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Fysiko Eyelash Growth Serum

Eyelash Growth Serum

Despite it's exotic-sounding name, Fysiko Eyelash Growth Serum is made in the good old USA using all natural ingredients. In fact, Fysiko - pronounced [fi-zi-ko'] - means “natural” in Greek. Thanks [more] [more] to that, Fysiko's eyelash serum contains no parabens nor prostaglandins, which means it doesn’t have any of the side effects of prostaglandin-containing products like permanent … [less]
Uploaded by: stephanie9870 on 08/10/2019

Skim through

Ingredient name what-it-does irr., com. ID-Rating
Water solvent
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar
Hydrolyzed Glycosaminoglycans moisturizer/​humectant
Panthenol (Vitamin B5) soothing, moisturizer/​humectant 0, 0 goodie
Vitis Vinifera (Grape) Seed Extract antioxidant goodie
Sodium Lactate buffering, moisturizer/​humectant goodie
Panax Ginseng Root Extract antioxidant, emollient goodie
Proline skin-identical ingredient goodie
Yeast Extract moisturizer/​humectant goodie
Phenoxyethanol preservative
Biotin
Hydrolyzed Soy Protein moisturizer/​humectant
Chamomilla Recutita (Matricaria) Flower Extract soothing, antioxidant 0, 0 goodie
Hexapeptide-11
Niacinamide (Vitamin B3) cell-communicating ingredient, skin brightening, anti-acne, moisturizer/​humectant superstar
Thyme Extract perfuming
Palmitoyl Pentapeptide-4 cell-communicating ingredient goodie
Arctostaphylos Uva- Ursi (Bearberry) Leaf Extract antioxidant, skin brightening goodie
Olive Oil antioxidant, emollient 0, 0-2 goodie
Sodium Hyaluronate skin-identical ingredient, moisturizer/​humectant 0, 0 goodie
Magnesium Ascorbyl Phosphate (Vitamin C) skin brightening goodie
Retinyl Palmitate (Vitamin A) cell-communicating ingredient 1-3, 1-3
Tocopheryl Acetate (Vitamin E) antioxidant 0, 0
Polysorbate 20 emulsifying 0, 0
Hydroxyethylcellulose viscosity controlling
Sorbitol moisturizer/​humectant 0, 0
Triethanolamine buffering 0, 2
Methylisothiazolinone preservative icky

Fysiko Eyelash Growth Serum
Ingredients explained

Also-called: Aqua | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

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Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

What-it-does: moisturizer/humectant

We don't have description for this ingredient yet.

Also-called: Pro-Vitamin B5 | What-it-does: soothing, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid). 

Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier. 

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Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.

Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation. 

If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.

As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily. 

Also-called: Grape Seed Extract | What-it-does: antioxidant

We wholeheartedly support the rise of seedless grapes as fruit snacks, but when it comes to skincare, we are big fans of the seeds.

They contain the majority of the skin goodies that -  similar to green tea - are mostly polyphenols (but not the same ones as in tea). The most abundant ones in grape are called proanthocyanidins, and 60-70% of them are found in the seeds (it's also often abbreviated as GSP - grape seed proanthocyanidins). In general, the darker the fruit, the more GSPs and other flavonoids it contains.

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So what's so special about GSPs? Well, they are super-potent antioxidants, much stronger than Vitamin C or Vitamin E. And if that's not enough, GSPs and other flavonoids in grape also show UV protecting and anti-cancer properties.

It's definitely a goodie to spot on the INCI list.

The sodium salt of lactic acid. It's a great skin moisturizer and also used to regulate the pH value of the cosmetic formula. It's a natural ingredient approved by both ECOCERT and COSMOS.

Also-called: True Ginseng, Ginseng, Korean Ginseng | What-it-does: antioxidant, emollient

A  traditional Korean medicine used for more than 2000 years. Regarding skin care, its main thing seems to be enhancing skin nutrition and metabolism as a result of improving blood circulation.

It also contains biologically active components referred to as ginseng saponins (ginsenosides) that have potent antioxidant properties

Proline - goodie

A non-essential amino acid (meaning that our body can produce it) that's also one of the major building blocks of collagen. According to the Futurederm blog, it might be able to improve wrinkles when combined with other amino acids, glycine and leucine

Yeast Extract - goodie
What-it-does: moisturizer/humectant

You probably know yeast from the kitchen where you put it into milk with a little sugar and then after a couple of minutes brownish bubbles form. That is the fungi fermenting the sugar

As for skin care, yeast contains beta-glucan that is a great soothing ingredient and also a mild antioxidant.  The yeast extract itself is a silky clear liquid that has some great moisturizing, skin protecting and film-forming properties on the skin. 

