Lactyferrin Sebum Facial Gel
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Sesderma Lactyferrin Sebum Facial GelIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
Propanediol is a natural alternative for the often used and often bad-mouthed propylene glycol. It's produced sustainably from corn sugar and it's Ecocert approved.
It's quite a multi-tasker: can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula.
A so-called polymer microsphere, i.e. little spherical shaped particles from repeated subunits. Similar to other microsphere powders, it can scatter the light to give products a soft focus or blurring effect. It also works as a texture enhancer giving formulas an exceptional smoothness and a velvet touch.
Bis-PEG-18 Methyl Ether Dimethyl Silane is a silicone that is water dispersible (as opposed to most other silicones that are usually oil dispersible). It makes the skin smooth and nice (emollient), moisturizes, helps to reduce tackiness, and also has some foam boosting properties. It is often used in light, watery formulas to give them an extra silky feel.
A very common ingredient that can be found in all cell membranes. In cosmetics it's quite the multi-tasker: it's an emollient and water-binding ingredient but it's also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes.
Simply alcohol refers to ethanol and it's a pretty controversial ingredient. It has many instant benefits: it's a great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent and antimicrobial. No wonder it's popular in toners and oily skin formulas.
The downside is that it can be very drying if it's in the first few ingredients on an ingredient list.
Some experts even think that regular exposure to alcohol damages skin barrier and causes inflammation though it's a debated opinion. If you wanna know more, we wrote a more detailed explanation about what's the deal with alcohol in skincare products at alcohol denat. (it's also alcohol, but with some additives to make sure no one drinks it).
It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic.
Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10).
It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.
A type of sugar molecule, that has water-binding properties and helps to keep your skin hydrated.
A nice little helper ingredient that can thicken up cosmetic products and create beautiful gel formulas. It's derived from cellulose, the major component of the cell wall of green plants. It is compatible with most co-ingredients and gives a very good slip to the formulas.
A kind of polymer (big molecule from repeated subunits) that helps to create beautiful gel-like textures. It's also a texturizer and thickener for oil-in-water emulsions. It gives products a good skin feel and does not make the formula tacky or sticky.
It works over a wide pH range and is used between 0.5-1.2%.
A form of skincare superstar, vitamin C. Even though we are massive vitamin C fans, Ascorbyl Palmitate (AP) is our least favorite. (Btw, if you do not know what the big deal with vitamin C is then you are missing out. You must go and read our geeky details about it.)
So, AP is one of the attempts by the cosmetics industry to solve the stability issues with vitamin C while preserving its benefits, but it seems to fall short on several things.
What's the problem?
Firstly, it's stability is only similar to that of pure ascorbic acid (AA), which means it is not really stable. A great study in the Journal of Cosmetic Dermatology compared a bunch of vitamin C derivatives and this derivative was the only one where the study said in terms of stability that it's "similar to AA". Not really that good.
Second, a study that examined the skin absorption of vitamin C found that ascorbyl palmitate did not increase the skin levels of AA. This does not mean that ascorbyl palmitate cannot penetrate the skin (because it can, it's oil soluble and the skin likes to absorb oil soluble things) but this means that it's questionable if ascorbyl palmitate can be converted into pure Vit C in the skin. Even if it can be converted, the palmitate part of the molecule is more than the half of it, so the efficacy will not be good and we have never seen a serum that contains a decent (and proudly disclosed) amount of AP. We are highly skeptical what effect a tiny amount of AP has in a formula.
Third, another study that wanted to examine the antioxidant properties of AP was surprised to find that even though AP does have nice antioxidant properties; following UVB radiation (the same one that comes from the sun) it also promotes lipid peroxidation and cytotoxicity. It was only an in-vitro study meaning that it was done on cell cultures and not on real people, but still, this also does not support the use of AP too much.
The only good thing we can write about Ascorbyl Palmitate is that there is an in-vitro (made in the lab, not on real people) study showing that it might be able to boost collagen production.
Regarding the skin-brightening properties of pure vitamin C, this is another magic property AP does not have, or at least there is no data, not even in-vitro, about it.
Overall, Ascorbyl Palmitate is our least favorite vitamin C derivative. It is there in lots of products in tiny amounts (honestly, we do not really understand why), however, we do not know about any vitamin C serum featuring AP in high amounts. That is probably no coincidence. If you are into vitamin C, you can take a look at more promising derivatives here.
