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Isosorbide Dicaprylate

Isosorbide Dicaprylate



Isosorbide Dicaprylate (IDC) is a smart, oil-loving skin hydrator and barrier builder molecule. It works synergistically with glycerin as it up-regulates Aquaporin 3 (AQP3), an important transmembrane protein that transports our beloved friend glycerin, along with its’ hydrating groupie water molecules that surround it, into the cell. To put it more simply - AQP3 makes sure that glycerin and water are well distributed in the outer layer of the skin and thus the skin is well-hydrated. 

IDC is also claimed to upregulate the expression of CD44 (a hyaluronic acid binding receptor), ceramide synthase (an enzyme required for ceramide synthesis), and decrease transepidermal water loss (TEWL).

The clinical study done by the manufacturer showed that a direct comparison between 2% IDC versus 2% glycerin lotions revealed a three-fold advantage of IDC in giving skin hydration. Severely dry skin treated with 2% IDC + 2% glycerin showed 133% improvement, whereas 35% improvement was observed with moderately dry skin.

Show me some proof

  • Chaudhuri, R. K., and K. Bojanowski. "Improvement of hydration and epidermal barrier function in human skin by a novel compound isosorbide dicaprylate." International journal of cosmetic science 39.5 (2017): 518-526.

Products with Isosorbide Dicaprylate

Pacifica Beauty Crystal Primer Powered Up Revision Skincare Retinol Complete .5 Apivita Bee Radiant Cream, Light Texture Demarché Labs Smartsync Probiotic Science Balancing Gel Cream ISOMERS Skincare Glutathiosome Booster Isomers Bio-Lift Gaba Eye Mask Pacifica Cherry Matte Primer Revision Skincare Bodifirm SkinBetter Solo Hydrating Defense Men Apivita Pure Jasmine Moisturizing Body Milk Apivita Rose Pepper Firming & Reshaping Body Cream Apivita Wine Elixir Wrinkle & Firmness Lift Cream (Light Cream) Apivita Wine Elixir Wrinkle & Firmness Lift Cream (Rich Texture) Apivita Wine Elixir Wrinkles & Firmness Lift Serum Formula 10.0.6 Mega Serum Vitamin E Restoring Face Serum ISOMERS Skincare Pro-Barrier Cica Body Cream ISOMERS Skincare Pro-Barrier Cica Cream Innbeauty Project Green Machine Innbeauty Project Green Machine Vitamin C + Green Superfood Jelly Serum Isomers All-In-One The Cream Jafra Revitalize Extra Hydration Serum Kid Sister Super Ego Face Oil Regimen Lab C.R.E.A.M. Revision Skincare Necktifirm Advanced Revision Skincare Nectifirm Advanced SIMPLICITEA Turn Back Time SkinBetter Hydration Boosting Cream Apivita Bee Radiant Age Defense Illuminating Eye Cream Apivita Caring Lavender Lotion Apivita Express Intensive Moisturization Face Mask (Cucumber) Apivita Wine Elixir Renewing Lift Night Cream Apivita Wine Elixir Wrinkle Lift Eye & Lip Cream Apivita Wine Elixir Wrinkle Lift Eye & Lip Cream Kate Somerville Kx Active Concentrates Squalane + Hyaluronic Serum MALIN + GOETZ Revitalizing Eye Cream PCA Skin C&E Advanced With Hexylresorcinol And Silymarin (1 Fl Oz.) PCA Skin Intensive Age Refining Treatment: 0.5% Pure Retinol REPLENIX Brightening Boost Pigment Correcting Cream Tan-Luxe Super Gloss SPF30 EVER Skincare Hydralift Oil-Free Moisture Injection Gel With Lsr10® Good Science Beauty 003-Hy Hydrating Face Cream Herbal Dynamics Beauty Prickly Pear & Vitamin C Daily Face Moisturizer Kate Somerville Dermal Quench Wrinkle Warrior Advanced Hydrating + Plumping Treatment LANCER Omega Hydrating Oil NYDG Formula 119 Cream Olive & June Cuticle Serum Palsons Hydranet Lotion Plexus Joyome Day Serum Apivita Wine Elixir Wrinkle & Firmness Lift Cream Rich Texture Formulathions Dead Sea Age Smart Anti-Age Cream