AZ & Salicylic Acid + Licorice Root Serum
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SKINMADE AZ & Salicylic Acid + Licorice Root SerumIngredients explained
Aloe Vera is one of today’s magic plants. It does have some very nice properties indeed, though famous dermatologist Leslie Baumann warns us in her book that most of the evidence is anecdotal and the plant might be a bit overhyped.
What research does confirm about Aloe is that it’s a great moisturizer and has several anti-inflammatory (among others contains salicylates, polysaccharides, magnesium lactate and C-glucosyl chromone) as well as some antibacterial components. It also helps wound healing and skin regeneration in general. All in all definitely a goodie.
A derivative of clinically proven, superstar ingredient Azelaic Acid and hydrating amino acid Glycine. Azelaic acid is an awesome ingredient with anti-inflammatory, skin lightening and anti-acne effects, but its insolubility (it's soluble neither in water nor in oil) makes it difficult to use it in a cosmetically elegant and versatile way.
The solution is supposed to be Potassium Azeloyl Diglycinate, at least according to the manufacturer. The derivative is very water soluble, easy to use in nice formulas and inherits all the lovely properties of Azelaic acid. It acts as a skin brightening agent via Tyrosinase (a famous enzyme needed to make melanin) inhibition and also has significant sebum normalizing activity.
Regarding research, we could find two studies where Potassium Azeloyl Diglycinate's name popped up. One study examined the management of rosacea and the other one researched the treatment of melasma. Both were successful (we mean people showed improvement :)) but our Azelaic acid derivative was combined with other actives so it's hard to know what to attribute to this guy only.
Overall, a promising multi-function active that's worth checking out if you have pigmentation-prone, acne-prone or rosacea-prone skin.
Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.
BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.
It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
You might know licorice as a sweet treat from your childhood, but it's actually a legume that grows around the Mediterranean Sea, the Middle East, central and southern Russia. It's sweet and yellow and not only used for licorice all sorts but it's also a skincare superstar thanks to two magic properties:
Nr. 1 magic property is that it has skin-lightening or to say it another way depigmenting properties. The most active part is called glabridin. The topical application (meaning when you put it on your face) of 0.5% glabridin was shown to inhibit UVB caused pigmentation of guinea pigs. Another study even suggested that licorice is more effective than the gold standard skin-lightening agent hydroquinone. All in all, licorice is considered to be one of the safest skin lightening agents with the fewest side effects.
There is just one catch regarding glabridin and licorice: the amount of glabridin in commercial licorice extracts can vary a lot. We have seen extracts with only 4% glabridin as well as 40% glabridin. The latter one is a very-very expensive ingredient, so if you are after the depigmenting properties try to choose a product that boasts its high-quality licorice extract.
Nr. 2 magic property is that licorice is a potent anti-inflammatory. Glabridin has also some soothing properties but the main active anti-inflammatory component is glycyrrhizin. It’s used to treat several skin diseases that are connected to inflammation including atopic dermatitis, rosacea or eczema.
Oh, and one more thing: glabridin seems to be also an antioxidant, which is just one more reason to be happy about licorice root extract on an ingredient list.
Bottom line: Licorice is a great skincare ingredient with significant depigmenting, anti-inflammatory and even some antioxidant properties. Be happy if it's on the ingredient list. :)
An amino acid sugar that can be found in the skin and does there good and important things. One of them is that it's a precursor for the biosynthesis of superstar moisturizer, hyaluronic acid. So acetyl glucosamine itself is also an important skin-identical ingredient and natural moisturizing factor.
But that is not all, acetyl glucosamine has two other great properties proved by double-blind clinical trials. First, it's a promising ingredient against wrinkles: 2% can improve wrinkles, particularly in the eye area.
Second, the same amount can also fade - always stubborn - brown spots. (Do not expect magic, though - the photos from the study show the difference after 8 weeks of daily use. The difference is visible, but not that big. It's always good to have realistic expectations. :)) Combined with skincare superstar niacinamide the duo is synergistic and is more effective at improving hyperpigmentation, so if you are after the skin-lightening benefit look out for products that contain both.
- It's one of the gold standard ingredients for treating problem skin
- It can exfoliate skin both on the surface and in the pores
- It's a potent anti-inflammatory agent
- It's more effective for treating blackheads than acne
- For acne combine it with antibacterial agents like benzoyl peroxide or azelaic acid
Though its name says acid, it's not really an exfoliant. It's a plant extract with some antioxidant properties. Its main thing in cosmetic products is to neutralize the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. It's a natural alternative to sometimes bad-mouthed chelating agents, EDTAs.
- A multi-functional skincare superstar with several proven benefits for the skin
- Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
- Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
- Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
- Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid).
Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier.
Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.
Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation.
If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.
As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily.
We don't have description for this ingredient yet.
- Green tea is one of the most researched natural ingredients
- The active parts are called polyphenols, or more precisely catechins (EGCG being the most abundant and most active catechin)
- There can be huge quality differences between green tea extracts. The good ones contain 50-90% catechins (and often make the product brown and give it a distinctive smell)
- Green tea is proven to be a great antioxidant, UV protectant, anti-inflammatory, anticarcinogenic and antimicrobial
- Because of these awesome properties green tea is a great choice for anti-aging and also for skin diseases including rosacea, acne and atopic dermatitis
We wholeheartedly support the rise of seedless grapes as fruit snacks, but when it comes to skincare, we are big fans of the seeds.
They contain the majority of the skin goodies that - similar to green tea - are mostly polyphenols (but not the same ones as in tea). The most abundant ones in grape are called proanthocyanidins, and 60-70% of them are found in the seeds (it's also often abbreviated as GSP - grape seed proanthocyanidins). In general, the darker the fruit, the more GSPs and other flavonoids it contains.
