions with different properties:
- 100-300 kDa version: apart from moisturizing, this size might also help the skin to repair itself by increasing its self-defense. It is also claimed to boost the wound healing process and is especially helpful for sensitive skin types (acne, rosacea, inflammation-related skin diseases).
- 50k Da version: this is the size that is claimed to be able to absorb into the skin and plump up wrinkles, so it is used mainly as an "anti-aging ingredient"
- below 50k, around 10k Da version: there is a Japanese version trade named Hyalo-Oligo that has only a 10k molecular weight and is claimed to penetrate the skin very well, have a unique touch and give deep and long-lasting moisturization. Based on the Evonik-research and the natural role of LMW-HA in the body working as a pro-inflammatory signal molecule, this ultra-low molecular weight version is a controversial ingredient.
If you wanna become a real HA-and-the-skin expert, you can read much more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
A glycerin-derived gentle cleansing agent that is described as being skin and eye-friendly, and not leaving the skin dry or tight. It's also used as a co-emulsifier or solubilizer that helps to blend small amounts of oily things into water-based products.
Soluble Collagen refers to the big, natural collagen molecules mostly extracted from fish or bovine skin. Spotting collagen on the ingredient list, you might think that, aha, this must be there to supplement the collagen content of our own skin, but you have to know that collagen is a huge-huge molecule that cannot absorb to the middle layer of the skin where collagen is and even if it could, it cannot just magically go the right places to become part of the skin's own collagen network. Putting collagen on your skin for anti-aging purposes is like throwing tent poles onto a ramshackle tent and expecting the tent to magically become nice and firm again.
The strong point of collagen is being a large molecule with tremendous water binding capacity, i.e. an amazing humectant and moisturizer. It produces a water-rich film on the skin giving the stratum corneum (the uppermost layer of the skin) great hydration, making it nice and smooth and reducing trans-epidermal-water loss (the process of water evaporating out of your skin).
It is also so gentle and non-irritant that it can actually be used in cleansers to reduce the irritating potential of harsh surfactants, aka cleansing agents.
If you are fine with animal-derived ingredients and know that collagen in a jar has nothing to do with wrinkles but everything to do with skin hydration, Soluble Collagen is a nice ingredient.
Lactobacillus ferment is an interesting probiotic ingredient with some promising properties.
First, according to a 2009 Estee Lauder patent, it’s a DNA repair enzyme and it can help to protect the skin against environmental aggressors.
Second, still according to Estee Lauder research but now from 2012 the ingredient has anti-microbial and anti-inflammatory properties and holds promise in the treatment of acne and rosacea. For the former one 5% was needed to show effectiveness, but for reducing skin sensitivity already 1% showed results.
The anti-acne effect is confirmed also by US manufacturer, Barnet, that says that Lactobacillus ferment is helpful in killing harmful bacteria and creating a healthy balanced microflora. Compared to well-known anti-acne and anti-inflammatory salicylic acid the probiotic worked faster at reducing the size and redness of acne lesions.
It also goes by the trade name Leucidal Liquid SF and can serve in the formula as a natural preservative.
Bottom line: It’s not the most proven ingredient (yet) but definitely a very promising one especially if you have sensitive skin, acne or rosacea.
- GHK-Cu is a copper-peptide complex found naturally in yucky bodily fluids (plasma, saliva, and urine)
- It has unique wound healing properties by stimulating the breakdown of unhealthy, too large collagen in scar tissue and stimulating nice and healthy collagen production afterwards
- It stimulates the production of several important skin-identical ingredients (e.g. collagen, elastin, and glycosaminoglycans)
- It has significant anti-inflammatory and antioxidant effect
- There are a few promising studies showing GHK-Cu can improve skin elasticity, clarity, firmness and reduce lines and wrinkles
- It can improve hair growth by enlarging hair follicles (and bigger follicles produce longer, thicker hair)
- There are some urban legends about possible overdosing or facial hair problems (read more in geeky details)
If you see a cosmetic product that claims that it has "Botox-like effect" then two things are almost certain: one, the product overpromises and two, it contains Argireline.
So this one is the famous peptide that's marketed by its manufacturer as the "Botox in a jar". The basis for this claim is that it targets the same wrinkle forming mechanism (wrinkles caused by facial muscle movement) as Botox, but the way it works is very different. In addition, the extent to which it can prevent muscles from contracting (and to smooth wrinkles) is very different (otherwise why would anyone use still Botox?).
The manufacturer did several studies to prove that Argireline really works and it does (just not as well as Botox). In-vivo (made on real people) tests showed that using 10% Argireline solution around the eyes for 15 days decreased wrinkles depth by 17%, while a 5% Argireline formula applied for 28 days did almost the same with a decrease in wrinkle depth by 16.26%. A Spanish University also did some research and found that Argireline increased the level of skin moisturization and decreased both the depth and width of wrinkles "significantly".
