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Perricone MD Thio:Plex Intensive 2-Step Brightening System [Step 1: Intensive Base]

Perricone MD
Thio:Plex Intensive 2-Step Brightening System [Step 1: Intensive Base]

This unique two-step product offers a combination of skin brightening, discoloration reducing, and lifting and tightening benefits that is rarely available in a single product. [Step 1:Intensive Base] contains unprecedented levels of Thio Antioxidant, the body’s master detoxification and repair agent.
Uploaded by: cassidygxoxo on 17/07/2018

Perricone MD Thio:Plex Intensive 2-Step Brightening System [Step 1: Intensive Base]
Ingredients explained

Also-called: Aqua;Water | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

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Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

We don't have description for this ingredient yet.

Kaolin - goodie
Also-called: Type of clay, China clay | What-it-does: abrasive/scrub, colorant, absorbent/mattifier | Irritancy: 0 | Comedogenicity: 0

Kaolin is a type of clay or to be precise, a naturally occurring hydrous aluminum silicate. When you hear clay, you probably think of a muddy greenish-black mess, but that one is bentonite, and this one is a fine, white powder. It is so white that it's also often used, in small amounts, as a helper ingredient to give opacity and whiteness to the cosmetic formulas.

As a clay, it's absorbent and can suck up excess sebum and gunk from your skin, but less so than the more aggressive bentonite. As it's less absorbent, it's also less drying and gentler on the skin, so it's ideal for dry and sensitive skin types.  

What-it-does: viscosity controlling, absorbent/mattifier | Irritancy: 0 | Comedogenicity: 0

A type of clay mineral that works as a nice helper ingredient to thicken and stabilize formulas. As a clay, it consists of platelets that have a negative charge on the surface (face) and a positive on the edge. So the face of one platelet attracts the edge of the other and this builds a so-called "house of card" structure meaning that Magnesium Aluminum Silicate (MAS) thickens up products and helps to suspend non-soluble particles such as color pigments or inorganic sunscreens (zinc oxide and titanium dioxide).

As the "house of card" structure takes some time to form but collapses quickly if the formula is stirred, products thickened with MAS can be thick in the jar but become easily spreadable upon application (called thixotropy). MAS also gives nice sensory properties, it is not tacky or sticky and gives a rich, creamy skin feel. Also a good team player and works in synergy with other thickeners such as Cellulose Gum or Xanthan Gum

What-it-does: astringent, deodorant

We don't have description for this ingredient yet.

What-it-does: chelating

Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.

Also-called: Fragrance, Parfum;Parfum/Fragrance | What-it-does: perfuming

Exactly what it sounds: nice smelling stuff put into cosmetic products so that the end product also smells nice. Fragrance in the US and parfum in the EU is a generic term on the ingredient list that is made up of 30 to 50 chemicals on average (but it can have as much as 200 components!). 

If you are someone who likes to know what you put on your face than fragrance is not your best friend - no way to know what’s really in it.  

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Also, if your skin is sensitive, fragrance is again not your best friend. It’s the number one cause of contact allergy to cosmetics. It’s definitely a smart thing to avoid with sensitive skin (and fragrance of any type - natural is just as allergic as synthetic, if not worse!). 

What-it-does: emollient, emulsifying | Irritancy: 0 | Comedogenicity: 1-2

A super common, waxy, white, solid stuff that helps water and oil to mix together, gives body to creams and leaves the skin feeling soft and smooth.

Chemically speaking, it is the attachment of a glycerin molecule to the fatty acid called stearic acid. It can be produced from most vegetable oils (in oils three fatty acid molecules are attached to glycerin instead of just one like here) in a pretty simple, "green" process that is similar to soap making. It's readily biodegradable.

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It also occurs naturally in our body and is used as a food additive. As cosmetic chemist Colins writes it, "its safety really is beyond any doubt".

  • It's a super common and super debated skincare ingredient
  • It has several benefits: great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent and antimicrobial
  • It can be very drying if it's in the first few ingredients on an ingredient list
  • Some experts even think that regular exposure to alcohol damages skin barrier and causes inflammation though it's a debated opinion (read more in geeky details tab)
Read all the geeky details about Alcohol Denat. here >>

Also-called: DMAE | What-it-does: buffering

We don't have description for this ingredient yet.

What-it-does: emulsifying

We don't have description for this ingredient yet.

Thioctic Acid - goodie
Also-called: Alpha-Lipoic Acid | What-it-does: antioxidant

Alpha-Lipoic Acid (ALA) is a great antioxidant that's also part of the body's natural antioxidant system. It's soluble both in water-rich and lipid-rich environments so it's versatile and can interact with many types of evil oxidants as well as other nice antioxidants. 

ALA seems to be a great choice for topical use as studies show it can penetrate the skin rapidly where it's converted to DHLA (dihydrolipoic acid), an even more potent antioxidant molecule.  A nicely designed (we mean double-blind, placebo-controlled) 12-week study from 2003 confirmed that 5% ALA cream can decrease skin roughness and improve general signs of photoaging statistically significantly.  A slight catch, though, is that burning and warmth in the skin was quite a common side effect, especially in the first 4 weeks. 

