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SkinBetter Interfuse® Treatment Cream - Eye

Interfuse® Treatment Cream - Eye

Improving the appearance of crow’s feet, wrinkles, puffiness and under-eye darkness.
Uploaded by: mards23 on

Skim through

Ingredient name what-it-does irr., com. ID-Rating
Aqua/Water solvent
Caprylyl Methicone emollient
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar
Jojoba Esters soothing, emollient, moisturizer/​humectant
Niacinamide cell-communicating ingredient, skin brightening, anti-acne, moisturizer/​humectant superstar
PEG-16 Macadamia Glycerides emollient, emulsifying
Cetearyl Alcohol emollient, viscosity controlling, emulsifying, surfactant/​cleansing 1, 2
Glyceryl Stearate emollient, emulsifying 0, 1-2
Ceteareth-20 emulsifying, surfactant/​cleansing 3, 2
PEG-100 Stearate surfactant/​cleansing, emulsifying 0, 0
Caprylic/Capric Triglyceride emollient
Alcohol Denat antimicrobial/​antibacterial, solvent, viscosity controlling icky
Palmitoyl Tripeptide-38 cell-communicating ingredient goodie
Caffeine antioxidant, perfuming goodie
S-Mu-Conotoxin Cniiic Acetate
Copper Lysinate/Prolinate cell-communicating ingredient goodie
Hydrolyzed Lupine Protein
Terminalia Ferdinandiana Fruit Extract antioxidant, skin brightening
Methylglucoside Phosphate cell-communicating ingredient goodie
Sodium Hyaluronate skin-identical ingredient, moisturizer/​humectant 0, 0 goodie
Saccharomyces Cerevisiae Extract moisturizer/​humectant goodie
Arginine skin-identical ingredient goodie
Glycine skin-identical ingredient goodie
Hydroxypropyl Cyclodextrin goodie
Carbomer viscosity controlling 0, 1
Hexylene Glycol solvent, emulsifying, perfuming, surfactant/​cleansing 0-1, 0-2
Citric Acid buffering
Sodium Hydroxide buffering
Ethylhexylglycerin preservative
Caprylyl Glycol moisturizer/​humectant, emollient
Phenoxyethanol preservative

SkinBetter Interfuse® Treatment Cream - Eye
Ingredients explained

Also-called: Aqua;Water | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

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Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

What-it-does: emollient

A clear, colorless, low viscosity, volatile (does not absorb into the skin but rather evaporates from it) silicone fluid that has excellent spreadability and leaves a light, silky and smooth feel on the skin.

According to manufacturer info, its big advantage is that it's compatible both with other silicones and with natural plant oils, so it's a great ingredient to formulate products with good-sounding, consumer-pleasing vegetable oils but still maintain a cosmetically elegant, non-greasy and non-tacky feel.

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

Jojoba-derived emollient wax esters (fatty acid + fatty alcohol) that make your skin feel nice and smooth. Chemically speaking, pure jojoba oil is also a wax ester (read our shiny explanation here), however, the ingredients called jojoba esters on the ingredient lists are made from jojoba oil and/or hydrogenated jojoba oil via interesterification. 

They have multiple versions with variable fatty acid chain length and the ingredient can have a liquid, a creamy, a soft or firm paste, or even a hard wax consistency. The common thing between all versions is, that unlike most normal triglyceride oils, jojoba esters have superior stability, provide non-greasy emolliency and are readily absorbed into the skin

Niacinamide - superstar
Also-called: vitamin B3, nicotinamide | What-it-does: cell-communicating ingredient, skin brightening, anti-acne, moisturizer/humectant
  • A multi-functional skincare superstar with several proven benefits for the skin
  • Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
  • Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
  • Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
  • Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
Read all the geeky details about Niacinamide here >>

What-it-does: emollient, emulsifying

We don't have description for this ingredient yet.

What-it-does: emollient, viscosity controlling, emulsifying, emulsion stabilising, surfactant/cleansing | Irritancy: 1 | Comedogenicity: 2

An extremely common multitasker ingredient that gives your skin a nice soft feel (emollient) and gives body to creams and lotions. It also helps to stabilize oil-water mixes (emulsions), though it does not function as an emulsifier in itself. Its typical use level in most cream type formulas is 2-3%.  

It’s a so-called fatty alcohol, a mix of cetyl and stearyl alcohol, other two emollient fatty alcohols.  Though chemically speaking, it is alcohol (as in, it has an -OH group in its molecule), its properties are totally different from the properties of low molecular weight or drying alcohols such as denat. alcohol. Fatty alcohols have a long oil-soluble (and thus emollient) tail part that makes them absolutely non-drying and non-irritating and are totally ok for the skin.

