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Derma E Anti-aging Regenerative Night Cream

Anti-aging Regenerative Night Cream

This powerful anti-aging night cream is specially formulated to nurture skin with potent antioxidants as well as other natural ingredients that have proven effectiveness when it comes to creating the appearance of a radiant complexion. The night cream contains two of the strongest antioxidants for topical application: astaxanthin and pycnogenol®.
Uploaded by: cmackay1 on

Skim through

Ingredient name what-it-does irr., com. ID-Rating
Purified Water solvent
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar
Caprylic/Capric Triglyceride emollient
Cetyl Alcohol emollient, viscosity controlling 2, 2
Stearic Acid emollient, viscosity controlling 0, 2-3
Glyceryl Stearate Citrate emollient, emulsifying
Dimethicone emollient 0, 1
Glyceryl Stearate emollient, emulsifying 0, 1
Simmondsia Chinensis (Jojoba) Seed Oil emollient 0, 0-2 goodie
Tocopheryl Acetate antioxidant 0, 0
Xanthan Gum viscosity controlling
Panthenol soothing, moisturizer/​humectant 0, 0 goodie
Potassium Sorbate preservative
Allantoin soothing 0, 0 goodie
Cetearyl Glucoside emulsifying, surfactant/​cleansing
Pinus Pinaster Bark Extract antioxidant goodie
Astaxanthin antioxidant goodie
Bakuchiol cell-communicating ingredient, antioxidant, antimicrobial/​antibacterial goodie
Lavandula Angustifolia (Lavender) Oil antimicrobial/​antibacterial, perfuming icky
Salvia Officinalis (Sage) Oil
Limonene perfuming, solvent icky
Polysorbate 20 emulsifying, surfactant/​cleansing 0, 0
Retinol cell-communicating ingredient superstar
Eucalyptol perfuming
Copaifera Reticulata Balsam Oil perfuming
Mentha Viridis (Spearmint) Leaf Oil
Beta-Caryophyllene perfuming
Camphor
Citral perfuming icky
L-Alpha-Pinene perfuming
Geranyl Acetate perfuming
Anthemis Nobilis Flower Oil soothing, perfuming goodie
L-Beta-Pinene perfuming
Melaleuca Alternifolia (Tea Tree) Leaf Oil soothing, anti-acne, antioxidant, antimicrobial/​antibacterial, perfuming goodie
Isobornyl Acetate perfuming
Neryl Acetate perfuming
Menthone perfuming
Benzyl Acetate perfuming
Citronellal
Terpineol perfuming
Menthyl Acetate
Phenoxyethanol preservative
Ethylhexylglycerin preservative
Sodium Hydroxide buffering

Derma E Anti-aging Regenerative Night Cream
Ingredients explained

Also-called: Aqua;Water | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

What-it-does: emollient

A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, is super well tolerated by every skin type and easy to formulate with. No wonder it’s popular. 

What-it-does: emollient, viscosity controlling, emulsion stabilising | Irritancy: 2 | Comedogenicity: 2

A so-called fatty (the good, non-drying kind of) alcohol that does all kinds of things in a skincare product: it makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier). Can be derived from coconut or palm kernel oil.

What-it-does: emollient, viscosity controlling | Irritancy: 0 | Comedogenicity: 2-3

A common multi-tasker fatty acid. It makes your skin feel nice and smooth (emollient), gives body to cream type products and helps to stabilize water and oil mixes (aka emulsions).

What-it-does: emollient, emulsifying

Glyceryl stearate citrate is similar to the super common skincare ingredient glyceryl stearate, and is similarly used to help combine waters and oils (emulsifier) and to make your skin feel nice and soft (emollient). 

The main difference between glyceryl stearate citrate and its cousin glyceryl stearate is that this one has a citric acid molecule also attached to its glycerin. This makes it what chemists call a diacylglycerol, which is a fancy word for two acids (in this case, citric acid and stearic acid) attached together with a glycerin bridge. But when it comes to cosmetics, all you need to know is that both glyceryl stearate citrate and glyceryl stearate are safe, tried and true emulsifiers. Expect to see them in formulas with both water-based and oil-based ingredients (think moisturizers and lotions).

What-it-does: emollient | Irritancy: 0 | Comedogenicity: 1

Probably the most common silicone of all. It is a polymer (created from repeating subunits) molecule and has different molecular weight and thus different viscosity versions from water-light to thick liquid.

As for skincare, it makes the skin silky smooth, creates a subtle gloss and forms a protective barrier (aka occlusive). Also, works well to fill in fine lines and wrinkles and give skin a plump look (of course that is only temporary, but still, it's nice). There are also scar treatment gels out there using dimethicone as their base ingredient. It helps to soften scars and increase their elasticity. 