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All in all, ALA is definitely a research-proven, great antioxidant but if your skin is sensitive higher concentrations might not be for you.

Also-called: Form of Vitamin C | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 2

A form of skincare superstar, vitamin C. Even though we are massive vitamin C fans,  Ascorbyl Palmitate  (AP) is our least favorite. (Btw, if you do not know what the big deal with vitamin C is then you are missing out. You must go and read our geeky details about it.) 

So, AP is one of the attempts by the cosmetics industry to solve the stability issues with vitamin C while preserving its benefits,  but it seems to fall short on several things.

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What's the problem?

Firstly, it's stability is only similar to that of pure ascorbic acid (AA), which means it is not really stable. A great study in the Journal of Cosmetic Dermatology compared a bunch of vitamin C derivatives and this derivative was the only one where the study said in terms of stability that it's "similar to AA". Not really that good.

Second, a study that examined the skin absorption of vitamin C found that ascorbyl palmitate did not increase the skin levels of AA. This does not mean that ascorbyl palmitate cannot penetrate the skin (because it can, it's oil soluble and the skin likes to absorb oil soluble things) but this means that it's questionable if ascorbyl palmitate can be converted into pure Vit C in the skin. Even if it can be converted, the palmitate part of the molecule is more than the half of it, so the efficacy will not be good and we have never seen a serum that contains a decent (and proudly disclosed) amount of AP.  We are highly skeptical what effect a tiny amount of AP has in a formula.

Third, another study that wanted to examine the antioxidant properties of AP was surprised to find that even though AP does have nice antioxidant properties; following UVB radiation (the same one that comes from the sun) it also promotes lipid peroxidation and cytotoxicity. It was only an in-vitro study meaning that it was done on cell cultures and not on real people, but still, this also does not support the use of AP too much. 

The only good thing we can write about Ascorbyl Palmitate is that there is an in-vitro (made in the lab, not on real people) study showing that it might be able to boost collagen production.

Regarding the skin-brightening properties of pure vitamin C, this is another magic property AP does not have, or at least there is no data, not even in-vitro, about it.

Overall, Ascorbyl Palmitate is our least favorite vitamin C derivative. It is there in lots of products in tiny amounts (honestly, we do not really understand why), however, we do not know about any vitamin C serum featuring AP in high amounts. That is probably no coincidence. If you are into vitamin C, you can take a look at more promising derivatives here

Also-called: Form of Vitamin C | What-it-does: antioxidant, skin brightening

A form of skincare superstar, vitamin C. If you do not know why vitamin C is such a big deal in skincare, we have a really detailed, geeky description that's good to read. :) 

So now you know that because pure vitamin C is such a diva (very unstable and hard to formulate) the cosmetic industry is trying to come up with some derivatives that have the badass anti-aging properties of vitamin C (antioxidant protection + collagen boosting + fading hyperpigmentation) but without the disadvantages. This is a hard task, and there is not yet a derivative that is really proven to be better in every aspect, but Ascorbyl Glucoside is one of the best options when it comes to vitamin C derivatives. Let's see why:

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First, it's really stable and easy to formulate, so the problems that come with pure vitamin C are solved here.

Second, in vitro (meaning made in the lab, not on real humans) studies show that ascorbyl glucoside can penetrate the skin. This is kind of important for an anti-aging ingredient to do the job, so this is good news, though in-vivo (made on real humans) studies are still needed. 

Third, in-vitro studies show that after ascorbyl glucoside is absorbed into the skin it is converted to pure vitamin C (though the rate of conversion is still a question mark). It also shows all the three anti-aging benefits (antioxidant protection + collagen boosting + fading hyperpigmentation) that pure vitamin C does

Bottom line: ascorbyl glucoside is one of the best and most promising vitamin C derivatives that shows similar benefits to that of pure vitamin C, but it's less proven (in vivo vs. in vitro studies) and the extent of the benefits are also not the same.  

Glycolic Acid - superstar
What-it-does: exfoliant
  • It’s the most researched AHA with the most proven skin benefits
  • It gently lifts off dead skin cells to reveal newer, fresher, smoother skin
  • It can help skin’s own collagen production that results in firmer, younger skin
  • It can fade brown spots caused by sun damage or PIH
  • Choose a product where you know the concentration and pH value because these two greatly influence effectiveness
  • Don’t forget to use your sunscreen (in any case but especially so next to an AHA product)
  • Slight stinging or burning with a stronger AHA product is normal
  • If your skin is very sensitive, rosacea prone choose rather a BHA or PHA product
Read all the geeky details about Glycolic Acid here >>

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little of xanthan gum will make it more gel-like.  Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

Also-called: Green Tea | What-it-does: antioxidant, soothing, antimicrobial/antibacterial
  • Green tea is one of the most researched natural ingredients
  • The active parts are called polyphenols, or more precisely catechins (EGCG being the most abundant and most active catechin)
  • There can be huge quality differences between green tea extracts. The good ones contain 50-90% catechins (and often make the product brown and give it a distinctive smell)
  • Green tea is proven to be a great antioxidant, UV protectant, anti-inflammatory, anticarcinogenic and antimicrobial
  • Because of these awesome properties green tea is a great choice for anti-aging and also for skin diseases including rosacea, acne and atopic dermatitis
Read all the geeky details about Camellia Sinensis Leaf Extract here >>

We don't have description for this ingredient yet.

