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This product has been discontinued. See the current version here.
Coxir Intensive Egf Peptide Cream

Intensive Egf Peptide Cream (Discontinued)

An anti-wrinkle repair cream with egf, peptides and collagen to keep skin smooth and resilient
Uploaded by: jg0906 on

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Ingredient name what-it-does irr., com. ID-Rating
Water solvent
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar
Glyceryl Acrylate/Acrylic Acid Copolymer moisturizer/​humectant, viscosity controlling
Propylene Glycol moisturizer/​humectant, solvent 0, 0
Butylene Glycol Dicaprylate/Dicaprate emollient
Dimethicone/Vinyl Dimethicone Crosspolymer viscosity controlling
Methyl Gluceth-20 moisturizer/​humectant goodie
Niacinamide cell-communicating ingredient, skin brightening, anti-acne, moisturizer/​humectant superstar
1,2-Hexanediol solvent
Betaine moisturizer/​humectant goodie
Diisostearyl Malate emollient, surfactant/​cleansing
Cyclomethicone emollient 0, 0
PEG/PPG-18/4 Copolymer solvent
Sodium Acrylate/Sodium Acryloyldimethyltaurate Copolymer viscosity controlling
Isohexadecane emollient, solvent
Polysorbate 80 emulsifying, surfactant/​cleansing 0, 0
Adenosine cell-communicating ingredient goodie
Butylene Glycol moisturizer/​humectant, solvent 0, 1
Hydrogenated Lecithin emollient, emulsifying goodie
SH-Oligopeptide-1 cell-communicating ingredient
Copper Tripeptide-1 cell-communicating ingredient, soothing, antioxidant goodie
Hydrogenated Vegetable Oil emollient 0, 3
Tri-C14-15 Alkyl Citrate emollient
Myrciaria Dubia Fruit Extract
Malpighia Emarginata (Acerola) Fruit Extract
Tocopheryl Acetate antioxidant 0, 0
Arginine skin-identical ingredient goodie
Carbomer viscosity controlling 0, 1
Panthenol soothing, moisturizer/​humectant 0, 0 goodie
Lonicera Japonica (Honeysuckle) Flower Extract soothing, antimicrobial/​antibacterial goodie
Solanum Lycopersicum (Tomato) Fruit Extract antioxidant
Lilium Tigrinum Extract
Nelumbo Nucifera Seed Extract antimicrobial/​antibacterial, antioxidant, emollient
Chrysanthemum Indicum Flower Extract
Hydrolyzed Collagen emollient, moisturizer/​humectant goodie
Acanthopanax Senticosus (Eleuthero) Root Extract soothing
Punica Granatum Fruit Extract
Panax Ginseng Root Extract antioxidant, emollient goodie
Carthamus Tinctorius (Safflower) Flower Extract
Xanthan Gum viscosity controlling
Malva Sylvestris (Mallow) Flower Extract
Buddleja Davidii Extract
Thymus Vulgaris (Thyme) Extract perfuming
Camellia Sinensis Callus Culture Extract perfuming
Phaseolus Radiatus Meristem Cell Culture Extract
Panax Ginseng Callus Culture Extract
Phenoxyethanol preservative
Ethylhexylglycerin preservative
Parfum perfuming icky

Coxir Intensive Egf Peptide Cream
Ingredients explained

Also-called: Aqua | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

Glyceryl acrylate/acrylic acid copolymer is the fancy word for a common polymer (big molecule from repeated subunits), namely polyacrylic acid (aka carbomer when it comes to cosmetics) with glycerin attached to it in some places.

The main thing of this polymer is that it forms a hydrogel (trade named Lubrajel) that can sit on top of the skin and provide moisturizing, water-soluble ingredients such as glycerin to the skin. Think of it as a very thin, wet sponge that a cosmetic manufacturer can fill with good ingredients for your skin. It also works as a thickening agent (remember, it is a carbomer type of molecule), and can provide the skin with a nice slippery feel. It can also draw water to the skin (thank you, pendant glycerol groups!), providing skin hydration.

What-it-does: moisturizer/humectant, solvent | Irritancy: 0 | Comedogenicity: 0
  • It's a helper ingredient that improves the freeze-thaw stability of products
  • It's also a solvent, humectant and to some extent a penetration enhancer
  • It has a bad reputation among natural cosmetics advocates but cosmetic scientists and toxicology experts do not agree (read more in the geeky details section)
Read all the geeky details about Propylene Glycol here >>

What-it-does: emollient

We don't have description for this ingredient yet.

What-it-does: viscosity controlling

A white, elastomeric silicone powder that gives a nice silky and powdery feel to the products. It also has some oil and sebum absorption capabilities. 

