Peptide Hair Serum
Ingredients overview
Highlights
Key Ingredients
Other Ingredients
Skim through
Blueprint Peptide Hair SerumIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product feel great on the skin. It works synergistically with preservatives and helps to improve water-resistance of sunscreens.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
This long-named, polymer molecule (big molecule from repeated subunits) is a helper ingredient that's good at emulsifying and stabilizing oils into water-based formulas. It also acts as a thickening and gelling agent that creates nice, non-sticky and supple textures. It works over a very wide pH range (3-12) and can be used to thicken up low-ph formulas, such as exfoliants. Its recommended used range is 0.3-3%.
Sh-Oligopeptide-1 is the famous molecule, which is also called Epidermal Growth Factor or EGF. Chemically speaking, Growth Factors are largish peptides or smallish proteins, or to put it in another way, medium-length amino acid sequences (EGF consists of 53 amino acids). Biologically speaking, Growth Factors are cellular signal molecules that can stimulate cell growth, proliferation, healing and/or differentiation.
There are lots of Growth Factors and EGF is just one of them. The topic of "Growth Factors and skincare" is a big, confusing and controversial one and we will try our best to summarize the story for you, including the pros and the cons.
EGF is a special snowflake when it comes to skincare as it was the first Growth Factor that made its way into cosmetic products and it is also the most common one. The American biochemist, Stanley Cohen discovered EGF and was awarded a Noble prize in 1986 for it. As the Noble prize may signify, the molecule is significant and powerful and directly stimulates the proliferation of epidermal cells.
When it comes to Sh-Oligopeptide-1 in a cosmetic product, it has pretty well-established wound healing and skin renewal properties. It might even do more than that. According to a 2012 study on a serum containing barley bioengineered epidermal growth factor, "clinical evaluations showed statistically significant improvement in the appearance of fine lines and rhytids, skin texture, pore size, and various dyschromatic conditions apparent within the first month of use, and continuing improvement trends for the duration of the study" (which was 3 months).
This all sounds amazing, "give me some EGF Serum", we can hear you say! But as we wrote in the intro, the topic is complex and controversial so here are some of the questions that keep coming up around slathering EGF all over our face.
The first and biggest concern is that if EGF is so good at stimulating cell proliferation, how does it relate to cancer? Is the definition of cancer not "cells proliferating out of control"? Most experts agree on this answer: EGF is mitogenic (= stimulates cell proliferation) but not mutagenic (= does not alter the cell to make it cancerous). If you do not have cancer, you will not get cancer from EGF. However, if you have cancerous cells, EGF will help them to spread, just like it helps healthy cells. So if you have a lot of moles, excessive UV exposure in the past, or if you have any of the skin cancer risk factors, we suggest you should think twice about using EGF products. The same is true if you have psoriasis, a skin disease related to the abnormal growth of epidermal skin cells. You do not want to add fuel to the fire with EGF.
Other (less serious) concerns are if EGF can properly penetrate the skin (as it is a medium-sized, polar molecule, so a special delivery system is probably needed), if it can affect collagen synthesis (or just works on the surface plumping up only the upmost layers of the skin) and if it has beneficial effects at all when used in isolation versus when used in a "conditioned media" that contains lots of growth factors resembling the synergistic balance found in the skin.
Overall, our impression is that EGF is definitely a potent molecule. Some EGF products have a cult-like following adding anecdotal evidence to the clinical studies showing EGF has a beneficial effect on the skin. If you like experimenting, by all means, go ahead (unless you have psoriasis or high skin cancer risk factors), but if you are a better safe than sorry type, stick to daily SPF + a good retinoid product. This duo is still the golden standard of anti-aging.
Are you interested in Growth Factors and skincare? We have some more here:
- Human Fibroblast Conditioned Media - a growth factor cocktail used in some cosmetic products
- Insulin-like growth factor 1, aka sh-Oligopeptide -2 - a pal of EGF composed of 70 amino acids
- Vascular Endothelial Growth Factor, aka Sh-Polypeptide-9 - part of a GF cocktail trade named BIO-Placenta
We don't have description for this ingredient yet.
Sh-Polypeptide-9 is a cell signaling protein also called Vascular Endothelial Growth Factor. As its name suggests, its main function is to stimulate the formation of blood vessels. As to what it does in cosmetic products, we found manufacturers info claiming that it plays a role in supplying fibroblast cells (VIP skin cells that make collagen) with nutrients, in the growth and migration of cells and in wound healing.
It usually comes to the formula as part of a Growth Factor mix trade named BIO-Placenta, that combines EGF, IGF-1, FGF1, FGF2 and this guy to form a synergistic growth factor cocktail. BIO Placenta is claimed to do pretty much everything you would want from an anti-aging active including anti-wrinkle, skin rejuvenation, elasticity enhancement, moisturizing and cell vitalization properties.
