Micro Serum
Ingredients overview
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Key Ingredients
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NeoCutis Micro SerumIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, is super well tolerated by every skin type and easy to formulate with. No wonder it’s popular.
This long-named, polymer molecule (big molecule from repeated subunits) is a helper ingredient that's good at emulsifying and stabilizing oils into water-based formulas. It also acts as a thickening and gelling agent that creates nice, non-sticky and supple textures. It works over a very wide pH range (3-12) and can be used to thicken up low-ph formulas, such as exfoliants. Its recommended used range is 0.3-3%.
It seems to us that squalane is in fashion and there is a reason for it. Chemically speaking, it is a saturated (no double bonds) hydrocarbon (a molecule consisting only of carbon and hydrogen), meaning that it's a nice and stable oily liquid with a long shelf life.
It occurs naturally in certain fish and plant oils (e.g. olive), and in the sebum (the oily stuff our skin produces) of the human skin. As f.c. puts it in his awesome blog post, squalane's main things are "emolliency, surface occlusion, and TEWL prevention all with extreme cosmetic elegance". In other words, it's a superb moisturizer that makes your skin nice and smooth, without being heavy or greasy.
Another advantage of squalane is that it is pretty much compatible with all skin types and skin conditions. It is excellent for acne-prone skin and safe to use even if you have fungi-related skin issues, like seborrhea or fungal acne.
The unsaturated (with double bonds) and hence less stable version of Squalane is Squalene, you can read about it here >>
A vitamin C derivative that's created by combining ascorbic acid (pure vitamin C) with a molecule called 3-APPA (it stands for 3-aminoproply dehydrogen phosphate). If you do not know what the big deal about vitamin C is, you are missing out, and you have to click here and read all the geeky details about it.
So now, you know that vitamin C is awesome. It's proven to have antioxidant, collagen-boosting and skin-brightening magic abilities, but the problem is that it's really really unstable. To solve the stability issue, the cosmetic industry is coming up with derivatives and Aminopropyl Ascorbyl Phosphate (AAP) is a newish version created by a Korean company.
According to the manufacturer, AAP is a water soluble, stable derivative that has both anti-wrinkle and whitening effects. They conducted an in-vivo (made on real people) study with 33 participants and found that the test formula, with just 0.5% AAP, "significantly" reduced hyperpigmentation (age spots) after 8 weeks (by 29-33%). They also measured a "dramatic" decrease in the total number of wrinkles, about 23% after 8 weeks. (If that's dramatic, we are not sure. Also, be patient because after 4 weeks, the wrinkle reduction was only a couple of percent.)
As for published studies on AAP, we found hardly anything. We found one done by Estee Lauder that briefly mentions AAP as an antioxidant that adds additional UV protection to sunscreen formulas. Another one done by Oriflame reviewed skin-whitening ingredients and also briefly mentioned AAP as a skin-lightening active.
Overall, there is not much data on Aminopropyl Ascorbyl Phosphate, but it does seem like a promising derivative with antioxidant, anti-wrinkle and skin-brightening properties. If you are into vitamin C derivatives and are happy to experiment, it's worth a go.
If you ever wondered what those little Listerine breath strips were made of, you found your answer! Pullulan is a polysaccharide polymer, which basically means that it’s a big molecule made up of smaller sugar molecule units.
It dissolves in water and can make a thin, elastic, and moisture-absorbing film when spread on the skin that can cause an instant tightening effect. It can also be used as a thickener to get a silicone-like feel and can be used in peel-off masks. Btw, it's made from fungus via fermentation.
Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.
BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.
It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive.
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
An amino acid sugar that can be found in the skin and does there good and important things. One of them is that it's a precursor for the biosynthesis of superstar moisturizer, hyaluronic acid. So acetyl glucosamine itself is also an important skin-identical ingredient and natural moisturizing factor.
But that is not all, acetyl glucosamine has two other great properties proved by double-blind clinical trials. First, it's a promising ingredient against wrinkles: 2% can improve wrinkles, particularly in the eye area.
Second, the same amount can also fade - always stubborn - brown spots. (Do not expect magic, though - the photos from the study show the difference after 8 weeks of daily use. The difference is visible, but not that big. It's always good to have realistic expectations. :)) Combined with skincare superstar niacinamide the duo is synergistic and is more effective at improving hyperpigmentation, so if you are after the skin-lightening benefit look out for products that contain both.
A semi-essential (infants cannot synthesize it, but adults can) amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor, a skin hydrator and might also help to speed up wound healing.
Arginine usually has a positive charge (cationic) that makes it substantive to skin and hair (those are more negatively charged surfaces) and an excellent film former. Thanks to the positive charge, it also creates a complex with AHAs (AHAs like to lose a hydrogen ion and be negatively charged, so the positive and the negative ions attract each other) that causes a "time-release AHA effect" and reduces the irritation associated with AHAs.
A non-essential amino acid (meaning that our body can produce it) that's also one of the major building blocks of collagen. According to the Futurederm blog, it might be able to improve wrinkles when combined with other amino acids, glycine and leucine
A non-essential amino acid (the building blocks of skin proteins, like collagen or elastin), that the body can produce itself, but its production decreases with age. When you put it all over your face, it works as a moisturizer and maybe more.
According to great skincare blog Futurederm, glycine might help with wound healing and tissue repair and when used together with other amino acids, leucine and proline it might improve wrinkles.
BTW, it's also a building block of a bunch of important and famous peptides, including copper-tripeptide-1, palmitoyl tripeptide-1 or palmitoyl hexapeptide-12.
We don't have description for this ingredient yet.
