Tns Advanced+ Serum
Ingredients overview
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Key Ingredients
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SkinMedica Tns Advanced+ SerumIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product feel great on the skin. It works synergistically with preservatives and helps to improve water-resistance of sunscreens.
Human Fibroblast Conditioned Media (HFCM) essentially means a "Growth Factor Cocktail" for your skin. We have written more about the most common GF used in skincare, the Epidermal Growth Factor here, so if you are new to the topic head over there to catch up. The TL;DR version is that a Growth Factor is a medium long amino acid sequence (= small protein = big peptide) that works as a cell signaling molecule to stimulate cell growth, proliferation, healing and/or differentiation.
Ingredients called "Conditioned Media" cover not one but a mix of Growth Factors derived from some cells grown in a lab. In the EU, human cell-derived ingredients are illegal, so GF products available in the EU usually use a plant source (e.g. barley). In the US, human-derived GFs are all OK, and Human Fibroblast Conditioned Media is derived, as its name suggests, from human fibroblast cells (VIP skin cells for collagen production).
The company Skinmedica was a pioneer in using GFs in cosmeceutical skincare, and their version of HFCM contains a "proprietary mixture of growth factors, cytokines, and soluble matrix proteins secreted by cultured neonatal human dermal fibroblasts during the production of extracellular matrix (ECM)". It is claimed to be a physiologically balanced mix of GFs that are ideal for skin cells to regenerate themselves. More specifically, it contains growth factors that can promote angiogenesis (VEGF and hepatocyte growth factor), modulate inflammation (IL-6 and IL-8), and enhance ECM deposition (TGF-β1 and platelet-derived growth factor-A).
Skinmedica has pretty convincing research showing that their products containing GFs (TNS line) work and have great anti-aging benefits. Multiple clinical studies show that the TNS Recovery Complex improves the appearance of fine lines, wrinkles, skin tone and texture. The benefits are even greater when GFs are combined with tried and true anti-aging actives such as antioxidants and retinol.
This all sounds really good, however, GFs in skincare are somewhat controversial. As potent mitogenic (= stimulates cell proliferation) molecules, you should not use them if you have any of the skin cancer risk factors high or if you have psoriasis. We have written more about the concerns at EGF.
Overall, Growth Factors have increasing evidence (both proper clinical studies as well as some GF products with a cult following) showing that they have great anti-aging benefits. Whether you are comfortable with using human-derived ingredients or if you feel the cons outweigh the pros, is up to you. If you are a better safe than sorry type, daily SPF + retinol is still the golden standard of anti-aging.
We don't have description for this ingredient yet.
An "eco-designed" emollient ester coming from shea butter. While pure shea butter is a rich emollient that might feel greasy on the skin, this one is designed for its light, silky-soft feeling.
The manufacturer claims that it has a great sustainability profile, long lasting stability and a unique, light and silky feel that's ideal as a base for modern, eco-friendly body lotions and facial care products.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
A nice odorless liquid used mainly as a superior solubilizer and efficacy booster for cosmetic active ingredients such as skincare bigshot vitamin C, self-tanning active DHA or the anti-acne gold standard, benzoyl peroxide.
Other than that it can also be used in hair care products where it gives a longer-lasting and more uniform coloring. According to a manufacturer, it might even prevent the formation of split ends.
Lactococcus Ferment Lysate is a fairly new probiotic ingredient that is obtained from the Gram-positive bacteria, Lactococcus lactis. The lysate is a fluid substance that is produced when you break down the cell membrane, which means it contains interesting things including cytoplasm and cell wall fragments.
According to the manufacturer, it positively influences both the speed and quality of epidermal growth that results in better barrier function and overall skin quality. To prove their point, the German manufacturer conducted several in-vitro (made in test tubes) tests examining how the treatment with Lactococcus Ferment Lysate (LFL) affects important skin proteins.
They found that gene expression influencing the proteins binding the live skin cells together (such as Occludin, Desmocollin 1 and Desmoglein 1) is stimulated by LFL, as well as the expression of enzymes (Kallikrein 5 and 7) breaking the bonds between the shedding dead skin cells. LFL also had a positive influence on epidermal growth and on the thickness of the stratum corneum (the outermost layer of the skin). Another positive finding was that LFL stimulated the production of antimicrobial peptides that play an important role in the immunocompetence of the skin cells.
As for in-vivo tests, the manufacturer only did one and that had only 5 volunteers. They did some tape stripping (exactly what it sounds, hurting the skin by stripping off the top layers) and examined skin renewal and barrier recovery. 4 days after the experiment 3% Lactococcus Ferment Lysate used twice daily resulted in thicker stratum corneum (the difference was about 2 µm) and less trans-epidermal water loss.
Overall, Lactococcus Ferment Lysate is a promising but fairly unproven ingredient that might help with the natural skin renewal process as well as with a healthy skin barrier and skin flora.
