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Also-called-like-this: Sytenol A, Phyto Retinol


At first glance, you could think that Bakuchiol is your average plant extract. It is derived from the seeds of Psoralea Corylifolia, aka Babchi, a plant important in Indian and Chinese medicine. The molecule was first isolated in 1973 and several anti-something properties are known about it: it has anti-inflammatory, antioxidant, anti-tumor, anti-bacterial and hepatoprotective magical abilities like plenty of other Ayurvedic plant extracts.

What makes Bakuchiol a special snowflake is the recent discovery that it behaves on the skin in a way very similar to well-known skincare superstar, retinol. While chemically, it has nothing to do with the vitamin-A family, aka retinoids, comparative gene expression profiling (a fancy way of saying that they compared how retinol and bakuchiol modify the way  skin cells behave and produce important skin proteins such as collagen) shows that retinol and bakuchiol regulate skin cell behavior in a similar way. 

To be more specific, both Bakuchiol and retinol upregulate collagen I, III and IV production and downregulate MMP, the evil collagen attacking enzyme in our skin. This means more collagen stays in our skin and we all know that more collagen equals firmer, more wrinkle-free skin.  A 12-week clinical study using a 0.5% Bakuchiol formula with 17 people using it twice a day confirmed a significant improvement in lines and wrinkles, elasticity, firmness and an overall reduction in photo-damage. Also, the test formula was very well tolerated, without any retinol-like side effects. 

What's more, a 2018 double-blind study with 44 people compared 0.5% Bakuchiol with 0.5% retinol cream and found that "bakuchiol is comparable to retinol in its ability to improve photoaging and is better tolerated than retinol". A super promising result after 12 weeks. 

If you are not a daredevil-type who doesn't want to stop using a super well-proven retinol for a newbie like Bakuchiol, we have good news. The two also work very nicely together and Bakuchiol can actually help to stabilize the otherwise unstable and hard to formulate retinol.

And we are still not done, as Bakuchiol shows not only anti-aging properties but also nice anti-acne effects. 1% Bakuchiol seems to be very effective in itself (57% reduction in acne after 6 weeks treatment) and even better when combined with 2% salicylic acid (67% reduction in acne after 6 weeks). We like that Bakuchiol is such a good team player!  The molecule works against acne in multiple ways: It downregulates 5α-reductase (a sebum-controlling enzyme), it is antibacterial (including P. acnes), anti-inflammatory and it inhibits lipid-peroxidation, an evil oxidative process that is recently thought to be a very early trigger in the acne process. 

We feel that this description is becoming very long so we will just mention that Bakuchiol also seems to positively regulate hydration-related genes such as Aquaporin 3 and also shows some melanin-inhibiting properties

Overall, we think Bakuchiol is an awesome molecule with lots of promise both for anti-aging and anti-acne. But the proof compared to the well-established superstars is far from solid, so in a skincare routine, we would rather add Bakuchiol next to retinol than straight up replace it. Unless you are a gimme-the-newest-shiny-thing-under-the-sun-type. 

Show me some proof

  • Chaudhuri, R. K., and K. Bojanowski. "Bakuchiol: a retinol‐like functional compound revealed by gene expression profiling and clinically proven to have anti‐aging effects." International journal of cosmetic science 36.3 (2014): 221-230.
  • Chaudhuri, Ratan K. "Bakuchiol: A Retinol-Like Functional Compound, Modulating Multiple Retinol and Non-Retinol Targets." Cosmeceuticals and Active Cosmetics, 3rd edn, Francis & Taylor, Boca Raton (2015): 1-18.
  • Chaudhuri, Ratan K., and Francois Marchio. "Bakuchiol in the management of acne-affected skin." Cosmetics and Toiletries 126.7 (2011): 502.
  • Ratan K. Chaudhuri, PhD, Sytheon Ltd., "Bakuchiol to Stabilize Retinol and Polyunsaturated Lipids", Cosmetics and Toiletries (2015)
  • Dhaliwal, S., et al. "Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoaging." British Journal of Dermatology (2018).

Products with a known amount of Bakuchiol

Other products with Bakuchiol

Ayele & Co. Deep Gellie Ointment Bade Natural Alternatif Retinol Serum Makeup Artist's Choice Bakuchiol Oil Qurez Bakuchiol - Revitalizing Facial Oil With Hempseed, Vetiver And Turmeric ACF by dadatina Vol. 3 Renovación Adorn Borage & Bakuchiol Natural Retinol Facial Oil Aizen Bakuchiol 10% Ultra Ampoule Aromazone Sérum Bakuchiol (anti-âge) Aromazone Sérum Visage Concentré Bakuchiol - Serum Base Bakuchiol Botanicals Bakuchiol Face Serum Bloomka Bakuchiol + Almond Anti-Aging Facial Oil Bloomka Bakuchiol + Grapeseed Facial Oil Bybi Bakuchoil Booster Bybi Booster Serum Dear Me Beauty 1% Bakuchiol + Blueberry Extract Face Serum Dr. Sheth Rosehip & Retinoid Power Emulsion ElsheSkin Bakuchiol Revitalizing Serum Evershine Pure Bakuchiol 2% Blemish & Age Define Serum Garden of Wisdom Super Bakuchiol Serum Glow.Inc Potion Forever+ Pro Youth Essence Toner Handmade Heroes The Ultimate Bakuchiol Booster Oil Kri Skincare Bakuchiol Antioxidant Oil Made by Sunday Got It Like That McLellan Night Elixir - Anti Aging Oil Melaleuca Sei Bella Advanced Microbiome Overnight Peptide Boost ORGANIC THE NEW BEAUTY 2% Bakuchiol Serum Organic makers Bakuichol Purivera Labs Blue Grapeseed Oil Purivera Labs Everlasting Tamanu Oil Purivera Labs Sea Ceramide Serum SKIN ALPHABET .3% Retinol And 1,2% Bakuchiol Serum THE CLINICAL BEAUTY Retinol And Bakuchiol Lecithin-In-Oil-Serum joi Bakuchiol Skin Booster the bath box Bloomka Bakuchiol + Tamanu Spot Oil Afrodita Bakuchiol Phyto Retinol Shot 2% Azarine Miracle Oil Serum Bloomka Bakuchiol + Vitamin B3 Facial Treatment Serum Daymellow Galactomy Bakuchiol Serum Dr. Zenovia Skincare 10% Benzoyl Peroxide Acne Cleanser FYI A.c.e Serum Fitglow Vita Youth Oil Good Molecules Bakuchiol Oil Blend For Dry Skin Good Molecules Bakuchiol Oil Blend For Oily Skin Medik8 Bakuchiol Peptides Natrèceutique Bakuchiol Building Blocks Pacifica Future Youth Crystal Ball Serum Purivera Labs Almond Sea Buckthorn Oil SAUVE Age Control System SUIT Matters Bakuchiol Thisworks My Wrinkles Cbd Booster + Bakuchiol