Follow us on our new Insta page »




A four amino acid (Glycine – Glutamic acid – Lysine – Glycine) peptide that belongs to the group of signal peptides that mimic skin-protein breakdown products to trick the skin into creating some nice new skin proteins, such as collagen (if this sentence is not clear, here is a bit longer and nicer explanation). 

According to its manufacturer, Tetrapeptide-21 shows superior collagen, hyaluronic acid and fibronectin (all nice and important skin elements) boosting activity, and can smooth and minimize all kinds of wrinkles. Their in-vivo (made on real people) tests confirmed that the peptide improves skin elasticity after 8 weeks of use, and they also have some nice before and after pictures showing visible-to-the-naked-eye wrinkle reduction around the eye area. 

Show me some proof

  • Farwick, Mike, et al. "Bioactive tetrapeptide GEKG boosts extracellular matrix formation: in vitro and in vivo molecular and clinical proof." Experimental dermatology 20.7 (2011): 602-604.

Products with Tetrapeptide-21

Matte Growth Factor Serum Pearlessence Firming Eye Serum Caffeine Peptide Perricone MD No:Rinse Intensive Pore Minimizing Toner TAHNYC Contour Concentrated 10 Peptide Serum Mawilove 01 – Anti Age Serum Serum Aktiv Tetrapeptid Booster NeoCutis Micro Gel Seratopical Revolution Adoring Advanced Eye Formulation Serum TAHNYC Complex B5 ISOMERS Skincare Glutathiosome Booster ISOMERS Skincare Ultimate Super Skin Booster Vials Cyberderm H2O Hydration Pearlessence Retinol + Collagen Truefitt & Hill Authentic No. 10 Sensitive Moisturiser Aramore Retinol Peptide Boosting Serum Peach & Lily Copper Peptide Pro Firming Serum TAHNYC Illume Dr Dennis Gross Triple C Firming Peptide Oil NeoCutis Bio Serum Firm Peter Thomas Roth Un-Wrinkle Turbo Line Smoothing Toning Lotion Basiclab Esteticus Skin Structure Regenerating Serum with 1% Ceramides and 5% Peptides Beauty Counter Countertime Tetrapeptide Supreme Cream Cleanbeauty Vitamin C And Hyaluronic Acid Anti-pollution Moisturizer Dr Dennis Gross Firming Peptide Milk Dr Dennis Gross Hydra-Pure Oil-Free Moisturiser Findley Vitamin C Complex Isomers All-In-One The Cream NeoCutis Micro Night Pearlessence Works Like Magic | All-in-one Cream Philosophy Miracle Worker SPF 50 Miraculous Anti-aging Fluid ACO Face Anti Age 40+ Lift & Fill Hydrating Serum Pearlessence Ultra Hydrating Face Serum ACO Face Age Delay Night Cream Normal Skin NeoCutis Biocream Firm ACO Face Anti Age 40+ Lift & Fill Night Cream Normal Skin Algenist Concentrated Reconstruting Serum Azarine Revitalizing Anti Aging Serum Biodermal Anti age 40+ night cream Cliniderm Age Correct Day Cream Daytox Peptide Booster Medik8 Liquid Peptides Rodan + Fields Restorative Lotion ACO Face Anti Age 40+ Lift & Fill Firming Eye Cream Algenist Power Advanced Wrinkle Fighter Serum Cliniderm by ACO Cliniderm Age Correct Night Cream Eubos IN A SECOND Wow Now Lift Boost Melina Organics Intimate Whitening Gel NeoCutis Micro Day NeoCutis Micro Serum NeoCutis Neo Firm Neck & Decollete Tightening Cream Rodan + Fields Redefine Triple Defense Treatment Spf 30