This all sounds great and Growth Factors are for sure potent cell signaling molecules, but the use of them in cosmetic products is somewhat controversial, so if you are new to the topic, read our explanation at EGF to get a (hopefully) balanced view.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
- GHK-Cu is a copper-peptide complex found naturally in yucky bodily fluids (plasma, saliva, and urine)
- It has unique wound healing properties by stimulating the breakdown of unhealthy, too large collagen in scar tissue and stimulating nice and healthy collagen production afterwards
- It stimulates the production of several important skin-identical ingredients (e.g. collagen, elastin, and glycosaminoglycans)
- It has significant anti-inflammatory and antioxidant effect
- There are a few promising studies showing GHK-Cu can improve skin elasticity, clarity, firmness and reduce lines and wrinkles
- It can improve hair growth by enlarging hair follicles (and bigger follicles produce longer, thicker hair)
- There are some urban legends about possible overdosing or facial hair problems (read more in geeky details)
An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid).
Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier.
Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.
Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation.
If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.
As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily.
Hello, our favorite molecule that helps us wake up in the morning and then keeps us going through the day. As a super well-known stimulant from coffee, tea and plenty of other soft drinks, Caffeine needs no introduction. So we will skip right to the part where we talk about what the hell it does in so-so many cosmetic products.
Looking at the research, we were surprised to find how versatile Caffeine is. It is a small, water-loving molecule with pretty good skin penetration abilties. Once in the skin, it has nice antioxidant properties, meaning that it reduces the formation of evil free radicals and it might even be useful in preventing UV-induced skin cancers.
A well-known thing about Caffeine is that it improves the microcirculation of the blood vessels. Though conventional wisdom and anecdotal evidence says that this property is helpful for dark under-eye circles and puffy eyes, we have to mention that the double-blind research we have found about a 3% caffeine gel concluded that "the overall efficacy of the selected caffeine gel in reducing puffy eyes was not significantly different from that of its gel base." But you know, the proof is in the pudding.
Another thing Caffeine is used for in body care products is its anti-cellulite effects. In theory, it can speed up the lipolysis process (the "fat burning" by our cells) and stimulate the draining lymph system that might lead to the improvement of cellulite. But here again, the evidence that it actually makes a measurable, let alone visible, improvement on actual human beings is limited (we could find only some animal skin studies or caffeine being combined with other actives).
Last, but not least, we have to write about caffeine and hair growth. The theory is that it can inhibit the activity of the 5-α-reductase enzyme that plays an important role in hair loss and allows a renewed growth phase of the hair. We have found some recent and promising research to back this up. A 2017 study compared a 0.2% caffeine liquid with a 5% Minoxidil (an FDA approved active to treat baldness) solution and found that "a caffeine-based topical liquid should be considered as not inferior to minoxidil 5% solution in men with androgenetic alopecia", or English translation means that the caffeine liquid was pretty much as good as the FDA-approved Minoxidil stuff. Not bad!
Overall, we think that caffeine is a very versatile and biologically active ingredient. Even though some of its effects are more hyped up than backed up, it is still a nice to have on many ingredient lists.
Adenosine is an important little compound in our body that has a vital cell-signalling role. Research on smearing it on our face is also promising and shows so far a couple of things:
- It can help with wound healing
- It’s a good anti-inflammatory agent
- It might even help with skin’s own collagen production and improve skin firmness and elasticity
- It helps with barrier repair and protection
- It might be even useful for the hair helping with hair thickness and hair growth
- A multi-functional skincare superstar with several proven benefits for the skin
- Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
- Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
- Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
- Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
A semi-essential (infants cannot synthesize it, but adults can) amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor, a skin hydrator and might also help to speed up wound healing.
Arginine usually has a positive charge (cationic) that makes it substantive to skin and hair (those are more negatively charged surfaces) and an excellent film former. Thanks to the positive charge, it also creates a complex with AHAs (AHAs like to lose a hydrogen ion and be negatively charged, so the positive and the negative ions attract each other) that causes a "time-release AHA effect" and reduces the irritation associated with AHAs.
- It's one of the gold standard ingredients for treating problem skin
- It can exfoliate skin both on the surface and in the pores
- It's a potent anti-inflammatory agent
- It's more effective for treating blackheads than acne
- For acne combine it with antibacterial agents like benzoyl peroxide or azelaic acid
Alpha-Lipoic Acid (ALA) is a great antioxidant that's also part of the body's natural antioxidant system. It's soluble both in water-rich and lipid-rich environments so it's versatile and can interact with many types of evil oxidants as well as other nice antioxidants.
ALA seems to be a great choice for topical use as studies show it can penetrate the skin rapidly where it's converted to DHLA (dihydrolipoic acid), an even more potent antioxidant molecule. A nicely designed (we mean double-blind, placebo-controlled) 12-week study from 2003 confirmed that 5% ALA cream can decrease skin roughness and improve general signs of photoaging statistically significantly. A slight catch, though, is that burning and warmth in the skin was quite a common side effect, especially in the first 4 weeks.