At first glance, you could think that Bakuchiol is your average plant extract. It is derived from the seeds of Psoralea Corylifolia, aka Babchi, a plant important in Indian and Chinese medicine. The molecule was first isolated in 1973 and several anti-something properties are known about it: it has anti-inflammatory, antioxidant, anti-tumor, anti-bacterial and hepatoprotective magical abilities like plenty of other Ayurvedic plant extracts.
What makes Bakuchiol a special snowflake is the recent discovery that it behaves on the skin in a way very similar to well-known skincare superstar, retinol. While chemically, it has nothing to do with the vitamin-A family, aka retinoids, comparative gene expression profiling (a fancy way of saying that they compared how retinol and bakuchiol modify the way skin cells behave and produce important skin proteins such as collagen) shows that retinol and bakuchiol regulate skin cell behavior in a similar way.
To be more specific, both Bakuchiol and retinol upregulate collagen I, III and IV production and downregulate MMP, the evil collagen attacking enzyme in our skin. This means more collagen stays in our skin and we all know that more collagen equals firmer, more wrinkle-free skin. A 12-week clinical study using a 0.5% Bakuchiol formula with 17 people using it twice a day confirmed a significant improvement in lines and wrinkles, elasticity, firmness and an overall reduction in photo-damage. Also, the test formula was very well tolerated, without any retinol-like side effects.
What's more, a 2018 double-blind study with 44 people compared 0.5% Bakuchiol with 0.5% retinol cream and found that "bakuchiol is comparable to retinol in its ability to improve photoaging and is better tolerated than retinol". A super promising result after 12 weeks.
If you are not a daredevil-type who doesn't want to stop using a super well-proven retinol for a newbie like Bakuchiol, we have good news. The two also work very nicely together and Bakuchiol can actually help to stabilize the otherwise unstable and hard to formulate retinol.
And we are still not done, as Bakuchiol shows not only anti-aging properties but also nice anti-acne effects. 1% Bakuchiol seems to be very effective in itself (57% reduction in acne after 6 weeks treatment) and even better when combined with 2% salicylic acid (67% reduction in acne after 6 weeks). We like that Bakuchiol is such a good team player! The molecule works against acne in multiple ways: It downregulates 5α-reductase (a sebum-controlling enzyme), it is antibacterial (including P. acnes), anti-inflammatory and it inhibits lipid-peroxidation, an evil oxidative process that is recently thought to be a very early trigger in the acne process.
We feel that this description is becoming very long so we will just mention that Bakuchiol also seems to positively regulate hydration-related genes such as Aquaporin 3 and also shows some melanin-inhibiting properties.
Overall, we think Bakuchiol is an awesome molecule with lots of promise both for anti-aging and anti-acne. But the proof compared to the well-established superstars is far from solid, so in a skincare routine, we would rather add Bakuchiol next to retinol than straight up replace it. Unless you are a gimme-the-newest-shiny-thing-under-the-sun-type.
We don't have description for this ingredient yet.
Citric acid comes from citrus fruits and is an AHA. If these magic three letters don’t tell you anything, click here and read our detailed description on glycolic acid, the most famous AHA.
So citric acid is an exfoliant, that can - just like other AHAs - gently lift off the dead skin cells of your skin and make it more smooth and fresh.
There is also some research showing that citric acid with regular use (think three months and 20% concentration) can help sun-damaged skin, increase skin thickness and some nice hydrating things called glycosaminoglycans in the skin.
But according to a comparative study done in 1995, citric acid has less skin improving magic properties than glycolic or lactic acid. Probably that’s why citric acid is usually not used as an exfoliant but more as a helper ingredient in small amounts to adjust the pH of a formulation.
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.
It is typically used in tiny amounts, around 0.1% or less.
If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.
Also, it's an effective deodorant and a medium spreading emollient.
We don't have description for this ingredient yet.
The attachment of glycerin and oleic acid that works mainly as a co-emulsifier and stabilizer to create stable water-oil mixes, aka emulsions. It is also popular in cleansing products as it helps to thicken them up and has some refatting and skin-smoothing effect.
A super common, waxy, white, solid stuff that helps water and oil to mix together, gives body to creams and leaves the skin feeling soft and smooth.
Chemically speaking, it is the attachment of a glycerin molecule to the fatty acid called stearic acid. It can be produced from most vegetable oils (in oils three fatty acid molecules are attached to glycerin instead of just one like here) in a pretty simple, "green" process that is similar to soap making. It's readily biodegradable.
