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Whitelab Microbiome Complex SerumIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
A super commonly used 5 unit long, cyclic structured silicone that is water-thin and does not stay on the skin but evaporates from it (called volatile silicone). Similar to other silicones, it gives skin and hair a silky, smooth feel.
It's often combined with the non-volatile (i.e. stays on the skin) dimethicone as the two together form a water-resistant, breathable protective barrier on the skin without a negative tacky feel.
It's a type of glycol that - according to the manufacturer - is an extremely good replacement for other glycols like propylene or butylene glycol. Its main job is to be a solvent, but it has also very good antimicrobial properties and acts as a true preservative booster. Also helps with skin hydration without stickiness or tacky feel.
A light, velvety, unique skin feel liquid that is a good solvent and also makes the skin feel nice and smooth (aka emollient). It's often used in makeup products mixed with silicones to give shine and slip to the product. It's also great for cleansing dirt and oil from the skin as well as for taking off make-up.
We don't have description for this ingredient yet.
A famous water-like, yeast-derived ingredient that the whole SKII brand is built on. As legend has it, SKII scientists in the 1970's discovered by chance that aged Japanese sake brewers have amazingly soft and youthful hands in contrast to their aged and wrinkled faces. They concluded that the secret must lie in the yeast that the brewers’ hands were in constant contact with during the sake fermentation process.
So Pitera - obtained by a fermentation process of a certain yeast belonging to the genus Galactomyces - was discovered as an anti-aging, skin-nourishing magic liquid. The company claims that the clear, water-like liquid is loaded with good-for-the-skin stuff and is rich in vitamins, amino acids, minerals and organic acids.
As for the science behind Pitera, SKII parent company P&G did an in-vitro (made in the lab) study that confirmed that Pitera-containing moisturizers do indeed help to protect the skin against damage. More specifically, they found that Pitera has antioxidant effects and increases hyaluronan production in epidermal cells. And more hyaluronic acid in the skin means better hydrated, plumper, healthier skin.
If that would not be enough, there is also a 2014 study showing that Pitera might be able to help with skin pigmentation and a 2015 study finding that Galactomyces Ferment Filtrate can activate aryl hydrocarbon receptor (AhR) that's important in epidermal homeostasis by upregulating epidermal barrier proteins. English translation equals: Pitera might be able to help with a healthy skin barrier.
All in all, both anecdotal and scientific evidence show that Pitera is a skin goodie so if you are into essences and yeast-derived fermentations, it's definitely worth a try.
- A multi-functional skincare superstar with several proven benefits for the skin
- Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
- Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
- Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
- Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
A handy helper ingredient that comes in a white powder form and works as an anti-caking and oil-absorbing agent. It also gives products good spreadability, long lasting and velvet touch characteristics. It is popular both in skincare and makeup products.
We don't have description for this ingredient yet.
Saccharomyces Ferment Filtrate is the fancy name of a liquidy, almost-water-like stuff that you get by fermenting and filtering yeast.
According to manufacturer info it’s rich in all kinds of good-for-your-skin things: essential minerals, amino acids, beta-glucan and vitamins. It’s definitely great for skin moisturization and soothing, and might have some skin brightening and wrinkle repair magic activity as well.
When you hear oatmeal, you probably think of breakfast, but the finely ground version of whole oat kernels, aka colloidal oatmeal, can do good things for your skin, especially if it's dry, itchy or prone to skin-rashes or eczema.
Oat is loaded with compounds good for the body, inside or outside, such as soothing agent beta-glucan (5%), lipids (3-11%) including barrier repairing omega-3 and 6 fatty acids or phenolic antioxidant and anti-inflammatory agents (avenanthramides).
The soothing, antioxidant and skin-protecting abilities of oat are so well-established that it is an active natural ingredient covered by the FDA OTC Skin Protectant monograph in the US, meaning that colloidal oatmeal can be claimed as an active ingredient on the INCI list and Aveeno is a mass-market brand built around oat-containing products.
If your skin is dry, irritated, inflamed or eczema-prone, colloidal oatmeal is something to try.
