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Medicube Txa Niacinamide 15 Serum

Txa Niacinamide 15 Serum

Formulated with tranexamic acid, niacinamide and arbutin, this serum brightens uneven skin tone and dark spots while refining skin texture. Lightweight and non-sticky formula absorbs swiftly into skin for a clear and fresh finish.
Uploaded by: ameliedot on

Skim through

Ingredient name what-it-does irr., com. ID-Rating
Water solvent
Niacinamide(100,000Ppm) cell-communicating ingredient, skin brightening, anti-acne, moisturizer/​humectant superstar
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar
Butylene Glycol moisturizer/​humectant, solvent 0, 1
Tranexamic Acid(50,000Ppm) skin brightening, soothing goodie
Arbutin antioxidant, skin brightening goodie
Diethoxyethyl Succinate solvent
Chlorphenesin preservative, antimicrobial/​antibacterial
C12-14 Alketh-12
Ethylhexylglycerin preservative
Xanthan Gum viscosity controlling
Carbomer viscosity controlling 0, 1
Adenosine cell-communicating ingredient goodie
Disodium EDTA chelating
Melia Azadirachta Leaf Extract
Melia Azadirachta Flower Extract
1,2-Hexanediol solvent
Panthenol soothing, moisturizer/​humectant 0, 0 goodie
Cyanocobalamin
Betaine moisturizer/​humectant goodie
Coccinia Indica Fruit Extract
Rosa Centifolia Flower Oil
Ferulic Acid antioxidant, antimicrobial/​antibacterial goodie
Corallina Officinalis Extract
Pentylene Glycol solvent, moisturizer/​humectant
Glutathione
Hydrolyzed Hyaluronic Acid moisturizer/​humectant goodie
Hydrolyzed Sodium Hyaluronate moisturizer/​humectant
Dimethylsilanol Hyaluronate moisturizer/​humectant
Hyaluronic Acid skin-identical ingredient, moisturizer/​humectant goodie
Potassium Hyaluronate
Sodium Hyaluronate skin-identical ingredient, moisturizer/​humectant 0, 0 goodie
Hydroxypropyltrimonium Hyaluronate
Sodium Hyaluronate Crosspolymer skin-identical ingredient, antioxidant, moisturizer/​humectant goodie
Sodium Hyaluronate Dimethylsilanol moisturizer/​humectant
Sodium Acetylated Hyaluronate moisturizer/​humectant goodie
Acetyl Tetrapeptide-5 cell-communicating ingredient, moisturizer/​humectant goodie
Hexapeptide-9 cell-communicating ingredient goodie
Palmitoyl Tripeptide-5 cell-communicating ingredient goodie

Medicube Txa Niacinamide 15 Serum
Ingredients explained

Also-called: Aqua | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

Also-called: vitamin B3, nicotinamide | What-it-does: cell-communicating ingredient, skin brightening, anti-acne, moisturizer/humectant
  • A multi-functional skincare superstar with several proven benefits for the skin
  • Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
  • Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
  • Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
  • Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
Read all the geeky details about Niacinamide here >>

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

What-it-does: moisturizer/humectant, solvent | Irritancy: 0 | Comedogenicity: 1

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

What-it-does: skin brightening, soothing

We don't have description for this ingredient yet.

Arbutin - goodie
Also-called: Beta-Arbutin | What-it-does: antioxidant, skin brightening

A pretty well-known and often used ingredient with the magic ability to fade brown spots. It's used traditionally in Japan and can be found naturally in a couple of plants, including the leaves of pear trees, wheat and bearberry

Arbutin seems to work its magic and hinder the pigmentation process at the second step of it. An enzyme called tyrosinase is needed to create melanin (the pigment that causes the brown spots) and while several other skin lightening agents work to inhibit the synthesis of tyrosinase itself (like vitamin C or licorice), arbutin lets tyrosinase be and rather hinders the melanin-forming activity of the enzyme. (So it might be a good idea to combine arbutin with some direct tyrosinase inhibitors for more skin lightening effect.)

