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Manyo Factory Lactobacillus Bifida Mist
Manyo Factory

Lactobacillus Bifida Mist

A complex of bifidobacteria peptides and enzymes contained in the Lactobacillus Bifida Mist for face, moisturizes skin, protects from harmful environmental exposure, boosts skin protective functions by 93%, nourishes, soothes [more] [more] and prevents wrinkles formation, gives radiant and healthy looking skin. Does not contain alcohol and is dermatologically tested. [less]
Uploaded by: melioraspero on 26/06/2018

Skim through

Ingredient name what-it-does irr., com. ID-Rating
Paeonia Lactiflora Extract
Bifida Ferment Lysate (20%) goodie
Lactobacillus/Pumpkin Fruit Ferment Filtrate (10%)
Butylene Glycol moisturizer/​humectant, solvent 0, 1
Sodium Hyaluronate skin-identical ingredient, moisturizer/​humectant 0, 0 goodie
Bacillus/Soybean Ferment Extract
Phellinus Linteus Extract
Acetyl Hexapeptide-8 cell-communicating ingredient, moisturizer/​humectant goodie
Aureobasidium Pullulans Ferment Filtrate moisturizer/​humectant
Palmitoyl Dipeptide
Palmitoyl Tripeptide-1 cell-communicating ingredient goodie
Shiitake Mushroom Extract
Coriolus Versicolor Mushroom Extract moisturizer/​humectant
Copper Tripeptide-1 cell-communicating ingredient, soothing, antioxidant goodie
Allantoin soothing 0, 0 goodie
Panthenol soothing, moisturizer/​humectant 0, 0 goodie
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 goodie
Physalis Alkekengi Fruit Extract
Black Tea Extract antioxidant, soothing, antimicrobial/​antibacterial superstar
Fermented Pu Erh Tea
Epigallocatechin Gallate antioxidant, soothing superstar
Panax Ginseng Root Extract antioxidant, emollient goodie
Ginseng Extract antioxidant, emollient goodie
Algin viscosity controlling 4, 4
Forsythia Extract antioxidant
Dioscorea Opposita (Wild Yam) Root Extract
Methyl Gluceth-20 moisturizer/​humectant
Caffeine antioxidant goodie
Zanthoxylum Piperitum Fruit Extract antioxidant, antimicrobial/​antibacterial, preservative icky
Pasque Flower Extract
Usnea Extract preservative, antimicrobial/​antibacterial
Caprylyl Glycol moisturizer/​humectant, emollient
Scutellaria Baicalensis Root Extract soothing, antioxidant, antimicrobial/​antibacterial goodie
Illicium Verum (Anise) Fruit Extract perfuming
Adenosine cell-communicating ingredient goodie

Ingredients explained

What-it-does: astringent

We don't have description for this ingredient yet.

It’s a probiotic ingredient that’s used in one of the most iconic serums in the world, the Estee Lauder Advanced Night Repair.

Based on manufacturer info it potently protects against UV-induced damage in the skin and helps with DNA repair. An Estee Lauder patent from 2009 also talks about DNA repair activity.

Expand to read more

As far as published research goes we could find one promising one. It showed that applying 10% bacterial extract to sensitive, reactive skin helped with better barrier function and decreased skin sensitivity

So all in all: definitely a promising ingredient, even for sensitive skin types but not the most proven one (yet).

We don't have description for this ingredient yet.

What-it-does: moisturizer/humectant, solvent | Irritancy: 0 | Comedogenicity: 1

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

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It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive. 

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It’s the - sodium form - cousin of the famous NMFhyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

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In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).

What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists. 

If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Also-called: Argireline, Acetyl Hexapeptide-3 | What-it-does: cell-communicating ingredient, moisturizer/humectant

If you see a cosmetic product that claims that it has "Botox-like effect" then two things are almost certain: one, the product overpromises and two, it contains Argireline. 

