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Nature Republic Good Skin Ampoule Madecassoside

Good Skin Ampoule Madecassoside

Soothing. Madecassoside ampoule relaxes unstable skin condition.
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Ingredient name what-it-does irr., com. ID-Rating
Water solvent
Propanediol solvent, moisturizer/​humectant
Butylene Glycol moisturizer/​humectant, solvent, viscosity controlling 0, 1
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar
1,2-Hexanediol solvent
Melia Azadirachta Leaf Extract
Citrus Aurantium Bergamia (Bergamot) Fruit Oil perfuming icky
Melia Azadirachta Flower Extract
Boswellia Carterii Oil
Pelargonium Graveolens Flower Oil perfuming icky
Theobroma Cacao (Cocoa) Seed Extract antioxidant
Vetiveria Zizanoides Root Oil perfuming
Amyris Balsamifera Bark Oil perfuming
Melaleuca Alternifolia (Tea Tree) Leaf Oil soothing, anti-acne, antioxidant, antimicrobial/​antibacterial, perfuming goodie
Centella Asiatica Leaf Extract soothing, antioxidant, moisturizer/​humectant goodie
Daucus Carota Sativa (Carrot) Seed Oil emollient
Rose Flower Oil
Echium Plantagineum Seed Oil solvent
Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables soothing, skin-identical ingredient, emollient goodie
Cardiospermum Halicacabum Flower/Leaf/Vine Extract
Panthenol soothing, moisturizer/​humectant 0, 0 goodie
Choleth-24 emulsifying, surfactant/​cleansing 0, 0
Ammonium Acryloyldimethyltaurate/VP Copolymer viscosity controlling
Tromethamine buffering
Diphenyl Dimethicone emollient, emulsifying
Triethylhexanoin emollient, perfuming
Ethylhexylglycerin preservative
Hydrogenated Lecithin emollient, emulsifying goodie
Sodium Phytate chelating
Madecassoside antioxidant, soothing goodie
Dextrin viscosity controlling, moisturizer/​humectant
Asiaticoside antioxidant, perfuming goodie
Tocopherol antioxidant 0-3, 0-3 goodie
Octyldodecanol emollient, perfuming
Carbomer viscosity controlling 0, 1
Xanthan Gum viscosity controlling, emulsifying, surfactant/​cleansing
Linalool perfuming icky
Limonene perfuming, solvent icky
Citronellol perfuming icky

Nature Republic Good Skin Ampoule Madecassoside
Ingredients explained

Also-called: Aqua | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

Also-called: Zemea | What-it-does: solvent, moisturizer/humectant

Propanediol is a natural alternative for the often used and often bad-mouthed propylene glycol. It's produced sustainably from corn sugar and it's Ecocert approved. 

It's quite a multi-tasker: can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula. 

What-it-does: moisturizer/humectant, solvent, viscosity controlling | Irritancy: 0 | Comedogenicity: 1

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive. 

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

What-it-does: solvent

A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives

We don't have description for this ingredient yet.

Also-called: Bergamot Fruit Oil | What-it-does: perfuming

The essential oil coming from the fruit (probably the rind) of the bergamot orange.  It's a common top note in perfumes and contains (among others) fragrant compounds limonene (37%), linalyl acetate (30%) and linalool (8.8%). 

A well-known issue with bergamot oil (apart from the fragrance allergens) is that it contains phototoxic compounds called furanocoumarins, but more and more commonly furanocoumarin-free versions are used in cosmetic products. Still, if you have sensitive skin and prefer fragrance-free products, bergamot oil is not for you.

We don't have description for this ingredient yet.

Also-called: Frankincense Essential Oil

We don't have description for this ingredient yet.

Also-called: Rose Geranium Flower Essential Oil | What-it-does: perfuming

The fragrant essential oil coming from the flowers of Rose Geranium. Like most essential oils, it contains antioxidant and antimicrobial components, but the main ones are fragrant constituents (like citronellol and geraniol). Be careful with it, if your skin is sensitive. 