What-it-does: emulsifying

A silicone emulsifier that helps to create water in silicone emulsions. 

It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol

The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

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Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10). 

It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.

What-it-does: preservative

A mild, natural preservative that usually comes to the formula together with its other mild preservative friends, such as Benzoic Acid and/or Dehydroacetic Acid. Btw, it's also used as a food preservative.

Limonene - icky
What-it-does: perfuming, solvent, deodorant

A super common and cheap fragrance ingredient. It's in many plants, e.g. rosemary, eucalyptus, lavender, lemongrass, peppermint and it's the main component (about 50-90%) of the peel oil of citrus fruits.

It does smell nice but the problem is that it oxidizes on air exposure and the resulting stuff is not good for the skin. Oxidized limonene can cause allergic contact dermatitis and counts as a frequent skin sensitizer

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Limonene's nr1 function is definitely being a fragrance component, but there are several studies showing that it's also a penetration enhancer, mainly for oil-loving components.

All in all, limonene has some pros and cons, but - especially if your skin is sensitive - the cons probably outweigh the pros.  

You may also want to take a look at...

what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does abrasive/scrub | colorant
irritancy, com. 0, 0
A type of clay that's a fine, white powder and is used for its oil-absorbing and opacifying properties. It's less absorbent and less drying than bentonite clay. [more]
what‑it‑does viscosity controlling
irritancy, com. 0, 0
A type of clay mineral that works as a nice helper ingredient to thicken and stabilize formulas. As a clay, it consists of platelets that have a negative charge on the surface (face) and a positive on the edge. [more]
what‑it‑does chelating
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. [more]
what‑it‑does perfuming
The generic term for nice smelling stuff put into cosmetic products so that the end product also smells nice. It is made up of 30 to 50 chemicals on average. [more]
what‑it‑does emollient | emulsifying
irritancy, com. 0, 1-2
Waxy, white, solid stuff that helps water and oil to mix together and leaves the skin feeling soft and smooth. [more]
what‑it‑does antimicrobial/antibacterial | solvent | viscosity controlling
Alcohol with some additives to make it unconsumable. It is great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent, and antimicrobial. In large amounts, it can be very drying to the skin. [more]
what‑it‑does buffering
what‑it‑does emulsifying
what‑it‑does antioxidant
Alpha-Lipoic Acid (ALA) is a great antioxidant that's also part of the body's natural antioxidant system. It's soluble both in water-rich and lipid-rich environments so it's versatile and can interact with many types of evil oxidants as well as other nice antioxidants. ALA seems to be a great choice for topical use as studies show it can penetrate the skin rapidl [more]
what‑it‑does antioxidant
irritancy, com. 0, 2
An oil soluble vitamin C derivative that has mixed data about its effectiveness. [more]
what‑it‑does antioxidant | skin brightening
A stable and easy to formulate form of skincare superstar, vitamin C. In-vitro studies show that it shows all the three anti-aging benefits (antioxidant protection + collagen boosting + fading hyperpigmentation) that pure vitamin C does. [more]
what‑it‑does exfoliant
The most researched and well-known AHA exfoliant. It gently lifts off dead skin cells to reveal newer, fresher, smoother skin. In larger concentration (>10%) it's a proven collagen booster. [more]
what‑it‑does viscosity controlling
A super commonly used thickener and emulsion stabilizer. [more]
what‑it‑does antioxidant | soothing | antimicrobial/antibacterial
Green Tea - one of the most researched natural ingredients that contains the superstar actives called catechins. It has proven antioxidant, anti-inflammatory, antimicrobial and anticarcinogenic properties. [more]
what‑it‑does antimicrobial/antibacterial
what‑it‑does emulsifying
A silicone emulsifier that helps to create water in silicone emulsions. 
what‑it‑does moisturizer/humectant | emollient
A handy multi-tasking ingredient that gives the skin a nice, soft feel and also boosts the effectiveness of other preservatives. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
what‑it‑does preservative
A mild, natural preservative that usually comes to the formula together with its other mild preservative friends, such as Benzoic Acid and/or Dehydroacetic Acid. [more]
what‑it‑does perfuming | solvent
A super common fragrance ingredient found naturally in many plants including citrus peel oils, rosemary or lavender. It autoxidizes on air exposure and counts as a common skin sensitizer. [more]