So this one is the famous peptide that's marketed by its manufacturer as the "Botox in a jar". The basis for this claim is that it targets the same wrinkle forming mechanism (wrinkles caused by facial muscle movement) as Botox, but the way it works is very different. In addition, the extent to which it can prevent muscles from contracting (and to smooth wrinkles) is very different (otherwise why would anyone use still Botox?). 

Expand to read more

The manufacturer did several studies to prove that Argireline really works and it does (just not as well as Botox). In-vivo (made on real people) tests showed that using 10% Argireline solution around the eyes for 15 days decreased wrinkles depth by 17%. A Spanish University also did some research and found that Argireline increased the level of skin moisturization and decreased both the depth and width of wrinkles "significantly". 

This means, Acetyl Hexapeptide-8 does have some ability to smooth wrinkles (but not as well as Botox - sorry, if we sound like a broken record). Also, we have to agree with TruthInAging, that it's not a collagen builder and not a preventer of structural aging (think vitamin C, AHAs or retinol); it's just a quick fix. If you are looking for one, this could be your thing. If you are more of a "let's treat this aging thing properly" type, then it's probably not your thing.

What-it-does: moisturizer/humectant

We don't have description for this ingredient yet.

This ingredient name is not according to the INCI-standard. :( What, why?!

Also-called: Part of Matrixyl 3000, Pal-GHK, Formerly also Palmitoyl Oligopeptide | What-it-does: cell-communicating ingredient

A really famous peptide that is part of Matrixyl 3000, the most sold peptide complex in the word. Before we go and find out what the big deal with Matrixyl 3000 is, let's just focus on Palmitoyl Tripeptide-1 itself for a bit.

It's a small three amino acid (they are the building blocks of all proteins) peptide with the amino sequence of glycine-histidine-lysine, or GHK. GHK is attached to palmitic acid (a fatty acid) to increase oil solubility and skin penetration. 

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The GHK part is the important one as it's a type I collagen fragment. When collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen. Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more.

Therefore, Palmitoyl Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. 

In Matrixyl 3000, Palmitoyl Tripeptide-1 is coupled with Palmitoyl Tetrapeptide-7  and the duo works in synergy to reduce wrinkles and give younger looking skin. According to the manufacturer's in-vivo (made on real people) test, applying 3% Matrixyl 3000 twice a day for 2 months resulted in all of the following things:

  • 39.4% reduction in surface occupied by deep wrinkles
  • 32.9% reduction in main wrinkle density
  • 19.9% reduction in main wrinkle average depth
  • 16% improvement in roughness
  • 16.2% in lifting effect
  • 5.5% improvement in elasticity
  • 15.5% improvement in skin tone

Manufacturer results, of course, always have to be taken with a pinch of salt, but if you like peptides, the Matryxil 3000 duo is one of the best-proven and most well-known ones and it's something that is worth trying.

Also-called: Lentinus Edodes Extract

We don't have description for this ingredient yet.

What-it-does: moisturizer/humectant

We don't have description for this ingredient yet.

Also-called: GHK-Cu, Copper Peptide | What-it-does: cell-communicating ingredient, soothing, antioxidant
  • GHK-Cu is a copper-peptide complex found naturally in yucky bodily fluids (plasma, saliva, and urine)
  • It has unique wound healing properties by stimulating the breakdown of unhealthy, too large collagen in scar tissue and stimulating nice and healthy collagen production afterwards
  • It stimulates the production of several important skin-identical ingredients (e.g. collagen, elastin, and glycosaminoglycans)
  • It has significant anti-inflammatory and antioxidant effect
  • There are a few promising studies showing GHK-Cu can improve skin elasticity, clarity, firmness and reduce lines and wrinkles
  • It can improve hair growth by enlarging hair follicles (and bigger follicles produce longer, thicker hair)
  • There are some urban legends about possible overdosing or facial hair problems (read more in geeky details)
Read all the geeky details about Copper Tripeptide-1 here >>

Allantoin - goodie
What-it-does: soothing | Irritancy: 0 | Comedogenicity: 0

Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. 

It's not only soothing but it' also skin-softening and protecting and can promote wound healing.