What-it-does: emollient, emulsifying | Irritancy: 0 | Comedogenicity: 1

A super common, waxy, white, solid stuff that helps water and oil to mix together, gives body to creams and leaves the skin feeling soft and smooth.

Chemically speaking, it is the attachment of a glycerin molecule to the fatty acid called stearic acid. It can be produced from most vegetable oils (in oils three fatty acid molecules are attached to glycerin instead of just one like here) in a pretty simple, "green" process that is similar to soap making. It's readily biodegradable.

Also-called: Jojoba Oil | What-it-does: emollient | Irritancy: 0 | Comedogenicity: 0-2

Jojoba is a drought resistant evergreen shrub native to South-western North America. It's known and grown for jojoba oil, the golden yellow liquid coming from the seeds (about 50% of the weight of the seeds will be oil).  

At first glance, it seems like your average emollient plant oil: it looks like an oil and it's nourishing and moisturizing to the skin but if we dig a bit deeper, it turns out that jojoba oil is really special and unique: technically - or rather chemically - it's not an oil but a wax ester (and calling it an oil is kind of sloppy). 

Also-called: Vitamin E Acetate | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 0

It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version. 

According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E. 

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range. 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

Panthenol - goodie
Also-called: Pro-Vitamin B5 | What-it-does: soothing, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid). 

Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier. 

What-it-does: preservative

It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. It’s not a strong one and doesn’t really work against bacteria, but more against mold and yeast. To do that it has to break down to its active form, sorbic acid. For that to happen, there has to be water in the product and the right pH value (pH 3-4). 

But even if everything is right, it’s not enough on its own. If you see potassium sorbate you should see some other preservative next to it too.

Allantoin - goodie
What-it-does: soothing | Irritancy: 0 | Comedogenicity: 0

Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. 

It's not only soothing but it' also skin-softening and protecting and can promote wound healing.

A sugar based emulsifier that's especially great for low viscosity lotions or even sprays. It's effective in small amounts, only 1-1.5% is needed to form an emulsion. The resulting cream or lotion has great cosmetic properties with good spreadability and an enhanced soft skin feel. 

Also-called: Pycnogenol | What-it-does: antioxidant

A natural plant extract coming from the bark of the maritime pine that grows along the coast of southwest France. The extract contains potent antioxidant molecules, mainly procyanidins and phenolic acids.  Horphag Research trademarked the name 'Pycnogenol', which refers to a standardized, high-active content version of the pine bark extract. 

Pycnogenol is a very well researched ingredient with more than 370 published studies and review articles. Most of these are in-vitro (made in the lab, not on real people) or analyse Pycnogenol when taken orally. It's clear from them that Pycnogenol has a load of health benefits including antioxidant, anti-inflammatory, and anticarcinogenic magical properties (and a bunch of other things such as improving cognitive function, relieving premenstrual symptoms, or enhancing microcirculation). 

Astaxanthin - goodie
What-it-does: antioxidant

An oil-loving, red-orange colored pigment that is becoming more and more well-known as a potent antioxidant.

If being an orange-colored pigment reminds you of beta-carotene from carrots, that is no coincidence: astaxanthin also belongs to the chemical group called carotenoids known for giving yellow, orange, or red color to plants. Our guy comes mostly from microalgae, a well-known and often used source is Haematococcus Pluvialis

Bakuchiol - goodie
Also-called: Sytenol A, Phyto Retinol | What-it-does: cell-communicating ingredient, antioxidant, antimicrobial/antibacterial

At first glance, you could think that Bakuchiol is your average plant extract. It is derived from the seeds of Psoralea Corylifolia, aka Babchi, a plant important in Indian and Chinese medicine. The molecule was first isolated in 1973 and several anti-something properties are known about it: it has anti-inflammatory, antioxidant, anti-tumor, anti-bacterial and hepatoprotective magical abilities like plenty of other Ayurvedic plant extracts.

What makes Bakuchiol a special snowflake is the recent discovery that it behaves on the skin in a way very similar to well-known skincare superstar, retinol. While chemically, it has nothing to do with the vitamin-A family, aka retinoids, comparative gene expression profiling (a fancy way of saying that they compared how retinol and bakuchiol modify the way  skin cells behave and produce important skin proteins such as collagen) shows that retinol and bakuchiol regulate skin cell behavior in a similar way. 

Also-called: Lavender Essential Oil | What-it-does: antimicrobial/antibacterial, perfuming

We have to start by writing how fascinated we are by the amazing lavender fields of Provance and we do love pretty much everything about lavender: its look, its color, its scent.... but, when it comes to skincare, lavender is a questionable ingredient that you probably do not want in your skincare products.