All in all, ALA is definitely a research-proven, great antioxidant but if your skin is sensitive higher concentrations might not be for you.
A very common ingredient that can be found in all cell membranes. In cosmetics it's quite the multi-tasker: it's an emollient and water-binding ingredient but it's also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes.
A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives.
A non-essential amino acid (the building blocks of skin proteins, like collagen or elastin), that the body can produce itself, but its production decreases with age. When you put it all over your face, it works as a moisturizer and maybe more.
According to great skincare blog Futurederm, glycine might help with wound healing and tissue repair and when used together with other amino acids, leucine and proline it might improve wrinkles.
BTW, it's also a building block of a bunch of important and famous peptides, including copper-tripeptide-1, palmitoyl tripeptide-1 or palmitoyl hexapeptide-12.
A very stable and promising form of the skincare superstar, Vitamin C. If you do not know why Vitamin C is such a big deal in skin care, you can catch up here. In short, Vitamin C has three proven magic abilities: antioxidant, collagen booster, and skin brightener. The problem, though, is that it's very unstable, turns brown and becomes ineffective in no time (after a few month) and the cosmetics industry is trying to come up with smart derivatives that are stable and have the magic properties of pure Vitamin C.
Ethyl Ascorbic Acid or EAC for short is an "etherified derivative of ascorbic acid" that consists of vitamin C and an ethyl group bound to the third carbon position. This makes Vitamin C very stable and soluble in both water and oil.
However, for a Vitamin C derivative to work it's not enough just to be stable, they also have to be absorbed into the skin and be converted there to pure Vitamin C. We have good news regarding the absorption: on top of manufacturer claims, there is some data (animal study) demonstrating in can get into the skin, and it seems to be better at it than Ascorbyl Glucoside, another vitamin C derivative.
Regarding conversion, we can cite only a manufacturers claim saying that EAC is metabolized in the skin into pure ascorbic acid (and the ascorbic acid content of EAC is very high - 86,4% - compared to the usual 50-60% Vitamin C content of other derivatives).
As for the three magic abilities of Vitamin C, we again mostly have only the manufacturer's claims, but at least those are very promising. EAC seems to have both an antioxidant and anti-inflammatory effect, and it's claimed to be able to boost the skin's collagen production. The strong point of EAC though is skin brightening. On top of manufacturer claims, there is also clinical in-vivo (tested on real people) data showing that 2% EAC can improve skin tone and whiten the skin.
Overall, Ethyl Ascorbic Acid is a very promising but not a fully proven Vitamin C derivative. It's worth a try, especially if you are after Vitamin C's skin-brightening effects.
Though the official function of P-Anisic Acid is masking (meaning that it helps to mask not so nice smells in the product), according to manufacturer info it is rather used as a preservative. It is a skin friendly organic acid that works against fungi.
A common little helper ingredient that helps water and oil to mix together, aka emulsifier.
A little helper ingredient that is used to adjust the pH of the product. It also helps to keep products stay nice longer by neutralizing the metal ions in the formula (they usually come from water).
Citric acid comes from citrus fruits and is an AHA. If these magic three letters don’t tell you anything, click here and read our detailed description on glycolic acid, the most famous AHA.
So citric acid is an exfoliant, that can - just like other AHAs - gently lift off the dead skin cells of your skin and make it more smooth and fresh.
There is also some research showing that citric acid with regular use (think three months and 20% concentration) can help sun-damaged skin, increase skin thickness and some nice hydrating things called glycosaminoglycans in the skin.
But according to a comparative study done in 1995, citric acid has less skin improving magic properties than glycolic or lactic acid. Probably that’s why citric acid is usually not used as an exfoliant but more as a helper ingredient in small amounts to adjust the pH of a formulation.
We don't have description for this ingredient yet.
You may also want to take a look at...
| what‑it‑does | solvent |
| what‑it‑does | solvent | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | viscosity controlling |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | antioxidant |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | antioxidant |
| what‑it‑does | antioxidant | colorant |
| what‑it‑does | antioxidant |
| what‑it‑does | cell-communicating ingredient | soothing | antioxidant |
| what‑it‑does | soothing | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | antioxidant | perfuming |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | exfoliant | anti-acne | soothing | preservative |
| what‑it‑does | antioxidant |
| what‑it‑does | emollient | emulsifying |
| what‑it‑does | solvent |
| what‑it‑does | antioxidant |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | antioxidant | skin brightening |
| what‑it‑does | preservative |
| what‑it‑does | emulsifying | surfactant/cleansing |
| what‑it‑does | chelating | buffering |
| what‑it‑does | buffering |