What-it-does: emollient, emulsifying | Irritancy: 0 | Comedogenicity: 1-2

A super common, waxy, white, solid stuff that helps water and oil to mix together, gives body to creams and leaves the skin feeling soft and smooth.

Chemically speaking, it is the attachment of a glycerin molecule to the fatty acid called stearic acid. It can be produced from most vegetable oils (in oils three fatty acid molecules are attached to glycerin instead of just one like here) in a pretty simple, "green" process that is similar to soap making. It's readily biodegradable.

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It also occurs naturally in our body and is used as a food additive. As cosmetic chemist Colins writes it, "its safety really is beyond any doubt".

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 3 | Comedogenicity: 2

A common functional ingredient that helps to keep the oil-loving and water-loving ingredients together (emulsifier), stabilizes and thickens the products. 

Chemically speaking, it is ethoxylated Cetearyl alcohol, meaning that some ethylene oxide is added to the fatty alcohol to increase the water-soluble part in the molecule. The result is that the mainly oil soluble, emollient fatty alcohol is converted to an emulsifier molecule that keeps oil and water mixed in creams. The number in the name of Ceteareth emulsifiers refers to the average number of ethylene oxide molecules added and 20 makes a good emulsifier.

What-it-does: surfactant/cleansing, emulsifying | Irritancy: 0 | Comedogenicity: 0

A very common water-loving surfactant and emulsifier that helps to keep water and oil mixed nicely together. 

It's often paired with glyceryl stearate - the two together form a super effective emulsifier duo that's salt and acid tolerant and works over a wide pH range. It also gives a "pleasing product aesthetics", so no wonder it's popular.

What-it-does: emollient

A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, is super well tolerated by every skin type and easy to formulate with. No wonder it’s popular. 

  • It's a super common and super debated skincare ingredient
  • It has several benefits: great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent and antimicrobial
  • It can be very drying if it's in the first few ingredients on an ingredient list
  • Some experts even think that regular exposure to alcohol damages skin barrier and causes inflammation though it's a debated opinion (read more in geeky details tab)
Read all the geeky details about Alcohol Denat. here >>

Also-called: Matrixyl synthe'6 | What-it-does: cell-communicating ingredient

It's a pretty new peptide trade-named MATRIXYL™ synthe’6. The manufacturer claims that it can boost the production of 6 major components of the skin matrix (collagen I, III, IV, fibronectin, hyaluronic acid and laminin 5) that result in more even skin and fewer wrinkles particularly on the forehead and crow's feet. Using 2% of the active for two months daily, women reported a decrease in wrinkles by 31% up to 100%.

Caffeine - goodie
What-it-does: antioxidant, perfuming

Hello, our favorite molecule that helps us wake up in the morning and then keeps us going through the day. As a super well-known stimulant from coffee, tea and plenty of other soft drinks, Caffeine needs no introduction. So we will skip right to the part where we talk about what the hell it does in so-so many cosmetic products.

Looking at the research, we were surprised to find how versatile Caffeine is. It is a small, water-loving molecule with pretty good skin penetration abilties. Once in the skin, it has nice antioxidant properties, meaning that it reduces the formation of evil free radicals and it might even be useful in preventing UV-induced skin cancers. 

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A well-known thing about Caffeine is that it improves the microcirculation of the blood vessels. Though conventional wisdom and anecdotal evidence says that this property is helpful for dark under-eye circles and puffy eyes, we have to mention that the double-blind research we have found about a 3% caffeine gel concluded that "the overall efficacy of the selected caffeine gel in reducing puffy eyes was not significantly different from that of its gel base."  But you know, the proof is in the pudding.

Another thing Caffeine is used for in body care products is its anti-cellulite effects. In theory, it can speed up the lipolysis process (the "fat burning"  by our cells) and stimulate the draining lymph system that might lead to the improvement of cellulite. But here again, the evidence that it actually makes a measurable, let alone visible,  improvement on actual human beings is limited (we could find only some animal skin studies or caffeine being combined with other actives). 

Last, but not least, we have to write about caffeine and hair growth. The theory is that it can inhibit the activity of the 5-α-reductase enzyme that plays an important role in hair loss and allows a renewed growth phase of the hair. We have found some recent and promising research to back this up. A 2017 study compared a 0.2% caffeine liquid with a 5% Minoxidil  (an FDA approved active to treat baldness) solution and found that  "a caffeine-based topical liquid should be considered as not inferior to minoxidil 5% solution in men with androgenetic alopecia", or English translation means that the caffeine liquid was pretty much as good as the FDA-approved Minoxidil stuff. Not bad!

Overall, we think that caffeine is a very versatile and biologically active ingredient. Even though some of its effects are more hyped up than backed up, it is still a nice to have on many ingredient lists. 

