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Zelens Provitamin D Treatment Drops

Provitamin D Treatment Drops

A fortifying, line-lessening and elasticising powerhouse, ‘Power D’ dramatically enhances skin’s resilience – reinforcing barrier function to seal the ‘good stuff’ in and lock the ‘bad stuff’ out.
Uploaded by: judit on 04/06/2017

Zelens Provitamin D Treatment Drops
Ingredients explained

What-it-does: emollient

A light emollient ester (C8-10 fatty acids connected to C12-18 fatty alcohols) that absorbs quickly and leaves a dry but silky finish on the skin. In terms of skin feel, it is similar to Dicaprylyl Carbonate, another commonly used light emollient. 

What-it-does: emollient

A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, and it’s also easy to formulate with. No wonder it’s popular. 

Also-called: Super Sterol Liquid | What-it-does: emollient

A clear, pale yellow oil-like liquid that's claimed to be similar to the lipids that are naturally in the outermost layer of the skin.  It's not only similar to them but it is also biomimetic, meaning that it can mimic the functionality of our skin lipids.

The skin lipids play a super important role in maintaining a healthy skin barrier and keeping the skin nice and moisturized and not dry or cracked.  So C10-30 Cholesterol/Lanosterol Esters, aka Super Sterol Liquid can do something similar: it is an extremely efficient emollient that can repair even dry hands or cracked lips and it is great at maintaining a healthy skin barrier.

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A goodie for super dry skin.

What-it-does: emollient

A coconut or palm kernel oil derived, fast spreading emollient liquid that makes your skin feel nice and smooth. It is mild for sensitive skin, leaves a light and dry skin feel and is readily biodegradable. 

What-it-does: emollient

A naturally derived (Ecocert approved) colorless to yellowish oily liquid that's touted as a natural silicone alternative. It's claimed to have great sensorial properties: light but caring, velvety, silky and non-sticky.

It's also great at dissolving UV-filters in sunscreens or dispersing pigments in makeup products. You can also bump into Isoamyl Laurate in hair care products as a hair conditioner that makes combing easier without build up.

We don't have description for this ingredient yet.

Also-called: Corn Oil | What-it-does: emulsifying, perfuming | Irritancy: 0 | Comedogenicity: 0-3

We don't have description for this ingredient yet.

Linoleic Acid - goodie
Also-called: LA, omega-6 fatty acid, 18:2 cis-9,12, Form of Vitamin F | What-it-does: skin-identical ingredient, emollient

The famous omega-6 fatty acid, the mother of all ω-6 fatty acids in our body. It is a so-called polyunsaturated fatty acid meaning it has more than one (in this case two) double bonds and a somewhat kinky structure that makes LA and LA-rich oils a thin liquid.

It is also an essential fatty acid meaning our body cannot synthesize it and has to take it from food. This is not hard at all as plenty of nuts (such as flax, poppy or sesame seeds) and vegetable oils (such as sunflower or safflower) are rich in LA. The hard thing seems to be eating enough omega-3-s, more specifically eating a healthy ratio of omega-6 to omega-3, but that is a topic for a what-is-good-to-eat-site and not for us. 

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As for linoleic acid and the skin, LA is a really important little guy found naturally in our skin. It is the most abundant fatty acid in the epidermis and it serves as a structural precursor for important skin lipids called ceramides. Knowing this, it will not come as a surprise that Linoleic acid has a central role in the structure and function of stratum corneum permeability, aka healthy skin barrier.  LA deficiency leads to an impaired more permeable skin barrier and the topical application of LA-rich sunflower oil can fix this issue rapidly (while oleic-rich olive oil did not have the same barrier repairing effect).

LA is not only important for dry, barrier damaged skin types but also for acne-prone skin. Research shows that problem skin has lower levels of linoleic acid (and higher levels of oleic acid) than normal skin. So LA-deficiency in the skin seems to be connected not only to an impaired skin barrier but also to acne and smearing LA all over your face might help with your problem skin. A double-blind study using a 2.5% LA gel for 4 weeks found a 25% reduction in the size of microcomedones, the tiny blocked pores that can later lead to acne.

If that was not enough, we have one more thing to report about LA.  It lightens hyperpigmentation (aka UVB caused sun spots) both by blocking the melanin production of melanocytes (the skin cells that make the pigment melanin) and by enhancing the desquamation of melanin pigment from the upper layers of the skin.