So what's so special about GSPs? Well, they are super-potent antioxidants, much stronger than Vitamin C or Vitamin E. And if that's not enough, GSPs and other flavonoids in grape also show UV protecting and anti-cancer properties.
It's definitely a goodie to spot on the INCI list.
We don't have description for this ingredient yet.
The extract of a plant with nice purple flowers that's loaded with the phytochemical called silymarin. You have probably never heard of silymarin but let us tell you it's a pretty awesome ingredient.
There are quite a lot of research showing it can do all kinds of good things when taken orally: it has a proven ability to protect you from liver damage, and it also shows powerful antioxidant, anticarcinogenic, protective and regenerative properties with no more side effects than placebo.
But what about skincare? Well, there is less research about its topical use but it definitely deserves the goodie status: it's a potent antioxidant, an anti-inflammatory agent and it's also a great UV-protectant. It's useful as a complementary treatment for rosacea, keeping the skin hydrated and it's also a super nice addition to any sunscreen product thanks to its unique UV-protecting abilities.
If you have oily, acne-prone skin, Zinc PCA is one of the actives to put on your "TO TRY" list.
It's a synergistic association of two great things: Zinc and L-PCA. The Zinc part is there to help normalize sebum production and limit the proliferation of evil acne-causing bacteria. L-PCA stands for pyrrolidone carboxylic acid and it's a key molecule in the skin that helps with processes of hydration and energy (it's actually an NMF, a natural moisturizing factor).
L-PCA is not only there to hydrate the skin, but it also helps to increase the efficacy and bioavailability of zinc. An in-vivo (done on real people) test done by the manufacturer shows that Zinc PCA reduces sebum production statistically significantly after 28 days of application (1% was used in the test), and in-vitro (made in the lab) measurements show that Zinc PCA has strong anti-microbial activity against P. acnes (between 0.1-0.25%) and other bacterial strains.
If that would not be enough there is also a 2011 research paper saying that based on in-vitro (made in the lab, not on real people) findings Zinc PCA might be a promising anti-aging active that helps with the production of type I collagen (and we all know more collagen = firmer skin).
All in all, definitely a goodie for oily, acne-prone skin.
Beta-Glucan is a nice big molecule composed of many smaller sugar molecules (called polysaccharide). It’s in the cell walls of yeast, some mushrooms, seaweeds, and cereals.
It’s a real goodie no matter if you eat it or put it on your face. Eating it is anti-diabetic, anti-cancer, and even lowers blood cholesterol.
Putting it on your face also does a bunch of good things: it‘s shown to have intensive skin repairing & wound healing properties, it’s a mild antioxidant, a great skin soother, and moisturizer, and it even shows promising anti-aging benefits.
The manufacturer of the ingredient did a published study with 27 people and examined the effect of 0.1% beta-glucan. They found that despite the large molecular size the smaller factions of beta-glucan penetrate into the skin, even into the dermis (the middle layer of the skin where wrinkles form). After 8 weeks there was a significant reduction of wrinkle depth and height and skin roughness has also improved greatly.
Bottom line: Beta-glucan is a great ingredient, especially for sensitive or damaged skin. It soothes, moisturizes, and has some anti-aging magic properties.
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
It's one of the active parts of Chamomile that contains about 30% of bisabolol. It's a clear oily fluid that is used in skincare as a nice anti-inflammatory and soothing ingredient.
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically.
It's not only soothing but it' also skin-softening and protecting and can promote wound healing.
Adenosine is an important little compound in our body that has a vital cell-signalling role. Research on smearing it on our face is also promising and shows so far a couple of things:
- It can help with wound healing
- It’s a good anti-inflammatory agent
- It might even help with skin’s own collagen production and improve skin firmness and elasticity
- It helps with barrier repair and protection
- It might be even useful for the hair helping with hair thickness and hair growth
A little helper ingredient that is used to adjust the pH of the product. It also helps to keep products stay nice longer by neutralizing the metal ions in the formula (they usually come from water).
It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range.
Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415).
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.
It is typically used in tiny amounts, around 0.1% or less.
If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.
Also, it's an effective deodorant and a medium spreading emollient.
It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic.
Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10).
It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.
It's a type of lipid, a so-called sphingoid base that can be found naturally in the upper layer of the skin. It's found both in "free-form" and as part of famous skin lipids, ceramides.
There is emerging research about Phytosphingosine that shows that it has antimicrobial and cell-communicating properties and is considered part of the skin's natural defense system.
A 2007 study showed that Phytosphingosine even works against evil acne-causing bacteria, Propionibacterium acnes and shows promise as a complementing active ingredient in treating acne-prone skin thanks to its anti-inflammatory and antimicrobial activities.
A nice one to spot in the ingredient list. :)
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| what‑it‑does | soothing | moisturizer/humectant |
| what‑it‑does | skin brightening | anti-acne | soothing |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 1 |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | soothing | skin brightening |
| what‑it‑does | skin-identical ingredient | skin brightening |
| what‑it‑does | exfoliant | anti-acne | soothing | preservative |
| what‑it‑does | chelating |
| what‑it‑does | cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant |
| what‑it‑does | soothing | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | antioxidant | soothing |
| what‑it‑does | antioxidant | antimicrobial/antibacterial |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | antioxidant | soothing |
| what‑it‑does | anti-acne | moisturizer/humectant |
| what‑it‑does | soothing | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | soothing |
| what‑it‑does | soothing |
| irritancy, com. | 0, 0 |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | chelating | buffering |
| what‑it‑does | viscosity controlling |
| what‑it‑does | chelating |
| what‑it‑does | preservative |
| what‑it‑does | preservative |
| what‑it‑does | skin-identical ingredient | cell-communicating ingredient | anti-acne | antimicrobial/antibacterial |