We don't have description for this ingredient yet.

An essential amino acid - mineral complex that is part of the pretty new anti-aging complex called Neodermyl. The manufacturer claims that the complex is able to boost skin's own collagen I and III as well as elastin production. Read more details at methylglucoside phosphate.

We don't have description for this ingredient yet.

What-it-does: antioxidant, skin brightening

We don't have description for this ingredient yet.

It's a pretty new anti-aging ingredient that is a "safe and pre-activated source of energy to feed aging skin cells".  

It's part of an anti-aging complex trade named Neodermyl, where methylglucoside phosphate is combined with the essential amino acids proline, lysine and also copper. This complex is claimed to be able to increase the collagen I and III production of skin and even more surprisingly, also the elastin production. Both slow down with age and beeing able to boost the skin's own production of these super important proteins results in improved skin firmness and elasticity.

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This is a very big deal, especially the elastin part, as there is not yet a clinically proven active ingredient that is able to boost the skin's own elastin production. There are also very few ones (think vitamin C, glycolic acid, and retinol) that are proven to boost collagen.  The claims about Neodermyl are not yet confirmed in independent studies but the manufacturer did do some very convincing testing that showed a visible reduction of wrinkle depth and volume in just 15 days. If you are into anti-aging, this is a new active that might be worth a try. 

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It’s the - sodium form - cousin of the famous NMFhyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

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In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).

What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists. 

If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

Also-called: Baker's Yeast | What-it-does: moisturizer/humectant

Saccharomyces cerevisiae (SC)  is the fancy name for common baker’s yeast. 

Usually different kind of yeast extracts are used in skincare for their great hydrating, and general skin conditioning properties. We could find one research paper to back this up: It has found that SC indeed increases skin moisture and had improved skin microrelief (the small wrinkles and surface irregularities of skin). 

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According to manufacturer info coupled with the Mexican cactus, prickly pear it also helps to reduce neurosensory irritation that might occur from potent retinol or AHA products. 

Arginine - goodie

A semi-essential (infants cannot synthesize it, but adults can) amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor, a skin hydrator and might also help to speed up wound healing

Arginine usually has a positive charge (cationic) that makes it substantive to skin and hair (those are more negatively charged surfaces) and an excellent film former.  Thanks to the positive charge, it also creates a complex with AHAs (AHAs like to lose a hydrogen ion and be negatively charged, so the positive and the negative ions attract each other) that causes a "time-release AHA effect" and reduces the irritation associated with AHAs

Glycine - goodie

A non-essential amino acid (the building blocks of skin proteins, like collagen or elastin), that the body can produce itself, but its production decreases with age. When you put it all over your face, it works as a moisturizer and maybe more. 

According to great skincare blog Futurederm, glycine might help with wound healing and tissue repair and when used together with other amino acids, leucine and proline it might improve wrinkles

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BTW, it's also a building block of a bunch of important and famous peptides, including copper-tripeptide-1, palmitoyl tripeptide-1 or palmitoyl hexapeptide-12.

It goes by the trade name "Phytodermina Lifting" that refers to two things: it's a "lifting" ingredient and it comes from plant raw materials. 

The manufacturer claims that it gives the skin a marked lifting effect, moisturizes, makes the skin soft and smooth, enhances brightness, and helps make-up to stay on after application.

What-it-does: viscosity controlling, emulsion stabilising | Irritancy: 0 | Comedogenicity: 1

A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula.  It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.

What-it-does: solvent, emulsifying, perfuming, surfactant/cleansing | Irritancy: 0-1 | Comedogenicity: 0-2

Similar to other glycols, it's a helper ingredient used as a solvent, or to thin out thick formulas and make them more nicely spreadable. 

Hexylene Glycol is also part a preservative blend named Lexgard® HPO, where it helps the effectiveness of current IT-preservative, phenoxyethanol

What-it-does: buffering

Citric acid comes from citrus fruits and is an AHA. If these magic three letters don’t tell you anything, click here and read our detailed description on glycolic acid, the most famous AHA. 

So citric acid is an exfoliant, that can - just like other AHAs - gently lift off the dead skin cells of your skin and make it more smooth and fresh. 

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There is also some research showing that citric acid with regular use (think three months and 20% concentration) can help sun-damaged skin, increase skin thickness and some nice hydrating things called glycosaminoglycans in the skin. 

But according to a comparative study done in 1995, citric acid has less skin improving magic properties than glycolic or lactic acid. Probably that’s why citric acid is usually not used as an exfoliant but more as a helper ingredient in small amounts to adjust the pH of a formulation. 