What-it-does: moisturizer/humectant

A corn sugar derived, water-soluble, pale yellow syrup, that nicely moisturizes the skin. It has a light and smooth skin feel, it is non-tacky, and it can improve the after-feel of the formula. It is also mild and gentle, popular in sensitive skin formulas.

Niacinamide - superstar
Also-called: vitamin B3, nicotinamide | What-it-does: cell-communicating ingredient, skin brightening, anti-acne, moisturizer/humectant
  • A multi-functional skincare superstar with several proven benefits for the skin
  • Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
  • Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
  • Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
  • Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
Read all the geeky details about Niacinamide here >>

What-it-does: solvent

A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives

Betaine - goodie
What-it-does: moisturizer/humectant

A sugar beet-derived amino acid derivative with nice skin protection and moisturization properties. Betaine's special thing is being an osmolyte, a molecule that helps to control cell-water balance.  It is also a natural osmoprotectant, meaning that it attracts water away from the protein surface and thus protects them from denaturation and increases their thermodynamic stability. 

It also gives sensorial benefits to the formula and when used in cleansers, it helps to make them milder and gentler. 

We don't have description for this ingredient yet.

What-it-does: emollient | Irritancy: 0 | Comedogenicity: 0

Cyclomethicone is not one type of silicone, but a whole mixture of them: it's a mix of specific chain length (4 to 7) cyclic structured silicone molecules. (There seems to be a confusion on the internet whether Cyclomethicone and Cyclopentasiloxane are the same. They are not the same, but Cyclopentasiloxane is part of the mixture that makes up Cyclomethicone). 

All the silicones in the Cyclomethicone mixture are volatile, meaning they evaporate from the skin or hair rather than stay on it. This means that Cyclomethicone has a light skin feel with none-to-minimal after-feel.  It also makes the formulas easy to spread and has nice emollient properties.

What-it-does: solvent

We don't have description for this ingredient yet.

A copolymer is a big molecule that consists not of one but of two repeating subunits. This particular copolymer is a handy helper ingredient to form nice gel textures.

It usually comes to the formula combined with emollients (such as  C13-14 Isoparaffin, Isohexadecane, Isononyl Isononanoate or Squalane) and can be used as an emulsifier and/or thickener to produce milky gel emulsions with a soft and non-tacky skin feel. 

What-it-does: emollient, solvent

A light, velvety, unique skin feel liquid that is a good solvent and also makes the skin feel nice and smooth (aka emollient). It's often used in makeup products mixed with silicones to give shine and slip to the product. It's also great for cleansing dirt and oil from the skin as well as for taking off make-up.

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 0 | Comedogenicity: 0

A common little helper ingredient that helps water and oil to mix together, aka emulsifier. 

The number at the end refers to the oil-loving part and the bigger the number  the more emulsifying power it has. 20 is a weak emulsifier, rather called solubilizer used commonly in toners while 60 and 80 are more common in serums and creams.

Adenosine - goodie

Adenosine is an important little compound in our body that has a vital cell-signalling role. Research on smearing it on our face is also promising and shows so far a couple of things:

  • It can help with wound healing
  • It’s a good anti-inflammatory agent
  • It might even help with skin’s own collagen production and improve skin firmness and elasticity
  • It helps with barrier repair and protection
  • It might be even useful for the hair helping with hair thickness and hair growth
What-it-does: moisturizer/humectant, solvent | Irritancy: 0 | Comedogenicity: 1

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

What-it-does: emollient, emulsifying

It's the chemically chopped up version of normal lecithin. Most often it's used to create liposomes and to coat and stabilize other ingredients. 

Also-called: Epidermal Growth Factor, EGF, rh-Oligopeptide-1 | What-it-does: cell-communicating ingredient

Sh-Oligopeptide-1 is the famous molecule, which is also called Epidermal Growth Factor or EGF. Chemically speaking, Growth Factors are largish peptides or smallish proteins, or to put it in another way, medium-length amino acid sequences (EGF consists of 53 amino acids).  Biologically speaking, Growth Factors are cellular signal molecules that can stimulate cell growth, proliferation, healing and/or differentiation. 

There are lots of Growth Factors and EGF is just one of them. The topic of "Growth Factors and skincare" is a big, confusing and controversial one and we will try our best to summarize the story for you, including the pros and the cons. 