Protein fragments, aka peptides and growth factors derived from milk (whey). It is claimed to boost the production of important extracellular matrix components (the gooey stuff between the skin cells) such as hyaluronic acid, collagen I and fibronectin. The in-vivo (made on people) tests showed reduced wrinkles and improved firmness within two weeks by using 0.5% of Whey Protein.
We don't have description for this ingredient yet.
A 100% natural and plant-derived moisturizer that mimics the natural carbohydrate fraction found in the upper layer of the skin. Its special magic power is to bind to the skin stronger and longer than other moisturizer ingredients do so it can keep the skin hydrated longer than usual.
A 3 amino-acid peptide that works by inhibiting the production of progerin, a cell-aging accelerator protein. The manufacturer claims that Trifluoroacetyl Tripeptide-2 can bring back cell activity to a 20-year-old young cell level and the ingredient can nicely increase skin elasticity, firmness and reduce skin-sagging.
In their in-vivo (made on real people) tests, they found that 2% Progeline cream can lift the sagging jaw-line by up to 10% in 56 days and improve skin elasticity and firmness by about 20% in 28 days.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
We don't have description for this ingredient yet.
Apple needs no introduction as one of the most common fruits on planet Earth. It's not only a healthy fruit snack, it's also a goodie if you put in all over your face.
It's loaded with proteins, starch, sugars, acids, vitamins and salts. The sugars (mainly fructose, glucose, sucrose) give apple fruit extract nice moisturizing and smoothing properties, while the acids (mainly malic and gallic acid) give it mild exfoliant, skin brightening and antibacterial properties.
A handy multifunctional ingredient that works as a preservative booster, as well as an antioxidant and soothing agent.
It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version.
According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E.
Propanediol is a natural alternative for the often used and often bad-mouthed propylene glycol. It's produced sustainably from corn sugar and it's Ecocert approved.
It's quite a multi-tasker: can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula.
It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range.
Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415).
It's a helper ingredient that helps to thicken up formulas and form a nice gel texture. It leaves a rich, elegant feel with a velvety finish on the skin and works over a wide pH range.
A helper ingredient that functions as a film-forming polymer (big molecule from repeated subunits).
It usually comes to the formula as part of a thickener-emulsifier trio paired with Polyisobutene and Polysorbate 20. The three togeather have excellent thickening properties with remarkable emulsifying-stabilising abilities. They also have a nice silicone feel with glide-on spreading.
A polymer (big molecule from repeated subunits) that's used as a gloss improver for lipsticks and lipglosses. Its stickiness also helps lip products to stay on longer.
Combined with polyacrylate-13 and polysorbate 20, it forms a very effective tickener-emulsifier trio.
A big sugar molecule (polysaccharide) that is used as a natural thickening and gelling agent. It is similar to more commonly used Xanthan Gum, and the two are also often combined to create gel formulas or to stabilize emulsions.
A fluid silicone that reduces surface tension. It can improve oil (or silicone) in water emulsions with faster absorption, better spreading, and a lighter feel.
A very common ingredient that can be found in all cell membranes. In cosmetics it's quite the multi-tasker: it's an emollient and water-binding ingredient but it's also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes.
If you ever wondered what those little Listerine breath strips were made of, you found your answer! Pullulan is a polysaccharide polymer, which basically means that it’s a big molecule made up of smaller sugar molecule units.
It dissolves in water and can make a thin, elastic, and moisture-absorbing film when spread on the skin that can cause an instant tightening effect. It can also be used as a thickener to get a silicone-like feel and can be used in peel-off masks. Btw, it's made from fungus via fermentation.
Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.
BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.
It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive.
A little helper ingredient that is used to adjust the pH of the product. It also helps to keep products stay nice longer by neutralizing the metal ions in the formula (they usually come from water).
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula.
An alkaline (high pH, aka basic) material that is used to set the pH of the cosmetic formula to the right value.
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.
It is typically used in tiny amounts, around 0.1% or less.
It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic.
Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10).
It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.
If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.
Also, it's an effective deodorant and a medium spreading emollient.
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| what‑it‑does | solvent |
| what‑it‑does | solvent | moisturizer/humectant |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | emollient | solvent |
| what‑it‑does | emollient |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | solvent | moisturizer/humectant | perfuming |
| irritancy, com. | 0, 0 |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | antioxidant |
| what‑it‑does | antioxidant |
| irritancy, com. | 0, 0 |
| what‑it‑does | solvent | moisturizer/humectant |
| what‑it‑does | viscosity controlling |
| what‑it‑does | viscosity controlling |
| what‑it‑does | viscosity controlling |
| what‑it‑does | viscosity controlling |
| what‑it‑does | emollient | emulsifying |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 1 |
| what‑it‑does | chelating | buffering |
| what‑it‑does | emulsifying | surfactant/cleansing |
| irritancy, com. | 0, 0 |
| what‑it‑does | buffering |
| what‑it‑does | viscosity controlling |
| what‑it‑does | chelating |
| what‑it‑does | preservative |
| what‑it‑does | preservative |