Overall, linoleic acid is a multi-functional skin goodie with barrier repairing, acne-reducing, and skin-lightening magic abilities. It's a nice one to spot on the ingredient list pretty much for any skin type. 

Phospholipids - goodie

A type of lipid that's the major (about 75%) component of all cell membranes. As for skincare, it works as an emollient and skin-identical ingredient.

It has a water-loving head with two water-hating tails and this structure gives the molecule emulsifying properties. It is also often used to create liposomes, small spheres surrounded by phospholipid bi-layer designed to carry some active ingredient and help its absorption.

What-it-does: emollient

A clear, slightly yellow, odorless oil  that's a very common, medium-spreading emollient. It makes the skin feel nice and smooth and works in a wide range of formulas.

What-it-does: emollient

A natural emollient ester derived from sugar beets and coconut oil. It's a very light liquid that absorbs quickly into the skin and has a non-oily skin feel

The manufacturer says it's produced in an innovative, eco-friendly way that saves about 60% on energy consumption and CO2 emission compared to traditional manufacturing methods. 

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Also-called: Reishi Mushroom Extract

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Also-called: Shiitake Mushroom Extract

We don't have description for this ingredient yet.

Also-called: Lichen Extract | What-it-does: preservative, antimicrobial/antibacterial, deodorant

The extract coming from the alpine lichen, Usnea Barbata. It is known for its excellent efficacy against gram-positive bacteria, meaning that it can serve as a natural preservative and deodorant agent.

Its main biologically active component is usnic acid (a molecule produced only by lichens) that's not only an antibacterial agent, but also has antioxidant, anti-inflammatory and wound-healing promoting effects. According to manufacturer info,  the antibacterial activity of Usnea Barbata makes the ingredient helpful against body odor, blemished skin, and dandruff. 

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It is also very common in K-Beauty products, as it is part of a popular Korean natural preservative system trade named EURO-Napre (combined with Zanthoxylum Piperitum and Pulsatilla Koreana). 

Also-called: Baker's Yeast | What-it-does: moisturizer/humectant

Saccharomyces cerevisiae (SC)  is the fancy name for common baker’s yeast. 

Usually different kind of yeast extracts are used in skincare for their great hydrating, and general skin conditioning properties. We could find one research paper to back this up: It has found that SC indeed increases skin moisture and had improved skin microrelief (the small wrinkles and surface irregularities of skin). 

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According to manufacturer info coupled with the Mexican cactus, prickly pear it also helps to reduce neurosensory irritation that might occur from potent retinol or AHA products. 

Also-called: Soybean Sterols | What-it-does: emollient

We don't have description for this ingredient yet.

Lecithin - goodie
What-it-does: emollient, emulsifying

A very common ingredient that can be found in all cell membranes. In cosmetics it's quite the multi-tasker: it's an emollient and water-binding ingredient but it's also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes

Also-called: alpha-Linolenic acid, ALA, omega-3 fatty acid, Form of Vitamin F | What-it-does: skin-identical ingredient, emollient

The famous omega-3 fatty acid, the mother of all ω-3 fatty acids in our body. Next to linoleic acid, it is the other essential fatty acid that our body cannot synthesize and we have to ingest it from our food. It is also a PUFA, aka polyunsaturated fatty acid with three double bonds, a kinky chemical structure and thus a liquid consistency.

While linoleic acid is abundant in the skin, this is not the case with alpha-linolenic acid (ALA). It is not entirely clear if it is meant to be like that or if this is a consequence of not eating enough Omega-3 with the typical Western diet.

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Leafy green vegetables, walnuts, flax seeds and fish oils are rich sources of ALA and if you are not eating a lot from these, supplementing with fish oil is a pretty good idea backed by research. It is a good idea both in terms of general health benefits as well as potentially improving inflammation-related skin issues such as atopic dermatitis or acne.

As for using ALA topically, we have to say that its role and effects seem to be less direct than with LA. ALA's main role in the skin appears to be modulating the immune response of the epidermis. This is probably helpful for inflammatory skin diseases but most studies examine ALA as an oral supplement and not when applied topically. One exception, we could find, is a study that found that topically applied ALA has nice spot-fading abilities.

