Paula's Choice Resist Brightening Essence Treatment
Paula's Choice

Resist Brightening Essence Treatment

Treat lack-lustre complexions to the Paula's Choice RESIST Brightening Essence Treatment; a lightweight, radiance-reviving formula that works to combat uneven skin tone and texture. Infused with a host of beneficial ingredients, [more] [more] including plant extracts, vitamins and antioxidants, the fast-absorbing, anti-ageing treatment regenerates and revitalises skin, whilst Hyaluronic Acid delivers long-lasting moisture and hydration to reveal a smoother, more refined complexion. An innovative multi-brightening complex combats dull, sallow skin to restore a luminous, youthful glow. [less]
Uploaded by: btbitbt on 24/06/2017

Ingredients overview

Water
what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
,
Butylene Glycol
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
,
Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
,
Arbutin
what‑it‑does antioxidant | skin brightening
One of the better-known skin brightening agents that's found naturally for example in bearberry. [more]
,
Acetyl Glucosamine
what‑it‑does skin-identical ingredient | skin brightening
An amino sugar that helps the skin to stay hydrated, is also promising against wrinkles and can help to fade brown spots particularly when combined with niacinamide. [more]
,
Ascorbyl Glucoside
what‑it‑does antioxidant | skin brightening
A stable and easy to formulate form of skincare superstar, vitamin C. In-vitro studies show that it shows all the three anti-aging benefits (antioxidant protection + collagen boosting + fading hyperpigmentation) that pure vitamin C does. [more]
,
Glycyrrhiza Glabra (Licorice) Root Extract
what‑it‑does soothing | skin brightening
You might know licorice as a sweet treat from your childhood, but it's actually a legume that grows around the Mediterranean Sea, the Middle East, central and southern Russia. [more]
,
Arctostaphylos Uva-Ursi Leaf Extract
what‑it‑does antioxidant | skin brightening
Arctostaphylos Uva-Ursi is a little plant with nice red berries that lives in the North and is also called bearberry or kinnikinnick. According to Wikipedia the uva-ursi part means “grape of the bear”. [more]
,
Morus Alba Root Extract
what‑it‑does skin brightening
, [more]
Niacinamide
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
,
Sodium Hyaluronate
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
,
Hyaluronic Acid
what‑it‑does skin-identical ingredient | antioxidant | moisturizer/humectant
A famous natural moisturizing factor that can bind up to 1000 times its own weight in water. Works as an excellent surface hydrator in skincare. [more]
,
Palmitoyl Tripeptide-1
what‑it‑does cell-communicating ingredient
A three amino acid peptide that is part of famous peptide duo, Matrixyl 3000. It's a type I collagen fragment that might be able to trick the skin to think that collagen broke down and it's time to create some new one. [more]
,
Palmitoyl Tetrapeptide-7
what‑it‑does cell-communicating ingredient
The pal of Palmitoyl Tripeptide-1 in Matrixyl 3000. A four amino acid peptide that works by reducing the production of the signal molecule, inteleukin-6 (IL-6) that promotes inflammation in the skin. [more]
,
Allantoin
what‑it‑does soothing
irritancy, com. 0 0
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. It's not only soothing but it' [more]
,
Adenosine
what‑it‑does cell-communicating ingredient
An important compound in our body that has a vital cell-signalling role. It is wound healing, anti-inflammatory and can help with barrier repair. [more]
,
Silanetriol, Carbomer
what‑it‑does viscosity controlling
A handy white powder that magically converts a liquid into a nice gel formula. [more]
,
Polysorbate-20
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 0 0
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 
,
Citric Acid
what‑it‑does exfoliant | buffering
An AHA that comes from citrus fruits. It is usually used as a helper ingredient to adjust the pH of the formula. [more]
,
Sodium Citrate
what‑it‑does chelating | buffering
A helper ingredient that is used to adjust the pH of the product. Also helps to keep products stay nice longer by neutralizing the metal ions in the formula. 
,
Sodium Hydroxide
what‑it‑does buffering
Lye - A solid white stuff that’s very alkaline and used in small amount to adjust the pH of the product.  [more]
,
Disodium Edta
what‑it‑does chelating
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. [more]
,
Ethylhexylglycerin
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]
,
Phenoxyethanol
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
[less]

