Azelac Ru Liposomal Serum
Ingredients overview
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Sesderma Azelac Ru Liposomal SerumIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
A very common ingredient that can be found in all cell membranes. In cosmetics it's quite the multi-tasker: it's an emollient and water-binding ingredient but it's also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes.
Propanediol is a natural alternative for the often used and often bad-mouthed propylene glycol. It's produced sustainably from corn sugar and it's Ecocert approved.
It's quite a multi-tasker: can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula.
Simply alcohol refers to ethanol and it's a pretty controversial ingredient. It has many instant benefits: it's a great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent and antimicrobial. No wonder it's popular in toners and oily skin formulas.
The downside is that it can be very drying if it's in the first few ingredients on an ingredient list.
Some experts even think that regular exposure to alcohol damages skin barrier and causes inflammation though it's a debated opinion. If you wanna know more, we wrote a more detailed explanation about what's the deal with alcohol in skincare products at alcohol denat. (it's also alcohol, but with some additives to make sure no one drinks it).
A so-called polymer microsphere, i.e. little spherical shaped particles from repeated subunits. Similar to other microsphere powders, it can scatter the light to give products a soft focus or blurring effect. It also works as a texture enhancer giving formulas an exceptional smoothness and a velvet touch.
A mildly viscous, amber-colored liquid with fatty odor, made from Castor Oil and polyethylene glycol (PEG).
If it were a person, we’d say, it’s agile, diligent & multifunctional. It’s mostly used as an emulsifier and surfactant but most often it is used to solubilize fragrances into water-based formulas.
We don't have description for this ingredient yet.
- It's a helper ingredient that improves the freeze-thaw stability of products
- It's also a solvent, humectant and to some extent a penetration enhancer
- It has a bad reputation among natural cosmetics advocates but cosmetic scientists and toxicology experts do not agree (read more in the geeky details section)
If you have pigmentation issues, Undecylenoyl Phenylalanine is something to look at. It is an amino acid (Phenylalanine) derived molecule that is thought to hinder the pigmentation process in a unique way by being a so-called MSH-antagonist.
MSH stands for Melanocyte Stimulating Hormone, and as you have probably guessed by its name, it is important in the process of melanogenesis, i.e. the generation of melanin pigments. MSH binds to a receptor on the melanocyte (the skin cell that creates melanin) called Melanocortin 1 Receptor (MC1R), which kicks off a bunch of biological processes that result in the formation of pigment. Our guy, Undecylenoyl Phenylalanine can hinder this binding and thus the whole melanin creation process afterward.
The efficacy of the molecule is definitely promising. The manufacturer did several in-vitro (in test tubes) and in-vivo (on people) tests and found Undecylenoyl Phenylalanine to be more effective than a bunch of well-known skin-lightening molecules, such as arbutin, kojic acid or MAP (the vitamin C derivative).
We also found two research studies that show that 2% Undecylenoyl Phenylalanine is effective both in the treatment of age spots (or sunspots, the pigmentation that comes with UV and age) and melasma (that comes at a younger age and is usually influenced by hormones). A third study done by Procter&Gamble examined our amino-derivative, combined with Niacinamide and found that the combination of 1% Undecylenoyl Phenylalanine with 5% Niacinamide is more effective than niacinamide alone.
We don't have description for this ingredient yet.
- Retinol (pure Vitamin A) is probably the most proven anti-aging ingredient available OTC
- It has to be converted in the skin to retinoic acid to work its magic
- Once converted, it has the same effect as all-trans-retinoic acid, aka tretinoin
- A generally accepted ballpark number is that retinol is 10-to-20 times less potent than retinoic acid
- It makes skin less wrinkled, smoother, firmer and tighter
- It might also be helpful for acne prone skin as it normalizes keratinization and makes the pores produce less sebum
- Possible side effects and irritation are also much less than with retinoic acid
- Do not use whilst pregnant
If you are reading here, we are pretty sure the words retinoids and retinol ring a bell, but if not, you are seriously missing out, please click here immediately to catch up. The TL;DR version is that retinoids are the royal family of skincare with tretinoin being the king, the only FDA-approved ingredient to treat the signs of photoaging. Retinol is like a grandkid, it has to be converted (through two steps) in the skin to become retinoic acid. The conversion means retinol is both less effective and less harsh on the skin.
