Skin Pharmacist City Detox
Ingredients overview
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Highlights
Key Ingredients
Other Ingredients
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Intermed Skin Pharmacist City DetoxIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
A clear, colorless, almost odorless oil that spreads nicely and easily and gives a velvet dry skin feel. It is good friends with sunscreen agents and helps to solubilize them. Also, it makes sunscreens feel lighter and spread easier.
Diethylamino Hydroxybenzoyl Hexyl Benzoate is a new generation, chemical sunscreen agent (not available in the US due to impossible FDA regulations) that's designed for high UVA protection and high photostability. It gives sun protection in the whole UVA range (320-400 nm) with peak protection at 354nm. It can be used up to 10% worldwide except for the US and Canada.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
Ethylhexyl Triazone is a new generation, chemical sunscreen (not available in the US due to impossible FDA regulations) that gives the highest photo-stable absorption of all available UVB filters today. It protects in the UVB range (280-320nm) with a peak protection of 314nm. It is an oil soluble, odorless, colorless powder that works well in fragrance-free formulas. It can be used up to 5% worldwide except for the US and Canada.
A synthetic liquid oil that can replace mineral oil or silicone oils in the cosmetic formulas. There are different grades depending on the molecular weight ranging from very light, volatile, non-residue leaving ones to more substantial, slight residue leaving ones.
Apart from leaving the skin soft and smooth (emollient), it's also used as a waterproofing agent in sunscreens or makeup products and as a shine enhancer in lip gloss formulas.
A big sugar molecule (polysaccharide) that is used as a natural thickening and gelling agent. It is similar to more commonly used Xanthan Gum, and the two are also often combined to create gel formulas or to stabilize emulsions.
A chemical sunscreen agent that gives strong protection in the UVB (280-320nm) range with its peak protection at 306 nm. Its special property is that unlike most sunscreen agents, it is not oil but water soluble, so it is ideal to create light, oily skin compatible formulas. It is also fairly photostable and can be used to protect other less stable UV filters (like famous UVA blocker, avobenzone) in the formula. It is approved worldwide and can be used up to 4% in the US and up to 8% in the EU.
A clear, oil-soluble, "cosmetically-elegant" liquid that is the most commonly used chemical sunscreen. It absorbs UVB radiation (at wavelengths: 280-320 nm) with a peak protection at 310nm.
It only protects against UVB and not UVA rays (the 320-400 nm range) – so always choose products that contain other sunscreens too. It is not very stable either, when exposed to sunlight, it kind of breaks down and loses its effectiveness (not instantly, but over time - it loses 10% of its SPF protection ability within 35 mins). To make it more stable it can be - and should be - combined with other sunscreen agents to give stable and broad-spectrum protection (the new generation sunscreen agent, Tinosorb S is a particularly good one for that).
Regarding safety, there are also some concerns around Octinoxate. In vitro (made in the lab not on real people) and animal studies have shown that it may produce hormonal (estrogen-like) effects. Do not panic, the studies were not conducted under real life conditions on real human people, so it is probably over-cautious to avoid Octinoxate altogether. However, if you are pregnant or a small child (under 2 yrs. old), choose a physical (zinc oxide/titanium dioxide) or new-generation Tinosorb based sunscreen, just to be on the super-safe side. :)
Overall, Ethylhexyl Methoxycinnamate is an old-school chemical sunscreen agent. There are plenty of better options for sun protection today, but it is considered "safe as used" (and sunscreens are pretty well regulated) and it is available worldwide (can be used up to 10% in the EU and up to 7.5% in the US).
The long name covers a nice sunscreen agent and quite a special one at that: It's a "hybrid" sunscreen meaning it's half-way between physical (the ones that, at least partly, reflect the sun) and chemical agents (that absorb the rays, which most sunscreens do). It is a new generation UV filter and, just like its sister, Trinosorb S, it is not available in the US.
It gives nice broad-spectrum coverage (280-400 nm, meaning UVB as well as UVA protecion) with peak protection at 305 nm and 360 nm and it is highly photostable. It can also help to stabilize other less stable sunscreens, like Octinoxate and is generally happy to work together with other UV-filters.
