Follow us on our new Insta page »

Potassium Azeloyl Diglycinate

What-it-does: skin brightening, anti-acne


A derivative of clinically proven, superstar ingredient Azelaic Acid and hydrating amino acid Glycine. Azelaic acid is an awesome ingredient with anti-inflammatory, skin lightening and anti-acne effects, but its insolubility (it's soluble neither in water nor in oil) makes it difficult to use it in a cosmetically elegant and versatile way. 

The solution is supposed to be Potassium Azeloyl Diglycinate, at least according to the manufacturer. The derivative is very water soluble, easy to use in nice formulas and inherits all the lovely properties of Azelaic acid. It acts as a skin brightening agent via Tyrosinase (a famous enzyme needed to make melanin) inhibition and also has significant sebum normalizing activity. 

Regarding research, we could find two studies where Potassium Azeloyl Diglycinate's name popped up. One study examined the management of rosacea and the other one researched the treatment of melasma. Both were successful (we mean people showed improvement :)) but our Azelaic acid derivative was combined with other actives so it's hard to know what to attribute to this guy only. 

Overall, a promising multi-function active that's worth checking out if you have pigmentation-prone, acne-prone or rosacea-prone skin.

Show me some proof

  • Berardesca, Enzo, et al. "Clinical and instrumental assessment of the effects of a new product based on hydroxypropyl chitosan and potassium azeloyl diglycinate in the management of rosacea." Journal of cosmetic dermatology 11.1 (2012): 37-41.
  • Viyoch, Jarupa, et al. "Effects of trans-4-(aminomethyl) cyclohexanecarboxylic acid/potassium azeloyl diglycinate/niacinamide topical emulsion in Thai adults with melasma: a single-center, randomized, double-blind, controlled study." Current Therapeutic Research 71.6 (2010): 345-359.
  • Veraldi, Stefano, et al. "Treatment of symptoms of erythemato-telangiectatic rosacea with topical potassium azeloyl diglycinate and hydroxypropyl chitosan: Results of a sponsor-free, multicenter, open study." Journal of Dermatological Treatment 26.2 (2015): 191-192.

Products with Potassium Azeloyl Diglycinate

Dr. Medica Dermatological Anti-Acne Face Serum Geek & Gorgeous Apad 20% Azelaic Acid Derivative Serum Skin Actives T-Zone Serum Umoua Anti-Acne Gel Bielenda Zielona Herbata Serum (Green Tea) Consult Beauté Champagne Beauté Facial Concentrate Uncover Skincare Azelaic Acid Serum Allies of Skin Promise Keeper™ Blemish Facial Colleen Rothschild Skincare Mandelic Acid Radiance Serum Serious Skincare Ultra-Mare Pure Marine Infusion Concentrated Treatment Pads Dr Dennis Gross Ferulic Acid + Retinol Brightening Solution NIOD Re: Pigment Ren Ready Steady Glow Daily Aha Tonic BE.LOVED Fruits&Flowers Hidden Powers Toner With Aha Acids Dr. Medica Dermatological Anti-Acne Face Cream Azelique Age Refining Night Cream Glowbiotics Probiotic Brightening + Refining Layering Solution Dr Dennis Gross Ferulic + Retinol Serum Triple Correction Eye Serum Dr Dennis Gross Ferulic + Retinol Triple Correction Eye Serum Glytone Enhance Brightening Solution NIOD Flavanone Mud Sesderma Azelac Moisturising Gel Paula's Choice Defense Antioxidant Pore Purifier Rilastil Acnestil Sebum-Normalizing Moisturizing Cream dr. denese Black Clay Firming Facial Mask Dr Dennis Gross Alpha Beta Pore Perfecting Cleansing Gel Mesoestetic Mesoprotech Melan 130+ Pigment Control Spf50+ Cetaphil Rednesscontrol Dr Dennis Gross Clinical Grade Ipl Dark Spot Correcting Serum Paula's Choice Defense Nightly Reconditioning Moisturizer Skin Actives Skin Brightening Cream Dr Dennis Gross Clinical Concentrate Radiance Booster Rilastil Sun System Comfort Matt Formula Spf 50+ Ole Henriksen Banana Bright Face Primer Frezyderm Sensitive Red Skin Facial Cream Filorga Global-Repair Intensive Nutri-Restorative Multi-Revitalising Serum Filorga Global-Repair Nutri-Restorative Multi-Revitalising Cream