So where does our current molecule, Retinal, aka Retinaldehyde fit into the family (btw, here is a nice visual family tree about who is who)? Remember that retinol needed two conversion steps to become retinoic acid? Yes, you are right, Retinal is the intermediate step between retinoic acid and retinol, meaning it needs only one conversion step to become active in the skin. If we go with our royal family analogy, Retinal is Prince William, directly next in line to the throne.
Once retinal is converted, it becomes retinoic acid and does the same things we detailed in our tretinoin description. In a nutshell, it is everything you expect from an anti-aging superstar such as decreased wrinkles, smoother, firmer and more elastic skin.
This sounds good, but how does Retinal compare to retinoic acid? Good question! We found a study (a pretty good one with 125 patients) that compared 0.05% retinal with 0.05% retinoic acid (and vehicle). They concluded that "at week 18, a significant reduction of the wrinkle and roughness features was observed with both retinaldehyde and retinoic acid." and the difference between the two was not statistically significant. (Interestingly, in both groups, the results were less significant at week 44, so it might be a good idea to have a retinoid break from time to time?) Also, our guy, Retinal was much better tolerated than retinoic acid known for its harshness.
The good tolerability of retinal was also confirmed by another study that compared retinol (ROL), retinal (RAL) and retinoic acid (RA). They found that "the natural retinoids ROL and RAL do have a good tolerance profile, in contrast with the irritating potential of RA", meaning retinal is an awesome alternative if you have irritation and flaking issues with prescription products, such as Retin-A.
Last, but not least, we want to mention a pretty big (but subjectively evaluated), Avene (the French pharmacy brand famous for its Retinal products) sponsored study that examined the tolerability and efficacy of a 0.1 Retinal + 6% glycolic acid product in the treatment of acne. The product was added next to the standard anti-acne regimen of 1,709 patients for 90 days and the study concluded that the formula was both very well tolerated as well as effective next to other standard anti-acne medications such as benzoyl peroxide and antibiotics.
Overall, if you are into retinoids, Retinal is a really awesome and well-proven member of the family that is absolutely worth trying.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
- Superstar ingredient with antibacterial, skin cell regulating, anti-inflammatory and skin-lightening magic properties
- It is especially useful for acne-prone or rosacea-prone skin types (in concentration 10% and up)
- It is a prescription drug in the US but can be freely purchased in the EU in an up to 10% concentration
A form of skincare superstar, vitamin C. If you do not know why vitamin C is such a big deal in skincare, we have a really detailed, geeky description that's good to read. :)
So now you know that because pure vitamin C is such a diva (very unstable and hard to formulate) the cosmetic industry is trying to come up with some derivatives that have the badass anti-aging properties of vitamin C (antioxidant protection + collagen boosting + fading hyperpigmentation) but without the disadvantages. This is a hard task, and there is not yet a derivative that is really proven to be better in every aspect, but Ascorbyl Glucoside is one of the best options when it comes to vitamin C derivatives. Let's see why:
First, it's really stable and easy to formulate, so the problems that come with pure vitamin C are solved here.
Second, in vitro (meaning made in the lab, not on real humans) studies show that ascorbyl glucoside can penetrate the skin. This is kind of important for an anti-aging ingredient to do the job, so this is good news, though in-vivo (made on real humans) studies are still needed.
Third, in-vitro studies show that after ascorbyl glucoside is absorbed into the skin it is converted to pure vitamin C (though the rate of conversion is still a question mark). It also shows all the three anti-aging benefits (antioxidant protection + collagen boosting + fading hyperpigmentation) that pure vitamin C does.