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

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Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10). 

It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.

Also-called: Vitamin H

Also called vitamin H, biotin is the main component of many enzymes in our body. A nice ingredient to take as a supplement for stronger nails and hair. When you do not take it as a supplement its effects are a bit more questionable but according to manufacturer info it can smooth the skin and strengthen the hair.

What-it-does: moisturizer/humectant

We don't have description for this ingredient yet.

Also-called: German Chamomile Flower Extract | What-it-does: soothing, antioxidant | Irritancy: 0 | Comedogenicity: 0

Chamomile probably needs no introduction as it's one of the most widely used medicinal herbs. You probably drink it regularly as a nice, calming cup of tea and it's also a regular on skincare ingredient lists.

Cosmetic companies use it mainly for its anti-inflammatory properties. It contains the terpenoids chamazulene and bisabolol both of which show great anti-inflammatory action in animal studies. On top of that chamomile also has some antioxidant activity (thanks to some other active ingredients called matricine, apigenin and luteolin).  

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Though chamomile is usually a goodie for the skin, it's also not uncommon to have an allergic reaction to it. 

We don't have description for this ingredient yet.

Also-called: vitamin B3, nicotinamide | What-it-does: cell-communicating ingredient, skin brightening, anti-acne, moisturizer/humectant
  • A multi-functional skincare superstar with several proven benefits for the skin
  • Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
  • Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
  • Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
  • Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
Read all the geeky details about Niacinamide here >>

Also-called: Thyme;Thymus Vulgaris Extract | What-it-does: perfuming

We don't have description for this ingredient yet.

Also-called: Matrixyl, Pal-KTTKS, Formerly Palmitoyl Pentapeptide-3 | What-it-does: cell-communicating ingredient

A pretty famous and better-researched peptide consisting of five amino acids (the building blocks of all proteins). It was created in a joint effort by the French ingredient supplier, Sederma and the cosmetics industry big shot, Procter&Gamble.

The amino acid sequence of the peptide is lysine–threonine–threonine–lysine–serine (KTTKS). Sometimes, it's also called collagen pentapeptide, as it's a subfragment of skin-structure-giving type I collagen. The KTTKS amino sequence is then attached for better oil solubility and skin penetration to palmitic acid and BOOM; we get Palmitoyl Pentapeptide-4. 

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Though most research is manufacturer sponsored, the clinical studies about Palmitoyl Pentapeptide-4 are promising.  In short, it can reduce fine lines, wrinkles and improve skin texture significantly (and at crazy low concentrations, the studies were done with just 3 ppm that is 0.0003%).

There are also studies comparing Palmitoyl Pentapeptide-4 with anti-aging gold standard, retinol. One of them compared 3ppm Pal-KTTKS with 700 ppm (0.07%) retinol and found that they showed similar wrinkle improving ability with the peptide showing better skin tolerability.

Bottom line, if you are into peptides, this is a good one to try.

Also-called: Bearberry, Kinnikinnick;Arctostaphylos Uva-Ursi Leaf Extract | What-it-does: antioxidant, skin brightening

Arctostaphylos Uva-Ursi is a little plant with nice red berries that lives in the North and is also called bearberry or kinnikinnick. According to Wikipedia the uva-ursi part means “grape of the bear”.  

As for skincare bearberry is interesting because it contains the well-known skin lightening agent arbutin. The leaves contain 5-15% percent of it and might be able to help fading brown spots on the skin. Also, kinnikinnick (such a cool name :)) is an antioxidant and has some antibacterial activity

Olive Oil - goodie
Also-called: Olive Fruit Oil;Olea Europaea Fruit Oil | What-it-does: antioxidant, emollient | Irritancy: 0 | Comedogenicity: 0-2

You probably know olive oil from the kitchen as a great and healthy option for salad dressing but it's also a great and healthy option to moisturize and nourish the skin, especially if it's on the dry side. 

Similar to other emollient plant oils, it's loaded with nourishing fatty acids: oleic is the main component (55-83%), and also contains linoleic (3.5-20%) and palmitic acids (7-20%). It also contains antioxidant polyphenols, tocopherols (types of vitamin E) and carotenoids and it's one of the best plant sources of skin-identical emollient, Squalene

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Overall, a great option for dry skin but less so for acne-prone or damaged skin.

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It’s the - sodium form - cousin of the famous NMFhyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

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In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).

What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists. 

If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

Also-called: Form of Vitamin C, MAP | What-it-does: skin brightening

A form of skincare superstar, Vitamin C. If you do not know, what the big deal about Vitamin C is, click here and read all about it, we will wait here for you. 

