High Performance Neck & Décolletage Cream
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Dr Macrene High Performance Neck & Décolletage CreamIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
The unsaponifiable part of sunflower oil. It's the small part of the oil that resists saponification, the chemical reaction that happens during soap making.
If you want to understand saponification more, here is a short explanation (if not, we understand, just skip this paragraph): Oils are mostly made up of triglyceride molecules (a glycerin + three fatty acids attached to it) and during the soap making process a strong base splits the triglyceride molecule up to become a separate glycerin and three soap molecules (sodium salts of fatty acids). The fantastic Labmuffin blog has a handy explanation with great drawings about the soap-making reaction.
So, the triglyceride molecules are the saponifiable part of the oil, and the rest is the unsaponifiable part. In the case of sunflower oil, it's about 1.5-2% of the oil and consists of skin nourishing molecules like free fatty acids (fatty acids not bound up in a triglyceride molecule, it contains mainly (48-74% according to its spec) barrier building linoleic acid), tocopherol (vitamin E) and sterols.
According to manufacturer's info, it's an oily ingredient that not only simply moisturizes the skin but also has great lipid-replenishing and soothing properties. The clinical study done by the manufacturer (on 20 people) found that a cream with 2% active increases skin moisturization by 48.6% after 1 hour, and 34.2% after 24 hours. Applied twice daily for 4 weeks, the study participants had a major improvement in skin dryness, roughness, and desquamation (skin peeling) parameters.
Jojoba-derived emollient wax esters (fatty acid + fatty alcohol) that make your skin feel nice and smooth. Chemically speaking, pure jojoba oil is also a wax ester (read our shiny explanation here), however, the ingredients called jojoba esters on the ingredient lists are made from jojoba oil and/or hydrogenated jojoba oil via interesterification.
They have multiple versions with variable fatty acid chain length and the ingredient can have a liquid, a creamy, a soft or firm paste, or even a hard wax consistency. The common thing between all versions is, that unlike most normal triglyceride oils, jojoba esters have superior stability, provide non-greasy emolliency and are readily absorbed into the skin.
We don't have description for this ingredient yet.
A so-called fatty (the good, non-drying kind of) alcohol that does all kinds of things in a skincare product: it makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier). Can be derived from coconut or palm kernel oil.
A popular, vegetable-derived oil-loving emulsifier that helps water to mix with oil. In itself, it is suitable for water-in-oil emulsions (where water droplets are dispersed in oil), but it is more often used as a co-emulsifier next to other, water-loving emulsifiers.
Chemically speaking, it comes from the attachment of sorbitan (a dehydrated sorbitol (sugar) molecule) with the fatty acid Stearic Acid, that creates a partly water (the sorbitan part) and partly oil soluble (stearic part) molecule.
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
- Green tea is one of the most researched natural ingredients
- The active parts are called polyphenols, or more precisely catechins (EGCG being the most abundant and most active catechin)
- There can be huge quality differences between green tea extracts. The good ones contain 50-90% catechins (and often make the product brown and give it a distinctive smell)
- Green tea is proven to be a great antioxidant, UV protectant, anti-inflammatory, anticarcinogenic and antimicrobial
- Because of these awesome properties green tea is a great choice for anti-aging and also for skin diseases including rosacea, acne and atopic dermatitis
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
Theobroma means "food of the gods" in Greek though probably "treat of the people" would be more spot on. The cacao fruits and especially the seeds in it need no introduction as everyone knows them as the magical raw material of the magical sweet treat, chocolate (the flavour is composed of more than 1200(!) substances, and the exact chemical nature of it is not really understood, so it's indeed magic. :)).
As for skincare, cocoa butter counts as a rich emollient that can moisturize and nourish even the driest skin (think chapped hands or lips). It's solid at room temperature and melts nicely when you smear it on. It's loaded with good-for-the-skin things: it contains fatty acids, mainly oleic (35%), stearic (34%), and palmitic (25%) and it also has antioxidant vitamin E and polyphenols.
An ex-vivo (made on human skin but not on real people) study examined the cocoa polyphenols and found that 0.5-0.75% of them improved skin tone and elasticity and had a similarly positive impact on GAGs (important natural moisturizing factors in the skin) and collagen synthesis than a commercial high-end moisturizer (it was an Estee Lauder one).
All in all, cocoa butter is a goodie, especially for very dry skin.