This means, Acetyl Hexapeptide-8 does have some ability to smooth wrinkles (but not as well as Botox - sorry, if we sound like a broken record). Also, we have to agree with TruthInAging, that it's not a collagen builder and not a preventer of structural aging (think vitamin C, AHAs or retinol); it's just a quick fix. If you are looking for one, this could be your thing. If you are more of a "let's treat this aging thing properly" type, then it's probably not your thing.
A pretty famous and better-researched peptide consisting of five amino acids (the building blocks of all proteins). It was created in a joint effort by the French ingredient supplier, Sederma and the cosmetics industry big shot, Procter&Gamble.
The amino acid sequence of the peptide is lysine–threonine–threonine–lysine–serine (KTTKS). Sometimes, it's also called collagen pentapeptide, as it's a subfragment of skin-structure-giving type I collagen. The KTTKS amino sequence is then attached for better oil solubility and skin penetration to palmitic acid and BOOM; we get Palmitoyl Pentapeptide-4.
Though most research is manufacturer sponsored, the clinical studies about Palmitoyl Pentapeptide-4 are promising. In short, it can reduce fine lines, wrinkles and improve skin texture significantly (and at crazy low concentrations, the studies were done with just 3 ppm that is 0.0003%).
There are also studies comparing Palmitoyl Pentapeptide-4 with anti-aging gold standard, retinol. One of them compared 3ppm Pal-KTTKS with 700 ppm (0.07%) retinol and found that they showed similar wrinkle improving ability with the peptide showing better skin tolerability.
Bottom line, if you are into peptides, this is a good one to try.
A four amino acid peptide with the amino sequence of glycine-glutamine-proline-arginine. It is attached to palmitic acid (a fatty acid) to increase oil solubility and skin penetration.
It works by reducing the production of the signal molecule, interleukin-6 (IL-6) which promotes inflammation in the skin and less inflammation means slower degradation of important things (like collagen) that results in younger looking skin for a longer time.
It works in synergy with its pal, Palmitoyl Tripeptide-1 in the famous Matrixyl 3000 complex. You can read some more about the famous duo here.
A really famous peptide that is part of Matrixyl 3000, the most sold peptide complex in the word. Before we go and find out what the big deal with Matrixyl 3000 is, let's just focus on Palmitoyl Tripeptide-1 itself for a bit.
It's a small three amino acid (they are the building blocks of all proteins) peptide with the amino sequence of glycine-histidine-lysine, or GHK. GHK is attached to palmitic acid (a fatty acid) to increase oil solubility and skin penetration.
The GHK part is the important one as it's a type I collagen fragment. When collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen. Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more.
Therefore, Palmitoyl Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin.
In Matrixyl 3000, Palmitoyl Tripeptide-1 is coupled with Palmitoyl Tetrapeptide-7 and the duo works in synergy to reduce wrinkles and give younger looking skin. According to the manufacturer's in-vivo (made on real people) test, applying 3% Matrixyl 3000 twice a day for 2 months resulted in all of the following things:
- 39.4% reduction in surface occupied by deep wrinkles
- 32.9% reduction in main wrinkle density
- 19.9% reduction in main wrinkle average depth
- 16% improvement in roughness
- 16.2% in lifting effect
- 5.5% improvement in elasticity
- 15.5% improvement in skin tone
Manufacturer results, of course, always have to be taken with a pinch of salt, but if you like peptides, the Matryxil 3000 duo is one of the best-proven and most well-known ones and it's something that is worth trying.
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| what‑it‑does | solvent |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 1 |
| what‑it‑does | emollient |
| what‑it‑does | emollient | perfuming | solvent |
| what‑it‑does | cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant |
| what‑it‑does | soothing | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | emulsifying |
| what‑it‑does | emollient |
| irritancy, com. | 0, 0-2 |
| what‑it‑does | viscosity controlling |
| what‑it‑does | emulsifying |
| what‑it‑does | viscosity controlling |
| what‑it‑does | emulsifying |
| what‑it‑does | viscosity controlling |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | solvent |
| what‑it‑does | antioxidant | preservative |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | viscosity controlling |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | emollient |
| what‑it‑does | preservative |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | viscosity controlling |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | antioxidant | soothing |
| what‑it‑does | chelating |
| what‑it‑does | emollient | emulsifying |
| what‑it‑does | emulsifying | surfactant/cleansing |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | antimicrobial/antibacterial | perfuming |
| what‑it‑does | soothing | anti-acne | antioxidant | antimicrobial/antibacterial | perfuming |
| what‑it‑does | perfuming | antimicrobial/antibacterial |
| what‑it‑does | abrasive/scrub |
| what‑it‑does | perfuming |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | surfactant/cleansing | emulsifying |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | soothing | preservative |
| what‑it‑does | cell-communicating ingredient | soothing | antioxidant |
| what‑it‑does | cell-communicating ingredient | moisturizer/humectant |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | cell-communicating ingredient |