Follow us on our new Insta page »
Sanitas Peptiderm Firming Serum

Peptiderm Firming Serum

A fast-acting treatment serum that contains a multiplex of peptides to help firm skin and increase elasticity. A collagen cofactor complex helps reinforce the skin’s defense against environmental aggressors and helps reduce the appearance of fine lines and wrinkles.
Uploaded by: ojenny367 on

Skim through

Ingredient name what-it-does irr., com. ID-Rating
Water/Aqua/Eau solvent
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar
Polysorbate 80 emulsifying, surfactant/​cleansing 0, 0
Palmitoyl Tripeptide-5 cell-communicating ingredient goodie
Pentapeptide-18 cell-communicating ingredient goodie
Palmitoyl Tetrapeptide-7 cell-communicating ingredient goodie
Palmitoyl Tripeptide-1 cell-communicating ingredient goodie
Dipeptide-2 cell-communicating ingredient goodie
Acetyl Hexapeptide-8 cell-communicating ingredient, moisturizer/​humectant goodie
Acetyl Octapeptide-3 cell-communicating ingredient, moisturizer/​humectant goodie
Phospholipids skin-identical ingredient, emollient goodie
Bambusa Vulgaris Leaf/Stem Extract moisturizer/​humectant
Pisum Sativum (Pea) Extract
Carrageenan viscosity controlling
Hesperidin Methyl Chalcone antioxidant goodie
Beta-Glucan soothing, moisturizer/​humectant goodie
Glucosamine Hcl
Butylene Glycol moisturizer/​humectant, solvent, viscosity controlling 0, 1
Carbomer viscosity controlling 0, 1
Alcohol antimicrobial/​antibacterial, solvent, viscosity controlling icky
Steareth-20 emulsifying, surfactant/​cleansing 1, 2
Polysorbate 20 emulsifying, surfactant/​cleansing 0, 0
Xanthan Gum viscosity controlling
Glucose moisturizer/​humectant goodie
Hydroxypropyl Guar Hydroxypropyltrimonium Chloride
PEG-8/Smdi Copolymer
Phenoxyethanol preservative
Caprylyl Glycol moisturizer/​humectant, emollient
Ethylhexylglycerin preservative
Hexylene Glycol solvent, emulsifying, perfuming, surfactant/​cleansing 0-1, 0-2

Sanitas Peptiderm Firming Serum
Ingredients explained

Also-called: Aqua;Water | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 0 | Comedogenicity: 0

A common little helper ingredient that helps water and oil to mix together, aka emulsifier. 

The number at the end refers to the oil-loving part and the bigger the number  the more emulsifying power it has. 20 is a weak emulsifier, rather called solubilizer used commonly in toners while 60 and 80 are more common in serums and creams.

Also-called: Syn-Coll | What-it-does: cell-communicating ingredient

A tripeptide (three amino acids attached to each other: Lys-Val-Lys) that's claimed to protect and boost collagen and improve skin texture.

The manufacturer did an in-vivo (made on real people) study with 45 volunteers and found that used twice daily for 84 days 1% and 2.5% Syn-Coll reduces the appearance of wrinkles by 7 and 12% respectively. In another study (also by the manufacturer) with 33 female Chinese volunteers, 77% of the participants felt that Syn-Coll visibly improved the firmness and elasticity of the skin after 4 weeks. What's more, 60% of the participants also noticed a reduction in the look of the pore size also after 4 weeks of treatment. 

Also-called: Leuphasyl | What-it-does: cell-communicating ingredient

A five amino-acid peptide that is claimed to target expression wrinkles that appear due to facial movements. Its effect is similar to the older and more famous Argireline peptide. They achieve similar results but in a different way. 

The two together work in a synergistic way (the solution is trade named Argirelox) hindering the muscle contraction process in two different stages. The in-vivo (made on real people) test by the manufacturer showed that after 28 days 5% Leuphasyl alone reduced wrinkles by 11% and 5% Leuphasyl + 5% Argireline reduced wrinkles on average by 25% with max values up to 47%. 

Also-called: Part of Matrixyl 3000, Pal-GQPR, Previously Palmitoyl Tetrapeptide-3 | What-it-does: cell-communicating ingredient

A four amino acid peptide with the amino sequence of glycine-glutamine-proline-arginine. It is attached to palmitic acid (a fatty acid)  to increase oil solubility and skin penetration. 

It works by reducing the production of the signal moleculeinterleukin-6 (IL-6) which promotes inflammation in the skin and less inflammation means slower degradation of important things (like collagen) that results in younger looking skin for a longer time. 

It works in synergy with its pal, Palmitoyl Tripeptide-1 in the famous Matrixyl 3000 complex. You can read some more about the famous duo here.