What-it-does: solvent

We don't have description for this ingredient yet.

A little helper ingredient that works as a preservative. It works against bacteria and some species of fungi and yeast. It's often combined with IT-preservative, phenoxyethanol.

We don't have description for this ingredient yet.

What-it-does: preservative, deodorant

If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.

Also, it's an effective deodorant and a medium spreading emollient

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range. 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

What-it-does: viscosity controlling, emulsion stabilising | Irritancy: 0 | Comedogenicity: 1

A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula.  It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.

Adenosine - goodie

Adenosine is an important little compound in our body that has a vital cell-signalling role. Research on smearing it on our face is also promising and shows so far a couple of things:

  • It can help with wound healing
  • It’s a good anti-inflammatory agent
  • It might even help with skin’s own collagen production and improve skin firmness and elasticity
  • It helps with barrier repair and protection
  • It might be even useful for the hair helping with hair thickness and hair growth
What-it-does: chelating

Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.

It is typically used in tiny amounts, around 0.1% or less.

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

What-it-does: solvent

A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives

Panthenol - goodie
Also-called: Pro-Vitamin B5 | What-it-does: soothing, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid). 

Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier. 

We don't have description for this ingredient yet.

Betaine - goodie
What-it-does: moisturizer/humectant

A sugar beet-derived amino acid derivative with nice skin protection and moisturization properties. Betaine's special thing is being an osmolyte, a molecule that helps to control cell-water balance.  It is also a natural osmoprotectant, meaning that it attracts water away from the protein surface and thus protects them from denaturation and increases their thermodynamic stability. 

It also gives sensorial benefits to the formula and when used in cleansers, it helps to make them milder and gentler. 

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Ferulic Acid - goodie

Ferulic Acid (FA) is a goodie that can be found naturally in plant cell walls. There is a lot of it especially in the bran of grasses such as rice, wheat and oats. 

FA - whose main job is to be an antioxidant - owes its fame to a 2005 research that discovered that adding in 0.5% FA to a 15% Vitamin C + 1% Vitamin E solution not only stabilizes the highly unstable, divaish Vit C, but it also doubles the photoprotection abilities of the formula. 

We don't have description for this ingredient yet.

A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product feel great on the skin. It works synergistically with preservatives and helps to improve water-resistance of sunscreens. 

We don't have description for this ingredient yet.

What-it-does: moisturizer/humectant

Hydrolyzed Hyaluronic Acid is a low molecular weight, chemically chopped up version of the naturally big molecule and current IT-moisturizer, Hyaluronic Acid (HA). The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to retain water, making it plump and elastic. As HA is a polymer, the subunits can be repeated many times (as a high-molecular-weight version), or just a few times (as a low-molecular-weight version).

We wrote in detail at HA about how different molecular weight versions do different things both as a component of the skin and as a skincare ingredient, so click here and read about all the details. Hydrolyzed Hyaluronic Acid can also come in different molecular-weight versions with different properties:

Also-called: miniHA | What-it-does: moisturizer/humectant

It's a super small, chemically chopped up version of sodium hyaluronate. Its trade name is miniHA, and its molecular weight is 10 kDa. This counts as really tiny given that "normal" HA has a molecular weight of 0.5-2 million Da.

To be honest, low molecular weight (LMW), and especially this ultra-low molecular weight HA is a controversial ingredient. On the upside, it can penetrate the skin better (though 10kDa still counts as big!) and might be able to moisturize the deeper layers of the skin where normal HA cannot get. Also, according to the manufacturer of miniHA, it has better antioxidant activity than a 1.6MDa version HA and it also has better sun protection and after-sun repair abilities than the higher MW versions. It also works in synergy with higher molecular weight versions, and the combination of 0.1% 1.45MDa-HA + 0.1% 380 kDa-HA + 0.1% miniHA hydrated the skin significantly better than 0.3% 1.45MDa-HA alone.

What-it-does: moisturizer/humectant

We don't have description for this ingredient yet.