Also-called: lye | What-it-does: buffering

The unfancy name for it is lye. It’s a solid white stuff that’s very alkaline and used in small amounts to adjust the pH of the product and make it just right. 

For example, in case of AHA or BHA exfoliants, the right pH is super-duper important, and pH adjusters like sodium hydroxide are needed.  

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BTW, lye is not something new. It was already used by ancient Egyptians to help oil and fat magically turn into something else. Can you guess what? Yes, it’s soap. It still often shows up in the ingredient list of soaps and other cleansers.

Sodium hydroxide in itself is a potent skin irritant, but once it's reacted (as it is usually in skin care products, like exfoliants) it is totally harmless.

What-it-does: preservative, deodorant

If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.

Also, it's an effective deodorant and a medium spreading emollient

It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol

The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

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Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10). 

It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.

You may also want to take a look at...

what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does emollient
A light and volatile silicone fluid that has excellent spreadability and leaves a light, silky and smooth feel on the skin. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does soothing | emollient | moisturizer/humectant
Jojoba-derived emollient wax esters (fatty acid + fatty alcohol) that make your skin feel nice and smooth. [more]
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
what‑it‑does emollient | emulsifying
what‑it‑does emollient | viscosity controlling | emulsifying | surfactant/cleansing
irritancy, com. 1, 2
A super common multitasker ingredient that gives your skin a nice soft feel (emollient) and gives body to creams. [more]
what‑it‑does emollient | emulsifying
irritancy, com. 0, 1-2
Waxy, white, solid stuff that helps water and oil to mix together and leaves the skin feeling soft and smooth. [more]
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 3, 2
A common functional ingredient that helps to keep the oil-loving and water-loving ingredients together (emulsifier), stabilizes and thickens the products.  [more]
what‑it‑does surfactant/cleansing | emulsifying
irritancy, com. 0, 0
A commonly used water-soluble surfactant and emulsifier. [more]
what‑it‑does emollient
A very common emollient that makes your skin feel nice and smooth. Comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. [more]
what‑it‑does antimicrobial/antibacterial | solvent | viscosity controlling
Alcohol with some additives to make it unconsumable. It is great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent, and antimicrobial. In large amounts, it can be very drying to the skin. [more]
what‑it‑does cell-communicating ingredient
Matrixyl synthe'6 - A peptide that is claimed to be able to boost the production of 6 major components of the skin matrix (including collagen and hyaluronic acid). [more]
what‑it‑does antioxidant | perfuming
The well-known stimulant from coffee. It has nice antioxidant properties and can improve the microcirculation. Might be helpful for dark circles, puffy eyes, as well as cellulite and hair loss. [more]
what‑it‑does cell-communicating ingredient
An essential amino acid - mineral complex that is part of the pretty new anti-aging complex called Neodermyl. The manufacturer claims that the complex is able to boost skin's own collagen I and III as well as elastin production. [more]
what‑it‑does antioxidant | skin brightening
what‑it‑does cell-communicating ingredient
A new anti-aging ingredient that combined with essential amino acids proline and lysine and also copper can boost skin's own collagen and elastin production that result in improved skin firmness and elasticity. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
what‑it‑does moisturizer/humectant
Saccharomyces cerevisiae (SC)  is the fancy name for common baker’s yeast.  Usually different kind of yeast extracts are used in skincare for their great hydrating, and general skin conditioning properties. [more]
what‑it‑does skin-identical ingredient
An amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor and might also help to speed up wound healing.  [more]
what‑it‑does skin-identical ingredient
An amino acid (the building blocks of skin proteins, like collagen) that hydrates the skin and might help wound healing and improve wrinkles. [more]
It's a "lifting" ingredient coming from plant raw materials. The manufacturer claims that it moisturizes, gives the skin softness and smoothness, and helps make-up to stay on after application. [more]
what‑it‑does viscosity controlling
irritancy, com. 0, 1
A handy white powder that magically converts a liquid into a nice gel formula. [more]
what‑it‑does solvent | emulsifying | perfuming | surfactant/cleansing
irritancy, com. 0-1, 0-2
Similar to other glycols, it's a helper ingredient used as a solvent, or to thin out thick formulas and make them more nicely spreadable.  Hexylene Glycol is also part a preservative blend named Lexgard® [more]
what‑it‑does buffering
An AHA that comes from citrus fruits. It is usually used as a helper ingredient to adjust the pH of the formula. [more]
what‑it‑does buffering
Lye - A solid white stuff that’s very alkaline and used in small amount to adjust the pH of the product.  [more]
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]
what‑it‑does moisturizer/humectant | emollient
A handy multi-tasking ingredient that gives the skin a nice, soft feel and also boosts the effectiveness of other preservatives. [more]
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]