Also-called: Part of Matrixyl 3000, Pal-GHK, Formerly also Palmitoyl Oligopeptide | What-it-does: cell-communicating ingredient

A really famous peptide that is part of Matrixyl 3000, the most sold peptide complex in the word. Before we go and find out what the big deal with Matrixyl 3000 is, let's just focus on Palmitoyl Tripeptide-1 itself for a bit.

It's a small three amino acid (they are the building blocks of all proteins) peptide with the amino sequence of glycine-histidine-lysine, or GHK. GHK is attached to palmitic acid (a fatty acid) to increase oil solubility and skin penetration. 

The GHK part is the important one as it's a type I collagen fragment. When collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen. Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more.

Therefore, Palmitoyl Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. 

In Matrixyl 3000, Palmitoyl Tripeptide-1 is coupled with Palmitoyl Tetrapeptide-7  and the duo works in synergy to reduce wrinkles and give younger looking skin. According to the manufacturer's in-vivo (made on real people) test, applying 3% Matrixyl 3000 twice a day for 2 months resulted in all of the following things:

  • 39.4% reduction in surface occupied by deep wrinkles
  • 32.9% reduction in main wrinkle density
  • 19.9% reduction in main wrinkle average depth
  • 16% improvement in roughness
  • 16.2% in lifting effect
  • 5.5% improvement in elasticity
  • 15.5% improvement in skin tone

Manufacturer results, of course, always have to be taken with a pinch of salt, but if you like peptides, the Matryxil 3000 duo is one of the best-proven and most well-known ones and it's something that is worth trying.

Dipeptide-2 - goodie
Also-called: Part of Eyeliss | What-it-does: cell-communicating ingredient

A tiny peptide with only two amino acids (amino acids are the building block of proteins, and peptides are a few amino acids attached together), Valine and Tryptophan. It's part of a 3 actives complex called Eyeliss (with HMC and Palmitoyl Tetrapeptide-7) that's supposed to fight under-eye bags

The manufacturer claims that this dipeptide in Eyeliss can increase lymphatic circulation and the three actives together represent a "global approach to treating puffy eyes". The clinical study of the manufacturer with 20 people and 3% Eyeliss showed improvement after 56 days for 70% of the participants.

Also-called: Argireline, Acetyl Hexapeptide-3 | What-it-does: cell-communicating ingredient, moisturizer/humectant

If you see a cosmetic product that claims that it has "Botox-like effect" then two things are almost certain: one, the product overpromises and two, it contains Argireline. 

So this one is the famous peptide that's marketed by its manufacturer as the "Botox in a jar". The basis for this claim is that it targets the same wrinkle forming mechanism (wrinkles caused by facial muscle movement) as Botox, but the way it works is very different. In addition, the extent to which it can prevent muscles from contracting (and to smooth wrinkles) is very different (otherwise why would anyone use still Botox?). 

The manufacturer did several studies to prove that Argireline really works and it does (just not as well as Botox). In-vivo (made on real people) tests showed that using 10% Argireline solution around the eyes for 15 days decreased wrinkles depth by 17%. A Spanish University also did some research and found that Argireline increased the level of skin moisturization and decreased both the depth and width of wrinkles "significantly". 

This means, Acetyl Hexapeptide-8 does have some ability to smooth wrinkles (but not as well as Botox - sorry, if we sound like a broken record). Also, we have to agree with TruthInAging, that it's not a collagen builder and not a preventer of structural aging (think vitamin C, AHAs or retinol); it's just a quick fix. If you are looking for one, this could be your thing. If you are more of a "let's treat this aging thing properly" type, then it's probably not your thing.

Also-called: SNAP-8, Acetyl Glutamyl Heptapeptide-1 | What-it-does: cell-communicating ingredient, moisturizer/humectant

A newer and, molecule-wise, somewhat bigger version of the famous "Botox-like" peptide called Acetyl Hexapeptide-8 or Argireline. Just like Argireline, Acetyl Octapeptide-3 is also claimed to influence the muscle contraction process that results in a more relaxed and line-free face, especially around the forehead and the eyes.  

While Argireline counts as a pretty well-proven peptide, with multiple studies confirming its anti-wrinkle efficacy, we cannot say the same for Acetyl Octapeptide-3. What we have is the manufacturer's claim that comparing 10% Argireline with 10% SNAP-8 solution (that means 0.005% pure peptide powder) the SNAP-8 peptide did a bit better as it reduced wrinkles by 34.98% vs 27.05% reduction for Argireline (twice a day use for 28 days on 17 women). 