A polysaccharide (a big sugar molecule) coming from the edible fruit bodies of the Silver Ear mushroom in China. Legend has it, imperial Concubine Yang Kuei-fei - the most beautiful woman in Chinese history - used it for her facial care.
So Tremella Extract is a big molecule (more than 1M Da molecular weight) with sugar constituents of Mannose, Xylose, and Glucuronic acid (20%). The last one is the most important one, as Glucuronic acid is also a major component in hyaluronic acid (HA). Thanks to this, Tremella is claimed to be an awesome moisturizer with slightly greater water-holding capacities than HA itself. This is quite a big deal as HA is known for its crazy water-holding capacity (up to 1000 times its own weight).
Not only that but Tremella also seems to have some antioxidant effect, it's not sticky (humectants do tend to be sticky) and it leaves skin moist and smooth. No wonder, Concubine Yang Kuei-fei liked this mushroom.
We love a cold slice of watermelon on a hot summer day and we love watermelon as a skincare ingredient. It's really full of good-for-the-skin stuff: it contains a bunch of vitamins (A, B, C and E), mineral salts (K, Mg, Ca and Fe), amino acids citrulline and arginine and antioxidant carotenoids and phenolics.
It's especially rich in potent antioxidant, lycopene (a type of carotenoid), the cool pigment that's responsible for the red color of the watermelon. According to manufacturer info, in-vitro (made in the lab not on real people) studies show that watermelon extract gives significant DNA protection against UV damage. The in-vivo (made on real people) study also confirmed this and the watermelon formula showed 25% increase in skin protection compared to placebo.
All in all, a cool fruit extract with potent antioxidant magic abilities.
An extract coming from red algae that's rich in milk sugar polysaccharide called galactan. According to the manufacturer, it can stimulate the telosomic protein expression thus limiting the shortening of telomeres.
Telomeres are like the plastic tips at the end of shoelaces: they give a protective ending to the DNA strands. The problem is that they get shorter and shorter with chromosome replication and after a while, they cannot protect the DNA strands anymore so DNA gets damaged and our cells cannot do their job. Based on this theory, it's believed that limiting the shortening of telomeres can maintain skin cell longevity and delay the skin aging process.
The in-vitro (in the lab) tests by the manufacturer showed that 0.5% Telesomyl on pre-senescence human fibroblasts reduced stress-induced telomeres shortening by 65%. The in-vivo (on people) tests showed that after 42 days, Telesomyl improved the appearance of the dermal matrix by 30.2%, smoothed the skin’s surface around the crow’s feet area, and improved the perceived age of the panellists by 3 years.
We don't have description for this ingredient yet.
If you are looking for a reason why red wine is good for you, good news, you have found it! Resveratrol, aka the "red grape antioxidant" is the thing that's suspected to keep the French from coronary heart disease despite their not so healthy eating habits (such as high saturated fat intake).
So resveratrol, found in the seed and skin of the red grape (and berries), is a pretty well-known and well-studied molecule that has potent antioxidant, anti-inflammatory, and anticarcinogenic abilities. Most of the studies were done examining resveratrol's promising anti-cancer properties, but as for skin care, it shows a potent protective effect against UV-caused oxidative stress as well as promising effects against multiple types of skin cancer including the most severe one, melanoma (as an adjuvant therapy).
When it comes to skincare and antioxidants, "the more the merrier", so resveratrol is definitely a nice addition to any skincare routine.
It's one of the active parts of Chamomile that contains about 30% of bisabolol. It's a clear oily fluid that is used in skincare as a nice anti-inflammatory and soothing ingredient.
- Primary fat-soluble antioxidant in our skin
- Significant photoprotection against UVB rays
- Vit C + Vit E work in synergy and provide great photoprotection
- Has emollient properties
- Easy to formulate, stable and relatively inexpensive
Tetrahexyldecyl Ascorbate is a stable, oil-soluble form of skincare big shot Vitamin C. If you do not know, why Vitamin C is such a big deal in skincare, click here and read all about it. We are massive vitamin C fans and have written about it in excruciating detail.
So now, you know that Vitamin C is great and all, but it's really unstable and gives cosmetics companies many headaches. To solve this problem they came up with vitamin C derivatives, and one of them is Tetrahexyldecyl Ascorbate (let's call it THDA in short).
