R+ Cell to Cell Essence Gel Crème
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Postquam R+ Cell to Cell Essence Gel CrèmeIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, is super well tolerated by every skin type and easy to formulate with. No wonder it’s popular.
We don't have description for this ingredient yet.
It seems to us that squalane is in fashion and there is a reason for it. Chemically speaking, it is a saturated (no double bonds) hydrocarbon (a molecule consisting only of carbon and hydrogen), meaning that it's a nice and stable oily liquid with a long shelf life.
It occurs naturally in certain fish and plant oils (e.g. olive), and in the sebum (the oily stuff our skin produces) of the human skin. As f.c. puts it in his awesome blog post, squalane's main things are "emolliency, surface occlusion, and TEWL prevention all with extreme cosmetic elegance". In other words, it's a superb moisturizer that makes your skin nice and smooth, without being heavy or greasy.
Another advantage of squalane is that it is pretty much compatible with all skin types and skin conditions. It is excellent for acne-prone skin and safe to use even if you have fungi-related skin issues, like seborrhea or fungal acne.
The unsaturated (with double bonds) and hence less stable version of Squalane is Squalene, you can read about it here >>
- It's a helper ingredient that improves the freeze-thaw stability of products
- It's also a solvent, humectant and to some extent a penetration enhancer
- It has a bad reputation among natural cosmetics advocates but cosmetic scientists and toxicology experts do not agree (read more in the geeky details section)
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
We don't have description for this ingredient yet.
When it comes to grape and skincare, the seed extract and the seed oil steals most of the show. The reason for that is that the seed contains the majority of the skin goodies, the antioxidant superstar polyphenols.
The fruit also contains some, but it's less potent. However - according to manufacturer info - the fruit extract is not only an antioxidant, but it's also a soothing, moisturizing and nourishing agent.
An anti-aging active ingredient that's claimed by its manufacturer to fight "all signs of aging" from dehydration, damaged skin barrier, and redness to age spots, wrinkles, and even pores. It works by telomere (the protecting end part of the chromosomes that get shorter during chromosome replication) stabilization and DNA maintenance and is claimed to be able to expand cell lifespan by a third. It might also improve the tissue quality by optimizing cell communication and cell metabolism.
The manufacturer did a simple blind study of 24 participants to back up these rather extraordinary claims. They found that 3% Renovage cream used for 6 months increased skin moisturization by 30-58% for all panelists, improved barrier integrity by 19-46% for 75% of panelists and fade UVsunspotss by 42 to 56% for all panelists.
They also found that after 1 month 75% of the panelists showed an improvement in skin firmness (by 12-35%), elasticity (by 11-31%) and tone (by 19-45%). Renovage also helped skin surface smoothness (roughness on neckline improved by 36%), dilated pores (-17% after 1 month, -26% after 6 months) and skin redness (-30.5%).
Phew, that was a long list! The point is that Teprenone seems to be a promising fix-it-all kind of anti-aging ingredient though all this info comes from one small test made by the manufacturer, so at this point, it's more of a promise than a proven reality.
A biotechnologically derived ingredient that is produced by the fermentation of a marine bacteria living in the cold Antarctic Ocean. According to the manufacturer's info, it seems to have two different sets of magic properties:
The first set includes skin-protecting and anti-aging abilities: it can help to protect the skin from dryness and redness due to cold weather and it also promotes skin regeneration and smoother skin surface by stimulating protein synthesis in the skin. More specifically, these proteins are type I and IV collagen and elastin, all super important stuff for wrinkle-free, young looking skin (though these results came only from in-vitro tests and might or might not apply to living human skin).
As for in-vivo (tested on real people) efficacy, 1% Antarcticine (the trade name for the diluted version of the Pseudoalteromonas Ferment Extract) cream increased skin hydration by 14.8% in cold weather and 5% Antarcticine cream decreased the depth of wrinkles by 44% around the eyes.
The second set of magic properties are all about oily skin regulation, such as reducing sebum production, shininess, and pore size. It acts through reducing Melanocortin 5 receptor, a protein important in sebum production. According to the in-vivo tests of the manufacturer, it both immediately reduces skin gloss as well as significantly reduces the number of active follicles and their total surface with ongoing use (by 9.5% and 27.2% after 28 days).
Overall, an interesting, multifunctional ingredient both for anti-aging as well as oily skin control purposes.
