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Cosmedica 20% Vitamin C Serum For Face

Cosmedica
20% Vitamin C Serum For Face

Brighten, and help boost collagen production with proven anti-oxidant protection of Vitamin C, Vitamin E, Ferulic Acid and Hyaluronic Acid
Uploaded by: aswaim on 09/02/2018

Cosmedica 20% Vitamin C Serum For Face
Ingredients explained

Also-called: Aqua | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

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Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

Also-called: Aloe Vera;Aloe Barbadensis Leaf Juice | What-it-does: soothing, moisturizer/humectant

Aloe Vera is one of today’s magic plants. It does have some very nice properties indeed, though famous dermatologist Leslie Baumann warns us in her book that most of the evidence is anecdotal and the plant might be a bit overhyped.

What research does confirm about Aloe is that it’s a great moisturizer and has several anti-inflammatory (among others contains salicylates, polysaccharides, magnesium lactate and C-glucosyl chromone) as well as some antibacterial components. It also helps wound healing and skin regeneration in general. All in all definitely a goodie. 

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

Also-called: Form of Vitamin C, SAP | What-it-does: antioxidant, anti-acne

The sodium salt form of skincare superstar, vitamin C. If you do not know what the big fuss about vitamin C is, you are missing out and you have to click here and read all the geeky details about it.

Pure vitamin C (aka ascorbic acid, AA) is great and all, but its lack of stability is a big challenge for the cosmetics industry. One solution is to create stable derivatives that can be absorbed into the skin, convert there to AA and do all the magic AA is proven to do (which is being an antioxidant, a collagen booster, and a skin brightener).

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SAP (the vit C derivative, not the enterprise software, obvs) is a promising derivative that has great stability up to pH 7. The challenge with it though is skin penetration. Unfortunately, it seems to be limited, or to quote a great article from the Journal of Cosmetic Dermatology "topically applied ascorbyl phosphate salts are, at very best, poorly absorbed in comparison with AA". Regarding conversion to AA, there seems to be no data about it, so we can neither deny nor confirm it.

We have better news regarding the three magic abilities of vitamin C: there is in-vivo (tested on real people) data showing that SAP does have photo-protective (aka antioxidant) properties, though less than pure AA. SAP might also aid collagen boosting; in-vitro (made in the lab) data shows that it works, but is less effective than another vitamin C derivative, called MAP (that seems to be as effective as pure AA). As for skin-brightening, there is a trade publication with in-vivo data showing that SAP can fade brown spots

Another thing SAP might be able to do is to help with acne. A 2005 study showed in vitro (in test tubes) that 1% SAP has a strong antimicrobial activity on evil acne causing P. acnes and it also showed in vivo (on real people) that 5% SAP can strongly improve the inflammatory and non-inflammatory lesions of acne vulgaris. In fact, the results were comparable or even slightly better than with 5% benzoyl peroxide. 

And there is even more regarding SAP and acne. A nice double-blind study from 2009 showed that  5% SAP reduced the inflammatory lesions by 20.14% and 48.82% within 4 and 8 weeks respectively and when combined with 0.2% retinol the results were even better. With this combination treatment, the improvement was 29.28% after 4 weeks and 63.10% after 8 weeks of application. 

Aside from research studies, anecdotal evidence also supports SAP being a promising vitamin C derivative. One of the best-selling (vitamin C) serums in Sephora is the Ole Henriksen Truth Serum, while on Amazon it's the OzNaturals Vitamin C 20 Serum. Another popular choice is the Mad Hippie Vitamin C serum, and all of these contain vitamin C in the form of SAP. 

Overall, we think SAP is a goody!  In terms of anti-aging, it's probably not as effective as pure Ascorbic Acid, but it's totally worth a try. However, if your skin is acne-prone, SAP is your form of Vitamin C and it's a must-try.

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 0 | Comedogenicity: 0

It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 

It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol

The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

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Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10). 

It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.

What-it-does: preservative

A helper ingredient that helps to make the products stay nice longer, aka preservative. It works mainly against fungi. 

It’s pH dependent and works best at acidic pH levels (3-5). It’s not strong enough to be used in itself so it’s always combined with something else, often with potassium sorbate.

Also-called: Grapefruit Peel Oil | What-it-does: perfuming

The essential oil coming from the rind of the grapefruit. In general, the main component of citrus peel oils is limonene (86-95% for grapefruit peel), a super common fragrant ingredient that makes everything smell nice (but counts as a frequent skin sensitizer).