Bottom line: ascorbyl glucoside is one of the best and most promising vitamin C derivatives that shows similar benefits to that of pure vitamin C, but it's less proven (in vivo vs. in vitro studies) and the extent of the benefits are also not the same.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula.
We don't have description for this ingredient yet.
It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range.
Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415).
It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version.
According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E.
It’s a little helper ingredient that helps to set the pH of a cosmetic formulation to be just right. It’s very alkaline (you know the opposite of being very acidic): a 1% solution has a pH of around 10.
It does not have the very best safety reputation but in general, you do not have to worry about it.
What is true is that if a product contains so-called N-nitrogenating agents (e.g.: preservatives like 2-Bromo-2-Nitropropane-1,3-Diol, 5-Bromo-5-Nitro- 1,3-Dioxane or sodium nitrate - so look out for things with nitro, nitra in the name) that together with TEA can form some not nice carcinogenic stuff (that is called nitrosamines). But with proper formulation that does not happen, TEA in itself is not a bad guy.
But let’s assume a bad combination of ingredients were used and the nitrosamines formed. :( Even in that case you are probably fine because as far as we know it cannot penetrate the skin.
But to be on the safe side, if you see Triethanolamine in an INCI and also something with nitra, nitro in the name of it just skip the product, that cannot hurt.
A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula. It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.
It's the acronym for Butylated Hydroxy Toluene. It's a common synthetic antioxidant that's used as a preservative.
There is some controversy around BHT. It's not a new ingredient, it has been used both as a food and cosmetics additive since the 1970s. Plenty of studies tried to examine if it's a carcinogen or not. This Truth in Aging article details the situation and also writes that all these studies examine BHT when taken orally.
As for cosmetics, the CIR (Cosmetic Ingredient Review) concluded that the amount of BHT used in cosmetic products is low (usually around 0.01-0.1%), it does not penetrate skin far enough to be absorbed into the bloodstream and it is safe to use in cosmetics.
The unfancy name for it is lye. It’s a solid white stuff that’s very alkaline and used in small amounts to adjust the pH of the product and make it just right.
For example, in case of AHA or BHA exfoliants, the right pH is super-duper important, and pH adjusters like sodium hydroxide are needed.
BTW, lye is not something new. It was already used by ancient Egyptians to help oil and fat magically turn into something else. Can you guess what? Yes, it’s soap. It still often shows up in the ingredient list of soaps and other cleansers.
Sodium hydroxide in itself is a potent skin irritant, but once it's reacted (as it is usually in skin care products, like exfoliants) it is totally harmless.
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.
It is typically used in tiny amounts, around 0.1% or less.
A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, is super well tolerated by every skin type and easy to formulate with. No wonder it’s popular.
Sodium chloride is the fancy name of salt. Normal, everyday table salt.
If (similar to us) you are in the weird habit of reading the label on your shower gel while taking a shower, you might have noticed that sodium chloride is almost always on the ingredient list. The reason for this is that salt acts as a fantastic thickener in cleansing formulas created with ionic cleansing agents (aka surfactants) such as Sodium Laureth Sulfate. A couple of percents (typically 1-3%) turns a runny surfactant solution into a nice gel texture.
If you are into chemistry (if not, we understand, just skip this paragraph), the reason is that electrolytes (you know, the Na+ and Cl- ions) screen the electrostatic repulsion between the head groups of ionic surfactants and thus support the formation of long shaped micelles (instead of spherical ones) that entangle like spaghetti, and viola, a gel is formed. However, too much of it causes the phenomenon called "salting out", and the surfactant solution goes runny again.
Other than that, salt also works as an emulsion stabilizer in water-in-oil emulsions, that is when water droplets are dispersed in the outer oil (or silicone) phase. And last but not least, when salt is right at the first spot of the ingredient list (and is not dissolved), the product is usually a body scrub where salt is the physical exfoliating agent.