First, let us start with the pros: it has a lovely scent, so no wonder that it is popular as a fragrance ingredient in natural products wanting to be free from synthetic fragrances but still wanting to smell nice. The scent of lavender is famous for having calming and relaxing properties and some smallish scientific studies do support that. Inhaled volatile compounds seem to have a soothing effect on the central nervous system and studies have shown that lavender aromatherapy can improve patient's anxiety and experience in hospitals.   

We don't have description for this ingredient yet.

Limonene - icky
What-it-does: perfuming, solvent, deodorant

A super common and cheap fragrance ingredient. It's in many plants, e.g. rosemary, eucalyptus, lavender, lemongrass, peppermint and it's the main component (about 50-90%) of the peel oil of citrus fruits.

It does smell nice but the problem is that it oxidizes on air exposure and the resulting stuff is not good for the skin. Oxidized limonene can cause allergic contact dermatitis and counts as a frequent skin sensitizer

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 0 | Comedogenicity: 0

It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 

Retinol - superstar
Also-called: Vitamin A, Form of Retinoids | What-it-does: cell-communicating ingredient
  • Retinol (pure Vitamin A) is probably the most proven anti-aging ingredient available OTC
  • It has to be converted in the skin to retinoic acid to work its magic
  • Once converted, it has the same effect as all-trans-retinoic acid, aka tretinoin
  • A generally accepted ballpark number is that retinol is 10-to-20 times less potent than retinoic acid
  • It makes skin less wrinkled, smoother, firmer and tighter
  • It might also be helpful for acne prone skin as it normalizes keratinization and makes the pores produce less sebum
  • Possible side effects and irritation are also much less than with retinoic acid
  • Do not use whilst pregnant
Read all the geeky details about Retinol here >>

What-it-does: perfuming

We don't have description for this ingredient yet.

What-it-does: perfuming

We don't have description for this ingredient yet.

What-it-does: astringent

We don't have description for this ingredient yet.

What-it-does: perfuming

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Citral - icky
What-it-does: perfuming

It’s a common fragrance ingredient that smells like lemon and has a bittersweet taste.  It can be found in many plant oils, e.g. lemon, orange, lime or lemongrass. 

It’s one of the “EU 26 fragrances” that has to be labelled separately (and cannot be simply included in the term “fragrance/perfume” on the label) because of allergen potential. Best to avoid if your skin is sensitive.

What-it-does: perfuming

This ingredient name is not according to the INCI-standard. :( What, why?!

What-it-does: perfuming

We don't have description for this ingredient yet.

Also-called: Roman Chamomile Flower Oil | What-it-does: soothing, perfuming

The essential oil coming from the second most common type of chamomile, the Roman Chamomile. It also contains the biologically active anti-inflammatory componentsbisabolol, and chamazulene, but less than the more commonly used German Chamomile.  It's not clear what Roman Chamomile knows that the German one does not. 

What-it-does: perfuming

This ingredient name is not according to the INCI-standard. :( What, why?!

Also-called: Tea Tree Oil, TTO | What-it-does: soothing, anti-acne, antioxidant, antimicrobial/antibacterial, perfuming

The famous tea tree oil. One of the best known essential oils which comes from Australia where it has been used for almost 100 years for its antiseptic and anti-inflammatory actions. Legend has it that the medicinal benefits of the oil were considered so important that Australian soldiers were supplied with some tea tree oil in their World War II military kit.

Similar to other essential oils, tea tree oil is a very complex chemical mixture consisting of about 100 components, the major ones being terpinen-4-ol (40%), γ-Terpinene (23%) and α-Terpinene (10%). Terpinen-4-ol is considered to be the main active component but as a great article in Clinical Microbiology Reviews states "while some TTO components may be considered less active, none can be considered inactive" and most components contribute to TTO's strong antibacterial, antiviral and antifungal effects

What-it-does: perfuming

We don't have description for this ingredient yet.

What-it-does: perfuming

We don't have description for this ingredient yet.

What-it-does: perfuming

We don't have description for this ingredient yet.

What-it-does: perfuming

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

What-it-does: perfuming

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

What-it-does: preservative, deodorant

If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.

Also, it's an effective deodorant and a medium spreading emollient

Also-called: lye | What-it-does: buffering

The unfancy name for it is lye. It’s a solid white stuff that’s very alkaline and used in small amounts to adjust the pH of the product and make it just right. 

For example, in case of AHA or BHA exfoliants, the right pH is super-duper important, and pH adjusters like sodium hydroxide are needed.  