Other than that, citrus peel also contains the problematic compound called furanocoumarin that makes them mildly phototoxic. In general, the more sour-bitter the fruit, the more problematic it is regarding phototoxicity: orange and clementine peel contain less of it while lemon, grapefruit, and bergamot contain some more. Be careful with it if it is in a product for daytime use.  

What-it-does: preservative

We don't have description for this ingredient yet.

What-it-does: chelating

It’s one of those little helper ingredients that makes sure the product stays the same over time. No color change or anything like that. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. 

What-it-does: buffering

We don't have description for this ingredient yet.

What-it-does: buffering

We don't have description for this ingredient yet.

Also-called: Sweet Orange Peel Oil, Citrus Sinensis Oil | What-it-does: perfuming

The essential oil coming from the rind of the orange (the sweet one). In general, the main component of citrus peel oils is limonene (83-97% for sweet orange peel), a super common fragrant ingredient that makes everything smell nice (but counts as a frequent skin sensitizer).

Other than that, citrus peel also contains the problematic compound called furanocoumarin that makes them mildly phototoxic. Orange peel contains less of it than some other citruses (like bergamot or lime), but still, be careful with it especially if it is in a product for daytime use.  

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It’s the - sodium form - cousin of the famous NMFhyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

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In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).

What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists. 

If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

Also-called: Sugar Maple Extract

The extract coming from the Sugar Maple tree, the one whose leaf is on the Canadian flag and gives us maple syrup.

The main reason it is used in skin care is that it contains natural AHA acids, namely Malic and Tartaric, and hence why it supposedly helps slough off dead skin cells in combination with other acid-containing fruit extracts as part of the trade name ACB Fruit Mix. The manufacturer claims that both malic and tartaric increase elasticity in the skin, but from our research, the only confirmed uses of these acids are as pH adjusters, especially in the tiny amounts they can be found in the Fruit Mix (less than 1%).  

Also-called: Orange Fruit Extract

We have to start by writing that there are about 900 citrus species in the world, and plenty of them are used to make different kinds of extracts used in cosmetics. This particular one, Citrus Aurantium Dulcis Fruit Extract is a very common ingredient, however, the species "Citrus Aurantium Dulcis" seem to exist only on ingredient lists and the real world calls this guy Citrus Sinensis or, you know, orange. 

To complicate matters further, there are lots of varieties and lots of extraction methods, so it is a bit hard to know what you are getting with this one, but we will try our best to summarize the possibilities. 

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A very common scenario is that  Citrus Aurantium Dulcis Fruit Extract is on the ingredient list for its mild, natural exfoliant properties. It contains mainly citric acid and some malic acid, AHA exfoliants known for their skin renewing properties. If that's the case, it is usually combined with other AHA containing fruits such as bilberry, sugar cane, lemon, and sugar maple in a super popular ingredient mix trade named ACB Fruit Mix.

But orange fruit is loaded with lots of other active compounds with a wide variety of possible effects. A well-known one is the antioxidant vitamin C, aka ascorbic acid, but the dosage will vary based on the extraction method, and it’s possible that some of the ascorbic acid content will degrade before extraction process even takes place. If you want vitamin C in your skincare, that is smart, but do not rely on orange fruit extract for it.

Flavonoids (hesperidin, naringin, luteolin, and ferulic acid) are also nice active compounds with possible antioxidant, anti-inflammatory, and vasoprotective effects. Some of them (namely hesperidin and luteolin) might even have skin brightening activity by inhibiting tyrosinase, the famous enzyme needed for melanin production.

The orange extract also contains carbohydrates, aka sugars (mostly glucose, fructose, and sucrose, but also some bigger polysaccharides such as pectin) giving the ingredient some moisturizing properties.

Some essential oil content is usually also present in citrus fruit extracts, which means a nice scent and antibacterial properties, but also some questionable compounds such as fragrance allergen limonene or phototoxic compound bergaptene. If the amount is big enough to worry about is questionable, probably not, however, the same question applies to all the nice beneficial compounds. 

Overall, we think that the orange fruit extract is a very complex ingredient with lots of potentially good things in it, but we could not find proper in-vivo (made on real people) studies made with standardized extracts to validate what it really does or does not under real-world use cases. 

Also-called: Lemon Fruit Extract

If life gives the cosmetic industry lemon, it makes lemon fruit extract.  As to why, we can write here extremely similar things to our shiny description of orange fruit extract.  Being both of them citruses, they contain very similar active compounds with very similar (potential) effects on the skin. 