Panthenol - goodie
Also-called: Pro-Vitamin B5 | What-it-does: soothing, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid). 

Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier. 

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Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.

Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation. 

If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.

As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily. 

Glycerin - goodie
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • Super common, used for more than 50 years
  • Not only a simple moisturizer but plays an important role in keeping the stuff between our skin cells healthy
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

We don't have description for this ingredient yet.

Black Tea Extract - superstar
Also-called: Green Tea;Camellia Sinensis Leaf Extract | What-it-does: antioxidant, soothing, antimicrobial/antibacterial
  • Green tea is one of the most researched natural ingredients
  • The active parts are called polyphenols, or more precisely catechins (EGCG being the most abundant and most active catechin)
  • There can be huge quality differences between green tea extracts. The good ones contain 50-90% catechins (and often make the product brown and give it a distinctive smell)
  • Green tea is proven to be a great antioxidant, UV protectant, anti-inflammatory, anticarcinogenic and antimicrobial
  • Because of these awesome properties green tea is a great choice for anti-aging and also for skin diseases including rosacea, acne and atopic dermatitis
Read all the geeky details about Camellia Sinensis Leaf Extract here >>

We don't have description for this ingredient yet.

Also-called: EGCG | What-it-does: antioxidant, soothing

If EGCG does not tell you anything, green tea sure does. We have written about green tea in excruciating details, so if you wanna become an expert in the "green tea in skincare" topic,  click here and read it

So now you know that EGCG is the magic ingredient in green tea. It's the most active polyphenol that green tea owes most of its magic properties to. It's a fantastic antioxidant, anti-inflammatory and anticarcinogenic agent. Be happy, if you spot it on the ingredient list. 

Also-called: True Ginseng, Ginseng, Korean Ginseng | What-it-does: antioxidant, emollient

A  traditional Korean medicine used for more than 2000 years. Regarding skin care, its main thing seems to be enhancing skin nutrition and metabolism as a result of improving blood circulation.

It also contains biologically active components referred to as ginseng saponins (ginsenosides) that have potent antioxidant properties

Also-called: True Ginseng, Ginseng, Korean Ginseng;Panax Ginseng Root Extract | What-it-does: antioxidant, emollient

A  traditional Korean medicine used for more than 2000 years. Regarding skin care, its main thing seems to be enhancing skin nutrition and metabolism as a result of improving blood circulation.

It also contains biologically active components referred to as ginseng saponins (ginsenosides) that have potent antioxidant properties

Also-called: Sodium Alginate | What-it-does: viscosity controlling | Irritancy: 4 | Comedogenicity: 4

A large sugar molecule (aka polysaccharide) that's used as a gelling agent and comes from brown seaweed. 

Combined with calcium salts, it forms a rigid gel used in "rubber masks". 

What-it-does: antioxidant

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

What-it-does: moisturizer/humectant

A corn sugar derived, water-soluble, pale yellow syrup, that nicely moisturizes the skin. It has a light and smooth skin feel, it is non-tacky, and it can improve the after-feel of the formula. It is also mild and gentle, popular in sensitive skin formulas.

Caffeine - goodie
What-it-does: antioxidant

Hello, our favorite molecule that helps us wake up in the morning and then keeps us going through the day. As a super well-known stimulant from coffee, tea and plenty of other soft drinks, Caffeine needs no introduction. So we will skip right to the part where we talk about what the hell it does in so-so many cosmetic products.

Looking at the research, we were surprised to find how versatile Caffeine is. It is a small, water-loving molecule with pretty good skin penetration abilties. Once in the skin, it has nice antioxidant properties, meaning that it reduces the formation of evil free radicals and it might even be useful in preventing UV-induced skin cancers. 

Expand to read more

A well-known thing about Caffeine is that it improves the microcirculation of the blood vessels. Though conventional wisdom and anecdotal evidence says that this property is helpful for dark under-eye circles and puffy eyes, we have to mention that the double-blind research we have found about a 3% caffeine gel concluded that "the overall efficacy of the selected caffeine gel in reducing puffy eyes was not significantly different from that of its gel base."  But you know, the proof is in the pudding.

