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HighDroxy Retinaid Forte

Retinaid Forte

Advanced retinol care with stabilized retinaldehyde & bakuchiol and other active ingredients.
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Ingredients overview

Aqua (Water Serves As Solvent And Consistency Enhancer), Pentylene Glycol (Pentylene Glycol Is A Solvent With Moisture-Binding And Antimicrobial Properties), Passiflora Edulis Seed Oil (Passion Fruit Seed Oil Has A Calming And Anti-Inflammatory Effect Due To Its High Linoleic Acid Content), Glycerin, Hydrogenated Ethylhexyl Olivate (A Mixture Of Different Esters Derived From Olive Oil With Softening And Skin-Caring Properties), Hydrogenated Olive Oil Unsaponifiables (Lipid Extracted From Olive Oil With Nourishing Properties), Sr-Spider Polypeptide-1 (Silk Proteins Protect The Skin By Means Of A Breathable Film), Isosorbide Dicaprylate, Saccharide Isomerate (Natural Cosmetic Substance Derived From Glucose With Moisture-Binding Properties), [more]Orbignya Oleifera (Babassu) Seed Oil (Babassu Oil Is Quickly Absorbed, Has A Slightly Cooling Effect, Retains Moisture And Leaves The Skin Feeling Soft And Silky), Ubiquinone (Also Known As Q10 Co-Enzyme With Anti-Inflammatory And Antioxidant Properties), Tocopheryl Acetate (The Derivative Of Vitamin E Is An Antioxidant And Radical Scavenger, So It Protects The Skin From Harmful Influences), C12-15 Alkyl Benzoate (Skin-Friendly Lipid Of Synthetic Origin; Combines Nourishing And Antimicrobial Properties), Undaria Pinnatifida (Wakame) Extract (Extract Of The Wakame Algae With Skin-Protecting And Moisture-Preserving Properties), Pectin (Natural Cosmetic Thickener), Xanthan Gum (Xanthan Gum Is A Thickening Agent Derived From Sugar, Which Is Also Used For Organic Food), Chondrus Crispus Extract (Extract Of Red Seaweed With Skin-Caring Properties), Cyclodextrin (Oligosaccharide Complex, Which Is Used Here To Stabilise The Retina), Rubus Chamaemorus (Seed) Oil, Retinaldehyd 0.1%, Ceramide NP, Ceramide AP, Ceramide EOP (Ceramides Are An Endogenous Component Of The Skin Barrier; Protect Them From Harmful Environmental Influences And Regulate The Moisture Balance), Phytosphingosine (Belongs To The Group Of Ceramides; Endogenous Component Of The Skin Barrier), Cholesterol (Endogenous Lipid; Component Of The Cell Mortar In The Horny Layer Of The Skin (Stratum Corneum)), Sodium Lauroyl Lactylate (Sodium Salt Extracted From Vegetable Oil; Is Used As A Mild Emulsifier), Carbomer (Gelling Agent With Stabilizing Properties), Tetrahexyldecyl Ascorbate (Stabilized, As It Is An Oil-Soluble Form Of Vitamin C), Bakuchiol 0.5%, Dipotassium Glycyrrhizate (Extract From The Liquorice Root; Has Anti-Inflammatory And Skin Calming Properties), Magnolia Officinalis Bark Extract (Extract From The Bark Of The Magnolia Tree; Has Anti-Inflammatory, Antibacterial And Antioxidant Properties, Thus Slowing Down Skin Ageing), Sodium Hyaluronate (Hyaluronic Acid Stores Many Times Its Own Volume Of Moisture, Plumping Up The Skin And Stimulating Collagen Formation), Allantoin (Allantoin Has A Wound Healing Promoting, Anti-Inflammatory And Skin Calming Effect), Sodium Carboxymethyl Betaglucan (Film Former Of Plant Origin), Sodium Hydroxide (Sodium Hydroxide Is A Ph Regulator Of Mineral Origin)
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Highlights

#alcohol-free #fragrance & essentialoil-free #knownamountofactive
Alcohol Free
Fragrance and Essential Oil Free
Retinal: 0.1%
Bakuchiol: 0.5%