It also occurs naturally in our body and is used as a food additive. As cosmetic chemist Colins writes it, "its safety really is beyond any doubt".
- It’s the most researched AHA with the most proven skin benefits
- It gently lifts off dead skin cells to reveal newer, fresher, smoother skin
- It can help skin’s own collagen production that results in firmer, younger skin
- It can fade brown spots caused by sun damage or PIH
- Choose a product where you know the concentration and pH value because these two greatly influence effectiveness
- Don’t forget to use your sunscreen (in any case but especially so next to an AHA product)
- Slight stinging or burning with a stronger AHA product is normal
- If your skin is very sensitive, rosacea prone choose rather a BHA or PHA product
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
The oil coming from the plant Linum Usitatissimum or commonly called Flax. If you are into healthy eating, you probably know flaxseeds as a rich source of hard-to-eat-enough omega-3 fatty acids, or if you are into fashion, you probably have some light summer cloth made from linen.
As for skincare, flaxseed oil is one of the few natural plant oils that is a rich source (35-65%) of moisturizing and probably anti-inflammatory ω-3 fatty acid, aka linolenic acid. It also contains skin-nourishing oleic acid (11-35%) and barrier repairing linoleic acid (11-24%).
According to manufacturer claims, it is used as an emollient, anti-inflammatory and healing agent and it is well-known to create smooth and soft skin.
- Mandelic acid is an AHA that comes from bitter almond
- It can gently lift off dead surface skin cells and make the skin more smooth and even
- It has antibacterial properties
- It’s promising against acne and post inflammatory hyperpigmentation
- It’s light sensitive, so choose a product with opaque packaging
Exactly what it sounds: nice smelling stuff put into cosmetic products so that the end product also smells nice. Fragrance in the US and parfum in the EU is a generic term on the ingredient list that is made up of 30 to 50 chemicals on average (but it can have as much as 200 components!).
If you are someone who likes to know what you put on your face then fragrance is not your best friend - there's no way to know what’s really in it.
Also, if your skin is sensitive, fragrance is again not your best friend. It’s the number one cause of contact allergy to cosmetics. It’s definitely a smart thing to avoid with sensitive skin (and fragrance of any type - natural is just as allergic as synthetic, if not worse!).
A mildly viscous, amber-colored liquid with fatty odor, made from Castor Oil and polyethylene glycol (PEG).
If it were a person, we’d say, it’s agile, diligent & multifunctional. It’s mostly used as an emulsifier and surfactant but most often it is used to solubilize fragrances into water-based formulas.
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula.
It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. It’s not a strong one and doesn’t really work against bacteria, but more against mold and yeast. To do that it has to break down to its active form, sorbic acid. For that to happen, there has to be water in the product and the right pH value (pH 3-4).
But even if everything is right, it’s not enough on its own. If you see potassium sorbate you should see some other preservative next to it too.
BTW, it’s also a food preservative and even has an E number, E202.
If you are reading here, we are pretty sure the words retinoids and retinol ring a bell, but if not, you are seriously missing out, please click here immediately to catch up. The TL;DR version is that retinoids are the royal family of skincare with tretinoin being the king, the only FDA-approved ingredient to treat the signs of photoaging. Retinol is like a grandkid, it has to be converted (through two steps) in the skin to become retinoic acid. The conversion means retinol is both less effective and less harsh on the skin.
So where does our current molecule, Retinal, aka Retinaldehyde fit into the family (btw, here is a nice visual family tree about who is who)? Remember that retinol needed two conversion steps to become retinoic acid? Yes, you are right, Retinal is the intermediate step between retinoic acid and retinol, meaning it needs only one conversion step to become active in the skin. If we go with our royal family analogy, Retinal is Prince William, directly next in line to the throne.
Once retinal is converted, it becomes retinoic acid and does the same things we detailed in our tretinoin description. In a nutshell, it is everything you expect from an anti-aging superstar such as decreased wrinkles, smoother, firmer and more elastic skin.
This sounds good, but how does Retinal compare to retinoic acid? Good question! We found a study (a pretty good one with 125 patients) that compared 0.05% retinal with 0.05% retinoic acid (and vehicle). They concluded that "at week 18, a significant reduction of the wrinkle and roughness features was observed with both retinaldehyde and retinoic acid." and the difference between the two was not statistically significant. (Interestingly, in both groups, the results were less significant at week 44, so it might be a good idea to have a retinoid break from time to time?) Also, our guy, Retinal was much better tolerated than retinoic acid known for its harshness.