To be honest, it seems to us that oral supplementation of ALA is more important than smearing it all over your face. However, that is not to say that topical ALA is a bad thing, it is a good thing. It is a skin-identical ingredient, it is probably moisturizing and anti-inflammatory but its topical effects are less established than that of fellow omega fatty acid, linoleic acid

  • It’s naturally in our skin and behaves there like a sponge
  • It can bind up to 1000 times its own weight in water
  • It is a big molecule from repeated subunits (polymer) so different molecular weight versions exist (unfortunately there is no way to determine MW from INCI list only)
  • High-molecular-weight-HA (>500 kDa) is an excellent surface hydrator, skin protectant and can act as an osmotic pump helping water-soluble actives to penetrate deeper into the skin
  • Low-molecular-weight-HA (< 500 kDa) can hydrate the skin somewhat deeper though it is still a big molecule and works mainly in the epidermis (outer layer of the skin)
  • Low-molecular-weight-HA might also help the skin to repair itself by increasing its self-defense (~ 200kDa used in the study)
  • Ultra-low-molecular-weight-HA (<50kDa) is a controversial ingredient and might work as a pro-inflammatory signal molecule
Read all the geeky details about Hyaluronic Acid here >>

We don't have description for this ingredient yet.

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

Though its name does not reveal it, this molecule is a relative of famous IT-moisturizer, Hyaluronic Acid. Just like HA, it is a glycosaminoglycan (aka GAG), meaning that it is a big sugar molecule from repeated subunits (what's more, one of the subunits is the same, glucuronic acid). Along with HA and other GAGs, it likes to hang out in the dermis (middle) layer of the skin where it is part of the gooey, bouncy stuff outside of the cells called extracellular matrix (ECM). 

As for skincare, Sodium Chondroitin Sulfate is probably too big to go right into the dermis (though much smaller than HA with 5000-50 000 Da molecular weight), but it has a comparable water binding ability to HA (which means a crazy water binding ability) and better affinity for the skin surface. This means that it forms a nice, water-rich film on the skin bringing an immediate and strong moisturising effect. 

Also-called: Vitamin F Ethyl Ester | What-it-does: emollient

A type of oil soluble vitamin F that is used as an emollient. Read more at ethyl oleate.

Also-called: Vitamin F Ethyl Ester | What-it-does: emollient

A type of oil soluble vitamin F that is used as an emollient. Read more at ethyl oleate.

Also-called: Vitamin F Ethyl Ester | What-it-does: emollient

It's a Vitamin F Ethyl Ester, that is used as an emollient. Coupled with other two forms of vitamin F ethyl ester (ethyl linoleate and ethyl linolenate), the trio is intended to treat dry, seborrheic skin with damaged lipid barrier and dry scalps with brittle and shine-less hair.

What-it-does: emollient

We don't have description for this ingredient yet.

Also-called: Form of Retinoids | What-it-does: cell-communicating ingredient | Irritancy: 1-3 | Comedogenicity: 1-3

It's an ester form of vitamin A (retinol + palmitic acid) that belongs to the "retinoid family". The retinoid family is pretty much the royal family of skincare, with the queen being the FDA-approved anti-aging ingredient tretinoin. Retinol is also a very famous member of the family, but it's like Prince William, two steps away from the throne. Retinyl palmitate will be then little Prince George, quite far (3 steps) away from the throne. 

By steps, we mean metabolic steps. Tretinoin, aka retinoic acid, is the active ingredient our skin cells can understand and retinyl palmitate (RP) has to be converted by our metabolic machinery to actually do something. The conversion is a 3 step one and looks like this:

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retinyl palmitate --> retinol -- > retinaldehyde --> all-trans-retinoic acid

As we wrote in our lengthy retinol description the problem is that the conversion is not terribly effective. The evidence that RP is still an effective anti-aging ingredient is not very strong, in fact, it's weak. Dr. Leslie Baumann in her fantastic Cosmetic Dermatology book writes that RP is topically ineffective

What's more, the anti-aging effectiveness is not the only questionable thing about RP. It also exibits questionable behaviour in the presence of UV light and was the center of a debate between the non-profit group, EWG (whose intentions are no doubt good, but its credibility is often questioned by scientists) and a group of scientists and dermatologists lead by Steven Q. Wang, MD,  director of dermatologic surgery at Memorial-Sloan Kettering Cancer Centre. 