Another thing Caffeine is used for in body care products is its anti-cellulite effects. In theory, it can speed up the lipolysis process (the "fat burning"  by our cells) and stimulate the draining lymph system that might lead to the improvement of cellulite. But here again, the evidence that it actually makes a measurable, let alone visible,  improvement on actual human beings is limited (we could find only some animal skin studies or caffeine being combined with other actives). 

Last, but not least, we have to write about caffeine and hair growth. The theory is that it can inhibit the activity of the 5-α-reductase enzyme that plays an important role in hair loss and allows a renewed growth phase of the hair. We have found some recent and promising research to back this up. A 2017 study compared a 0.2% caffeine liquid with a 5% Minoxidil  (an FDA approved active to treat baldness) solution and found that  "a caffeine-based topical liquid should be considered as not inferior to minoxidil 5% solution in men with androgenetic alopecia", or English translation means that the caffeine liquid was pretty much as good as the FDA-approved Minoxidil stuff. Not bad!

Overall, we think that caffeine is a very versatile and biologically active ingredient. Even though some of its effects are more hyped up than backed up, it is still a nice to have on many ingredient lists. 

Also-called: Japanese Pepper, Korean Pepper, Sanshō, Chopi | What-it-does: antioxidant, antimicrobial/antibacterial, preservative

If you are into Japanese cuisine, you might know this guy as Japanese pepper or Sanshō pepper that is known for its unique fresh aroma and appetite increasing spicy sensation.

As for the skin benefits of Zanthoxylum Piperitum, it might have antioxidant effects (with active components called hyperoside and quercitrin), but more importantly, it is an antibacterial and natural preservative agent. It is pretty common in K-Beauty products, as it's one of the three natural extracts that make up the popular Korean preservative called EURO-NApre. 

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Combined with Usnea Barbata and Pulsatilla Koreana, these three extracts are claimed to form a natural preservative system that also has anti-inflammatory effects and might help with skin conditions such as blemishes, atopic dermatitis, and dandruff. 

On the flip side, Zanthoxylum Piperitum contains fragrant components (Limonene and Citrone), that might irritate sensitive skin. 

This ingredient name is not according to the INCI-standard. :( What, why?!

Also-called: Lichen Extract;Usnea Barbata Extract | What-it-does: preservative, antimicrobial/antibacterial, deodorant

The extract coming from the alpine lichen, Usnea Barbata. It is known for its excellent efficacy against gram-positive bacteria, meaning that it can serve as a natural preservative and deodorant agent.

Its main biologically active component is usnic acid (a molecule produced only by lichens) that's not only an antibacterial agent, but also has antioxidant, anti-inflammatory and wound-healing promoting effects. According to manufacturer info,  the antibacterial activity of Usnea Barbata makes the ingredient helpful against body odor, blemished skin, and dandruff. 

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It is also very common in K-Beauty products, as it is part of a popular Korean natural preservative system trade named EURO-Napre (combined with Zanthoxylum Piperitum and Pulsatilla Koreana). 

It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol

The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.

Also-called: Skullcap Root Extract | What-it-does: soothing, antioxidant, antimicrobial/antibacterial

A traditional Chinese herbal medicine loaded with potent antioxidant and anti-inflammatory flavonoids such as baicalin, baicalein, and wogonin.

If that would not be enough, Skullcap Root is also claimed to have antimicrobial and antifungal properties (also against P.acnes and Malassezia furfur) as well as some skin-brightening activity. A multi-functional skin-goodie.

What-it-does: perfuming

We don't have description for this ingredient yet.

Adenosine - goodie

Adenosine is an important little compound in our body that has a vital cell-signalling role. Research on smearing it on our face is also promising and shows so far a couple of things:

  • It can help with wound healing
  • It’s a good anti-inflammatory agent
  • It might even help with skin’s own collagen production and improve skin firmness and elasticity
  • It helps with barrier repair and protection
  • It might be even useful for the hair helping with hair thickness and hair growth

You may also want to take a look at...