Just like orange fruit, lemon fruit also contains citric acid so it is commonly used as a natural, mild exfoliating agent. If this is the case, it is usually combined with other AHA containing fruit extracts such as bilberrysugar cane, orange, and sugar maple in a super popular ingredient mix trade named ACB Fruit Mix.

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But, citrus fruits are chemically complex mixtures with a bunch of other active components such as vitamin C, flavonoids, phenolics, carbohydrates and essential oil (this latter one coming from the rind of the fruit, but still present in some amount in the fruit extract). These have the potential to give lemon extract antioxidant, antibacterial, anti-dandruff, venotonic and moisturizing properties, but the essential oil also brings some questionable compounds such as fragrance allergen limonene or phototoxic compound bergaptene. If your skin is sensitive, be careful with citrus extracts. 

Also-called: Sugar Cane Extract | What-it-does: moisturizer/humectant

Also known as Sugarcane, Saccharum Officinarum is a handy moisturizing ingredient mostly used as a humectant. This means that it can help the skin to attract water and then to hold onto it. 
 
It bears a close relationship to AHA superstar, Glycolic Acid that can be derived from it, so it's often claimed that Sugarcane Extract itself also exfoliates and brightens the skin. We could not find any research studies to back this up, but Saccharum Officinarum very often comes to the formula combined with other acid containing plant extracts trade named ACB Fruit Mix. According to manufacturer data, 5% of the fruit mix increases cellular renewal by 24%, while 4% pure Glycolic did the same by 33%. So maybe, a tiny bit of exfoliation, but if you want proven efficacy, stick to pure acids. 

What-it-does: astringent

We don't have description for this ingredient yet.

Also-called: Form of Vitamin C, Ascorbyl Isotetrapalmitate, Ascorbyl Tetraisopalmitate, ATIP | What-it-does: antioxidant, skin brightening

Tetrahexyldecyl Ascorbate is a stable, oil-soluble form of skincare big shot Vitamin C. If you do not know, why Vitamin C is such a big deal in skincare, click here and read all about it. We are massive vitamin C fans and have written about it in excruciating detail.

So now, you know that Vitamin C is great and all, but it's really unstable and gives cosmetics companies many headaches. To solve this problem they came up with vitamin C derivatives, and one of them is Tetrahexyldecyl Ascorbate (let's call it ATIP in short).

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It's a really promising candidate (see below), but while reading all the goodness about it in a minute, do not forget that derivatives not only have to be absorbed into the skin but also have to be converted to pure vitamin C (ascorbic acid or AA) and the efficacy of the conversion is often unknown. In addition, vitamin C's three magic properties (antioxidant, collagen booster, skin brightener) are all properly proven in-vivo (on real people), but for the derivatives, it's mostly in-vitro studies or in the case of ATIP, it's in-vitro and done by an ingredient supplier.

With this context in mind let's see what ATIP might be able to do. First, it is stable (if pH < 5), easy to formulate and a joy to work with for a cosmetic chemist.

Second, because it's oil-soluble, its skin penetration abilities seem to be great. So great in fact, that it surpasses the penetration of pure vitamin C threefold at the same concentration and it penetrates successfully into the deeper layers of the skin (that is usually important to do some anti-aging work). There is also in-vitro data showing that it converts to AA in the skin. 

Third, ATIP seems to have all three magic abilities of pure vitamin C: it gives antioxidant protection from both UVB and UVA rays, it increases collagen synthesis (even more than AA) and it has a skin brightening effect by reducing melanogenesis by more than 80% in human melanoma cell cultures.

So this all sounds really great, but these are only in-vitro results at this point. We could find Tetrahexyldecyl Ascorbate mentioned only in one published in-vivo study that examined the anti-aging properties of a silicone formula containing 10% AA and 7% ATIP. The authors theorized that the 10% AA is released slowly from the silicon delivery system and probably stays in the upper layer of the skin to give antioxidant benefits, while ATIP penetrates more rapidly and deeply and gives some wrinkle-reducing benefits. The study was a small (10 patients), double-blind experiment, and the formula did show some measurable anti-aging results. However, it is hard to know how much pure vitamin C or ATIP can be thanked.

Bottom line: a really promising, but not well-proven vitamin C derivative that can be worth a try especially if you like experimenting (but if you like the tried and true, pure vitamin C will be your best bet).

Also-called: Vitamin E Acetate | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 0

It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version. 

According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E. 