It's a really promising candidate (see below), but while reading all the goodness about it in a minute, do not forget that derivatives not only have to be absorbed into the skin but also have to be converted to pure vitamin C (ascorbic acid or AA) and the efficacy of the conversion is often unknown. In addition, vitamin C's three magic properties (antioxidant, collagen booster, skin brightener) are all properly proven in-vivo (on real people), but for the derivatives, it's mostly in-vitro studies or in the case of THDA, it's in-vitro and done by an ingredient supplier.
With this context in mind let's see what THDA might be able to do. First, it is stable (if pH < 5), easy to formulate, and a joy to work with for a cosmetic chemist.
Second, because it's oil-soluble, its skin penetration abilities seem to be great. So great in fact, that it surpasses the penetration of pure vitamin C threefold at the same concentration and it penetrates successfully into the deeper layers of the skin (that is usually important to do some anti-aging work). There is also in-vitro data showing that it converts to AA in the skin.
Third, THDA seems to have all three magic abilities of pure vitamin C: it gives antioxidant protection from both UVB and UVA rays, it increases collagen synthesis (even more than AA) and it has a skin brightening effect by reducing melanogenesis by more than 80% in human melanoma cell cultures.
So this all sounds really great, but these are only in-vitro results at this point. We could find Tetrahexyldecyl Ascorbate mentioned only in one published in-vivo study that examined the anti-aging properties of a silicone formula containing 10% AA and 7% THDA. The authors theorized that the 10% AA is released slowly from the silicon delivery system and probably stays in the upper layer of the skin to give antioxidant benefits, while THDA penetrates more rapidly and deeply and gives some wrinkle-reducing benefits. The study was a small (10 patients), double-blind experiment, and the formula did show some measurable anti-aging results. However, it is hard to know how much pure vitamin C or THDA can be thanked.
Bottom line: a really promising, but not well-proven vitamin C derivative that can be worth a try especially if you like experimenting (but if you like the tried and true, pure vitamin C will be your best bet).
Sodium Acetylated Hyaluronate is a variation of current IT moisturizer, Hyaluronic acid, where some water-loving -OH groups are replaced by amphipathic (partly water-loving and partly water-hating) acetyl groups. The modified molecule is claimed to have even better moisture retention ability than normal HA and better affinity to the skin surface.
The better affinity comes from the acetyl groups that act as tiny "anchors" to attach the HA molecule to the skin. Staying on top of the skin better and longer means longer-lasting surface hydration and improved elasticity. It is also less sticky and more cosmetically elegant than normal HA, so no wonder the nickname of this molecule is super hyaluronic acid.
It's a super small, chemically chopped up version of sodium hyaluronate. Its trade name is miniHA, and its molecular weight is 10 kDa. This counts as really tiny given that "normal" HA has a molecular weight of 0.5-2 million Da.
To be honest, low molecular weight (LMW), and especially this ultra-low molecular weight HA is a controversial ingredient. On the upside, it can penetrate the skin better (though 10kDa still counts as big!) and might be able to moisturize the deeper layers of the skin where normal HA cannot get. Also, according to the manufacturer of miniHA, it has better antioxidant activity than a 1.6MDa version HA and it also has better sun protection and after-sun repair abilities than the higher MW versions. It also works in synergy with higher molecular weight versions, and the combination of 0.1% 1.45MDa-HA + 0.1% 380 kDa-HA + 0.1% miniHA hydrated the skin significantly better than 0.3% 1.45MDa-HA alone.
On the downside, the biological role of LMW-HA in the skin is being a pro-inflammatory signaling agent and there is a study by another manufacturer called Evonik showing that HA versions with smaller than 50kDa molecular weight might be pro-inflammatory when put on the skin. Granted, the study was only done on reconstituted human epidermis, so it might or might not be like this on real human skin.
If you wanna get confused and read much more about hyaluronic acid and what the different molecular weight versions might or might not do, click here and read our excruciatingly long description.
It's a special "cross-linked" from of IT-moisturizer, hyaluronic acid (HA). Cross-linked means that "normal" HA pieces (1-2 million Da molecular weight) are chemically bound togeather to create a big, "infinite" mesh.
The special HA mesh has a remarkable water-binding capacity, 5 times more than the already crazy water-binding capacity of "normal" HA. This water filled crosslinked HA gel forms a smooth film on the skin and continuously delivers the bound water, so it gives long-term moisturizing benefits.
Btw, crosslinking HA was developed for dermal fillers (as crosslinking helps their longevity), and this guy is the topical version of FDA approved dermal filler called Hylan B gel. Smearing crosslinked version all over ourselves is a newish thing, and incoming evidence so far suggests that it's a great idea, even better than normal HA.
A very recent, 2016 research article compared the topical moisturizing effect of crosslinked HA (not Hylan B gel specifically, but something called Resilient HA or RHA), HMW-HA and LMW-HA and found that "TEWL (that is trans-epidermal water loss, the water that evaporates from the skin) was reduced by 27.8% with RHA, and by 15.6% with HMW HA, but increased by 55.5% with LMW HA." (You can read much more about HMW and LMW HA here in the geeky details section.)
All in all, we think Sodium Hyaluronate Crosspolymer is an awesome version of HA, probably superior to traditional versions, so be happy to spot it on the ingredient list.
It's a "bioengineered" from of skin building block N-acetylglucosamine-6-phosphate (NAG6P) that is used by the skin to synthesize important skin-identical humectants like GAGs and hyaluronan.
According to the manufacturer's in-vitro and ex-vivo (made in the lab not on real people) tests, NovHyal can boost GAGs production both in the upper and middle layer of the skin by 84% in 10 days. It can also increase hyaluronic acid synthesis by 282% in just 2 days. Sounds good, though some in-vivo tests (made on real people) would be nice.
We don't have description for this ingredient yet.
The sodium salt of lactic acid. It's a great skin moisturizer and also used to regulate the pH value of the cosmetic formula. It's a natural ingredient approved by both ECOCERT and COSMOS.
A semi-essential (infants cannot synthesize it, but adults can) amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor, a skin hydrator and might also help to speed up wound healing.
Arginine usually has a positive charge (cationic) that makes it substantive to skin and hair (those are more negatively charged surfaces) and an excellent film former. Thanks to the positive charge, it also creates a complex with AHAs (AHAs like to lose a hydrogen ion and be negatively charged, so the positive and the negative ions attract each other) that causes a "time-release AHA effect" and reduces the irritation associated with AHAs.
A non-essential amino acid (important building block of collagen and elastin) that hydrates the skin. It is also used to set the pH of the cosmetic product (buffering).
PCA stands for Pyrrolidone Carboxylic Acid and though it might not sound like it, it is a thing that can be found naturally in our skin. In fact, after amino acids, it is the second biggest NMF component of the skin with 12% being PCA of the NMF composition of normal skin. So similar to other NMFs, it's a skin goodie that helps the skin to hold onto water and stay nicely hydrated.
A non-essential amino acid (the building blocks of skin proteins, like collagen or elastin), that the body can produce itself, but its production decreases with age. When you put it all over your face, it works as a moisturizer and maybe more.
According to great skincare blog Futurederm, glycine might help with wound healing and tissue repair and when used together with other amino acids, leucine and proline it might improve wrinkles.
BTW, it's also a building block of a bunch of important and famous peptides, including copper-tripeptide-1, palmitoyl tripeptide-1 or palmitoyl hexapeptide-12.
A non-essential amino acid (a building block of skin proteins like collagen or elastin) that hydrates the skin.
Serine is an amino acid that most often comes to the formula as part of a moisturizing complex. It's a non-essential amino acid (meaning that our body can synthesize it) and serves as a water-binding ingredient.
In general, amino acids are great skincare ingredients that play an important role in proper skin hydration but there is not much info out there about what specifically serine can do for the skin.
An essential amino acid (a building block of skin proteins like collagen) that our body cannot produce itself but has to take from external sources, like diet.
It's a branched chain amino acid that is claimed to enhance energy, increase endurance and aid in muscle tissue recovery and repair when taken as a supplement. It's not clear what valine does when you put it on the skin, but as all amino acids, it must be at least a great skin hydrator.
A non-essential amino acid (meaning that our body can produce it) that's also one of the major building blocks of collagen. According to the Futurederm blog, it might be able to improve wrinkles when combined with other amino acids, glycine and leucine
An essential amino acid that's also a key building block of collagen and elastin. When taken orally, it helps the digestive and intestinal tracts function more smoothly and also helps the absorption of nutrients. As for skincare, it is not clear what it does other than being a skin hydrator.
A branch-chained, essential amino acid that can be found in things like almond, cashew or soy protein. When taken orally it may promote protein synthesis. As for skincare - like all the amino acids - it's a skin-identical ingredient and moisturizer. It also seems to be useful as a barrier repair ingredient.