What-it-does: antioxidant

We don't have description for this ingredient yet.

What-it-does: perfuming

We don't have description for this ingredient yet.

What-it-does: perfuming

We don't have description for this ingredient yet.

Also-called: Tea Tree Oil, TTO | What-it-does: soothing, anti-acne, antioxidant, antimicrobial/antibacterial, perfuming

The famous tea tree oil. One of the best known essential oils which comes from Australia where it has been used for almost 100 years for its antiseptic and anti-inflammatory actions. Legend has it that the medicinal benefits of the oil were considered so important that Australian soldiers were supplied with some tea tree oil in their World War II military kit.

Similar to other essential oils, tea tree oil is a very complex chemical mixture consisting of about 100 components, the major ones being terpinen-4-ol (40%), γ-Terpinene (23%) and α-Terpinene (10%). Terpinen-4-ol is considered to be the main active component but as a great article in Clinical Microbiology Reviews states "while some TTO components may be considered less active, none can be considered inactive" and most components contribute to TTO's strong antibacterial, antiviral and antifungal effects

Regarding skincare and tea tree oil, its most well-known effect is probably being a well established anti-acne ingredient. Multiple studies confirm that TTO is effective against the evil acne-causing bacteria called P. acnes and the effectiveness of 5% TTO gel is comparable to the gold standard anti-acne treatment, 5% Benzoyl Peroxide lotion. You need to be a bit more patient with TTO, though, as its effects come slower but also with fewer side effects.

Regarding TTO and sensitive skin, we say that you should be careful. Even if your skin is not sensitive you should never put undiluted TTO on your skin. Luckily, it contains only very small amounts of the common allergens (such as limonene), but irritant and allergic reactions still happen, especially by oxidation products that occur in older or not properly stored oil.  So if you have some pure TTO at home, know that storage matters, keep it in a cool, dry, dark place and use it up in a reasonable amount of time.

Overall, we do not often give a goodie status to essential oils, but we feel that TTO's unique antibacterial and anti-acne properties with its minimal allergen content warrant an exception. If your skin is acne-prone, TTO is something to experiment with.

We don't have description for this ingredient yet.

Also-called: Carrot Seed Oil | What-it-does: emollient

The oil coming from the seeds of the carrot, the orange root vegetable we all know and eat regularly. This oil is a really tricky one, as it can refer to two types of oil that can both be extracted from the carrot seeds: the essential oil (about 0.83% yield) and the fixed oil (about 7.84% yield). 

The two seed oils are very different and to make matters even worse these two oils are also very different from carrot root oil, or carrot oil, that is basically carrot root extract macerated in a carrier oil such as sunflower or olive oil and is the one that contains the vitamin A precursor, carotene. 

Let's start with the fixed oil: it's a nice emollient plant oil that is loaded with moisturizing fatty acids (petroselinic acid - 60% and linoleic acid - 12% are the main ones). Other important components are carotol (30%) and daucol (12%) that give the seed oil antifungal and antioxidant properties. Browsing cosmetic manufacturer info, the oil is also often described as revitalizing, toning and stimulating

As for the essential oil, it is a light yellow colored oil with a rich, spicy and earthy fragrance. Its main component is carotol (about 65%) but similar to other essential oils, it is a chemically complex mixture with lots of compounds in small amounts. The essential oil also has antifungal and antioxidant properties but also contains fragrant components that might irritate sensitive skin types. 

We don't have description for this ingredient yet.

What-it-does: solvent

We don't have description for this ingredient yet.

Also-called: Sunflower Oil Unsaponifiables | What-it-does: soothing, skin-identical ingredient, emollient

The unsaponifiable part of sunflower oil. It's the small part of the oil that resists saponification, the chemical reaction that happens during soap making.