  • It’s naturally in our skin and behaves there like a sponge
  • It can bind up to 1000 times its own weight in water
  • It is a big molecule from repeated subunits (polymer) so different molecular weight versions exist (unfortunately there is no way to determine MW from INCI list only)
  • High-molecular-weight-HA (>500 kDa) is an excellent surface hydrator, skin protectant and can act as an osmotic pump helping water-soluble actives to penetrate deeper into the skin
  • Low-molecular-weight-HA (< 500 kDa) can hydrate the skin somewhat deeper though it is still a big molecule and works mainly in the epidermis (outer layer of the skin)
  • Low-molecular-weight-HA might also help the skin to repair itself by increasing its self-defense (~ 200kDa used in the study)
  • Ultra-low-molecular-weight-HA (<50kDa) is a controversial ingredient and might work as a pro-inflammatory signal molecule
Read all the geeky details about Hyaluronic Acid here >>

We don't have description for this ingredient yet.

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It’s the - sodium form - cousin of the famous NMFhyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

We don't have description for this ingredient yet.

It's a special "cross-linked" from of IT-moisturizer, hyaluronic acid (HA). Cross-linked means that "normal" HA pieces (1-2 million Da molecular weight) are chemically bound togeather to create a big, "infinite" mesh.

The special HA mesh has a remarkable water-binding capacity, 5 times more than the already crazy water-binding capacity of "normal" HA. This water filled crosslinked HA gel forms a smooth film on the skin and continuously delivers the bound water, so it gives long-term moisturizing benefits.

What-it-does: moisturizer/humectant

We don't have description for this ingredient yet.

What-it-does: moisturizer/humectant

Sodium Acetylated Hyaluronate is a variation of current IT moisturizer, Hyaluronic acid, where some water-loving -OH groups are replaced by amphipathic (partly water-loving and partly water-hating) acetyl groups. The modified molecule is claimed to have even better moisture retention ability than normal HA and better affinity to the skin surface. 

The better affinity comes from the acetyl groups that act as tiny "anchors" to attach the HA molecule to the skin. Staying on top of the skin better and longer means longer-lasting surface hydration and improved elasticity. It is also less sticky and more cosmetically elegant than normal HA, so no wonder the nickname of this molecule is super hyaluronic acid. 

Also-called: EYESERYL | What-it-does: cell-communicating ingredient, moisturizer/humectant

A four amino acid peptide that is claimed to improve puffy eye bags via its anti-oedema and anti-glycation effects.

To back this claim up, the manufacturer created an in-vivo study with 20 volunteers using 10% of EYESERYL (that comes down to 0.01% (!) of the pure peptide) and found that by day 15, 70% of the volunteers improved, while 95% of the volunteers improved by the end of the study (60 days). About third of them improved only slightly, third of them showed an ok improvement and third showed a good improvement. They also have pretty convincing before and after photos, so we can tell you that for the lucky ones, the improvement can be real and visible.

Hexapeptide-9 - goodie

An anti-aging peptide that can visibly reduce the length and depth of wrinkles, at least according to its manufacturer. In vitro (meaning it was done in the lab, not on real people) studies show that it enhances epidermal regeneration, collagen type I and III synthesis as well as the synthesis of other important skin proteins. 

Also-called: Syn-Coll | What-it-does: cell-communicating ingredient

A tripeptide (three amino acids attached to each other: Lys-Val-Lys) that's claimed to protect and boost collagen and improve skin texture.

The manufacturer did an in-vivo (made on real people) study with 45 volunteers and found that used twice daily for 84 days 1% and 2.5% Syn-Coll reduces the appearance of wrinkles by 7 and 12% respectively. In another study (also by the manufacturer) with 33 female Chinese volunteers, 77% of the participants felt that Syn-Coll visibly improved the firmness and elasticity of the skin after 4 weeks. What's more, 60% of the participants also noticed a reduction in the look of the pore size also after 4 weeks of treatment. 