Key Ingredients

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Other Ingredients

Skim through

Ingredient name what-it-does irr., com. ID-Rating
Aqua (Water Serves As Solvent And Consistency Enhancer) solvent
Pentylene Glycol (Pentylene Glycol Is A Solvent With Moisture-Binding And Antimicrobial Properties) solvent, moisturizer/​humectant
Passiflora Edulis Seed Oil (Passion Fruit Seed Oil Has A Calming And Anti-Inflammatory Effect Due To Its High Linoleic Acid Content) emollient goodie
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar
Hydrogenated Ethylhexyl Olivate (A Mixture Of Different Esters Derived From Olive Oil With Softening And Skin-Caring Properties) emollient
Hydrogenated Olive Oil Unsaponifiables (Lipid Extracted From Olive Oil With Nourishing Properties) emollient
Sr-Spider Polypeptide-1 (Silk Proteins Protect The Skin By Means Of A Breathable Film)
Isosorbide Dicaprylate solvent, moisturizer/​humectant goodie
Saccharide Isomerate (Natural Cosmetic Substance Derived From Glucose With Moisture-Binding Properties) moisturizer/​humectant goodie
Orbignya Oleifera (Babassu) Seed Oil (Babassu Oil Is Quickly Absorbed, Has A Slightly Cooling Effect, Retains Moisture And Leaves The Skin Feeling Soft And Silky) emollient 0, 1
Ubiquinone (Also Known As Q10 Co-Enzyme With Anti-Inflammatory And Antioxidant Properties) antioxidant goodie
Tocopheryl Acetate (The Derivative Of Vitamin E Is An Antioxidant And Radical Scavenger, So It Protects The Skin From Harmful Influences) antioxidant 0, 0
C12-15 Alkyl Benzoate (Skin-Friendly Lipid Of Synthetic Origin; Combines Nourishing And Antimicrobial Properties) emollient, antimicrobial/​antibacterial
Undaria Pinnatifida (Wakame) Extract (Extract Of The Wakame Algae With Skin-Protecting And Moisture-Preserving Properties)
Pectin (Natural Cosmetic Thickener) viscosity controlling
Xanthan Gum (Xanthan Gum Is A Thickening Agent Derived From Sugar, Which Is Also Used For Organic Food) viscosity controlling, emulsifying, surfactant/​cleansing
Chondrus Crispus Extract (Extract Of Red Seaweed With Skin-Caring Properties) moisturizer/​humectant, viscosity controlling goodie
Cyclodextrin (Oligosaccharide Complex, Which Is Used Here To Stabilise The Retina) chelating
Rubus Chamaemorus (Seed) Oil
Retinaldehyd cell-communicating ingredient superstar
Ceramide NP skin-identical ingredient goodie
Ceramide AP skin-identical ingredient goodie
Ceramide EOP (Ceramides Are An Endogenous Component Of The Skin Barrier; Protect Them From Harmful Environmental Influences And Regulate The Moisture Balance) skin-identical ingredient goodie
Phytosphingosine (Belongs To The Group Of Ceramides; Endogenous Component Of The Skin Barrier) skin-identical ingredient, cell-communicating ingredient, anti-acne, antimicrobial/​antibacterial goodie
Cholesterol (Endogenous Lipid; Component Of The Cell Mortar In The Horny Layer Of The Skin (Stratum Corneum)) skin-identical ingredient, emollient 0, 0 goodie
Sodium Lauroyl Lactylate (Sodium Salt Extracted From Vegetable Oil; Is Used As A Mild Emulsifier) emulsifying
Carbomer (Gelling Agent With Stabilizing Properties) viscosity controlling 0, 1
Tetrahexyldecyl Ascorbate (Stabilized, As It Is An Oil-Soluble Form Of Vitamin C) antioxidant, skin brightening goodie
Bakuchiol cell-communicating ingredient, antimicrobial/​antibacterial, antioxidant, emollient goodie
Dipotassium Glycyrrhizate (Extract From The Liquorice Root; Has Anti-Inflammatory And Skin Calming Properties) soothing, moisturizer/​humectant goodie
Magnolia Officinalis Bark Extract (Extract From The Bark Of The Magnolia Tree; Has Anti-Inflammatory, Antibacterial And Antioxidant Properties, Thus Slowing Down Skin Ageing) antimicrobial/​antibacterial
Sodium Hyaluronate (Hyaluronic Acid Stores Many Times Its Own Volume Of Moisture, Plumping Up The Skin And Stimulating Collagen Formation) skin-identical ingredient, moisturizer/​humectant 0, 0 goodie
Allantoin (Allantoin Has A Wound Healing Promoting, Anti-Inflammatory And Skin Calming Effect) soothing 0, 0 goodie
Sodium Carboxymethyl Betaglucan (Film Former Of Plant Origin) viscosity controlling
Sodium Hydroxide (Sodium Hydroxide Is A Ph Regulator Of Mineral Origin) buffering

HighDroxy Retinaid Forte
Ingredients explained

Also-called: Water | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

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Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product feel great on the skin. It works synergistically with preservatives and helps to improve water-resistance of sunscreens. 