If you want to understand saponification more, here is a short explanation (if not, we understand, just skip this paragraph): Oils are mostly made up of triglyceride molecules (a glycerin + three fatty acids attached to it) and during the soap making process a strong base splits the triglyceride molecule up to become a separate glycerin and three soap molecules (sodium salts of fatty acids). The fantastic Labmuffin blog has a handy explanation with great drawings about the soap-making reaction. 

So, the triglyceride molecules are the saponifiable part of the oil, and the rest is the unsaponifiable part. In the case of sunflower oil, it's about 1.5-2% of the oil and consists of skin nourishing molecules like free fatty acids (fatty acids not bound up in a triglyceride molecule, it contains mainly (48-74% according to its spec) barrier building linoleic acid), tocopherol (vitamin E) and sterols.

According to manufacturer's info, it's an oily ingredient that not only simply moisturizes the skin but also has great lipid-replenishing and soothing properties. The clinical study done by the manufacturer (on 20 people) found that a cream with 2% active increases skin moisturization by 48.6% after 1 hour, and 34.2% after 24 hours. Applied twice daily for 4 weeks, the study participants had a major improvement in skin dryness, roughness, and desquamation (skin peeling) parameters.

We don't have description for this ingredient yet.

Panthenol - goodie
Also-called: Pro-Vitamin B5 | What-it-does: soothing, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid). 

Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier. 

Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.

Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation. 

If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.

As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily. 

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 0 | Comedogenicity: 0

We don't have description for this ingredient yet.

Also-called: Aristoflex AVC | What-it-does: viscosity controlling

A kind of polymer (big molecule from repeated subunits) that helps to create beautiful gel-like textures. It's also a texturizer and thickener for oil-in-water emulsions. It gives products a good skin feel and does not make the formula tacky or sticky. 

It works over a wide pH range and is used between 0.5-1.2%.

What-it-does: buffering

It's a little helper ingredient that helps to set the pH of the products to be right. It has an alkaline pH and can neutralize acidic ingredients.

What-it-does: emollient, emulsifying

We don't have description for this ingredient yet.

What-it-does: emollient, perfuming

Triethylhexanoin is a colorless to pale yellow liquid ester that makes the skin nice and smooth, aka emollient. It has a pleasant non-sticky, non-greasy feel to it, gives formulas smooth application properties and also helps moisture retention. 

What-it-does: preservative, deodorant

If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.

Also, it's an effective deodorant and a medium spreading emollient

What-it-does: emollient, emulsifying

It's the chemically chopped up version of normal lecithin. Most often it's used to create liposomes and to coat and stabilize other ingredients. 

What-it-does: chelating

It’s one of those little helper ingredients that makes sure the product stays the same over time. No color change or anything like that. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. 

Madecassoside - goodie
What-it-does: antioxidant, soothing

One of the main biologically active components of the famous medicinal plant, Centella Asiatica, aka Gotu Kola. It has well established wound healing, skin-soothing and antioxidant activities.

There is also a study by La Roche Posay (belongs to L'Oreal) that examined the anti-aging effects of 5% Vitamin C combined with 0.1% Madecassoside. They mention that " Madecassoside is known to induce collagen expression
and ⁄ or to modulate inflammatory mediators thus might  prevent and correct some signs of aging.
" The surprisingly long, 6-month study observed "significant improvement of the clinical score for deep and superficial wrinkles, suppleness, firmness, roughness, and skin hydration", but Vitamin C in itself is already an anti-aging superstar, so it is hard to know how much Madecassoside did. 

If you are into Gotu Kola, read more here >> 

A little helper ingredient that can be a thickener, a humectant, a foam booster, an adhesion promoter and a filler. It's a blend of polysaccharides that helps to moisturize and soften the skin. 

Asiaticoside - goodie
What-it-does: antioxidant, perfuming

One of the main biologically active components of the famous medicinal plant, Centella Asiatica, aka Gotu Kola. It has well established wound healing and antioxidant activities.  

In-vitro (made in the lab) studies also show that Asiaticoside stimulates GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells) production as well as collagen I synthesis.  Read more at Gotu Kola >>

Tocopherol - goodie
Also-called: Vitamin E | What-it-does: antioxidant | Irritancy: 0-3 | Comedogenicity: 0-3
  • Primary fat-soluble antioxidant in our skin
  • Significant photoprotection against UVB rays
  • Vit C + Vit E work in synergy and provide great photoprotection
  • Has emollient properties
  • Easy to formulate, stable and relatively inexpensive
Read all the geeky details about Tocopherol here >>

What-it-does: emollient, perfuming

A clear, slightly yellow, odorless oil  that's a very common, medium-spreading emollient. It makes the skin feel nice and smooth and works in a wide range of formulas.

What-it-does: viscosity controlling, emulsion stabilising | Irritancy: 0 | Comedogenicity: 1

A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula.  It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range. 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

Linalool - icky
What-it-does: perfuming, deodorant

Linalool is a super common fragrance ingredient. It’s kind of everywhere - both in plants and in cosmetic products. It’s part of 200 natural oils including lavender, ylang-ylang, bergamot, jasmine, geranium and it can be found in 90-95% of prestige perfumes on the market. 

The problem with linalool is, that just like limonene it oxidises on air exposure and becomes allergenic. That’s why a product containing linalool that has been opened for several months is more likely to be allergenic than a fresh one.

A study made in the UK with 483 people tested the allergic reaction to 3% oxidised linalool and 2.3% had positive test results. 

Limonene - icky
What-it-does: perfuming, solvent, deodorant

A super common and cheap fragrance ingredient. It's in many plants, e.g. rosemary, eucalyptus, lavender, lemongrass, peppermint and it's the main component (about 50-90%) of the peel oil of citrus fruits.

It does smell nice but the problem is that it oxidizes on air exposure and the resulting stuff is not good for the skin. Oxidized limonene can cause allergic contact dermatitis and counts as a frequent skin sensitizer

Limonene's nr1 function is definitely being a fragrance component, but there are several studies showing that it's also a penetration enhancer, mainly for oil-loving components.

All in all, limonene has some pros and cons, but - especially if your skin is sensitive - the cons probably outweigh the pros.  

What-it-does: perfuming

Citronellol is a very common fragrance ingredient with a nice rose-like odor. In the UK, it’s actually the third most often listed perfume on the ingredient lists. 

It can be naturally found in geranium oil (about 30%) or rose oil (about 25%). 

As with all fragrance ingredients, citronellol can also cause allergic contact dermatitis and should be avoided if you have perfume allergy. In a 2001 worldwide study with 178 people with known sensitization to fragrances citronellol tested positive in 5.6% of the cases.

There is no known anti-aging or positive skin benefits of the ingredient. It’s in our products to make it smell nice. 

You may also want to take a look at...

what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does solvent | moisturizer/humectant
A natural corn sugar derived glycol. It can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula. [more]
what‑it‑does moisturizer/humectant | solvent | viscosity controlling
irritancy, com. 0, 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does solvent
A multi-functional helper ingredient that acts as a humectant and emollient. It's also a solvent and can boost the effectiveness of preservatives. [more]
what‑it‑does perfuming
The essential oil coming from the fruit (probably the rind) of the bergamot orange.  It's a common top note in perfumes and contains (among others) fragrant compounds limonene (37%), linalyl acetate (30%) and linalool (8.8%).  A well-known issue with bergamot oil (apart from the fragrance allergens) is that it contains phototoxic  [more]
what‑it‑does perfuming
The essential oil coming from the flowers of Rose Geranium. Like most essential oils, it contains antioxidant and antimicrobial components, but the main ones are fragrant constituents. [more]
what‑it‑does antioxidant
what‑it‑does perfuming
what‑it‑does perfuming
what‑it‑does soothing | anti-acne | antioxidant | antimicrobial/antibacterial | perfuming
The famous tea tree oil. One of the best known essential oils which comes from Australia where it has been used for almost 100 years for its antiseptic and anti-inflammatory actions. [more]
what‑it‑does soothing | antioxidant | moisturizer/humectant
what‑it‑does emollient
The oil coming from the seeds of the carrot, the orange root vegetable we all know and eat regularly. This oil is a really tricky one, as it can refer to two types of oil that can both be extracted from the carrot seeds: [more]
what‑it‑does solvent
what‑it‑does soothing | skin-identical ingredient | emollient
The small (1.5-2%) part of sunflower oil that resists soap making. It contains valuable skin-nourishing molecules like vitamin E, sterols and fatty acids. It's also claimed to have lipid-replenishing and soothing properties. [more]
what‑it‑does soothing | moisturizer/humectant
irritancy, com. 0, 0
Pro-Vitamin B5 is a goodie that moisturises the skin, has anti-inflammatory, skin protecting and wound healing properties. [more]
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 0, 0
what‑it‑does viscosity controlling
A kind of polymer (big molecule from repeated subunits) that helps to create beautiful gel-like textures. It's also a texturizer and thickener for oil-in-water emulsions. [more]
what‑it‑does buffering
It's a little helper ingredient that helps to set the pH of the products to be right. It has an alkaline pH and can neutralize acidic ingredients.
what‑it‑does emollient | emulsifying
what‑it‑does emollient | perfuming
A colorless to pale yellow liquid ester that makes the skin nice and smooth, aka emollient. It has a pleasant non-sticky, non-greasy feel to it and gives formulas smooth application properties.
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]
what‑it‑does emollient | emulsifying
It's the chemically chopped up version of normal lecithin. Most often it's used to create liposomes and to coat and stabilize some other ingredient. 
what‑it‑does chelating
It’s one of those little helper ingredients that makes sure the product stays the same over time. No color change or anything like that. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.  [more]
what‑it‑does antioxidant | soothing
One of the main biologically active components of the famous medicinal plant, Centella Asiatica, aka Gotu Kola. It has well established wound healing, skin-soothing and antioxidant activities. There is also a study by La Roche Posay (belongs to L'Oreal) that examined the anti-aging effects of 5% Vitamin C combined with 0. [more]
what‑it‑does viscosity controlling | moisturizer/humectant
A little helper ingredient that can be a thickener, a humectant, a foam booster, an adhesion promoter and a filler. [more]
what‑it‑does antioxidant | perfuming
One of the main biologically active components of the famous medicinal plant, Centella Asiatica, aka Gotu Kola. It has well established wound healing and antioxidant activities.  In-vitro (made in the lab) studies also show that Asiaticoside stimulates GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells) production as well as coll [more]
what‑it‑does antioxidant
irritancy, com. 0-3, 0-3
Pure Vitamin E. Great antioxidant that gives significant photoprotection against UVB rays. Works in synergy with Vitamin C. [more]
what‑it‑does emollient | perfuming
A clear, slightly yellow, odorless oil  that's a very common, medium-spreading emollient. It makes the skin feel nice and smooth and works in a wide range of formulas.
what‑it‑does viscosity controlling
irritancy, com. 0, 1
A handy white powder that magically converts a liquid into a nice gel formula. [more]
what‑it‑does viscosity controlling | emulsifying | surfactant/cleansing
A super commonly used thickener and emulsion stabilizer. [more]
what‑it‑does perfuming
A super common fragrance ingredient that can be found among others in lavender, ylang-ylang, bergamot or jasmine. The downside of it is that it oxidises on air exposure and might become allergenic. [more]
what‑it‑does perfuming | solvent
A super common fragrance ingredient found naturally in many plants including citrus peel oils, rosemary or lavender. It autoxidizes on air exposure and counts as a common skin sensitizer. [more]
what‑it‑does perfuming
A common fragrance ingredient with a nice rose-like smell. [more]