A chemically chopped up version of wheat protein that consists mainly of amino acids (the building blocks), peptides (a couple of amino acids together), and proteins (lots of amino acids together).
It has moisturizing and film-forming properties and might be able to counteract the irritating effects of cleansing agents in cleansers and shampoos. It can also condition and repair damaged hair leaving it soft, silky and smooth.
We don't have description for this ingredient yet.
A small, three amino acid (glycine-histidine-lysine or GHK) peptide that is famous for being a type I collagen fragment. The theory behind collagen-fragment peptides is that when collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen.
Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more. So Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. FYI; Tripeptide-1 is the same peptide that can be found in the famous Matrixyl 3000, but in Matrixyl a palmitic acid is attached to it to increase its oil solubility and thus skin penetration.
Another reason why Tripeptide-1 is especially famous is that it is not only a signal peptide but also a so-called carrier peptide that helps to stabilize and deliver copper in the skin. It has a high affinity for copper ions and likes to form a complex with them called Copper-Tripeptide-1 or GHK-Cu. GHK-Cu is a famous and well-researched peptide that does a bunch of things in the skin and we have a shiny explanation about it here.
As for Tripeptide-1 in and of itself, without a palmitic acid or copper attached to it, it goes by the trade name Kollaren and according to the manufacturer, it not only stimulates collagen but also other essential skin proteins such as fibronectin, elastin, and laminin. Kollaren is also claimed to be beneficial for acne-prone skin as it can boost tissue repair and thus help acne scars to heal faster.
We don't have description for this ingredient yet.
A small, three amino acid (glycine-histidine-lysine or GHK) peptide that is famous for being a type I collagen fragment. The theory behind collagen-fragment peptides is that when collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen.
Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more. So Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. FYI; Tripeptide-1 is the same peptide that can be found in the famous Matrixyl 3000, but in Matrixyl a palmitic acid is attached to it to increase its oil solubility and thus skin penetration.
Another reason why Tripeptide-1 is especially famous is that it is not only a signal peptide but also a so-called carrier peptide that helps to stabilize and deliver copper in the skin. It has a high affinity for copper ions and likes to form a complex with them called Copper-Tripeptide-1 or GHK-Cu. GHK-Cu is a famous and well-researched peptide that does a bunch of things in the skin and we have a shiny explanation about it here.
As for Tripeptide-1 in and of itself, without a palmitic acid or copper attached to it, it goes by the trade name Kollaren and according to the manufacturer, it not only stimulates collagen but also other essential skin proteins such as fibronectin, elastin, and laminin. Kollaren is also claimed to be beneficial for acne-prone skin as it can boost tissue repair and thus help acne scars to heal faster.
A very common ingredient that can be found in all cell membranes. In cosmetics it's quite the multi-tasker: it's an emollient and water-binding ingredient but it's also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes.
It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range.
Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415).
A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula. It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.
It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol.
The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.
Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.
BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.
It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive.
An antimicrobial preservative that helps your products not to go wrong too quickly. It works especially well against bacteria, specifically gram-negative species, yeast, and mold.
Somewhat controversial, it belongs to an infamous family of formaldehyde-releasers. That is, it slowly breaks down to form formaldehyde when it is added to a formula. We have written more about formaldehyde-releasing preservatives and the concerns around them at Dmdm Hydantoin, but do not get too scared, those are more theories than proven facts.
As for Diazolidinyl Urea itself, a study from 1990 writes that at concentrations up to 0.4%, it was a mild cumulative skin irritant, but the CIR (Cosmetic Ingredient Review) reviewed it in 2006 and found that, in concentrations of <0.5%, it is safe as used, as the amount of formaldehyde released will be smaller than the recommended limit (of less than 0.2%).
All in all, it is up to your personal decision and skin sensitivity.
It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. Its strong point is being effective against yeasts and molds, and as a nice bonus seems to be non-comedogenic as well.
It is safe in concentrations of less than 0.1% but is acutely toxic when inhaled, so it's not the proper preservative choice for aerosol formulas like hairsprays. Used at 0.1%, Iodopropynyl Butylcarbamate has an extremely low rate of skin-irritation when applied directly for 24 hours (around 0.1% of 4,883 participants) and after 48 hours that figure was 0.5%, so it counts as mild and safe unless your skin is super-duper sensitive.
It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic.
Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10).
It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.
It’s a little helper ingredient that helps to set the pH of a cosmetic formulation to be just right. It’s very alkaline (you know the opposite of being very acidic): a 1% solution has a pH of around 10.