Also-called: Passion Fruit Oil | What-it-does: emollient

The emollient plant oil coming from the passion fruit. It is a high-linoleic acid oil (about 70% LA and 15% oleic acid), that makes your skin feel nice and smooth and supports a healthy skin barrier. As a high-LA oil, it is suitable for all skin types including acne-prone.

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

We don't have description for this ingredient yet.

What-it-does: moisturizer/humectant

A 100% natural and plant-derived moisturizer that mimics the natural carbohydrate fraction found in the upper layer of the skin. Its special magic power is to bind to the skin stronger and longer than other moisturizer ingredients do so it can keep the skin hydrated longer than usual.

Also-called: Babassu Oil | What-it-does: emollient | Irritancy: 0 | Comedogenicity: 1

We don't have description for this ingredient yet.

Also-called: Coenzyme Q10 | What-it-does: antioxidant

Thanks to Nivea, Q10 is a pretty well-known ingredient and the fame and Beiersdorf's (the parent company of Nivea) obsession with it are not for no reason. It's an antioxidant found naturally in human cells where it plays a big role in energy production.

In fact, it's so important for energy production that if taken as an oral supplement it has a caffeine-like effect and if taken at night you will probably not sleep very well (so you should take it in the morning). Q10 supplementation is not a bad idea: it not only gives you energy but research also shows that oral Q10 increases the Q10 level of the skin (of course, it decreases with age like pretty much every good thing in the skin) and may help to reduce wrinkles. If you are not for supplements, dietary sources include fish, spinach, and nuts.

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As for skincare, Q10 comes in the form of a yellow, oil-soluble powder that's shown to absorb into the upper layer of the skin and act there like an awesome antioxidant. It not only has preventative effects but might also be able to reduce the depth of wrinkles, though 0.3% Q10 was used in the study that counts as really high (products containing that much should be very yellow!). 

Also-called: Vitamin E Acetate | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 0

It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version. 

According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E. 

An often used emollient with a light and silky feel. It's very mild to both skin and eyes and spreads nicely and easily. It's often used in sunscreens as it's also an excellent solvent for sunscreen agents. 

We don't have description for this ingredient yet.

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range. 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

Also-called: Carrageenan Extract, Seaweed Extract | What-it-does: moisturizer/humectant, viscosity controlling

The extract of red seaweed that has nice film-forming, skin smoothing and moisturizing properties.​

The manufacturer claims that thanks to biomimetic properties between skin proteins and carrageenans it has a very long-lasting action and can form a "second skin". It also gives a "slow-release" effect to oil-loving active ingredients and measurably reduces trans-epidermal water loss (that's pretty much a synonym of saying that it moisturizes the skin). 

Also-called: Cloudberry Seed Oil;Rubus Chamaemorus Seed Oil

We don't have description for this ingredient yet.

Retinaldehyd - superstar
Also-called: Form of Retinoids, Retinaldehyde;Retinal | What-it-does: cell-communicating ingredient

If you are reading here, we are pretty sure the words retinoids and retinol ring a bell, but if not, you are seriously missing out, please click here immediately to catch up.  The TL;DR version is that retinoids are the royal family of skincare with tretinoin being the queen, the only FDA-approved ingredient to treat the signs of photoaging. Retinol is like a grandkid, it has to be converted (through two steps) in the skin to become retinoic acid. The conversion means retinol is both less effective and less harsh on the skin. 

So where does our current molecule, Retinal, aka Retinaldehyde fit into the family (btw, here is a nice visual family tree about who is who)?  Remember that retinol needed two conversion steps to become retinoic acid? Yes, you are right, Retinal is the intermediate step between retinoic acid and retinol, meaning it needs only one conversion step to become active in the skin. If we go with our royal family analogy, Retinal is Prince Charles, directly next in line to the throne. 