- It’s naturally in our skin and behaves there like a sponge
- It can bind up to 1000 times its own weight in water
- It is a big molecule from repeated subunits (polymer) so different molecular weight versions exist (unfortunately there is no way to determine MW from INCI list only)
- High-molecular-weight-HA (>500 kDa) is an excellent surface hydrator, skin protectant and can act as an osmotic pump helping water-soluble actives to penetrate deeper into the skin
- Low-molecular-weight-HA (< 500 kDa) can hydrate the skin somewhat deeper though it is still a big molecule and works mainly in the epidermis (outer layer of the skin)
- Low-molecular-weight-HA might also help the skin to repair itself by increasing its self-defense (~ 200kDa used in the study)
- Ultra-low-molecular-weight-HA (<50kDa) is a controversial ingredient and might work as a pro-inflammatory signal molecule
Hydrolyzed Hyaluronic Acid is a low molecular weight, chemically chopped up version of the naturally big molecule and current IT-moisturizer, Hyaluronic Acid (HA). The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to retain water, making it plump and elastic. As HA is a polymer, the subunits can be repeated many times (as a high-molecular-weight version), or just a few times (as a low-molecular-weight version).
We wrote in detail at HA about how different molecular weight versions do different things both as a component of the skin and as a skincare ingredient, so click here and read about all the details. Hydrolyzed Hyaluronic Acid can also come in different molecular-weight versions with different properties:
- 100-300 kDa version: apart from moisturizing, this size might also help the skin to repair itself by increasing its self-defense. It is also claimed to boost the wound healing process and is especially helpful for sensitive skin types (acne, rosacea, inflammation-related skin diseases).
- 50k Da version: this is the size that is claimed to be able to absorb into the skin and plump up wrinkles, so it is used mainly as an "anti-aging ingredient"
- below 50k, around 10k Da version: there is a Japanese version trade named Hyalo-Oligo that has only a 10k molecular weight and is claimed to penetrate the skin very well, have a unique touch and give deep and long-lasting moisturization. Based on the Evonik-research and the natural role of LMW-HA in the body working as a pro-inflammatory signal molecule, this ultra-low molecular weight version is a controversial ingredient.
If you wanna become a real HA-and-the-skin expert, you can read much more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
It's a special "cross-linked" from of IT-moisturizer, hyaluronic acid (HA). Cross-linked means that "normal" HA pieces (1-2 million Da molecular weight) are chemically bound togeather to create a big, "infinite" mesh.
The special HA mesh has a remarkable water-binding capacity, 5 times more than the already crazy water-binding capacity of "normal" HA. This water filled crosslinked HA gel forms a smooth film on the skin and continuously delivers the bound water, so it gives long-term moisturizing benefits.
Btw, crosslinking HA was developed for dermal fillers (as crosslinking helps their longevity), and this guy is the topical version of FDA approved dermal filler called Hylan B gel. Smearing crosslinked version all over ourselves is a newish thing, and incoming evidence so far suggests that it's a great idea, even better than normal HA.
A very recent, 2016 research article compared the topical moisturizing effect of crosslinked HA (not Hylan B gel specifically, but something called Resilient HA or RHA), HMW-HA and LMW-HA and found that "TEWL (that is trans-epidermal water loss, the water that evaporates from the skin) was reduced by 27.8% with RHA, and by 15.6% with HMW HA, but increased by 55.5% with LMW HA." (You can read much more about HMW and LMW HA here in the geeky details section.)
All in all, we think Sodium Hyaluronate Crosspolymer is an awesome version of HA, probably superior to traditional versions, so be happy to spot it on the ingredient list.
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
It's a super small, chemically chopped up version of sodium hyaluronate. Its trade name is miniHA, and its molecular weight is 10 kDa. This counts as really tiny given that "normal" HA has a molecular weight of 0.5-2 million Da.
To be honest, low molecular weight (LMW), and especially this ultra-low molecular weight HA is a controversial ingredient. On the upside, it can penetrate the skin better (though 10kDa still counts as big!) and might be able to moisturize the deeper layers of the skin where normal HA cannot get. Also, according to the manufacturer of miniHA, it has better antioxidant activity than a 1.6MDa version HA and it also has better sun protection and after-sun repair abilities than the higher MW versions. It also works in synergy with higher molecular weight versions, and the combination of 0.1% 1.45MDa-HA + 0.1% 380 kDa-HA + 0.1% miniHA hydrated the skin significantly better than 0.3% 1.45MDa-HA alone.
On the downside, the biological role of LMW-HA in the skin is being a pro-inflammatory signaling agent and there is a study by another manufacturer called Evonik showing that HA versions with smaller than 50kDa molecular weight might be pro-inflammatory when put on the skin. Granted, the study was only done on reconstituted human epidermis, so it might or might not be like this on real human skin.