Dr. Leslie Baumann wrote a great review of the debate and summarized the research available about retinyl palmitate here.  It seems that there is a study showing RP being photo protective against UVB rays but there is also a study showing RP causing DNA damage and cytotoxicity in association with UVA. 

We think that the truth lies somewhere in the middle, and we agree with Dr. Baumann's conclusion: "sufficient evidence to establish a causal link between RP and skin cancer has not been produced. Nor, I’m afraid, are there any good reasons to recommend the use of RP". We would add especially during the day!

Bottom line: If you wanna get serious about retinoids, RP is not your ingredient (retinol or tretinoin is!). However, if you use a product that you like and it also contains RP, there is no reason to throw it away. If possible use it at night, just to be on the safe side.

Tocopherol - goodie
Also-called: Vitamin E | What-it-does: antioxidant | Irritancy: 0-3 | Comedogenicity: 0-3
  • Primary fat-soluble antioxidant in our skin
  • Significant photoprotection against UVB rays
  • Vit C + Vit E work in synergy and provide great photoprotection
  • Has emollient properties
  • Easy to formulate, stable and relatively inexpensive
Read all the geeky details about Tocopherol here >>

Also-called: Rose Geranium Leaf Essential Oil | What-it-does: perfuming, antimicrobial/antibacterial

A yellow to brownish essential oil coming from the leaves of Rose Geranium. It contains flavonoid and phenolic compounds that give the oil antibacterial and antifungal properties. The main components though are fragrant onescitronellol (33%), geraniol (26%) and linalool (10%) - so it might be a good idea to avoid if your skin is sensitive. 

What-it-does: perfuming

Citronellol is a very common fragrance ingredient with a nice rose-like odor. In the UK, it’s actually the third most often listed perfume on the ingredient lists. 

It can be naturally found in geranium oil (about 30%) or rose oil (about 25%). 

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As with all fragrance ingredients, citronellol can also cause allergic contact dermatitis and should be avoided if you have perfume allergy. In a 2001 worldwide study with 178 people with known sensitization to fragrances citronellol tested positive in 5.6% of the cases.

There is no known anti-aging or positive skin benefits of the ingredient. It’s in our products to make it smell nice. 

Geraniol - icky
What-it-does: perfuming

Geraniol is a common fragrance ingredient. It smells like rose and can be found in rose oil or in small quantities in geranium, lemon and many other essential oils. 

Just like other similar fragrance ingredients (like linalool and limonene) geraniol also oxidises on air exposure and becomes allergenic. Best to avoid if you have sensitive skin.

Linalool - icky
What-it-does: perfuming, deodorant

Linalool is a super common fragrance ingredient. It’s kind of everywhere - both in plants and in cosmetic products. It’s part of 200 natural oils including lavender, ylang-ylang, bergamot, jasmine, geranium and it can be found in 90-95% of prestige perfumes on the market. 

The problem with linalool is, that just like limonene it oxidises on air exposure and becomes allergenic. That’s why a product containing linalool that has been opened for several months is more likely to be allergenic than a fresh one.

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A study made in the UK with 483 people tested the allergic reaction to 3% oxidised linalool and 2.3% had positive test results. 

You may also want to take a look at...