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Once retinal is converted, it becomes retinoic acid and does the same things we detailed in our tretinoin description. In a nutshell, it is everything you expect from an anti-aging superstar such as decreased wrinkles, smoother, firmer and more elastic skin

This sounds good, but how does Retinal compare to retinoic acid? Good question! We found a study (a pretty good one with 125 patients) that compared 0.05% retinal with 0.05% retinoic acid (and vehicle).  They concluded that "at week 18, a significant reduction of the wrinkle and roughness features was observed with both retinaldehyde and retinoic acid." and the difference between the two was not statistically significant. (Interestingly, in both groups, the results were less significant at week 44, so it might be a good idea to have a retinoid break from time to time?) Also, our guy, Retinal was much better tolerated than retinoic acid known for its harshness. 

The good tolerability of retinal was also confirmed by another study that compared retinol (ROL), retinal (RAL) and retinoic acid (RA). They found that "the natural retinoids ROL and RAL do have a good tolerance profile, in contrast with the irritating potential of RA", meaning retinal is an awesome alternative if you have irritation and flaking issues with prescription products, such as Retin-A. 

Last, but not least, we want to mention a pretty big (but subjectively evaluated), Avene (the French pharmacy brand famous for its Retinal products) sponsored study that examined the tolerability and efficacy of a 0.1 Retinal + 6% glycolic acid product in the treatment of acne. The product was added next to the standard anti-acne regimen of 1,709 patients for 90 days and the study concluded that the formula was both very well tolerated as well as effective next to other standard anti-acne medications such as benzoyl peroxide and antibiotics.

Overall, if you are into retinoids, Retinal is a really awesome and well-proven member of the family that is absolutely worth trying. 

Ceramide NP - goodie
Also-called: Ceramide 3 | What-it-does: skin-identical ingredient

One of the many types of ceramides that can be found naturally in the upper layer of the skin. Ceramides make up about 50% of the goopy stuff that's between our skin cells and play a super important role in having a healthy skin barrier and keeping the skin hydrated. It works even better when combined with its pal, Ceramide 1.

We wrote way more about ceramides at ceramide 1, so click here to know more.

Ceramide AP - goodie
Also-called: Ceramide 6 II | What-it-does: skin-identical ingredient

A type of ceramide that can be found naturally in the upper layer of the skin. Ceramides make up 50% of the goopy stuff that's between our skin cells and play a super important role in having a healthy skin barrier and keeping the skin hydrated. 

We have written way more about ceramides at ceramide 1, so click here to know more.

Also-called: Ceramide 1 | What-it-does: skin-identical ingredient

Ceramides get quite a lot of hype recently and good news: there is a reason for that. But before we go into the details, let's just quickly define what the heck ceramides are:

They are waxy lipids that can be found naturally in the outer layer of the skin (called stratum corneum - SC). And they are there in big amounts! The goopy stuff between our skin cells is called extracellular matrix that consists mainly of lipids. And ceramides are about 50% of those lipids (the other important ones are cholesterol with 25% and fatty acids with 15%). 

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Ok, so now we know what ceramides are, let's see what they do in our skin: research shows clearly that they play a super important role in keeping the skin barrier healthy and the skin hydrated. If ceramides in the skin are decreased, more water can evaporate from the skin and there is less water remaining in the skin. So ceramides form kind of a "water-proof" protecting layer and make sure that our skin remains nice and hydrated. 

Now the question is only this: If we put ceramides all over our face do they work as well as ceramides already naturally in our skin? Well, the answer is probably a no, but they do work to some extent. The BeautyBrains blog made a fantastic article about ceramides and they have listed a couple of examples about studies showing that ceramides - especially when used in certain ratios with cholesterol and fatty acids  - do hydrate the skin and can help to repair the skin barrier.

So far we were writing about ceramides in plural. It's because there are lots of different ceramides, a 2014 article writes that currently 12 base classes of ceramides are known with over 340 specific species. Chemically speaking, ceramides are the connection of a fatty acid and a sphingoid base and both parts can have different variations that result in the different types of ceramides. 

Our current one, Ceramide 1, or more recently called Ceramide EOP, was the first one that was identified in 1982 and it's a special snowflake. It contains the essential fatty acid, linoleic acid and has a unique structure. It's believed that ceramide 1 plays a "binding role" in the lipid layers of the extracellular matrix. Along with ceramides 4 and 7, they also play a vital role in epidermal integrity and serve as the main storage areas for linoleic acid (a fatty acid that's also very important for barrier repair).  