Thioctic Acid - goodie
Also-called: Alpha-Lipoic Acid | What-it-does: antioxidant

Alpha-Lipoic Acid (ALA) is a great antioxidant that's also part of the body's natural antioxidant system. It's soluble both in water-rich and lipid-rich environments so it's versatile and can interact with many types of evil oxidants as well as other nice antioxidants. 

ALA seems to be a great choice for topical use as studies show it can penetrate the skin rapidly where it's converted to DHLA (dihydrolipoic acid), an even more potent antioxidant molecule.  A nicely designed (we mean double-blind, placebo-controlled) 12-week study from 2003 confirmed that 5% ALA cream can decrease skin roughness and improve general signs of photoaging statistically significantly.  A slight catch, though, is that burning and warmth in the skin was quite a common side effect, especially in the first 4 weeks. 

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All in all, ALA is definitely a research-proven, great antioxidant but if your skin is sensitive higher concentrations might not be for you.

You may also want to take a look at...

what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does soothing | moisturizer/humectant
The famous aloe vera. A great moisturizer and anti-inflammatory ingredient that also helps wound healing and skin regeneration. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does antioxidant | anti-acne
The sodium salt form of skincare superstar, vitamin C. If you do not know what the big fuss about vitamin C is, you are missing out and you have to click here and read all the geeky details about it. Pure vitamin C (aka ascorbic acid, AA) is great and all, but its lack of stability is a big challenge for the cosmetics industry. [more]
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 0, 0
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 
what‑it‑does viscosity controlling
A pre-neutralised form of super common thickener and emulsion stabilizer, Acrylates/ C10-30 Alkyl Acrylate Crosspolymer. We have more info at Carbomer and Acrylates/​C10-30 Alkyl Acrylate Crosspolymer.  [more]
what‑it‑does moisturizer/humectant | emollient
A handy multi-tasking ingredient that gives the skin a nice, soft feel and also boosts the effectiveness of other preservatives. [more]
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
what‑it‑does preservative
A preservative that works mainly against fungi. Has to be combined with other preservatives. [more]
what‑it‑does perfuming
The essential oil coming from the rind of the grapefruit. Its main component (86-95%) is limonene, the super common fragrant ingredient. [more]
what‑it‑does preservative
what‑it‑does chelating
It’s one of those little helper ingredients that makes sure the product stays the same over time. No color change or anything like that. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.  [more]
what‑it‑does buffering
what‑it‑does buffering
what‑it‑does perfuming
The essential oil coming from the rind of the orange. Its main component (83-97%) is limonene, the super common fragrant ingredient. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
The extract coming from the Sugar Maple tree, the one whose leaf is on the Canadian flag and gives us maple syrup.The main reason it is used in skin care is that it contains natural AHA acids, namely Malic and Tartaric, and hence why it supposedly helps slough off dead skin cells in combination with other acid-containing fruit extracts as part of the trade name ACB Fruit Mix. [more]
We have to start by writing that there are about 900 citrus species in the world, and plenty of them are used to make different kinds of extracts used in cosmetics. This particular one, Citrus Aurantium Dulcis Fruit Extract is a very common ingredient, however, the species "Citrus Aurantium Dulcis" [more]
If life gives the cosmetic industry lemon, it makes lemon fruit extract.  As to why, we can write here extremely similar things to our shiny description of orange fruit extract.  Being both of them citruses, they contain very similar active compounds with very similar (potential) effects on the skin.  [more]
what‑it‑does moisturizer/humectant
Also known as Sugarcane, Saccharum Officinarum is a handy moisturizing ingredient mostly used as a humectant. This means that it can help the skin to attract water and then to hold onto it.  It bears a close relationship to AHA superstar, Glycolic Acid that can be derived from it, so it's often claimed that Sugarcane  [more]
what‑it‑does antioxidant | skin brightening
A stable, oil-soluble form of Vitamin C, that might have (in-vitro results) all the magic abilities of pure vitamin C (antioxidant, collagen booster, skin brightener). [more]
what‑it‑does antioxidant
irritancy, com. 0, 0
A form of vitamin E that works as an antioxidant. Compared to the pure form it's more stable, has longer shelf life, but it's also more poorly absorbed by the skin. [more]
what‑it‑does antioxidant
Alpha-Lipoic Acid (ALA) is a great antioxidant that's also part of the body's natural antioxidant system. It's soluble both in water-rich and lipid-rich environments so it's versatile and can interact with many types of evil oxidants as well as other nice antioxidants. ALA seems to be a great choice for topical use as studies show it can penetrate the skin rapidl [more]