A probiotic ingredient that might protect against UV-induced damage, help barrier repair and decrease skin sensitivity. [more]
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0, 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
what‑it‑does cell-communicating ingredient | moisturizer/humectant
Argireline - famous peptide that's often referred to as "Botox in a jar". In reality, it's nowhere near that powerful, but it can smooth wrinkles to some extent by preventing facial muscles from contracting. [more]
what‑it‑does moisturizer/humectant
what‑it‑does cell-communicating ingredient
A three amino acid peptide that is part of famous peptide duo, Matrixyl 3000. It's a type I collagen fragment that might be able to trick the skin to think that collagen broke down and it's time to create some new one. [more]
what‑it‑does moisturizer/humectant
what‑it‑does cell-communicating ingredient | soothing | antioxidant
A copper-peptide complex that has unique wound healing and skin remodelling properties. It's also an anti-inflammatory and antioxidant agent. [more]
what‑it‑does soothing
irritancy, com. 0, 0
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. It's not only soothing but it' [more]
what‑it‑does soothing | moisturizer/humectant
irritancy, com. 0, 0
Pro-Vitamin B5 is a goodie that moisturises the skin, has anti-inflammatory, skin protecting and wound healing properties. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does antioxidant | soothing | antimicrobial/antibacterial
Green Tea - one of the most researched natural ingredients that contains the superstar actives called catechins. It has proven antioxidant, anti-inflammatory, antimicrobial and anticarcinogenic properties. [more]
what‑it‑does antioxidant | soothing
The most active polyphenol in green tea. A fantastic antioxidant, anti-inflammatory and anticarcinogenic agent. [more]
what‑it‑does antioxidant | emollient
Ginseng - A traditional Korean medicine that has antioxidant properties, and is known to improve blood circulation. [more]
what‑it‑does antioxidant | emollient
Ginseng - A traditional Korean medicine that has antioxidant properties, and is known to improve blood circulation. [more]
what‑it‑does viscosity controlling
irritancy, com. 4, 4
A large sugar molecule (aka polysaccharide) that's used as a gelling agent and comes from brown seaweed. Combined with calcium salts, it forms a rigid gel used in "rubber masks".  [more]
what‑it‑does antioxidant
what‑it‑does moisturizer/humectant
A corn sugar-derived, water-soluble, pale yellow syrup, that nicely moisturizes the skin. It has a light and smooth skin feel. [more]
what‑it‑does antioxidant
The well-known stimulant from coffee. It has nice antioxidant properties and can improve the microcirculation. Might be helpful for dark circles, puffy eyes, as well as cellulite and hair loss. [more]
what‑it‑does antioxidant | antimicrobial/antibacterial | preservative
Japanese pepper extract that has natural antibacterial and preservative activities. Combined with Usnea Barbata and Pulsatilla Koreana, it is part of a popular Korean preservative system called EURO-NApre. [more]
what‑it‑does preservative | antimicrobial/antibacterial
The extract coming from the alpine lichen, Usnea Barbata. It is known for its excellent efficacy against gram-positive bacteria, meaning that it can serve as a natural preservative and deodorant agent.Its main biologically active component is usnic acid (a molecule produced only by lichens) that's not only an antibacterial agent, but also has antioxidant, anti-inflammatory and wound-h [more]
what‑it‑does moisturizer/humectant | emollient
A handy multi-tasking ingredient that gives the skin a nice, soft feel and also boosts the effectiveness of other preservatives. [more]
what‑it‑does soothing | antioxidant | antimicrobial/antibacterial
A traditional Chinese herbal medicine loaded with potent antioxidant and anti-inflammatory flavonoids such as baicalin, baicalein, and wogonin.If that would not be enough, Skullcap Root is also claimed to have antimicrobial and antifungal properties (also against P.acnes and Malassezia furfur) as well  [more]
what‑it‑does perfuming
what‑it‑does cell-communicating ingredient
An important compound in our body that has a vital cell-signalling role. It is wound healing, anti-inflammatory and can help with barrier repair. [more]
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