Oh, and one more thing: alkaline pH inhibits enzymes that help ceramide synthesis in our skin. So if you use a soap and you notice your skin is becoming dry, now you know why. 

It's a type of lipid, a so-called sphingoid base that can be found naturally in the upper layer of the skin. It's found both in "free-form" and as part of famous skin lipids, ceramides.

There is emerging research about Phytosphingosine that shows that it has antimicrobial and cell-communicating properties and is considered part of the skin's natural defense system.

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A 2007 study showed that Phytosphingosine even works against evil acne-causing bacteria, Propionibacterium acnes and shows promise as a complementing active ingredient in treating acne-prone skin thanks to its anti-inflammatory and antimicrobial activities.  

A nice one to spot in the ingredient list. :)

What-it-does: skin-identical ingredient, emollient | Irritancy: 0 | Comedogenicity: 0

It's one of the important lipids that can be found naturally in the outer layer of the skin. About 25% of the goopy stuff between our skin cells consists of cholesterol. Together with ceramides and fatty acids, they play a vital role in having a healthy skin barrier and keeping the skin hydrated. 

Apart from being an important skin-identical ingredient, it's also an emollient and stabilizer

What-it-does: emulsifying

A helper ingredient that's used as a co-emulsifier (meaning next to other emulsifiers in the formula it helps water and oil to mix) and as a stabilization agent for foams. Also, has some antimicrobial activity so it can help to boost the effectiveness of the preservative system.

What-it-does: viscosity controlling, emulsion stabilising | Irritancy: 0 | Comedogenicity: 1

A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula.  It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.

Also-called: Form of Vitamin C, Ascorbyl Isotetrapalmitate, Ascorbyl Tetraisopalmitate, ATIP | What-it-does: antioxidant, skin brightening

Tetrahexyldecyl Ascorbate is a stable, oil-soluble form of skincare big shot Vitamin C. If you do not know, why Vitamin C is such a big deal in skincare, click here and read all about it. We are massive vitamin C fans and have written about it in excruciating detail.

So now, you know that Vitamin C is great and all, but it's really unstable and gives cosmetics companies many headaches. To solve this problem they came up with vitamin C derivatives, and one of them is Tetrahexyldecyl Ascorbate (let's call it ATIP in short).

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It's a really promising candidate (see below), but while reading all the goodness about it in a minute, do not forget that derivatives not only have to be absorbed into the skin but also have to be converted to pure vitamin C (ascorbic acid or AA) and the efficacy of the conversion is often unknown. In addition, vitamin C's three magic properties (antioxidant, collagen booster, skin brightener) are all properly proven in-vivo (on real people), but for the derivatives, it's mostly in-vitro studies or in the case of ATIP, it's in-vitro and done by an ingredient supplier.

With this context in mind let's see what ATIP might be able to do. First, it is stable (if pH < 5), easy to formulate and a joy to work with for a cosmetic chemist.

Second, because it's oil-soluble, its skin penetration abilities seem to be great. So great in fact, that it surpasses the penetration of pure vitamin C threefold at the same concentration and it penetrates successfully into the deeper layers of the skin (that is usually important to do some anti-aging work). There is also in-vitro data showing that it converts to AA in the skin. 

Third, ATIP seems to have all three magic abilities of pure vitamin C: it gives antioxidant protection from both UVB and UVA rays, it increases collagen synthesis (even more than AA) and it has a skin brightening effect by reducing melanogenesis by more than 80% in human melanoma cell cultures.

So this all sounds really great, but these are only in-vitro results at this point. We could find Tetrahexyldecyl Ascorbate mentioned only in one published in-vivo study that examined the anti-aging properties of a silicone formula containing 10% AA and 7% ATIP. The authors theorized that the 10% AA is released slowly from the silicon delivery system and probably stays in the upper layer of the skin to give antioxidant benefits, while ATIP penetrates more rapidly and deeply and gives some wrinkle-reducing benefits. The study was a small (10 patients), double-blind experiment, and the formula did show some measurable anti-aging results. However, it is hard to know how much pure vitamin C or ATIP can be thanked.

Bottom line: a really promising, but not well-proven vitamin C derivative that can be worth a try especially if you like experimenting (but if you like the tried and true, pure vitamin C will be your best bet).