It does not have the very best safety reputation but in general, you do not have to worry about it.
What is true is that if a product contains so-called N-nitrogenating agents (e.g.: preservatives like 2-Bromo-2-Nitropropane-1,3-Diol, 5-Bromo-5-Nitro- 1,3-Dioxane or sodium nitrate - so look out for things with nitro, nitra in the name) that together with TEA can form some not nice carcinogenic stuff (that is called nitrosamines). But with proper formulation that does not happen, TEA in itself is not a bad guy.
But let’s assume a bad combination of ingredients were used and the nitrosamines formed. :( Even in that case you are probably fine because as far as we know it cannot penetrate the skin.
But to be on the safe side, if you see Triethanolamine in an INCI and also something with nitra, nitro in the name of it just skip the product, that cannot hurt.
It's a little helper ingredient coming from corn, rice or potato starch that can help to keep skin mat (absorbent), to stabilise emulsions, and to keep the product together (binding).
This ingredient name is not according to the INCI-standard. :( What, why?!
Citronellol is a very common fragrance ingredient with a nice rose-like odor. In the UK, it’s actually the third most often listed perfume on the ingredient lists.
It can be naturally found in geranium oil (about 30%) or rose oil (about 25%).
As with all fragrance ingredients, citronellol can also cause allergic contact dermatitis and should be avoided if you have perfume allergy. In a 2001 worldwide study with 178 people with known sensitization to fragrances citronellol tested positive in 5.6% of the cases.
There is no known anti-aging or positive skin benefits of the ingredient. It’s in our products to make it smell nice.
A common fragrance ingredient that has a sweet, vanilla, nutty scent. When diluted it smells like freshly-mown hay.
It’s one of the “EU 26 fragrances” that has to be labelled separately (and cannot be simply included in the term “fragrance/perfume” on the label) because of allergen potential. Best to avoid if your skin is sensitive.
A common fragrance ingredient that smells like jasmine. It is one of the “EU 26 fragrances” that has to be labelled separately because of allergen potential. Best to avoid if your skin is sensitive.
A common fragrance ingredient that has a nice floral scent and also goes by the name Lilial. It is a known fragrance allergen and as of 1st of March 2022, it has been banned in the EU due to animal studies showing a possible link to infertility (in rats - so no need to panic even if you used a product before with Butylphenyl Methylpropional).
Linalool is a super common fragrance ingredient. It’s kind of everywhere - both in plants and in cosmetic products. It’s part of 200 natural oils including lavender, ylang-ylang, bergamot, jasmine, geranium and it can be found in 90-95% of prestige perfumes on the market.
The problem with linalool is, that just like limonene it oxidises on air exposure and becomes allergenic. That’s why a product containing linalool that has been opened for several months is more likely to be allergenic than a fresh one.
A study made in the UK with 483 people tested the allergic reaction to 3% oxidised linalool and 2.3% had positive test results.
Exactly what it sounds: nice smelling stuff put into cosmetic products so that the end product also smells nice. Fragrance in the US and parfum in the EU is a generic term on the ingredient list that is made up of 30 to 50 chemicals on average (but it can have as much as 200 components!).
If you are someone who likes to know what you put on your face then fragrance is not your best friend - there's no way to know what’s really in it.
Also, if your skin is sensitive, fragrance is again not your best friend. It’s the number one cause of contact allergy to cosmetics. It’s definitely a smart thing to avoid with sensitive skin (and fragrance of any type - natural is just as allergic as synthetic, if not worse!).
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| what‑it‑does | solvent |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | emollient |
| what‑it‑does | skin-identical ingredient | emollient |
| irritancy, com. | 0, 1 |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 0 |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | soothing | antioxidant | moisturizer/humectant |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | soothing | moisturizer/humectant |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | emollient | emulsifying |
| what‑it‑does | viscosity controlling |
| what‑it‑does | viscosity controlling |
| irritancy, com. | 0, 1 |
| what‑it‑does | moisturizer/humectant | emollient |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 1 |
| what‑it‑does | preservative |
| what‑it‑does | preservative |
| what‑it‑does | preservative |
| what‑it‑does | buffering |
| irritancy, com. | 0, 2 |
| what‑it‑does | perfuming |
| what‑it‑does | perfuming |
| what‑it‑does | perfuming |
| what‑it‑does | perfuming |
| what‑it‑does | perfuming |
| what‑it‑does | perfuming |