So now you know that pure vitamin C (aka ascorbic acid, AA) is really unstable and hard to formulate so the cosmetics industry is coming up with a bunch of derivatives to solve the problem and Magnesium Ascorbyl Phosphate (or MAP) is one of them.  

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MAP does solve the stability problem: it's stable up to pH 7, so far so good. What is not so good is that, as the great review study about vitamin C derivatives in the Journal of Cosmetic Dermatology writes, MAP is "at very best, poorly absorbed in comparison to AA." 

Moreover,  derivatives not only have to be absorbed into the skin, they also have to be converted into pure AA. The good news is that in-vitro data shows that MAP does convert, but the bad news is we do not really know if the same is true on real, living human skin. Even if it does, we don't know how good the conversion rate is (but to be fair the same is true for all other derivatives).

Regarding the three magic abilities of pure vitamin C (antioxidant, collagen booster, skin brightener), there is no published data about MAP's antioxidant or photoprotection capabilities. We have better news about the other two things: in-vitro data shows that MAP can boost collagen synthesis similar to AA (though in the case of AA it's proven in-vivo) and even better, MAP is proven to work as a skin brightener in-vivo (on real people). 

Bottom line: when it comes to vitamin C derivatives, MAP is definitely an option. We especially recommend it if you are after skin brightening as this seems to be the strongest point of MAP. 

 

Also-called: Form of Retinoids | What-it-does: cell-communicating ingredient | Irritancy: 1-3 | Comedogenicity: 1-3

It's an ester form of vitamin A (retinol + palmitic acid) that belongs to the "retinoid family". The retinoid family is pretty much the royal family of skincare, with the queen being the FDA-approved anti-aging ingredient tretinoin. Retinol is also a very famous member of the family, but it's like Prince William, two steps away from the throne. Retinyl palmitate will be then little Prince George, quite far (3 steps) away from the throne. 

By steps, we mean metabolic steps. Tretinoin, aka retinoic acid, is the active ingredient our skin cells can understand and retinyl palmitate (RP) has to be converted by our metabolic machinery to actually do something. The conversion is a 3 step one and looks like this:

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retinyl palmitate --> retinol -- > retinaldehyde --> all-trans-retinoic acid

As we wrote in our lengthy retinol description the problem is that the conversion is not terribly effective. The evidence that RP is still an effective anti-aging ingredient is not very strong, in fact, it's weak. Dr. Leslie Baumann in her fantastic Cosmetic Dermatology book writes that RP is topically ineffective

What's more, the anti-aging effectiveness is not the only questionable thing about RP. It also exibits questionable behaviour in the presence of UV light and was the center of a debate between the non-profit group, EWG (whose intentions are no doubt good, but its credibility is often questioned by scientists) and a group of scientists and dermatologists lead by Steven Q. Wang, MD,  director of dermatologic surgery at Memorial-Sloan Kettering Cancer Centre. 

Dr. Leslie Baumann wrote a great review of the debate and summarized the research available about retinyl palmitate here.  It seems that there is a study showing RP being photo protective against UVB rays but there is also a study showing RP causing DNA damage and cytotoxicity in association with UVA. 

We think that the truth lies somewhere in the middle, and we agree with Dr. Baumann's conclusion: "sufficient evidence to establish a causal link between RP and skin cancer has not been produced. Nor, I’m afraid, are there any good reasons to recommend the use of RP". We would add especially during the day!

Bottom line: If you wanna get serious about retinoids, RP is not your ingredient (retinol or tretinoin is!). However, if you use a product that you like and it also contains RP, there is no reason to throw it away. If possible use it at night, just to be on the safe side.

Also-called: Vitamin E Acetate | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 0

It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version. 

According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E. 

What-it-does: emulsifying | Irritancy: 0 | Comedogenicity: 0

It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 

Also-called: HEC | What-it-does: viscosity controlling

A nice little helper ingredient that can thicken up cosmetic products and create beautiful gel formulas. It's derived from cellulose, the major component of the cell wall of green plants. It is compatible with most co-ingredients and gives a very good slip to the formulas. 

What-it-does: moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It's a sweet tasting sugar substitute that helps your skin to hold onto water when used in cosmetic products. It also helps to thicken up products and give them a bit more slip. 

What-it-does: buffering | Irritancy: 0 | Comedogenicity: 2

It’s a little helper ingredient that helps to set the pH of a cosmetic formulation to be just right. It’s very alkaline (you know the opposite of being very acidic): a 1% solution has a pH of around 10.

It does not have the very best safety reputation but in general, you do not have to worry about it. 

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What is true is that if a product contains so-called N-nitrogenating agents (e.g.: preservatives like 2-Bromo-2-Nitropropane-1,3-Diol, 5-Bromo-5-Nitro- 1,3-Dioxane or sodium nitrate - so look out for things with nitro, nitra in the name) that together with TEA can form some not nice carcinogenic stuff (that is called nitrosamines). But with proper formulation that does not happen, TEA in itself is not a bad guy. 