Also-called: GHK-Cu, Copper Peptide | What-it-does: cell-communicating ingredient, soothing, antioxidant
  • GHK-Cu is a copper-peptide complex found naturally in yucky bodily fluids (plasma, saliva, and urine)
  • It has unique wound healing properties by stimulating the breakdown of unhealthy, too large collagen in scar tissue and stimulating nice and healthy collagen production afterwards
  • It stimulates the production of several important skin-identical ingredients (e.g. collagen, elastin, and glycosaminoglycans)
  • It has significant anti-inflammatory and antioxidant effect
  • There are a few promising studies showing GHK-Cu can improve skin elasticity, clarity, firmness and reduce lines and wrinkles
  • It can improve hair growth by enlarging hair follicles (and bigger follicles produce longer, thicker hair)
  • There are some urban legends about possible overdosing or facial hair problems (read more in geeky details)
Read all the geeky details about Copper Tripeptide-1 here >>

What-it-does: emollient | Irritancy: 0 | Comedogenicity: 3

We don't have description for this ingredient yet.

What-it-does: emollient

We don't have description for this ingredient yet.

Also-called: Camu Camu Fruit Extract

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Also-called: Vitamin E Acetate | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 0

It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version. 

According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E. 

Arginine - goodie

A semi-essential (infants cannot synthesize it, but adults can) amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor, a skin hydrator and might also help to speed up wound healing

Arginine usually has a positive charge (cationic) that makes it substantive to skin and hair (those are more negatively charged surfaces) and an excellent film former.  Thanks to the positive charge, it also creates a complex with AHAs (AHAs like to lose a hydrogen ion and be negatively charged, so the positive and the negative ions attract each other) that causes a "time-release AHA effect" and reduces the irritation associated with AHAs

What-it-does: viscosity controlling, emulsion stabilising | Irritancy: 0 | Comedogenicity: 1

A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula.  It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.

Panthenol - goodie
Also-called: Pro-Vitamin B5 | What-it-does: soothing, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid). 

Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier. 

Also-called: Japanese Honeysuckle Flower Extract | What-it-does: soothing, antimicrobial/antibacterial

Lonicera Japonica, or Japanese Honeysuckle as normal people call it, is a white-flowered honeysuckle known for being a traditional Chinese medicine. Modern research confirms that the plant has a super complex chemical composition with more than 140 compounds identified with possible anti-inflammatory, antibacterial, antiviral, antioxidative and hepatoprotective activities.

As for Lonicera Japonica Flower Extract in skin care, it can have two main roles. The first one is being an anti-inflammatory and soothing ingredient, probably due to chlorogenic acid, a polyphenol thought to be the main bioactive component of the flower.

What-it-does: antioxidant

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

The chemically chopped up version of the big protein molecule, collagen. It is often derived from fish or bovine sources and works as a nice moisturizer and humectant that helps the skin to hold onto water.  

To understand a bit more what Hydrolyzed Collagen is, you have to know that proteins are large chains of amino acids connected with so-called peptide bonds. These bonds can be broken up when a water molecule is added and the resulting thing is a mix of shorter length amino acids, also called peptides. So Hydrolyzed Collagen is not really collagen, it is rather an undefined and varying mix of largish peptides. Based on a manufacturer's data, the whole, soluble collagen has an average molecular weight of 300 000 Da, while this chopped up mixture has an average MW of 12 000 Da (still pretty big). 

What-it-does: soothing

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Also-called: True Ginseng, Ginseng, Korean Ginseng | What-it-does: antioxidant, emollient

A  traditional Korean medicine used for more than 2000 years. Regarding skin care, its main thing seems to be enhancing skin nutrition and metabolism as a result of improving blood circulation.

It also contains biologically active components referred to as ginseng saponins (ginsenosides) that have potent antioxidant properties

We don't have description for this ingredient yet.

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range. 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Also-called: Thyme | What-it-does: perfuming

We don't have description for this ingredient yet.

What-it-does: perfuming

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

What-it-does: preservative, deodorant

If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.

Also, it's an effective deodorant and a medium spreading emollient

Parfum - icky
Also-called: Fragrance, Parfum;Parfum/Fragrance | What-it-does: perfuming

Exactly what it sounds: nice smelling stuff put into cosmetic products so that the end product also smells nice. Fragrance in the US and parfum in the EU is a generic term on the ingredient list that is made up of 30 to 50 chemicals on average (but it can have as much as 200 components!). 

If you are someone who likes to know what you put on your face then fragrance is not your best friend - there's no way to know what’s really in it.  