If you wanna get confused and read much more about hyaluronic acid and what the different molecular weight versions might or might not do, click here and read our excruciatingly long description.
We don't have description for this ingredient yet.
Sodium Acetylated Hyaluronate is a variation of current IT moisturizer, Hyaluronic acid, where some water-loving -OH groups are replaced by amphipathic (partly water-loving and partly water-hating) acetyl groups. The modified molecule is claimed to have even better moisture retention ability than normal HA and better affinity to the skin surface.
The better affinity comes from the acetyl groups that act as tiny "anchors" to attach the HA molecule to the skin. Staying on top of the skin better and longer means longer-lasting surface hydration and improved elasticity. It is also less sticky and more cosmetically elegant than normal HA, so no wonder the nickname of this molecule is super hyaluronic acid.
The chemically chopped up version of collagen coming from a marine (fish) source. It works as a moisturizer and emollient. Read more about hydrolyzed collagen here >>
Soluble Collagen refers to the big, natural collagen molecules mostly extracted from fish or bovine skin. Spotting collagen on the ingredient list, you might think that, aha, this must be there to supplement the collagen content of our own skin, but you have to know that collagen is a huge-huge molecule that cannot absorb to the middle layer of the skin where collagen is and even if it could, it cannot just magically go the right places to become part of the skin's own collagen network. Putting collagen on your skin for anti-aging purposes is like throwing tent poles onto a ramshackle tent and expecting the tent to magically become nice and firm again.
The strong point of collagen is being a large molecule with tremendous water binding capacity, i.e. an amazing humectant and moisturizer. It produces a water-rich film on the skin giving the stratum corneum (the uppermost layer of the skin) great hydration, making it nice and smooth and reducing trans-epidermal-water loss (the process of water evaporating out of your skin).
It is also so gentle and non-irritant that it can actually be used in cleansers to reduce the irritating potential of harsh surfactants, aka cleansing agents.
If you are fine with animal-derived ingredients and know that collagen in a jar has nothing to do with wrinkles but everything to do with skin hydration, Soluble Collagen is a nice ingredient.
The salt form of one of the main anti-inflammatory ingredients in the licorice plant, monoammonium glycyrrhizinate. It’s a yellowish powder with a nice sweet smell.
It’s used mainly for its soothing and anti-inflammatory properties, but according to manufacturer info, it’s also sebum regulating so it's a perfect ingredient for problem skin products.
Read more about licorice and why it's a skincare superstar here.
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically.
It's not only soothing but it' also skin-softening and protecting and can promote wound healing.
We don't have description for this ingredient yet.
It's a film-forming and thickening polymer (a large molecule composed of many repeated subunits) that comes to the formula usually as part of an emulsifier, thickener trio (with C13-14 Isoparaffin and Laureth-7, trade named Sepigel 305). This trio is an easy-to-use liquid that helps to create nice, non-tacky gel formulas.
It's a petroleum derived emollient and thickener. It often comes to the formula as part of an emulsifier, thickener trio (with Polyacrylamide and Laureth-7). This trio is an easy-to-use liquid that helps to create nice, non-tacky gel formulas.
We don't have description for this ingredient yet.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
We don't have description for this ingredient yet.
A water-loving liquid that's clearly soluble in aqueous surfactant solutions, can solubilize oils and oil-soluble ingredients and has a nice skin feel. It's a popular ingredient in micellar cleansing waters.
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula.
A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula. It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.
It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. It’s not a strong one and doesn’t really work against bacteria, but more against mold and yeast. To do that it has to break down to its active form, sorbic acid. For that to happen, there has to be water in the product and the right pH value (pH 3-4).
But even if everything is right, it’s not enough on its own. If you see potassium sorbate you should see some other preservative next to it too.
BTW, it’s also a food preservative and even has an E number, E202.
A helper ingredient that helps to make the products stay nice longer, aka preservative. It works mainly against fungi.
It’s pH dependent and works best at acidic pH levels (3-5). It’s not strong enough to be used in itself so it’s always combined with something else, often with potassium sorbate.
A controversial preservative that has formaldehyde-releasing properties. It works great against bacteria and also has mild fungicide abilities.