A four amino acid (Glycine – Glutamic acid – Lysine – Glycine) peptide that belongs to the group of signal peptides that mimic skin-protein breakdown products to trick the skin into creating some nice new skin proteins, such as collagen (if this sentence is not clear, here is a bit longer and nicer explanation).
According to its manufacturer, Tetrapeptide-21 shows superior collagen, hyaluronic acid and fibronectin (all nice and important skin elements) boosting activity, and can smooth and minimize all kinds of wrinkles. The in-vitro data (made on human dermal fibroblast culture) showed that compared to Matrixyl (the first-generation Matrixyl peptide called Palmitoyl Pentapeptide-4), the collagen production in the presence of Tetrapeptide-21 was almost 2-fold higher (and about 2.5-fold vs the control). This data was confirmed by an in-vivo study that compared on 60 volunteers 0.5% Tego Pep 4-17 (10ppm of Tetrapeptide-21), 5% Tego Pep 4-17 (100ppm of Tetrapeptide-21) and 10% Matrixyl (10ppm of Palmitoyl Pentapeptide-4) and found that Tetrapeptide-21 performed better after 8 weeks for skin volume, roughness and elasticity.
The manufacturer also did another 60 people anti-wrinkle study with 4% Tego Pep 4-17 (compared to vehicle) where they have some nice before and after pictures showing visible-to-the-naked-eye wrinkle reduction around the eye area.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
A 3 amino-acid peptide that works by inhibiting the production of progerin, a cell-aging accelerator protein. The manufacturer claims that Trifluoroacetyl Tripeptide-2 can bring back cell activity to a 20-year-old young cell level and the ingredient can nicely increase skin elasticity, firmness and reduce skin-sagging.
In their in-vivo (made on real people) tests, they found that 2% Progeline cream can lift the sagging jaw-line by up to 10% in 56 days and improve skin elasticity and firmness by about 20% in 28 days.
We have to admit that Algae Extract is not our favorite ingredient name. It does comply with the INCI standard (the official list about how ingredients on the product labels have to be called, the thing we help you to decode here :)), but there are about 20 000 different kinds of algae and an extract from them can be made in another 10 000 ways.
So, Algae Extract can be anything from La Mer's "Miracle Broth" to a simple brown algae extract that helps to smooth the hair. The official description in the Europiean Cosmetic Ingredient listing is this: "an extract of various species of Algae; Extract of the Seaweed, Fucus vesiculosus, Furaceae". Its official functions include being a humectant (helps skin to attract water), emollient (makes skin feel smooth and nice) and skin conditioner (a catchall phrase for saying it does something good for the skin).
A 2015 research paper on the potential of uses of algae in cosmetics summarizes that algae are rich sources of biologically active metabolites including antioxidants, anti-inflammatory agents, alginates, polysaccharides, and carotenoids. Currently, algae extracts are mostly used as moisturizing and thickening agents, but algae also have great potential to combat skin aging, pigmentation as well as working as an antimicrobial.
We have also browsed through Prospector to see what manufacturers say about their algae. There is, for example, an algae extract trade-named Lanablue that comes from blue-green algae (green algae is rare, less than 1% of the total macroalgae in the world) and is claimed to have retinoid like effects (i.e. reduce wrinkles, smooth skin) but without the side effects (though it seems now that the INCI name of Lanablue was changed to Aphanizomenon Flos-Aquae Extract).
There is another algae extract from another manufacturer that comes from red algae (much more common, about 40% of total macroalgae worldwide) and is claimed to have not only moisturizing but also skin smoothing and densifying effects.
Here is a brown algae extract (the most common type, about 59% of macroalgae), also just called Algae Extract on the product label that is simply claimed to be a free radical scavenger, aka antioxidant. These were just three random examples from three manufacturers all called Algae extract even though they all come from different algae with different claims.
Anyhow, the point is this; there are tons of different types of Algae Extracts out there. Unless the brand tells you what they use, it's impossible to know for sure. The most probable scenario for the Alge Extract is that it works as a moisturizer and emollient and it might have some additional anti-aging properties.
A common little helper ingredient that helps water and oil to mix together, aka emulsifier.
If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.
Also, it's an effective deodorant and a medium spreading emollient.
We don't have description for this ingredient yet.
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.
It is typically used in tiny amounts, around 0.1% or less.
The unfancy name for it is lye. It’s a solid white stuff that’s very alkaline and used in small amounts to adjust the pH of the product and make it just right.
For example, in case of AHA or BHA exfoliants, the right pH is super-duper important, and pH adjusters like sodium hydroxide are needed.
BTW, lye is not something new. It was already used by ancient Egyptians to help oil and fat magically turn into something else. Can you guess what? Yes, it’s soap. It still often shows up in the ingredient list of soaps and other cleansers.
Sodium hydroxide in itself is a potent skin irritant, but once it's reacted (as it is usually in skin care products, like exfoliants) it is totally harmless.
A little helper ingredient that works as a preservative. It works against bacteria and some species of fungi and yeast. It's often combined with IT-preservative, phenoxyethanol.
It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic.
Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10).
It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.
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| what‑it‑does | solvent |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | emollient |
| what‑it‑does | viscosity controlling |
| what‑it‑does | skin-identical ingredient | emollient |
| irritancy, com. | 0, 1 |
| what‑it‑does | antioxidant | skin brightening |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 1 |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | skin-identical ingredient | skin brightening |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | emollient | moisturizer/humectant |
| what‑it‑does | emulsifying | surfactant/cleansing |
| what‑it‑does | viscosity controlling |
| what‑it‑does | preservative |
| what‑it‑does | chelating |
| what‑it‑does | buffering |
| what‑it‑does | preservative | antimicrobial/antibacterial |
| what‑it‑does | preservative |