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Hesperidin Methyl Chalcone

Also-called-like-this: Part of Eyeliss
What-it-does: antioxidant

Official CosIng Information


This guy - let's just call it simply HMC - is a so-called flavonoid (flavonoids are natural things found it lots of fruits and vegetables). Hesperidin, in particular, is a flavonone and is found in citrus fruits. The methylation of hesperidin gives HMC, that has well-established blood vessel protecting properties and can be found in drugs that treat problems related to blood vessels.

As for skincare, there is a mouse study showing HMC has very promising abilities in the "treatment of UVB irradiation-induced skin inflammation and oxidative stress", or English translation = it's an antioxidant and anti-inflammatory

HMC is also part of a 3 active ingredient complex called Eyeliss (with Dipeptide-2 and Palmitoyl Tetrapeptide-7), that's supposed to fight under-eye bags. The manufacturer claims that in their ex-vivo test HMC decreased capillary permeability by 25%.

All in all, HMC definitely deserves a goodie status, at least as an antioxidant but it might even do something with under-eye bags.

Show me some proof

  • Chemico-Biological Interactions, 25 February 2015, Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: Role of TRPV1, oxidative stress, cytokines and NF-κB
  • Journal of Photochemistry and Photobiology B: Biology, Jul 1, 2015, Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage

Products with Hesperidin Methyl Chalcone

Isomers All-In-One Mesmer-Eyez Tightening Eye Formula UniLipo Peptide Packed Eye Serum Eyetitude Fixzer Instant Eye Repair ACM Duolys Eye Contour Cream Skin Authority Dramatic Eye Lift Joanna Vargas Bright Eye Hydrating Mask G.M. Collin Bota-Peptide Eye Contour Simple Beauty Fine Line Eye Serum Avene Antirougeurs Calm Soothing Repair Mask Skin Actives Antioxidant Serum Avene Antirougeurs Cleansing Milk Bottle Chantecaille Nano Gold Energising Eye Serum Kate Ryan Vitamin C Daytime Repair Serum Rilastil Micro' Eye Contour Cream Verso Super Eye Serum Serious Skincare Pure-Pep Peptide Eye Treatment OSEA White Algae Mask ISDIN K-Ox Eyes ISDIN K-Ox EYES Complete Under Eye Treatment. Drunk Elephant Shaba Complex Eye Serum Eve Rebirth Bio-Intelligent Eye Contour Cream Open Formula Multi-Peptide Eye Cream (13% peptides) REPLENIX All-Trans-Retinol Eye Repair Cream själ Orbe Eye Contour Crème Avene Antirougeurs Fort Regimen Lab Vitamin X Avene Physiolift Night Balm Filorga Optim-Eyes Eye Contour Le Mieux Eye Wrinkle Corrector LeMieux Eye Wrinkle Corrector Skin Actives Bright-I Cream Ziaja Acai Berry Day Cream SPF10 Avene Antirougeurs Jour Emulsion Hydratante Protectrice Spf20 Dr Sebagh Supreme Eye Serum StriVectin 360° Tightening Eye Serum Versed Zero-G Smoothing Eye Cream Ziaja Acai Berry Face & Neck Cream Avene Antirougeurs Jour Redness Relief Moisturizing Protecting Cream Spf20 MDSolarSciences Daily Eye Repair Emulsion Peter Thomas Roth Instant Firm X Eye Clinique Acne Solutions™ BB Cream SPF 40 Cosmedix Eye Genius Brilliant Eye Complex Clinique Fit Workout Makeup Broad Spectrum Spf 40 Nars Skin Total Replenishing Eye Cream NCN PRO SKINCARE Ncn Eye Fix Perricone MD High Potency Classics Firming Eye Lift Skin Inc. My Daily Dose For Bright Eyes Cream Perricone MD Neuropeptide Night Cream Benefit It’S Potent! Eye Cream Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream