Cliniderm

Hydra-Defense Hydrating Cream

PCA stands for Pyrrolidone Carboxylic Acid and though it might not sound like it, it is a thing that can be found naturally in our skin. The sodium salt form of PCA is an important skin-identical ingredient and great natural moisturizer that helps the skin to hold onto water and stay nicely hydrated. 

A type of sugar that has water-binding properties and helps to keep your skin hydrated. 

A biocompatible copolymer (a big molecule that consists of more than one type of building blocks) that has the same structure as important cell membrane ingredient, phospholipid. It's a good skin moisturizer, leaves a silky, smooth feel on the skin and can help to reduce irritation caused by some not-so-nice ingredients (like surfactants).

We don't have description for this ingredient yet.

It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

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A super common, waxy, white, solid stuff that helps water and oil to mix together, gives body to creams and leaves the skin feeling soft and smooth.

Chemically speaking, it is the attachment of a glycerin molecule to the fatty acid called stearic acid. It can be produced from most vegetable oils (in oils three fatty acid molecules are attached to glycerin instead of just one like here) in a pretty simple, "green" process that is similar to soap making. It's readily biodegradable.

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A very common water-loving surfactant and emulsifier that helps to keep water and oil mixed nicely together. 

It's often paired with glyceryl stearate - the two together form a super effective emulsifier duo that's salt and acid tolerant and works over a wide pH range. It also gives a "pleasing product aesthetics", so no wonder it's popular.

A super common, medium-spreading emollient ester that gives richness to the formula and a mild feel during rubout. It can be a replacement for mineral oil and is often combined with other emollients to achieve different sensorial properties.

The oil coming from the pulp of one of the most nutritious fruits in the world, the avocado. It's loaded with the nourishing and moisturizing fatty acid, oleic (70%) and contains some others including palmitic (10%) and linoleic acid (8%). It also contains a bunch of minerals and vitamins A, E and D. 

Avocado oil has extraordinary skin penetration abilities and can nourish different skin layers. It's a very rich, highly moisturizing emollient oil that makes the skin smooth and nourished. Thanks to its vitamin E content it also has some antioxidant properties. As a high-oleic plant oil, it is recommended for dry skin. 

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A sugar based emulsifier that's especially great for low viscosity lotions or even sprays. It's effective in small amounts, only 1-1.5% is needed to form an emulsion. The resulting cream or lotion has great cosmetic properties with good spreadability and an enhanced soft skin feel. 

An extremely common multitasker ingredient that gives your skin a nice soft feel (emollient) and gives body to creams and lotions. It also helps to stabilize oil-water mixes (emulsions), though it does not function as an emulsifier in itself. Its typical use level in most cream type formulas is 2-3%.  

It’s a so-called fatty alcohol, a mix of cetyl and stearyl alcohol, other two emollient fatty alcohols.  Though chemically speaking, it is alcohol (as in, it has an -OH group in its molecule), its properties are totally different from the properties of low molecular weight or drying alcohols such as denat. alcohol. Fatty alcohols have a long oil-soluble (and thus emollient) tail part that makes them absolutely non-drying and non-irritating and are totally ok for the skin.

Lactococcus Ferment Lysate is a fairly new probiotic ingredient that is obtained from the Gram-positive bacteria, Lactococcus lactis. The lysate is a fluid substance that is produced when you break down the cell membrane, which means it contains interesting things including cytoplasm and cell wall fragments.

According to the manufacturer, it positively influences both the speed and quality of epidermal growth that results in better barrier function and overall skin quality. To prove their point, the German manufacturer conducted several in-vitro (made in test tubes) tests examining how the treatment with Lactococcus Ferment Lysate (LFL) affects important skin proteins.

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We don't have description for this ingredient yet.

Serine is an amino acid that most often comes to the formula as part of a moisturizing complex. It's a non-essential amino acid (meaning that our body can synthesize it) and serves as a water-binding ingredient.

In general, amino acids are great skincare ingredients that play an important role in proper skin hydration but there is not much info out there about what specifically serine can do for the skin.

A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product feel great on the skin. It works synergistically with preservatives and helps to improve water-resistance of sunscreens. 

A large sugar molecule (aka polysaccharide) that's used as a gelling agent and comes from brown seaweed. 

Combined with calcium salts, it forms a rigid gel used in "rubber masks". 

It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol. 

The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.

If you ever wondered what those little Listerine breath strips were made of, you found your answer! Pullulan is a polysaccharide polymer, which basically means that it’s a big molecule made up of smaller sugar molecule units.

It dissolves in water and can make a thin, elastic, and moisture-absorbing film when spread on the skin that can cause an instant tightening effect. It can also be used as a thickener to get a silicone-like feel and can be used in peel-off masks. Btw, it's made from fungus via fermentation. 

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It’s a little helper ingredient that helps to set the pH of a cosmetic formulation to be just right.

We all know honey as the sweet, gooey stuff that is lovely to sweeten a good cup of tea and we have good news about putting honey all over our skin. It is just as lovely on the skin as it is in the tea. 

The great review article about honey in the Journal of Cosmetic Dermatology writes that it is arguably the oldest skincare ingredient and evidence from around 4500 BC mentions honey in some eye cream recipes. Chemically speaking, it is a bee-derived, supersaturated sugar solution.  About 95% of honey dry weight is sugar and the other 5% consists of a great number of other minor components including proteins, amino acids, vitamins, enzymes, and minerals. 

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A type of lipid that's the major (about 75%) component of all cell membranes. As for skincare, it works as an emollient and skin-identical ingredient.

It has a water-loving head with two water-hating tails and this structure gives the molecule emulsifying properties. It is also often used to create liposomes, small spheres surrounded by phospholipid bi-layer designed to carry some active ingredient and help its absorption.

We don't have description for this ingredient yet.

• It’s naturally in our skin and behaves there like a sponge
• It can bind up to 1000 times its own weight in water
• It is a big molecule from repeated subunits (polymer) so different molecular weight versions exist (unfortunately there is no way to determine MW from INCI list only)
• High-molecular-weight-HA (>500 kDa) is an excellent surface hydrator, skin protectant and can act as an osmotic pump helping water-soluble actives to penetrate deeper into the skin
• Low-molecular-weight-HA (< 500 kDa) can hydrate the skin somewhat deeper though it is still a big molecule and works mainly in the epidermis (outer layer of the skin)
• Low-molecular-weight-HA might also help the skin to repair itself by increasing its self-defense (~ 200kDa used in the study)
• Ultra-low-molecular-weight-HA (<50kDa) is a controversial ingredient and might work as a pro-inflammatory signal molecule

Castor oil is sourced from the castor bean plant native to tropical areas in Eastern Africa and the Mediterranean Basin. It is an age-old ingredient (it’s over 4,000 years old!) with many uses including as a shoe polish, food additive and motor lubricant. You would be reasonable to think that putting shoe polish on your face wouldn’t be the best idea, but it turns out castor oil has some unique properties that make it a stalwart in thick and gloss-giving formulas (think lipsticks and highlighters).

So what is so special about it? The answer is its main fatty acid, called ricinoleic acid (85-95%).  Unlike other fatty acids, ricinoleic acid has an extra water-loving part (aka -OH group) on its fatty chain that gives Castor Oil several unique properties. First, it is thicker than other oils, then its solubility is different (e.g. dissolves in alcohol but not in mineral oil), and it allows all kinds of chemical modifications other oils do not, hence the lots of Castor oil-derived ingredients. It is also more glossy than other oils, in fact, it creates the highest gloss of all natural oils when applied to the skin. Other than that, it is a very effective emollient and occlusive that reduces skin moisture loss so it is quite common in smaller amounts in moisturizers. 

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A chemically modified version of castor oil that results in a solid, waxy material that serves as an emollient and consistency building material.

It also has some unique moisturizing properties as it is both occlusive and humectant.  The former one is common for oils and waxes and it means that it sits on top of the skin hindering water to evaporate out of the top layers. The latter one, the humectant property, is surprising and comes from the unique property of ricinoleic acid (the dominant fatty acid in castor oil)  having an extra water-loving -OH group on its otherwise oil-loving fatty chain. We have some more info about this at castor oil, so if you are interested, read on here.  

A vegetable wax coming from the leaves of the Brazilian tropical palm tree, Copernicia cerifera. Similar to other waxes, it is used to stabilize and give body to products, or to keep stick type formulas solid. It is the hardest natural wax with a high melting point (around 85C) and high gloss making it a great wax choice for lip products.

It's the yellow, solid stuff that you probably know from beeswax candles. It's a natural material produced by honey bees to build their honeycomb.

As for skincare, it's used as an emollient and thickening agent. It's super common in lip balms and lipsticks. 

We don't have description for this ingredient yet.

A super commonly used 5 unit long, cyclic structured silicone that is water-thin and does not stay on the skin but evaporates from it (called volatile silicone). Similar to other silicones, it gives skin and hair a silky, smooth feel. 

It's often combined with the non-volatile (i.e. stays on the skin) dimethicone as the two together form a water-resistant, breathable protective barrier on the skin without a negative tacky feel.

A thick, high molecular weight silicone that is usually diluted in another, lighter silicone fluid (like dimethicone or cyclopentasiloxane). The dimethiconol containing silicone blends leave a silky smooth, non-greasy film on the skin.

We don't have description for this ingredient yet.

A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives. 

A pale yellow solid material that helps cosmetic products not to go wrong too soon aka preservative.

It has antioxidant and antibacterial activity and can be used synergistically with IT-preservative phenoxyethanol or 1,2-Hexanediol and Caprylyl Glycol to form a broad spectrum preservative system for cosmetic formulas. 

A kind of polymer (big molecule from repeated subunits) that helps to create beautiful gel-like textures. It's also a texturizer and thickener for oil-in-water emulsions. It gives products a good skin feel and does not make the formula tacky or sticky. 

It works over a wide pH range and is used between 0.5-1.2%.

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range. 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

We don't have description for this ingredient yet.

Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.

It is typically used in tiny amounts, around 0.1% or less.

The extract coming from the lovely herb, rosemary. It contains lots of chemicals, including flavonoids, phenolic acids, and diterpenes. Its main active is rosmarinic acid, a potent antioxidant, and anti-inflammatory. It has also anti-bacterial, astringent and toning properties. 

The leaves contain a small amount of essential oil (1-2%) with fragrant components, so if you are allergic to fragrance, it might be better to avoid it.