The good tolerability of retinal was also confirmed by another study that compared retinol (ROL), retinal (RAL) and retinoic acid (RA). They found that "the natural retinoids ROL and RAL do have a good tolerance profile, in contrast with the irritating potential of RA", meaning retinal is an awesome alternative if you have irritation and flaking issues with prescription products, such as Retin-A.
Last, but not least, we want to mention a pretty big (but subjectively evaluated), Avene (the French pharmacy brand famous for its Retinal products) sponsored study that examined the tolerability and efficacy of a 0.1 Retinal + 6% glycolic acid product in the treatment of acne. The product was added next to the standard anti-acne regimen of 1,709 patients for 90 days and the study concluded that the formula was both very well tolerated as well as effective next to other standard anti-acne medications such as benzoyl peroxide and antibiotics.
Overall, if you are into retinoids, Retinal is a really awesome and well-proven member of the family that is absolutely worth trying.
Sodium chloride is the fancy name of salt. Normal, everyday table salt.
If (similar to us) you are in the weird habit of reading the label on your shower gel while taking a shower, you might have noticed that sodium chloride is almost always on the ingredient list. The reason for this is that salt acts as a fantastic thickener in cleansing formulas created with ionic cleansing agents (aka surfactants) such as Sodium Laureth Sulfate. A couple of percents (typically 1-3%) turns a runny surfactant solution into a nice gel texture.
If you are into chemistry (if not, we understand, just skip this paragraph), the reason is that electrolytes (you know, the Na+ and Cl- ions) screen the electrostatic repulsion between the head groups of ionic surfactants and thus support the formation of long shaped micelles (instead of spherical ones) that entangle like spaghetti, and viola, a gel is formed. However, too much of it causes the phenomenon called "salting out", and the surfactant solution goes runny again.
Other than that, salt also works as an emulsion stabilizer in water-in-oil emulsions, that is when water droplets are dispersed in the outer oil (or silicone) phase. And last but not least, when salt is right at the first spot of the ingredient list (and is not dissolved), the product is usually a body scrub where salt is the physical exfoliating agent.
We don't have description for this ingredient yet.
The unfancy name for it is lye. It’s a solid white stuff that’s very alkaline and used in small amounts to adjust the pH of the product and make it just right.
For example, in case of AHA or BHA exfoliants, the right pH is super-duper important, and pH adjusters like sodium hydroxide are needed.
BTW, lye is not something new. It was already used by ancient Egyptians to help oil and fat magically turn into something else. Can you guess what? Yes, it’s soap. It still often shows up in the ingredient list of soaps and other cleansers.
Sodium hydroxide in itself is a potent skin irritant, but once it's reacted (as it is usually in skin care products, like exfoliants) it is totally harmless.
A standardized powdered extract from the roots of the Curcuma longa (Turmeric) plant (together with this and this). The trio is called Tetrahydrocurcuminoids (THC) and has skin-brightening, anti-inflammatory and antioxidant magic properties.
Other turmeric extracts have brilliant yellow color that makes them difficult to use but this one is color-free.
Titanium Dioxide is one of the two members of the elite sunscreen group called physical sunscreens (or inorganic sunscreens if you’re a science geek and want to be precise).
Traditionally, UV-filters are categorized as either chemical or physical. The big difference is supposed to be that chemical agents absorb UV-light while physical agents reflect it like a bunch of mini umbrellas on top of the skin. While this categorization is easy and logical it turns out it's not true. A recent, 2016 study shows that inorganic sunscreens work mostly by absorption, just like chemical filters, and only a little bit by reflection (they do reflect the light in the visible spectrum, but mostly absorb in the UV spectrum).
Anyway, it doesn't matter if it reflects or absorbs, Titanium Dioxide is a pretty awesome sunscreen agent for two main reasons: it gives a nice broad spectrum coverage and it's highly stable. Its protection is very good between 290 - 350 nm (UVB and UVA II range), and less good at 350-400 nm (UVA I) range. Regular sized Titanium Dioxide also has a great safety profile, it's non-irritating and is pretty much free from any health concerns (like estrogenic effect worries with some chemical filters).