You may also want to take a look at...

what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0, 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
what‑it‑does skin brightening | soothing
what‑it‑does antioxidant | skin brightening
One of the better-known skin brightening agents that's found naturally for example in bearberry. [more]
what‑it‑does solvent
what‑it‑does preservative | antimicrobial/antibacterial
A little helper ingredient that works as a preservative. It works against bacteria and some species of fungi and yeast. [more]
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]
what‑it‑does viscosity controlling
A super commonly used thickener and emulsion stabilizer. [more]
what‑it‑does viscosity controlling
irritancy, com. 0, 1
A handy white powder that magically converts a liquid into a nice gel formula. [more]
what‑it‑does cell-communicating ingredient
An important compound in our body that has a vital cell-signalling role. It is wound healing, anti-inflammatory and can help with barrier repair. [more]
what‑it‑does chelating
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. [more]
what‑it‑does solvent
A multi-functional helper ingredient that acts as a humectant and emollient. It's also a solvent and can boost the effectiveness of preservatives. [more]
what‑it‑does soothing | moisturizer/humectant
irritancy, com. 0, 0
Pro-Vitamin B5 is a goodie that moisturises the skin, has anti-inflammatory, skin protecting and wound healing properties. [more]
what‑it‑does moisturizer/humectant
A sugar beet derived amino acid derivative with nice skin protection and moisturization properties. Its special thing is being an osmolyte, a molecule that helps to control cell-water balance.  [more]
what‑it‑does antioxidant | antimicrobial/antibacterial
A great antioxidant that is most famous for stabilizing the highly unstable Vitamin C. It also doubles the photoprotection abilities of Vit C+E formulas. [more]
what‑it‑does solvent | moisturizer/humectant
A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent, and a broad spectrum antimicrobial. [more]
what‑it‑does moisturizer/humectant
Hydrolyzed Hyaluronic Acid is a low molecular weight, chemically chopped up version of the naturally big molecule and current IT-moisturizer, Hyaluronic Acid (HA). The TL; [more]
what‑it‑does moisturizer/humectant
A super small, chemically chopped up version of sodium hyaluronate. Small molecular weight (SMW) HA is a controversial ingredient: it can penetrate deep into the skin and moisturize deeper layers but might act as a pro-inflammatory agent. [more]
what‑it‑does moisturizer/humectant
what‑it‑does skin-identical ingredient | moisturizer/humectant
A famous natural moisturizing factor that can bind up to 1000 times its own weight in water. Works as an excellent surface hydrator in skincare. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
what‑it‑does skin-identical ingredient | antioxidant | moisturizer/humectant
A special, "cross-linked" from of hyaluronic acid (HA). Claimed to have five times the water-binding capacity of normal HA, also acts as an antioxidant and gives skin long-term moisture. [more]
what‑it‑does moisturizer/humectant
what‑it‑does moisturizer/humectant
Sodium Acetylated Hyaluronate is a variation of current IT moisturizer, Hyaluronic acid, where some water-loving -OH groups are replaced by amphipathic (partly water-loving and partly water-hating) acetyl groups. [more]
what‑it‑does cell-communicating ingredient | moisturizer/humectant
A four amino acid peptide that is claimed to improve puffy eye bags via its anti-oedema and anti-glycation effects.To back this claim up, the manufacturer created an in-vivo study with 20 volunteers using 10% of EYESERYL (that comes down to 0.01% (!) of the pure peptide) and found that by day 15, 70% of the volunteers improved, while 95% of the volunteers improved by the end of the study (60 d [more]
what‑it‑does cell-communicating ingredient
An anti-aging peptide that can visibly reduce the length and depth of wrinkles, at least according to its manufacturer. In vitro (meaning it was done in the lab, not on real people) studies show that it enhances epidermal regeneration, collagen type I and III synthesis as well as the synthesis of other important skin proteins. [more]
what‑it‑does cell-communicating ingredient
Syn-Coll - An anti-aging tripeptide that's claimed to protect and boost collagen and improve skin texture. [more]