You may also want to take a look at...

what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does moisturizer/humectant | viscosity controlling
Glyceryl acrylate/acrylic acid copolymer is the fancy word for a common polymer (big molecule from repeated subunits), namely polyacrylic acid (aka carbomer when it comes to cosmetics) with glycerin attached to it in some places. The main thing of this polymer is that it forms a hydrogel (trade named Lubrajel) that can sit on top of the skin and provide moisturizing, water-soluble [more]
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0, 0
A common glycol that improves the freeze-thaw stability of products. It's also a solvent, humectant and to some extent a penetration enhancer. [more]
what‑it‑does emollient
what‑it‑does viscosity controlling
A white, elastomeric silicone powder that gives a nice silky and powdery feel to the products. [more]
what‑it‑does moisturizer/humectant
A corn sugar-derived, water-soluble, pale yellow syrup, that nicely moisturizes the skin. It has a light and smooth skin feel. [more]
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
what‑it‑does solvent
A multi-functional helper ingredient that acts as a humectant and emollient. It's also a solvent and can boost the effectiveness of preservatives. [more]
what‑it‑does moisturizer/humectant
A sugar beet derived amino acid derivative with nice skin protection and moisturization properties. Its special thing is being an osmolyte, a molecule that helps to control cell-water balance.  [more]
what‑it‑does emollient | surfactant/cleansing
what‑it‑does emollient
irritancy, com. 0, 0
A mixture of 4 to 7 chain length cyclic silicones. It's a light, volatile ingredient that gives skin or hair a smooth feel and has emollient properties. [more]
what‑it‑does solvent
what‑it‑does viscosity controlling
A big molecule used as a helper ingredient to form nice gel textures. [more]
what‑it‑does emollient | solvent
A light, velvety, unique skin feel liquid that is a good solvent and also makes the skin feel nice and smooth. [more]
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 0, 0
A common little helper ingredient that helps water and oil to mix together, aka emulsifier. [more]
what‑it‑does cell-communicating ingredient
An important compound in our body that has a vital cell-signalling role. It is wound healing, anti-inflammatory and can help with barrier repair. [more]
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0, 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
what‑it‑does emollient | emulsifying
It's the chemically chopped up version of normal lecithin. Most often it's used to create liposomes and to coat and stabilize some other ingredient. 
what‑it‑does cell-communicating ingredient
Epidermal Growth Factor - a smallish protein that works as a potent cell signaling molecule. It stimulates cell proliferation, wound healing and skin renewal. Do not use if you have psoriasis or high skin cancer risk factors. [more]
what‑it‑does cell-communicating ingredient | soothing | antioxidant
A copper-peptide complex that has unique wound healing and skin remodelling properties. It's also an anti-inflammatory and antioxidant agent. [more]
what‑it‑does emollient
irritancy, com. 0, 3
what‑it‑does emollient
what‑it‑does antioxidant
irritancy, com. 0, 0
A form of vitamin E that works as an antioxidant. Compared to the pure form it's more stable, has longer shelf life, but it's also more poorly absorbed by the skin. [more]
what‑it‑does skin-identical ingredient
An amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor and might also help to speed up wound healing.  [more]
what‑it‑does viscosity controlling
irritancy, com. 0, 1
A handy white powder that magically converts a liquid into a nice gel formula. [more]
what‑it‑does soothing | moisturizer/humectant
irritancy, com. 0, 0
Pro-Vitamin B5 is a goodie that moisturises the skin, has anti-inflammatory, skin protecting and wound healing properties. [more]
what‑it‑does soothing | antimicrobial/antibacterial
Lonicera Japonica, or Japanese Honeysuckle as normal people call it, is a white-flowered honeysuckle known for being a traditional Chinese medicine. Modern research confirms that the plant has a super complex chemical composition with more than 140 compounds identified with possible anti-inflammatory, antibacterial, antiviral, antioxidative and hepatoprotective activities. [more]
what‑it‑does antioxidant
what‑it‑does antimicrobial/antibacterial | antioxidant | emollient
what‑it‑does emollient | moisturizer/humectant
The chemically chopped up version of the big protein molecule, collagen. It is often derived from fish or bovine sources and works as a nice moisturizer and humectant that helps the skin to hold onto water.   To understand a bit more what Hydrolyzed Collagen is, you have to know that proteins are large chains of amino acids connected with so-called peptide bonds. [more]
what‑it‑does soothing
what‑it‑does antioxidant | emollient
Ginseng - A traditional Korean medicine that has antioxidant properties, and is known to improve blood circulation. [more]
what‑it‑does viscosity controlling
A super commonly used thickener and emulsion stabilizer. [more]
what‑it‑does perfuming
what‑it‑does perfuming
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]
what‑it‑does perfuming
The generic term for nice smelling stuff put into cosmetic products so that the end product also smells nice. It is made up of 30 to 50 chemicals on average. [more]