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Hesperidin Methyl Chalcone

Also-called-like-this: Part of Eyeliss
What-it-does: antioxidant


This guy - let's just call it simply HMC - is a so-called flavonoid (flavonoids are natural things found it lots of fruits and vegetables). Hesperidin, in particular, is a flavonone and is found in citrus fruits. The methylation of hesperidin gives HMC, that has well-established blood vessel protecting properties and can be found in drugs that treat problems related to blood vessels.

As for skincare, there is a mouse study showing HMC has very promising abilities in the "treatment of UVB irradiation-induced skin inflammation and oxidative stress", or English translation = it's an antioxidant and anti-inflammatory

HMC is also part of a 3 active ingredient complex called Eyeliss (with Dipeptide-2 and Palmitoyl Tetrapeptide-7), that's supposed to fight under-eye bags. The manufacturer claims that in their ex-vivo test HMC decreased capillary permeability by 25%.

All in all, HMC definitely deserves a goodie status, at least as an antioxidant but it might even do something with under-eye bags.

Show me some proof

  • Chemico-Biological Interactions, 25 February 2015, Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: Role of TRPV1, oxidative stress, cytokines and NF-κB
  • Journal of Photochemistry and Photobiology B: Biology, Jul 1, 2015, Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage

Products with Hesperidin Methyl Chalcone

Isomers All-In-One Mesmer-Eyez Tightening Eye Formula UniLipo Peptide Packed Eye Serum Joanna Vargas Bright Eye Hydrating Mask G.M. Collin Bota-Peptide Eye Contour Simple Beauty Fine Line Eye Serum Avene Antirougeurs Calm Soothing Repair Mask Skin Actives Antioxidant Serum Avene Antirougeurs Cleansing Milk Bottle Rilastil Micro' Eye Contour Cream Verso Super Eye Serum Serious Skincare Pure-Pep Peptide Eye Treatment OSEA White Algae Mask ISDIN K-Ox Eyes ISDIN K-Ox EYES Complete Under Eye Treatment. Drunk Elephant Shaba Complex Eye Serum Avene Antirougeurs Fort Avene Physiolift Night Balm LeMieux Eye Wrinkle Corrector Skin Actives Bright-I Cream Dr Sebagh Supreme Eye Serum Avene Antirougeurs Jour Redness Relief Moisturizing Protecting Cream Spf20 MDSolarSciences Daily Eye Repair Emulsion Peter Thomas Roth Instant Firm X Eye Cosmedix Eye Genius Brilliant Eye Complex Clinique Fit Workout Makeup Broad Spectrum Spf 40 Nars Skin Total Replenishing Eye Cream Perricone MD High Potency Classics Firming Eye Lift Skin Inc. My Daily Dose For Bright Eyes Cream Benefit It’S Potent! Eye Cream Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream Philosophy Take A Deep Breath Oxygenating Eye Gel Cream No7 Protect & Perfect Intense Advanced Eye Cream Dr Dennis Gross C + Collagen Brighten + Firm Eye Cream SkinCeuticals A.G.E. Eye Complex No7 Lift And Luminate Triple Action Eye Cream SkinCeuticals A.G.E. Eye Complex South Beach Skincare Lifecell AlumierMD Alumineye Origins Ginzing Refreshing Eye Cream Origins Ginzing Refreshing Eye Cream To Brighten And Depuff Drunk Elephant C-Tango Multivitamin Eye Cream StriVectin Advanced Retinol Eye Cream Murad Renewing Eye Cream Ahava Extreme Night Treatment La Mer The Eye Concentrate Chantecaille Nano Gold Energizing Eye Cream MAC Lightful C + Coral Grass Vibrancy Eye Cream Dermalogica Age Reversal Eye Complex StriVectin Intensive Eye Concentrate For Wrinkles