Bakuchiol - goodie
Also-called: Sytenol A, Phyto Retinol | What-it-does: cell-communicating ingredient, antimicrobial/antibacterial, antioxidant, emollient

At first glance, you could think that Bakuchiol is your average plant extract. It is derived from the seeds of Psoralea Corylifolia, aka Babchi, a plant important in Indian and Chinese medicine. The molecule was first isolated in 1973 and several anti-something properties are known about it: it has anti-inflammatory, antioxidant, anti-tumor, anti-bacterial and hepatoprotective magical abilities like plenty of other Ayurvedic plant extracts.

What makes Bakuchiol a special snowflake is the recent discovery that it behaves on the skin in a way very similar to well-known skincare superstar, retinol. While chemically, it has nothing to do with the vitamin-A family, aka retinoids, comparative gene expression profiling (a fancy way of saying that they compared how retinol and bakuchiol modify the way  skin cells behave and produce important skin proteins such as collagen) shows that retinol and bakuchiol regulate skin cell behavior in a similar way. 

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To be more specific, both Bakuchiol and retinol upregulate collagen I, III and IV production and downregulate MMP, the evil collagen attacking enzyme in our skin. This means more collagen stays in our skin and we all know that more collagen equals firmer, more wrinkle-free skin.  A 12-week clinical study using a 0.5% Bakuchiol formula with 17 people using it twice a day confirmed a significant improvement in lines and wrinkles, elasticity, firmness and an overall reduction in photo-damage. Also, the test formula was very well tolerated, without any retinol-like side effects. 

What's more, a 2018 double-blind study with 44 people compared 0.5% Bakuchiol with 0.5% retinol cream and found that "bakuchiol is comparable to retinol in its ability to improve photoaging and is better tolerated than retinol". A super promising result after 12 weeks. 

If you are not a daredevil-type who doesn't want to stop using a super well-proven retinol for a newbie like Bakuchiol, we have good news. The two also work very nicely together and Bakuchiol can actually help to stabilize the otherwise unstable and hard to formulate retinol.

And we are still not done, as Bakuchiol shows not only anti-aging properties but also nice anti-acne effects. 1% Bakuchiol seems to be very effective in itself (57% reduction in acne after 6 weeks treatment) and even better when combined with 2% salicylic acid (67% reduction in acne after 6 weeks). We like that Bakuchiol is such a good team player!  The molecule works against acne in multiple ways: It downregulates 5α-reductase (a sebum-controlling enzyme), it is antibacterial (including P. acnes), anti-inflammatory and it inhibits lipid-peroxidation, an evil oxidative process that is recently thought to be a very early trigger in the acne process. 

We feel that this description is becoming very long so we will just mention that Bakuchiol also seems to positively regulate hydration-related genes such as Aquaporin 3 and also shows some melanin-inhibiting properties

Overall, we think Bakuchiol is an awesome molecule with lots of promise both for anti-aging and anti-acne. But the proof compared to the well-established superstars is far from solid, so in a skincare routine, we would rather add Bakuchiol next to retinol than straight up replace it. Unless you are a gimme-the-newest-shiny-thing-under-the-sun-type. 

Also-called: Licorice | What-it-does: soothing, moisturizer/humectant

The salt form of one of the main anti-inflammatory ingredients in the licorice plant, monoammonium glycyrrhizinate. It’s a yellowish powder with a nice sweet smell. 

It’s used mainly for its soothing and anti-inflammatory properties, but according to manufacturer info, it’s also sebum regulating so it's a perfect ingredient for problem skin products. 

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Read more about licorice and why it's a skincare superstar here. 

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It’s the - sodium form - cousin of the famous NMFhyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

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In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).

What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists. 

If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

What-it-does: soothing | Irritancy: 0 | Comedogenicity: 0

Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. 

It's not only soothing but it' also skin-softening and protecting and can promote wound healing.

What-it-does: viscosity controlling

We don't have description for this ingredient yet.

Also-called: lye | What-it-does: buffering

The unfancy name for it is lye. It’s a solid white stuff that’s very alkaline and used in small amounts to adjust the pH of the product and make it just right. 

For example, in case of AHA or BHA exfoliants, the right pH is super-duper important, and pH adjusters like sodium hydroxide are needed.  

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BTW, lye is not something new. It was already used by ancient Egyptians to help oil and fat magically turn into something else. Can you guess what? Yes, it’s soap. It still often shows up in the ingredient list of soaps and other cleansers.

Sodium hydroxide in itself is a potent skin irritant, but once it's reacted (as it is usually in skin care products, like exfoliants) it is totally harmless.

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