Cosmetic chemist, Colin wrote a great article about formaldehyde and DMDM Hydantoin. He writes that formaldehyde is the perfect example of "the dose makes the poison" principle. It's a natural stuff that can also be found in fresh fruits and vegetables, and eating it in tiny amounts is totally ok. However, in larger amounts (according to Wikipedia 30 mL of a solution containing 37% formaldehyde) it's deadly.
The amount of formaldehyde used in cosmetics either neat or through formaldehyde-releasing preservatives is tiny. Probably that is why the Cosmetic Ingredient Review Broad concluded both in 1988 and in 2008 that DMDM Hydantoin is "safe as used in cosmetics".
However, Colins argues that in the case of formaldehyde-releasing preservatives, formaldehyde is released slowly and the skin has probably not evolved to deal with that. The lingering formaldehyde might be toxic to the Langerhans Cells that are important for the skin's defense system. Another potential issue is that formaldehyde-releasers might also release other things while reacting with amino acids in the skin that is probably the explanation why some people are not allergic to formaldehyde but are allergic to formaldehyde-releasing preservatives. These are all theories, far from proven facts, but we feel that there are some justified reasons why formaldehyde-releasing preservatives and Dmdm Hydantoin count as controversial.
All in all, it's up to you to decide if you wanna avoid this preservative group or not. If so, there are other, less risky and more skin-friendly options out there.
A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives.
A helper ingredient that's used as a co-emulsifier (meaning next to other emulsifiers in the formula it helps water and oil to mix) and as a stabilization agent for foams. Also, has some antimicrobial activity so it can help to boost the effectiveness of the preservative system.
It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range.
Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415).
A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product feel great on the skin. It works synergistically with preservatives and helps to improve water-resistance of sunscreens.
Exactly what it sounds: nice smelling stuff put into cosmetic products so that the end product also smells nice. Fragrance in the US and parfum in the EU is a generic term on the ingredient list that is made up of 30 to 50 chemicals on average (but it can have as much as 200 components!).
If you are someone who likes to know what you put on your face then fragrance is not your best friend - there's no way to know what’s really in it.
Also, if your skin is sensitive, fragrance is again not your best friend. It’s the number one cause of contact allergy to cosmetics. It’s definitely a smart thing to avoid with sensitive skin (and fragrance of any type - natural is just as allergic as synthetic, if not worse!).
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what‑it‑does | solvent |
what‑it‑does | emollient | solvent |
what‑it‑does | solvent |
what‑it‑does | emollient | solvent |
what‑it‑does | moisturizer/humectant |
what‑it‑does | cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant |
what‑it‑does | viscosity controlling |
what‑it‑does | soothing | moisturizer/humectant |
what‑it‑does | antioxidant | soothing | emollient | abrasive/scrub |
what‑it‑does | skin-identical ingredient | moisturizer/humectant |
what‑it‑does | moisturizer/humectant |
what‑it‑does | skin-identical ingredient | antioxidant | moisturizer/humectant |
what‑it‑does | skin-identical ingredient | moisturizer/humectant |
irritancy, com. | 0, 0 |
what‑it‑does | moisturizer/humectant |
what‑it‑does | moisturizer/humectant |
what‑it‑does | moisturizer/humectant |
what‑it‑does | moisturizer/humectant |
what‑it‑does | emollient | moisturizer/humectant |
what‑it‑does | moisturizer/humectant |
what‑it‑does | soothing | moisturizer/humectant |
what‑it‑does | soothing |
irritancy, com. | 0, 0 |
what‑it‑does | moisturizer/humectant |
what‑it‑does | viscosity controlling |
what‑it‑does | emollient | viscosity controlling | solvent |
what‑it‑does | emulsifying | surfactant/cleansing |
what‑it‑does | skin-identical ingredient | moisturizer/humectant |
irritancy, com. | 0, 0 |
what‑it‑does | emulsifying | surfactant/cleansing |
what‑it‑does | emulsifying | surfactant/cleansing |
irritancy, com. | 0, 0 |
what‑it‑does | viscosity controlling |
irritancy, com. | 0, 1 |
what‑it‑does | preservative |
what‑it‑does | preservative |
what‑it‑does | preservative |
what‑it‑does | solvent |
what‑it‑does | emulsifying |
what‑it‑does | viscosity controlling |
what‑it‑does | solvent | moisturizer/humectant |
what‑it‑does | perfuming |