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Hesperidin Methyl Chalcone

Also-called-like-this: Part of Eyeliss
What-it-does: antioxidant

Official CosIng Information


This guy - let's just call it simply HMC - is a so-called flavonoid (flavonoids are natural things found it lots of fruits and vegetables). Hesperidin, in particular, is a flavonone and is found in citrus fruits. The methylation of hesperidin gives HMC, that has well-established blood vessel protecting properties and can be found in drugs that treat problems related to blood vessels.

As for skincare, there is a mouse study showing HMC has very promising abilities in the "treatment of UVB irradiation-induced skin inflammation and oxidative stress", or English translation = it's an antioxidant and anti-inflammatory

HMC is also part of a 3 active ingredient complex called Eyeliss (with Dipeptide-2 and Palmitoyl Tetrapeptide-7), that's supposed to fight under-eye bags. The manufacturer claims that in their ex-vivo test HMC decreased capillary permeability by 25%.

All in all, HMC definitely deserves a goodie status, at least as an antioxidant but it might even do something with under-eye bags.

Show me some proof

  • Chemico-Biological Interactions, 25 February 2015, Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: Role of TRPV1, oxidative stress, cytokines and NF-κB
  • Journal of Photochemistry and Photobiology B: Biology, Jul 1, 2015, Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage

Products with Hesperidin Methyl Chalcone

Isomers All-In-One Mesmer-Eyez Tightening Eye Formula UniLipo Peptide Packed Eye Serum NeoGenesis Eye Serum Eyetitude Fixzer Instant Eye Repair Dennis Knudsen Eye Gel ACM Duolys Eye Contour Cream Skin Authority Dramatic Eye Lift Joanna Vargas Bright Eye Hydrating Mask Medik8 Eyelift™ Peptides G.M. Collin Bota-Peptide Eye Contour REDNESS CARE FIRMING SERUM Renee Rouleau Redness Care Rare Paris Carbone Glacé - Masque Visage Purifiant Renee Rouleau Redness Care Firming Serum Simple Beauty Fine Line Eye Serum Avene Antirougeurs Calm Soothing Repair Mask Dr. Brandt Needles No More No More Baggage Skin Actives Antioxidant Serum Thin Lizzy Puffy Eye Remover Avene Antirougeurs Cleansing Milk Bottle Chantecaille Nano Gold Energising Eye Serum Liva Healthcare Faireye Advanced Dark Circle Cream Air Repair Super Hydrating Eye Cream Circadia Full Circle Eye Night Cream Kate Ryan Vitamin C Daytime Repair Serum Rilastil Micro' Eye Contour Cream Verso Super Eye Serum Yeouth Radiance Eye Gel Serious Skincare Pure-Pep Peptide Eye Treatment Timeless Dark Circle Eye Cream OSEA White Algae Mask Sanitas Peptiderm Firming Serum Viva Cosmetics Revitalizing Eye Cream ISDIN K-Ox Eyes ISDIN K-Ox EYES Complete Under Eye Treatment. torf tołpa Dermo Face 40+ Firming Anti-Wrinkle Eye Cream torf tołpa Dermo Face 45+ Relift Eye Cream Anatomicals No Old Bags Allowed Eye Gel Drunk Elephant Shaba Complex Eye Serum Eve Rebirth Bio-Intelligent Eye Contour Cream Image Skincare The Max Stem Cell Facial Cleanser Open Formula Multi-Peptide Eye Cream (13% peptides) REPLENIX All-Trans-Retinol Eye Repair Cream Yeouth Retinol Eye Cream själ Orbe Eye Contour Crème Avene Antirougeurs Fort Filorga Optim-Eyes Refresh Stick Pharmaceris Capilar & Sun Protect Spf 50+ Regimen Lab Vitamin X Rilastil Eye Contour Cream SkinCeuticals Eye Cream