what‑it‑does emollient
A light emollient ester (C8-10 fatty acids connected to C12-18 fatty alcohols) that absorbs quickly and leaves a dry but silky finish on the skin. In terms of skin feel, it is similar to Dicaprylyl Carbonate, another commonly used light emollient.  [more]
what‑it‑does emollient
A very common emollient that makes your skin feel nice and smooth. Comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. [more]
what‑it‑does emollient
A clear, pale yellow oil-like liquid that mimics the properties of the skin lipids. It is an extremely efficient emollient that can repair even dry hands or cracked lips. [more]
what‑it‑does emollient
A coconut or palm kernel oil derived, fast spreading emollient liquid that makes your skin feel nice and smooth. [more]
what‑it‑does emollient
A naturally derived (Ecocert approved) oily liquid that's touted as a natural silicone alternative. It's claimed to have great sensorial properties: light but caring, velvety, silky and non-sticky. [more]
what‑it‑does emulsifying | perfuming
irritancy, com. 0, 0-3
what‑it‑does skin-identical ingredient | emollient
The famous omega-6 fatty acid, the mother of all ω-6 fatty acids in our body. It is a so-called polyunsaturated fatty acid meaning it has more than one (in this case two) double bonds and a somewhat kinky structure that makes LA and LA-rich oils a thin liquid.It is also an essential fatty acid meaning our body cannot synthesize  [more]
what‑it‑does skin-identical ingredient | emollient
A type of lipid that's the major component of all cell membranes. As for skincare, it works as an emollient and skin-identical ingredient. It's also often used to create liposomes. [more]
what‑it‑does emollient
A clear, slightly yellow, odorless oil  that's a very common, medium-spreading emollient. It makes the skin feel nice and smooth and works in a wide range of formulas.
what‑it‑does emollient
A natural emollient ester derived from sugar beets and coconut oil. It's a very light liquid that absorbs quickly into the skin and has a non-oily skin feel.  [more]
what‑it‑does viscosity controlling
what‑it‑does preservative | antimicrobial/antibacterial
The extract coming from the alpine lichen, Usnea Barbata. It is known for its excellent efficacy against gram-positive bacteria, meaning that it can serve as a natural preservative and deodorant agent.Its main biologically active component is usnic acid (a molecule produced only by lichens) that's not only an antibacterial agent, but also has antioxidant, anti-inflammatory and wound-h [more]
what‑it‑does moisturizer/humectant
Saccharomyces cerevisiae (SC)  is the fancy name for common baker’s yeast.  Usually different kind of yeast extracts are used in skincare for their great hydrating, and general skin conditioning properties. [more]
what‑it‑does emollient
what‑it‑does emollient | emulsifying
It's quite the multi-tasker: an emollient and water-binding ingredient but also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes.  [more]
what‑it‑does skin-identical ingredient | emollient
The famous omega-3 fatty acid, the mother of all ω-3 fatty acids in our body. Next to linoleic acid, it is the other essential fatty acid that our body cannot synthesize and we have to ingest it from our food. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
A famous natural moisturizing factor that can bind up to 1000 times its own weight in water. Works as an excellent surface hydrator in skincare. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
Though its name does not reveal it, this molecule is a relative of famous IT-moisturizer, Hyaluronic Acid. Just like HA, it is a glycosaminoglycan (aka GAG), meaning that it is a big sugar molecule from repeated subunits (what's more, one of the subunits is the same, glucuronic acid). [more]
what‑it‑does emollient
A type of oil soluble vitamin F that is used as an emollient. Read more at ethyl oleate. [more]
what‑it‑does emollient
A type of oil soluble vitamin F that is used as an emollient. Read more at ethyl oleate. [more]
what‑it‑does emollient
It's a Vitamin F Ethyl Ester, that is used as an emollient. Coupled with other two forms of vitamin F ethyl ester (ethyl linoleate and ethyl linolenate), the trio is intended to treat dry, seborrheic skin with damaged lipid barrier and dry scalps with brittle and shine-less hair. [more]
what‑it‑does emollient
what‑it‑does cell-communicating ingredient
irritancy, com. 1-3, 1-3
An ester form of vitamin A (retinol + palmitic acid) that is pretty much the least effective member of the retinoid family. Its anti-aging effects are quite questionable as well as its behavior in the presence of UVA light. (Use it at night if possible!) [more]
what‑it‑does antioxidant
irritancy, com. 0-3, 0-3
Pure Vitamin E. Great antioxidant that gives significant photoprotection against UVB rays. Works in synergy with Vitamin C. [more]
what‑it‑does perfuming | antimicrobial/antibacterial
A yellow to brownish essential oil with antibacterial and antifungal properties. Contains fragrant components citronellol, geraniol, and linalool. [more]
what‑it‑does perfuming
A common fragrance ingredient with a nice rose-like smell. [more]
what‑it‑does perfuming
A common fragrance ingredient that smells like rose and can be found in rose oil. [more]
what‑it‑does perfuming
A super common fragrance ingredient that can be found among others in lavender, ylang-ylang, bergamot or jasmine. The downside of it is that it oxidises on air exposure and might become allergenic. [more]