A semi-essential amino acid meaning that enough has to be eaten from it so that the body does not use up essential amino acids (that our body cannot produce itself) to synthesize it. It has an important role in regulating the immune defense, allergic reactions, and inflammatory processes in the body.
As for skincare, it's a skin moisturizer that might also protect from some skin infections.
An essential amino acid that the body cannot produce itself but has to take from the diet. Combined with UVA exposure, phenylalanine is used in the treatment of vitiligo (a pigmentation disorder where patches of the skin lose the pigment).
PCA stands for Pyrrolidone Carboxylic Acid and though it might not sound like it, it is a thing that can be found naturally in our skin. The sodium salt form of PCA is an important skin-identical ingredient and great natural moisturizer that helps the skin to hold onto water and stay nicely hydrated.
It's the chemically chopped up version of normal lecithin. Most often it's used to create liposomes and to coat and stabilize other ingredients.
A 100% plant derived, natural (Ecocert approved) multi-functional ingredient that has emollient and moisturizing properties, can work as a co-emulsifier (meaning that next to other emulsifiers it can help water and oil to mix) and even more importantly has a strong antimicrobial activity.
Thanks to this last thing, it allows a lower percentage of traditional preservative or it might even be able to completely replace them.
We don't have description for this ingredient yet.
It’s one of those little helper ingredients that makes sure the product stays the same over time. No color change or anything like that. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.
A chelating agent that helps to preserve cosmetic products by neutralizing the metal ions (especially iron) in the formula (that usually get into there from water). Its special thing is that it also acts as a biostatic and fungistatic agent and remains active even at high pH.
It is often coupled with antimicrobial glycols (such as propanediol) to create a "preservative free preservative system" for cosmetic products.
A helper ingredient that helps to make the products stay nice longer, aka preservative. It works mainly against fungi.
It’s pH dependent and works best at acidic pH levels (3-5). It’s not strong enough to be used in itself so it’s always combined with something else, often with potassium sorbate.
A mild cleansing agent that's used mainly next to other cleansing agents (co-surfactant) to improve foam density and regulate viscosity.
It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. It’s not a strong one and doesn’t really work against bacteria, but more against mold and yeast. To do that it has to break down to its active form, sorbic acid. For that to happen, there has to be water in the product and the right pH value (pH 3-4).
But even if everything is right, it’s not enough on its own. If you see potassium sorbate you should see some other preservative next to it too.
BTW, it’s also a food preservative and even has an E number, E202.
If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.
Also, it's an effective deodorant and a medium spreading emollient.
Simply alcohol refers to ethanol and it's a pretty controversial ingredient. It has many instant benefits: it's a great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent and antimicrobial. No wonder it's popular in toners and oily skin formulas.
The downside is that it can be very drying if it's in the first few ingredients on an ingredient list.
Some experts even think that regular exposure to alcohol damages skin barrier and causes inflammation though it's a debated opinion. If you wanna know more, we wrote a more detailed explanation about what's the deal with alcohol in skincare products at alcohol denat. (it's also alcohol, but with some additives to make sure no one drinks it).
We don't have description for this ingredient yet.
It's one of the important lipids that can be found naturally in the outer layer of the skin. About 25% of the goopy stuff between our skin cells consists of cholesterol. Together with ceramides and fatty acids, they play a vital role in having a healthy skin barrier and keeping the skin hydrated.
Apart from being an important skin-identical ingredient, it's also an emollient and stabilizer.
It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version.
According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E.
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what‑it‑does | solvent |
what‑it‑does | emollient |
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what‑it‑does | antioxidant | moisturizer/humectant |
what‑it‑does | antioxidant |
what‑it‑does | cell-communicating ingredient |
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what‑it‑does | skin-identical ingredient | antioxidant | moisturizer/humectant |
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what‑it‑does | skin-identical ingredient |
what‑it‑does | skin-identical ingredient |
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what‑it‑does | skin-identical ingredient |
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what‑it‑does | skin-identical ingredient |
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what‑it‑does | skin-identical ingredient |
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what‑it‑does | skin-identical ingredient |
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irritancy, com. | 0, 0 |
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what‑it‑does | viscosity controlling |
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what‑it‑does | preservative |
what‑it‑does | preservative |
what‑it‑does | antimicrobial/antibacterial | solvent | viscosity controlling |
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