You may also want to take a look at...

what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does emollient
A very common emollient that makes your skin feel nice and smooth. Comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. [more]
what‑it‑does emollient | viscosity controlling
irritancy, com. 2, 2
A fatty (the good, non-drying kind of) alcohol that makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier).
what‑it‑does emollient | viscosity controlling
irritancy, com. 0, 2-3
A common multi-tasker fatty acid that works as an emollient, thickener and emulsion stabilizer. [more]
what‑it‑does emollient | emulsifying
Glyceryl stearate citrate is similar to the super common skincare ingredient glyceryl stearate, and is similarly used to help combine waters and oils (emulsifier) and to make your skin feel nice and soft (emollient).  The main difference between glyceryl stearate citrate and its cousin glyceryl stearate is that this one has a citric acid molecule also attached to its glycerin. [more]
what‑it‑does emollient
irritancy, com. 0, 1
A very common silicone that gives both skin and hair a silky smooth feel. It also forms a protective barrier on the skin and fills in fine lines. Also used for scar treatment. [more]
what‑it‑does emollient | emulsifying
irritancy, com. 0, 1
Waxy, white, solid stuff that helps water and oil to mix together and leaves the skin feeling soft and smooth. [more]
what‑it‑does emollient
irritancy, com. 0, 0-2
Jojoba oil - a wax ester (chemically not a real oil), that's very similar to human sebum. It's uniquely excellent at helping the skin with its protective barrier and helping it to stay moisturized. [more]
what‑it‑does antioxidant
irritancy, com. 0, 0
A form of vitamin E that works as an antioxidant. Compared to the pure form it's more stable, has longer shelf life, but it's also more poorly absorbed by the skin. [more]
what‑it‑does viscosity controlling
A super commonly used thickener and emulsion stabilizer. [more]
what‑it‑does soothing | moisturizer/humectant
irritancy, com. 0, 0
Pro-Vitamin B5 is a goodie that moisturises the skin, has anti-inflammatory, skin protecting and wound healing properties. [more]
what‑it‑does preservative
A not so strong preservative that doesn’t really work against bacteria, but more against mold and yeast. [more]
what‑it‑does soothing
irritancy, com. 0, 0
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. It's not only soothing but it' [more]
what‑it‑does emulsifying | surfactant/cleansing
A sugar based emulsifier that's especially great for low viscosity lotions or even sprays. [more]
what‑it‑does antioxidant
Pycnogenol - A natural plant extract coming from the bark of the maritime pine. It's a well-researched and potent antioxidant. [more]
what‑it‑does antioxidant
An oil-loving, red-orange colored pigment known for being a potent antioxidant. [more]
what‑it‑does cell-communicating ingredient | antioxidant | antimicrobial/antibacterial
At first glance, you could think that Bakuchiol is your average plant extract. It is derived from the seeds of Psoralea Corylifolia, aka Babchi, a plant important in Indian and Chinese medicine. [more]
what‑it‑does antimicrobial/antibacterial | perfuming
Lavender - essential oil with a calming scent and antimicrobial properties. Contains fragrant components (linalyl acetate - 50% and linalool - 35%) and might be cytotoxic from 0.25%. [more]
what‑it‑does perfuming | solvent
A super common fragrance ingredient found naturally in many plants including citrus peel oils, rosemary or lavender. It autoxidizes on air exposure and counts as a common skin sensitizer. [more]
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 0, 0
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 
what‑it‑does cell-communicating ingredient
Vitamin A - the most proven anti-aging ingredient available OTC that can smooth wrinkles and make skin firmer. It might also be useful for acne-prone skin as it normalizes keratinization. [more]
what‑it‑does perfuming
what‑it‑does perfuming
what‑it‑does perfuming
what‑it‑does perfuming
A common fragrance ingredient that smells like lemon. [more]
what‑it‑does perfuming
what‑it‑does perfuming
what‑it‑does soothing | perfuming
The essential oil coming from the second most common type of chamomile, the Roman Chamomile. It also contains the biologically active anti-inflammatory components, bisabolol, and chamazulene, but less than the more commonly used German Chamomile. [more]
what‑it‑does perfuming
what‑it‑does soothing | anti-acne | antioxidant | antimicrobial/antibacterial | perfuming
The famous tea tree oil. One of the best known essential oils which comes from Australia where it has been used for almost 100 years for its antiseptic and anti-inflammatory actions. [more]
what‑it‑does perfuming
what‑it‑does perfuming
what‑it‑does perfuming
what‑it‑does perfuming
what‑it‑does perfuming
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]
what‑it‑does buffering
Lye - A solid white stuff that’s very alkaline and used in small amount to adjust the pH of the product.  [more]