Highlights

Key Ingredients

Anti-acne: Niacinamide
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
Antioxidant: Arbutin
what‑it‑does antioxidant | skin brightening
One of the better-known skin brightening agents that's found naturally for example in bearberry. [more]
,
Ascorbyl Glucoside
what‑it‑does antioxidant | skin brightening
A stable and easy to formulate form of skincare superstar, vitamin C. In-vitro studies show that it shows all the three anti-aging benefits (antioxidant protection + collagen boosting + fading hyperpigmentation) that pure vitamin C does. [more]
,
Arctostaphylos Uva-Ursi Leaf Extract
what‑it‑does antioxidant | skin brightening
Arctostaphylos Uva-Ursi is a little plant with nice red berries that lives in the North and is also called bearberry or kinnikinnick. According to Wikipedia the uva-ursi part means “grape of the bear”. [more]
,
Hyaluronic Acid
what‑it‑does skin-identical ingredient | antioxidant | moisturizer/humectant
A famous natural moisturizing factor that can bind up to 1000 times its own weight in water. Works as an excellent surface hydrator in skincare. [more]
Cell-communicating ingredient: Niacinamide
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
,
Palmitoyl Tripeptide-1
what‑it‑does cell-communicating ingredient
A three amino acid peptide that is part of famous peptide duo, Matrixyl 3000. It's a type I collagen fragment that might be able to trick the skin to think that collagen broke down and it's time to create some new one. [more]
,
Palmitoyl Tetrapeptide-7
what‑it‑does cell-communicating ingredient
The pal of Palmitoyl Tripeptide-1 in Matrixyl 3000. A four amino acid peptide that works by reducing the production of the signal molecule, inteleukin-6 (IL-6) that promotes inflammation in the skin. [more]
,
Adenosine
what‑it‑does cell-communicating ingredient
An important compound in our body that has a vital cell-signalling role. It is wound healing, anti-inflammatory and can help with barrier repair. [more]
Skin brightening: Arbutin
what‑it‑does antioxidant | skin brightening
One of the better-known skin brightening agents that's found naturally for example in bearberry. [more]
,
Acetyl Glucosamine
what‑it‑does skin-identical ingredient | skin brightening
An amino sugar that helps the skin to stay hydrated, is also promising against wrinkles and can help to fade brown spots particularly when combined with niacinamide. [more]
,
Ascorbyl Glucoside
what‑it‑does antioxidant | skin brightening
A stable and easy to formulate form of skincare superstar, vitamin C. In-vitro studies show that it shows all the three anti-aging benefits (antioxidant protection + collagen boosting + fading hyperpigmentation) that pure vitamin C does. [more]
,
Glycyrrhiza Glabra (Licorice) Root Extract
what‑it‑does soothing | skin brightening
You might know licorice as a sweet treat from your childhood, but it's actually a legume that grows around the Mediterranean Sea, the Middle East, central and southern Russia. [more]
,
Arctostaphylos Uva-Ursi Leaf Extract
what‑it‑does antioxidant | skin brightening
Arctostaphylos Uva-Ursi is a little plant with nice red berries that lives in the North and is also called bearberry or kinnikinnick. According to Wikipedia the uva-ursi part means “grape of the bear”. [more]
,
Morus Alba Root Extract
what‑it‑does skin brightening
,
Niacinamide
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
Skin-identical ingredient: Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
,
Acetyl Glucosamine
what‑it‑does skin-identical ingredient | skin brightening
An amino sugar that helps the skin to stay hydrated, is also promising against wrinkles and can help to fade brown spots particularly when combined with niacinamide. [more]
,
Sodium Hyaluronate
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
,
Hyaluronic Acid
what‑it‑does skin-identical ingredient | antioxidant | moisturizer/humectant
A famous natural moisturizing factor that can bind up to 1000 times its own weight in water. Works as an excellent surface hydrator in skincare. [more]
Soothing: Glycyrrhiza Glabra (Licorice) Root Extract
what‑it‑does soothing | skin brightening
You might know licorice as a sweet treat from your childhood, but it's actually a legume that grows around the Mediterranean Sea, the Middle East, central and southern Russia. [more]
,
Allantoin
what‑it‑does soothing
irritancy, com. 0 0
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. It's not only soothing but it' [more]

Show all ingredients by function

Other Ingredients

Buffering: Citric Acid
what‑it‑does exfoliant | buffering
An AHA that comes from citrus fruits. It is usually used as a helper ingredient to adjust the pH of the formula. [more]
,
Sodium Citrate
what‑it‑does chelating | buffering
A helper ingredient that is used to adjust the pH of the product. Also helps to keep products stay nice longer by neutralizing the metal ions in the formula. 
,
Sodium Hydroxide
what‑it‑does buffering
Lye - A solid white stuff that’s very alkaline and used in small amount to adjust the pH of the product.  [more]
Chelating: Sodium Citrate
what‑it‑does chelating | buffering
A helper ingredient that is used to adjust the pH of the product. Also helps to keep products stay nice longer by neutralizing the metal ions in the formula. 
,
Disodium Edta
what‑it‑does chelating
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. [more]
Emulsifying: Polysorbate-20
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 0 0
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 
Exfoliant: Citric Acid
what‑it‑does exfoliant | buffering
An AHA that comes from citrus fruits. It is usually used as a helper ingredient to adjust the pH of the formula. [more]
Moisturizer/humectant: Butylene Glycol
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
,
Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
,
Niacinamide
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
,
Sodium Hyaluronate
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
,
Hyaluronic Acid
what‑it‑does skin-identical ingredient | antioxidant | moisturizer/humectant
A famous natural moisturizing factor that can bind up to 1000 times its own weight in water. Works as an excellent surface hydrator in skincare. [more]
Preservative: Ethylhexylglycerin
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]
,
Phenoxyethanol
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
Solvent: Water
what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
,
Butylene Glycol
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
Surfactant/cleansing: Polysorbate-20
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 0 0
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 
Viscosity controlling: Carbomer
what‑it‑does viscosity controlling
A handy white powder that magically converts a liquid into a nice gel formula. [more]

Ingredients explained

Also-called: Aqua | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

Expand to read more

Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

What-it-does: moisturizer/humectant, solvent | Irritancy: 0 | Comedogenicity: 1

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

Expand to read more

It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive. 

Glycerin - goodie
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • Super common, used for more than 50 years
  • Not only a simple moisturizer but plays an important role in keeping the stuff between our skin cells healthy
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

Arbutin - goodie
Also-called: Beta-Arbutin | What-it-does: antioxidant, skin brightening

A pretty well-known and often used ingredient with the magic ability to fade brown spots. It's used traditionally in Japan and can be found naturally in a couple of plants, including the leaves of pear trees, wheat and bearberry

Arbutin seems to work its magic and hinder the pigmentation process at the second step of it. An enzyme called tyrosinase is needed to create melanin (the pigment that causes the brown spots) and while several other skin lightening agents work to inhibit the synthesis of tyrosinase itself (like vitamin C or licorice), arbutin lets tyrosinase be and rather hinders the melanin-forming activity of the enzyme. (So it might be a good idea to combine arbutin with some direct tyrosinase inhibitors for more skin lightening effect.)

Expand to read more

All in all, arbutin is one of the better-known skin brightening agents, that's probably worth a try if pigmentation is an issue for you.

An amino acid sugar that can be found in the skin and does there good and important things. One of them is that it's a precursor for the biosynthesis of superstar moisturizer, hyaluronic acid. So acetyl glucosamine itself is also an important skin-identical ingredient and natural moisturizing factor.

But that is not all, acetyl glucosamine has two other great properties proved by double-blind clinical trials. First, it's a promising ingredient against wrinkles:  2% can improve wrinkles, particularly in the eye area.

Expand to read more

Second, the same amount can also fade - always stubborn - brown spots. (Do not expect magic, though - the photos from the study show the difference after 8 weeks of daily use. The difference is visible, but not that big. It's always good to have realistic expectations. :))  Combined with skincare superstar niacinamide the duo is synergistic and is more effective at improving hyperpigmentation, so if you are after the skin-lightening benefit look out for products that contain both. 

Also-called: Form of Vitamin C | What-it-does: antioxidant, skin brightening

A form of skincare superstar, vitamin C. If you do not know why vitamin C is such a big deal in skincare, we have a really detailed, geeky description that's good to read. :) 

So now you know that because pure vitamin C is such a diva (very unstable and hard to formulate) the cosmetic industry is trying to come up with some derivatives that have the badass anti-aging properties of vitamin C (antioxidant protection + collagen boosting + fading hyperpigmentation) but without the disadvantages. This is a hard task, and there is not yet a derivative that is really proven to be better in every aspect, but Ascorbyl Glucoside is one of the best options when it comes to vitamin C derivatives. Let's see why:

Expand to read more

First, it's really stable and easy to formulate, so the problems that come with pure vitamin C are solved here.

Second, in vitro (meaning made in the lab, not on real humans) studies show that ascorbyl glucoside can penetrate the skin. This is kind of important for an anti-aging ingredient to do the job, so this is good news, though in-vivo (made on real humans) studies are still needed. 

Third, in-vitro studies show that after ascorbyl glucoside is absorbed into the skin it is converted to pure vitamin C (though the rate of conversion is still a question mark). It also shows all the three anti-aging benefits (antioxidant protection + collagen boosting + fading hyperpigmentation) that pure vitamin C does

Bottom line: ascorbyl glucoside is one of the best and most promising vitamin C derivatives that shows similar benefits to that of pure vitamin C, but it's less proven (in vivo vs. in vitro studies) and the extent of the benefits are also not the same.  

Also-called: Licorice Root | What-it-does: soothing, skin brightening

You might know licorice as a sweet treat from your childhood, but it's actually a legume that grows around the Mediterranean Sea, the Middle East, central and southern Russia. It's sweet and yellow and not only used for licorice all sorts but it's also a skincare superstar thanks to two magic properties:

Nr. 1 magic property is that it has skin-lightening or to say it another way depigmenting properties. The most active part is called glabridin. The topical application (meaning when you put it on your face) of 0.5% glabridin was shown to inhibit UVB caused pigmentation of guinea pigs. Another study even suggested that licorice is more effective than the gold standard skin-lightening agent hydroquinone. All in all, licorice is considered to be one of the safest skin lightening agents with the fewest side effects.

Expand to read more

There is just one catch regarding glabridin and licorice: the amount of glabridin in commercial licorice extracts can vary a lot. We have seen extracts with only 4% glabridin as well as 40% glabridin. The latter one is a very-very expensive ingredient, so if you are after the depigmenting properties try to choose a product that boasts its high-quality licorice extract. 

Nr. 2 magic property is that licorice is a potent anti-inflammatory. Glabridin has also some soothing properties but the main active anti-inflammatory component is glycyrrhizin. It’s used to treat several skin diseases that are connected to inflammation including atopic dermatitis, rosacea or eczema. 

Oh, and one more thing: glabridin seems to be also an antioxidant, which is just one more reason to be happy about licorice root extract on an ingredient list. 

Bottom line: Licorice is a great skincare ingredient with significant depigmenting, anti-inflammatory and even some antioxidant properties. Be happy if it's on the ingredient list. :)

Also-called: Bearberry, Kinnikinnick | What-it-does: antioxidant, skin brightening

Arctostaphylos Uva-Ursi is a little plant with nice red berries that lives in the North and is also called bearberry or kinnikinnick. According to Wikipedia the uva-ursi part means “grape of the bear”.  

As for skincare bearberry is interesting because it contains the well-known skin lightening agent arbutin. The leaves contain 5-15% percent of it and might be able to help fading brown spots on the skin. Also, kinnikinnick (such a cool name :)) is an antioxidant and has some antibacterial activity

What-it-does: skin brightening

We don't have description for this ingredient yet.

Niacinamide - superstar
Also-called: vitamin B3, nicotinamide | What-it-does: cell-communicating ingredient, skin brightening, anti-acne, moisturizer/humectant
  • A multi-functional skincare superstar with several proven benefits for the skin
  • Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
  • Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
  • Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
  • Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
Read all the geeky details about Niacinamide here >>

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It’s the - sodium form - cousin of the famous NMFhyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

Expand to read more

In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).

What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists. 

If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

Hyaluronic Acid - goodie
  • It’s naturally in our skin and behaves there like a sponge
  • It can bind up to 1000 times its own weight in water
  • It is a big molecule from repeated subunits (polymer) so different molecular weight versions exist
  • High-molecular-weight-HA (>500 kDa) is an excellent surface hydrator, skin protectant and can act as an osmotic pump helping water-soluble actives to penetrate deeper into the skin
  • Low-molecular-weight-HA (< 500 kDa) can hydrate the skin somewhat deeper though it is still a big molecule and works mainly in the epidermis (outer layer of the skin)
  • Low-molecular-weight-HA might also help the skin to repair itself by increasing its self-defense (~ 200kDa used in the study)
  • Ultra-low-molecular-weight-HA (<50kDa) is a controversial ingredient and might work as a pro-inflammatory signal molecule
Read all the geeky details about Hyaluronic Acid here >>

Also-called: Part of Matrixyl 3000, Pal-GHK, Formerly also Palmitoyl Oligopeptide | What-it-does: cell-communicating ingredient

A really famous peptide that is part of Matrixyl 3000, the most sold peptide complex in the word. Before we go and find out what the big deal with Matrixyl 3000 is, let's just focus on Palmitoyl Tripeptide-1 itself for a bit.