The disadvantage of Titanium Dioxide is that it's not cosmetically elegant, meaning it's a white, "unspreadable" mess. Sunscreens containing Titanium Dioxide are often hard to spread on the skin and they leave a disturbing whitish tint. The cosmetic industry is, of course, really trying to solve this problem and the best solution so far is using nanoparticles. The itsy-bitsy Nano-sized particles improve both spreadability and reduce the whitish tint a lot, but unfortunately, it also introduces new health concerns.
The main concern with nanoparticles is that they are so tiny that they are absorbed into the skin more than we want them (ideally sunscreen should remain on the surface of the skin). Once absorbed they might form unwanted complexes with proteins and they might promote the formation of evil free radicals. But do not panic, these are concerns under investigation. A 2009 review article about the safety of nanoparticles summarizes this, "to date, in-vivo and in-vitro studies have not demonstrated percutaneous penetration of nanosized particles in titanium dioxide and zinc oxide sunscreens". The English translation is, so far it looks like sunscreens with nanoparticles do stay on the surface of the skin where they should be.
All in all, Titanium Dioxide is a famous sunscreen agent and for good reason, it gives broad spectrum UV protection (best at UVB and UVA II), it's highly stable, and it has a good safety profile. It's definitely one of the best UV-filter agents we have today, especially in the US where new-generation Tinosorb filters are not (yet) approved.
- Primary fat-soluble antioxidant in our skin
- Significant photoprotection against UVB rays
- Vit C + Vit E work in synergy and provide great photoprotection
- Has emollient properties
- Easy to formulate, stable and relatively inexpensive
It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version.
According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E.
It’s a little helper ingredient that helps to set the pH of a cosmetic formulation to be just right. It’s very alkaline (you know the opposite of being very acidic): a 1% solution has a pH of around 10.
It does not have the very best safety reputation but in general, you do not have to worry about it.
What is true is that if a product contains so-called N-nitrogenating agents (e.g.: preservatives like 2-Bromo-2-Nitropropane-1,3-Diol, 5-Bromo-5-Nitro- 1,3-Dioxane or sodium nitrate - so look out for things with nitro, nitra in the name) that together with TEA can form some not nice carcinogenic stuff (that is called nitrosamines). But with proper formulation that does not happen, TEA in itself is not a bad guy.
But let’s assume a bad combination of ingredients were used and the nitrosamines formed. :( Even in that case you are probably fine because as far as we know it cannot penetrate the skin.
But to be on the safe side, if you see Triethanolamine in an INCI and also something with nitra, nitro in the name of it just skip the product, that cannot hurt.
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| what‑it‑does | solvent |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | solvent | moisturizer/humectant |
| what‑it‑does | emollient | moisturizer/humectant | surfactant/cleansing |
| what‑it‑does | emollient | emulsifying |
| what‑it‑does | antimicrobial/antibacterial | solvent | viscosity controlling |
| what‑it‑does | preservative |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | viscosity controlling |
| what‑it‑does | viscosity controlling |
| what‑it‑does | antioxidant |
| irritancy, com. | 0, 2 |
| what‑it‑does | cell-communicating ingredient | antioxidant | antimicrobial/antibacterial |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | buffering |
| what‑it‑does | chelating |
| what‑it‑does | emollient |
| what‑it‑does | preservative |
| what‑it‑does | emollient | emulsifying | perfuming |
| what‑it‑does | emollient | emulsifying |
| irritancy, com. | 0, 1-2 |
| what‑it‑does | exfoliant | buffering |
| what‑it‑does | emollient |
| irritancy, com. | 2, 3 |
| what‑it‑does | emollient | perfuming |
| what‑it‑does | exfoliant | antimicrobial/antibacterial |
| what‑it‑does | perfuming |
| what‑it‑does | emulsifying | surfactant/cleansing |
| what‑it‑does | emulsifying | surfactant/cleansing |
| irritancy, com. | 0, 0 |
| what‑it‑does | preservative |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | viscosity controlling |
| what‑it‑does | buffering |
| what‑it‑does | antioxidant | skin brightening | soothing |
| what‑it‑does | sunscreen | colorant |
| what‑it‑does | antioxidant |
| irritancy, com. | 0-3, 0-3 |
| what‑it‑does | antioxidant |
| irritancy, com. | 0, 0 |
| what‑it‑does | buffering |
| irritancy, com. | 0, 2 |
| what‑it‑does | soothing |