Other than that, we can write here pretty much the same as at Argireline. Obviously, no peptide works as effectively as real Botox, and the Botox-inspired peptides are quick fixes rather than being collagen builders or real preventers of structural aging. They are nice additions to an anti-aging skincare routine but not the real superstars (think vitamin CAHAs or retinol).

Phospholipids - goodie

A type of lipid that's the major (about 75%) component of all cell membranes. As for skincare, it works as an emollient and skin-identical ingredient.

It has a water-loving head with two water-hating tails and this structure gives the molecule emulsifying properties. It is also often used to create liposomes, small spheres surrounded by phospholipid bi-layer designed to carry some active ingredient and help its absorption.

Also-called: Bamboo Leaf/Stem Extract | What-it-does: moisturizer/humectant

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

What-it-does: viscosity controlling

A natural polysaccharide (big sugar molecule) coming from red edible seaweeds. It is used as a helper ingredient for its gelling, thickening and stabilizing properties.  

Also-called: Part of Eyeliss | What-it-does: antioxidant

This guy - let's just call it simply HMC - is a so-called flavonoid (flavonoids are natural things found it lots of fruits and vegetables). Hesperidin, in particular, is a flavonone and is found in citrus fruits. The methylation of hesperidin gives HMC, that has well-established blood vessel protecting properties and can be found in drugs that treat problems related to blood vessels.

As for skincare, there is a mouse study showing HMC has very promising abilities in the "treatment of UVB irradiation-induced skin inflammation and oxidative stress", or English translation = it's an antioxidant and anti-inflammatory

HMC is also part of a 3 active ingredient complex called Eyeliss (with Dipeptide-2 and Palmitoyl Tetrapeptide-7), that's supposed to fight under-eye bags. The manufacturer claims that in their ex-vivo test HMC decreased capillary permeability by 25%.

All in all, HMC definitely deserves a goodie status, at least as an antioxidant but it might even do something with under-eye bags.

Beta-Glucan - goodie

Beta-Glucan is a nice big molecule composed of many smaller sugar molecules (called polysaccharide). It’s in the cell walls of yeast, some mushrooms, seaweeds, and cereals.

It’s a real goodie no matter if you eat it or put it on your face. Eating it is anti-diabetic, anti-cancer, and even lowers blood cholesterol. 

Putting it on your face also does a bunch of good things: it‘s shown to have wound healing properties, it’s a mild antioxidant, a great skin soother, and moisturizer, and it even shows promising anti-aging benefits

The manufacturer of the ingredient did a published study with 27 people and examined the effect of 0.1% beta-glucan. They found that despite the large molecular size beta-glucan does penetrate into the skin, even into the dermis (the middle layer of the skin where wrinkles form). After 8 weeks there was a significant reduction of wrinkle depth and height and skin roughness has also improved greatly. 

Bottom line: Beta-glucan is a great ingredient, especially for sensitive skin. It soothes, moisturizes, and has some anti-aging magic properties. 

We don't have description for this ingredient yet.

What-it-does: moisturizer/humectant, solvent, viscosity controlling | Irritancy: 0 | Comedogenicity: 1

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive. 

What-it-does: viscosity controlling, emulsion stabilising | Irritancy: 0 | Comedogenicity: 1

A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula.  It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.

Alcohol - icky
Also-called: Ethanol | What-it-does: antimicrobial/antibacterial, solvent, viscosity controlling, astringent

Simply alcohol refers to ethanol and it's a pretty controversial ingredient. It has many instant benefits: it's a great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent and antimicrobial. No wonder it's popular in toners and oily skin formulas. 

The downside is that it can be very drying if it's in the first few ingredients on an ingredient list. 

Some experts even think that regular exposure to alcohol damages skin barrier and causes inflammation though it's a debated opinion. If you wanna know more, we wrote a more detailed explanation about what's the deal with alcohol in skincare products at alcohol denat. (it's also alcohol, but with some additives to make sure no one drinks it).

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 1 | Comedogenicity: 2

A waxy solid material that helps oil and water to mix together, aka emulsifier. It is derived from the fatty alcohol called stearyl alcohol by ethoxylating it and thus making the molecule more water-soluble.

The end result is a mostly water-loving emulsifier, also called solubilizer that can help to dissolve small amounts of oil-loving ingredients into water-based products. Or it can be combined with more oil-loving emulsifiers (such as its sister, Steareth-2) to create stable emulsions. 

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 0 | Comedogenicity: 0

It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range. 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

Glucose - goodie
What-it-does: moisturizer/humectant

A fancy name for sugar. Luckily when you put it on your skin it's good for you not like when you eat it. :) It has water-binding properties, which means that it helps to keep your skin nice and hydrated

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10). 

It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.