But let’s assume a bad combination of ingredients were used and the nitrosamines formed. :( Even in that case you are probably fine because as far as we know it cannot penetrate the skin. 

But to be on the safe side, if you see Triethanolamine in an INCI and also something with nitra, nitro in the name of it just skip the product, that cannot hurt.

What-it-does: preservative

As you may guess, if something is only recommended in products that you rinse off (cleansers and shampoos), then it’s probably not the best ingredient for the skin.

Methylisothiazolinone (MI) is a preservative that' super efficient against bacteria at surprisingly low concentrations. The problem with it though is that it can also sensitize and irritate the skin quite easily when it comes in leave-on formulas.

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Currently, some countries are considering to ban it entirely (like Denmark) and the permitted use level is very low (under 0.01%). Luckily there are plenty of products on the market with other preservative options so if you are a better safe than sorry type it's probably best to avoid it. 

You may also want to take a look at...

what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does moisturizer/humectant
what‑it‑does soothing | moisturizer/humectant
irritancy, com. 0, 0
Pro-Vitamin B5 is a goodie that moisturises the skin, has anti-inflammatory, skin protecting and wound healing properties. [more]
what‑it‑does antioxidant
Grape Seed Extract - contains awesome polyphenols that are super-potent antioxidants and also have UV-protecting and anti-cancer properties. [more]
what‑it‑does buffering | moisturizer/humectant
The sodium salt of lactic acid. It's a great skin moisturizer and also used to regulate the pH value of the cosmetic formula. [more]
what‑it‑does antioxidant | emollient
Ginseng - A traditional Korean medicine that has antioxidant properties, and is known to improve blood circulation. [more]
what‑it‑does skin-identical ingredient
A non-essential amino acid (meaning that our body can produce it) that might be able to improve wrinkles combined with other amino acids, glycine and leucine. [more]
what‑it‑does moisturizer/humectant
A silky clear liquid that has great moisturizing, skin protecting and film-forming properties on the skin. [more]
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
Vitamin H is a great supplement for stronger nails and hair. As a skincare ingredient, it's a bit more questionable, but it might smooth the skin and strengthen the hair. [more]
what‑it‑does moisturizer/humectant
what‑it‑does soothing | antioxidant
irritancy, com. 0, 0
Chamomile extract - has great anti-inflammatory and some antioxidant properties. [more]
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
what‑it‑does perfuming
what‑it‑does cell-communicating ingredient
Matrixyl - A 5 amino acid peptide with promising research showing that it can reduce fine lines, wrinkles and improve skin texture. [more]
what‑it‑does antioxidant | skin brightening
Arctostaphylos Uva-Ursi is a little plant with nice red berries that lives in the North and is also called bearberry or kinnikinnick. According to Wikipedia the uva-ursi part means “grape of the bear”. [more]
what‑it‑does antioxidant | emollient
irritancy, com. 0, 0-2
Olive oil - an oleic acid-rich (55-83%) emollient plant oil that can moisturize dry skin. Also, it contains antioxidant polyphenols and vitamin E. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
what‑it‑does skin brightening
A form of skincare superstar, Vitamin C - it has proven skin-brightening abilities (in-vivo) and it might be able to boost collagen production as well (in-vitro). [more]
what‑it‑does cell-communicating ingredient
irritancy, com. 1-3, 1-3
An ester form of vitamin A (retinol + palmitic acid) that is pretty much the least effective member of the retinoid family. Its anti-aging effects are quite questionable as well as its behavior in the presence of UVA light. (Use it at night if possible!) [more]
what‑it‑does antioxidant
irritancy, com. 0, 0
A form of vitamin E that works as an antioxidant. Compared to the pure form it's more stable, has longer shelf life, but it's also more poorly absorbed by the skin. [more]
what‑it‑does emulsifying
irritancy, com. 0, 0
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 
what‑it‑does viscosity controlling
A nice little helper ingredient that can thicken up cosmetic products and create beautiful gel formulas. It's derived from cellulose, the major component of the cell wall of green plants. [more]
what‑it‑does moisturizer/humectant
irritancy, com. 0, 0
It's a sweet tasting sugar substitute that helps your skin to hold onto water when used in cosmetic products. It also helps to thicken up products and give them a bit more slip.  [more]
what‑it‑does buffering
irritancy, com. 0, 2
Helps to set the pH of a cosmetic formulation to be right. It’s very alkaline. [more]
what‑it‑does preservative
Preservative with relatively high irritation risk that is used mainly in rinse-off products. [more]