It's a small three amino acid (they are the building blocks of all proteins) peptide with the amino sequence of glycine-histidine-lysine, or GHK. GHK is attached to palmitic acid (a fatty acid) to increase oil solubility and skin penetration. 

Expand to read more

The GHK part is the important one as it's a type I collagen fragment. When collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen. Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more.

Therefore, Palmitoyl Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin. 

In Matrixyl 3000, Palmitoyl Tripeptide-1 is coupled with Palmitoyl Tetrapeptide-7  and the duo works in synergy to reduce wrinkles and give younger looking skin. According to the manufacturer's in-vivo (made on real people) test, applying 3% Matrixyl 3000 twice a day for 2 months resulted in all of the following things:

  • 39.4% reduction in surface occupied by deep wrinkles
  • 32.9% reduction in main wrinkle density
  • 19.9% reduction in main wrinkle average depth
  • 16% improvement in roughness
  • 16.2% in lifting effect
  • 5.5% improvement in elasticity
  • 15.5% improvement in skin tone

Manufacturer results, of course, always have to be taken with a pinch of salt, but if you like peptides, the Matryxil 3000 duo is one of the best-proven and most well-known ones and it's something that is worth trying.

Also-called: Part of Matrixyl 3000, Pal-GQPR, Previously Palmitoyl Tetrapeptide-3 | What-it-does: cell-communicating ingredient

A four amino acid peptide with the amino sequence of glycine-glutamine-proline-arginine. It is attached to palmitic acid (a fatty acid)  to increase oil solubility and skin penetration. 

It works by reducing the production of the signal moleculeinteleukin-6 (IL-6) which promotes inflammation in the skin and less inflammation means slower degradation of important things (like collagen) that results in younger looking skin for a longer time. 

Expand to read more

It works in synergy with its pal, Palmitoyl Tripeptide-1 in the famous Matrixyl 3000 complex. You can read some more about the famous duo here.

Allantoin - goodie
What-it-does: soothing | Irritancy: 0 | Comedogenicity: 0

Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. 

It's not only soothing but it' also skin-softening and protecting and can promote wound healing.

Adenosine - goodie

Adenosine is an important little compound in our body that has a vital cell-signalling role. Research on smearing it on our face is also promising and shows so far a couple of things:

  • It can help with wound healing
  • It’s a good anti-inflammatory agent
  • It might even help with skin’s own collagen production and improve skin firmness and elasticity
  • It helps with barrier repair and protection
  • It might be even useful for the hair helping with hair thickness and hair growth

We don't have description for this ingredient yet.

What-it-does: viscosity controlling

A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula. If you see gel in the name of a moisturizer type thing, chances are carbomer will be in the ingredient list. 

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 0 | Comedogenicity: 0

It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 

Citric Acid - goodie
What-it-does: exfoliant, buffering

Citric acid comes from citrus fruits and is an AHA. If these magic three letters don’t tell you anything, click here and read our detailed description on glycolic acid, the most famous AHA. 

So citric acid is an exfoliant, that can - just like other AHAs - gently lift off the dead skin cells of your skin and make it more smooth and fresh. 

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There is also some research showing that citric acid with regular use (think three months and 20% concentration) can help sun-damaged skin, increase skin thickness and some nice hydrating things called glycosaminoglycans in the skin. 

But according to a comparative study done in 1995, citric acid has less skin improving magic properties than glycolic or lactic acid. Probably that’s why citric acid is usually not used as an exfoliant but more as a helper ingredient in small amounts to adjust the pH of a formulation. 

What-it-does: chelating, buffering

A little helper ingredient that is used to adjust the pH of the product. It also helps to keep products stay nice longer by neutralizing the metal ions in the formula (they usually come from water). 

Also-called: lye | What-it-does: buffering

The unfancy name for it is lye. It’s a solid white stuff that’s very alkaline and used in small amounts to adjust the pH of the product and make it just right. 

For example, in case of AHA or BHA exfoliants, the right pH is super-duper important, and pH adjusters like sodium hydroxide are needed.  

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BTW, lye is not something new. It was already used by ancient Egyptians to help oil and fat magically turn into something else. Can you guess what? Yes, it’s soap. It still often shows up in the ingredient list of soaps and other cleansers.

Sodium hydroxide in itself is a potent skin irritant, but once it's reacted (as it is usually in skin care products, like exfoliants) it is totally harmless.

What-it-does: chelating

Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.

What-it-does: preservative

If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.

Also, it's an effective deodorant and a medium spreading emollient

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

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Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10). 

It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.

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