It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol

The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.

What-it-does: preservative, deodorant

If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.

Also, it's an effective deodorant and a medium spreading emollient

What-it-does: solvent, emulsifying, perfuming, surfactant/cleansing | Irritancy: 0-1 | Comedogenicity: 0-2

Similar to other glycols, it's a helper ingredient used as a solvent, or to thin out thick formulas and make them more nicely spreadable. 

Hexylene Glycol is also part a preservative blend named Lexgard® HPO, where it helps the effectiveness of current IT-preservative, phenoxyethanol

You may also want to take a look at...

what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 0, 0
A common little helper ingredient that helps water and oil to mix together, aka emulsifier. [more]
what‑it‑does cell-communicating ingredient
Syn-Coll - An anti-aging tripeptide that's claimed to protect and boost collagen and improve skin texture. [more]
what‑it‑does cell-communicating ingredient
A five amino-acid peptide that's claimed to target expression wrinkles that appear due to facial movements. Its effect is similar to famous Argireline, and they work synergistic together. [more]
what‑it‑does cell-communicating ingredient
The pal of Palmitoyl Tripeptide-1 in Matrixyl 3000. A four amino acid peptide that works by reducing the production of the signal molecule, inteleukin-6 (IL-6) that promotes inflammation in the skin. [more]
what‑it‑does cell-communicating ingredient
A three amino acid peptide that is part of famous peptide duo, Matrixyl 3000. It's a type I collagen fragment that might be able to trick the skin to think that collagen broke down and it's time to create some new one. [more]
what‑it‑does cell-communicating ingredient
A tiny peptide with only two amino acids (amino acids are the building block of proteins, and peptides are a few amino acids attached together), Valine and Tryptophan. [more]
what‑it‑does cell-communicating ingredient | moisturizer/humectant
Argireline - famous peptide that's often referred to as "Botox in a jar". In reality, it's nowhere near that powerful, but it can smooth wrinkles to some extent by preventing facial muscles from contracting. [more]
what‑it‑does cell-communicating ingredient | moisturizer/humectant
A newer and molecule-wise somewhat bigger version of famous "Botox-like" peptide, Argireline. It is also claimed to influence the muscle contraction process that results in a more relaxed and line-free face. [more]
what‑it‑does skin-identical ingredient | emollient
A type of lipid that's the major component of all cell membranes. As for skincare, it works as an emollient and skin-identical ingredient. It's also often used to create liposomes. [more]
what‑it‑does moisturizer/humectant
what‑it‑does viscosity controlling
A natural polysaccharide (big sugar molecule) coming from red edible seaweeds. It is used as a helper ingredient for its gelling, thickening and stabilizing properties. [more]
what‑it‑does antioxidant
This guy - let's just call it simply HMC - is a so-called flavonoid (flavonoids are natural things found it lots of fruits and vegetables). Hesperidin, in particular, is a flavonone and is found in citrus fruits. [more]
what‑it‑does soothing | moisturizer/humectant
A great skin soother and moisturizer, and it even shows promising anti-aging benefits. It‘s also shown to have wound healing properties and is a mild antioxidant. [more]
what‑it‑does moisturizer/humectant | solvent | viscosity controlling
irritancy, com. 0, 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
what‑it‑does viscosity controlling
irritancy, com. 0, 1
A handy white powder that magically converts a liquid into a nice gel formula. [more]
what‑it‑does antimicrobial/antibacterial | solvent | viscosity controlling
Simple alcohol that's a great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent, and antimicrobial. In large amount can be very drying. [more]
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 1, 2
A waxy solid material that helps oil and water to mix together, aka emulsifier. It is derived from the fatty alcohol called stearyl alcohol by ethoxylating it and thus making the molecule more water-soluble.The end result is a mostly water-loving emulsifier, also called solubilizer that can help to dissolve small amounts of oil-loving ingredients into water-based  [more]
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 0, 0
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 
what‑it‑does viscosity controlling
A super commonly used thickener and emulsion stabilizer. [more]
what‑it‑does moisturizer/humectant
Sugar - as a skincare ingredient it has water-binding properties, which means that it helps to keep your skin nice and hydrated.  [more]
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
what‑it‑does moisturizer/humectant | emollient
A handy multi-tasking ingredient that gives the skin a nice, soft feel and also boosts the effectiveness of other preservatives. [more]
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]
what‑it‑does solvent | emulsifying | perfuming | surfactant/cleansing
irritancy, com. 0-1, 0-2
Similar to other glycols, it's a helper ingredient used as a solvent, or to thin out thick formulas and make them more nicely spreadable.  Hexylene Glycol is also part a preservative blend named Lexgard® [more]