Its hybrid nature means that it is organic like the chemical agents, but it is neither water nor oil soluble and works as a suspension of micro fine particles. If the small particles scare you, we have good news: the safety profile of Tinosorb M is great. It is not absorbed into the skin and unlike some other chemical sunscreens, it does not show estrogenic activity.
The downside of its hybrid nature is that - similar to the inorganic sunscreens zinc and titanium dioxide - Tinosorb M also leaves a white cast on the skin that can be bothersome on darker skin tones.
It’s a little helper ingredient that helps to set the pH of a cosmetic formulation to be just right. It’s very alkaline (you know the opposite of being very acidic): a 1% solution has a pH of around 10.
It does not have the very best safety reputation but in general, you do not have to worry about it.
What is true is that if a product contains so-called N-nitrogenating agents (e.g.: preservatives like 2-Bromo-2-Nitropropane-1,3-Diol, 5-Bromo-5-Nitro- 1,3-Dioxane or sodium nitrate - so look out for things with nitro, nitra in the name) that together with TEA can form some not nice carcinogenic stuff (that is called nitrosamines). But with proper formulation that does not happen, TEA in itself is not a bad guy.
But let’s assume a bad combination of ingredients were used and the nitrosamines formed. :( Even in that case you are probably fine because as far as we know it cannot penetrate the skin.
But to be on the safe side, if you see Triethanolamine in an INCI and also something with nitra, nitro in the name of it just skip the product, that cannot hurt.
A high-performance emulsifier that helps water and oil to nicely mix together. It has exceptional stabilizing power and can be used in all kinds of formulas including hard to create sunscreens.
An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid).
Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier.
Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.
Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation.
If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.
As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily.
We don't have description for this ingredient yet.
It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range.
Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415).
A so-called fatty (the good, non-drying kind of) alcohol that does all kinds of things in a skincare product: it makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier). Can be derived from coconut or palm kernel oil.
A handy multi-tasker, white to light yellowish oil-loving wax that works very well in oil-in-water emulsions. It makes your skin feel nice and smooth (emollient), stabilizes oil-water mixes and gives body to them.
Oh, and one more thing: it's a so-called fatty alcohol - the good, emollient type of alcohol that is non-drying and non-irritating. It is often mixed with fellow fatty alcohol, Cetyl Alcohol, and the mixture is called Cetearyl Alcohol in the ingredient list.
It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version.
According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E.
A vegetable origin (coconut or palm kernel oil and glucose) cleansing agent with great foaming abilities. It's also mild to the skin and readily biodegradable.
- It's a helper ingredient that improves the freeze-thaw stability of products
- It's also a solvent, humectant and to some extent a penetration enhancer
- It has a bad reputation among natural cosmetics advocates but cosmetic scientists and toxicology experts do not agree (read more in the geeky details section)
An antimicrobial preservative that helps your products not to go wrong too quickly. It works especially well against bacteria, specifically gram-negative species, yeast, and mold.
Somewhat controversial, it belongs to an infamous family of formaldehyde-releasers. That is, it slowly breaks down to form formaldehyde when it is added to a formula. We have written more about formaldehyde-releasing preservatives and the concerns around them at Dmdm Hydantoin, but do not get too scared, those are more theories than proven facts.
As for Diazolidinyl Urea itself, a study from 1990 writes that at concentrations up to 0.4%, it was a mild cumulative skin irritant, but the CIR (Cosmetic Ingredient Review) reviewed it in 2006 and found that, in concentrations of <0.5%, it is safe as used, as the amount of formaldehyde released will be smaller than the recommended limit (of less than 0.2%).
All in all, it is up to your personal decision and skin sensitivity.
You might know licorice as a sweet treat from your childhood, but it's actually a legume that grows around the Mediterranean Sea, the Middle East, central and southern Russia. It's sweet and yellow and not only used for licorice all sorts but it's also a skincare superstar thanks to two magic properties:
Nr. 1 magic property is that it has skin-lightening or to say it another way depigmenting properties. The most active part is called glabridin. The topical application (meaning when you put it on your face) of 0.5% glabridin was shown to inhibit UVB caused pigmentation of guinea pigs. Another study even suggested that licorice is more effective than the gold standard skin-lightening agent hydroquinone. All in all, licorice is considered to be one of the safest skin lightening agents with the fewest side effects.