A type of bucket or donut-shaped molecule with a water-loving outer side and an oil-loving inner side that is used mostly to encapsulate other actives in cosmetics.
It's the acronym for Butylated Hydroxy Anisole. It's a synthetic antioxidant that's used as a preservative.
It's a somewhat controversial ingredient: The U.S. National Institutes of Health says that BHA is "reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals" (source: wikipedia). But, and this is a big but: these experiments were made on animals and BHA was used in high doses as part of their diet. There is no evidence that the same is true when used in tiny amounts in cosmetics products. So you probably have nothing to worry about, but if you are a better safe than sorry type there are plenty of nice products without BHA to choose from. :)
Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate is an antioxidant molecule used in small amounts (less than 0.8%) to help products stay nice longer. More specifically, it is great at preventing discoloration or other types of oxidative degradation. It is a trendy alternative to often bad-mouthed synthetic antioxidant and stabilizer, BHT.
It’s a little helper ingredient that helps to set the pH of a cosmetic formulation to be just right.
It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic.
Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10).
It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.
If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.
Also, it's an effective deodorant and a medium spreading emollient.
It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. It’s not a strong one and doesn’t really work against bacteria, but more against mold and yeast. To do that it has to break down to its active form, sorbic acid. For that to happen, there has to be water in the product and the right pH value (pH 3-4).
But even if everything is right, it’s not enough on its own. If you see potassium sorbate you should see some other preservative next to it too.
BTW, it’s also a food preservative and even has an E number, E202.
Exactly what it sounds: nice smelling stuff put into cosmetic products so that the end product also smells nice. Fragrance in the US and parfum in the EU is a generic term on the ingredient list that is made up of 30 to 50 chemicals on average (but it can have as much as 200 components!).
If you are someone who likes to know what you put on your face then fragrance is not your best friend - there's no way to know what’s really in it.
Also, if your skin is sensitive, fragrance is again not your best friend. It’s the number one cause of contact allergy to cosmetics. It’s definitely a smart thing to avoid with sensitive skin (and fragrance of any type - natural is just as allergic as synthetic, if not worse!).
We don't have description for this ingredient yet.
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| what‑it‑does | solvent |
| what‑it‑does | emollient | emulsifying |
| what‑it‑does | solvent | moisturizer/humectant |
| what‑it‑does | antimicrobial/antibacterial | solvent | viscosity controlling |
| what‑it‑does | emulsifying | surfactant/cleansing |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 0 |
| what‑it‑does | skin brightening |
| what‑it‑does | skin brightening | soothing |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | skin brightening |
| what‑it‑does | anti-acne | soothing | buffering |
| what‑it‑does | antioxidant | skin brightening |
| what‑it‑does | antioxidant |
| what‑it‑does | emulsifying |
| what‑it‑does | emulsifying | surfactant/cleansing |
| irritancy, com. | 0, 0 |
| what‑it‑does | perfuming |
| what‑it‑does | viscosity controlling |
| what‑it‑does | antioxidant |
| irritancy, com. | 0, 0 |
| what‑it‑does | buffering |
| irritancy, com. | 0, 2 |
| what‑it‑does | viscosity controlling |
| irritancy, com. | 0, 1 |
| what‑it‑does | antioxidant | preservative |
| what‑it‑does | buffering |
| what‑it‑does | chelating |
| what‑it‑does | emollient |
| what‑it‑does | viscosity controlling |
| what‑it‑does | antioxidant | preservative |
| what‑it‑does | buffering |
| what‑it‑does | antioxidant | preservative |
| what‑it‑does | buffering |
| what‑it‑does | buffering |
| what‑it‑does | buffering |
| what‑it‑does | preservative |
| what‑it‑does | preservative |
| what‑it‑does | preservative |
| what‑it‑does | perfuming |
| what‑it‑does | perfuming |