There is just one catch regarding glabridin and licorice: the amount of glabridin in commercial licorice extracts can vary a lot. We have seen extracts with only 4% glabridin as well as 40% glabridin. The latter one is a very-very expensive ingredient, so if you are after the depigmenting properties try to choose a product that boasts its high-quality licorice extract.
Nr. 2 magic property is that licorice is a potent anti-inflammatory. Glabridin has also some soothing properties but the main active anti-inflammatory component is glycyrrhizin. It’s used to treat several skin diseases that are connected to inflammation including atopic dermatitis, rosacea or eczema.
Oh, and one more thing: glabridin seems to be also an antioxidant, which is just one more reason to be happy about licorice root extract on an ingredient list.
Bottom line: Licorice is a great skincare ingredient with significant depigmenting, anti-inflammatory and even some antioxidant properties. Be happy if it's on the ingredient list. :)
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives.
It's the acronym for Butylated Hydroxy Toluene. It's a common synthetic antioxidant that's used as a preservative.
There is some controversy around BHT. It's not a new ingredient, it has been used both as a food and cosmetics additive since the 1970s. Plenty of studies tried to examine if it's a carcinogen or not. This Truth in Aging article details the situation and also writes that all these studies examine BHT when taken orally.
As for cosmetics, the CIR (Cosmetic Ingredient Review) concluded that the amount of BHT used in cosmetic products is low (usually around 0.01-0.1%), it does not penetrate skin far enough to be absorbed into the bloodstream and it is safe to use in cosmetics.
It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic.
Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10).
It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.
- Works best between a concentration of 5-20%
- Boosts the skin’s own collagen production
- Fades pigmentation and brown spots
- If used under sunscreen it boosts its UV protection
- Extremely unstable and oxidizes very easily in presence of light or air
- Stable in solutions with water only if pH is less than 3.5 or in waterless formulations
- Vit E + C work in synergy and provide superb photoprotection
- Ferulic acid doubles the photoprotection effect of Vit C+E and helps to stabilize Vit C
- Potent Vit. C serums might cause a slight tingling on sensitive skin
We don't have description for this ingredient yet.
A spray-dried or freeze-dried version of Aloe Leaf Juice. The point of both drying methods is to make water evaporate from the juice and leave just the "useful" components behind.
So the aloe powder has similar soothing, emollient and moisturizing properties as the juice. You can read a bit more about the juice here.
It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. Its strong point is being effective against yeasts and molds, and as a nice bonus seems to be non-comedogenic as well.
It is safe in concentrations of less than 0.1% but is acutely toxic when inhaled, so it's not the proper preservative choice for aerosol formulas like hairsprays. Used at 0.1%, Iodopropynyl Butylcarbamate has an extremely low rate of skin-irritation when applied directly for 24 hours (around 0.1% of 4,883 participants) and after 48 hours that figure was 0.5%, so it counts as mild and safe unless your skin is super-duper sensitive.
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| what‑it‑does | solvent |
| what‑it‑does | emollient |
| what‑it‑does | sunscreen |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | sunscreen |
| what‑it‑does | emollient | viscosity controlling |
| irritancy, com. | 2, 1 |
| what‑it‑does | viscosity controlling |
| what‑it‑does | sunscreen |
| what‑it‑does | sunscreen |
| irritancy, com. | 0, 0 |
| what‑it‑does | sunscreen |
| what‑it‑does | buffering |
| irritancy, com. | 0, 2 |
| what‑it‑does | emulsifying | surfactant/cleansing |
| what‑it‑does | soothing | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | emollient | emulsifying | surfactant/cleansing |
| what‑it‑does | viscosity controlling |
| what‑it‑does | emollient | viscosity controlling |
| irritancy, com. | 2, 2 |
| what‑it‑does | emollient | viscosity controlling | emulsifying | surfactant/cleansing |
| irritancy, com. | 2, 2 |
| what‑it‑does | antioxidant |
| irritancy, com. | 0, 0 |
| what‑it‑does | surfactant/cleansing |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 0 |
| what‑it‑does | preservative |
| what‑it‑does | soothing | skin brightening |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | solvent |
| what‑it‑does | antioxidant | preservative |
| what‑it‑does | preservative |
| what‑it‑does | antioxidant | skin brightening | buffering |
| what‑it‑does | soothing | moisturizer/humectant |
| what‑it‑does | preservative |