H2 Elemental Energy Hydrating Booster Serum
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Perricone MD H2 Elemental Energy Hydrating Booster SerumIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
A corn sugar derived, water-soluble, pale yellow syrup, that nicely moisturizes the skin. It has a light and smooth skin feel, it is non-tacky, and it can improve the after-feel of the formula. It is also mild and gentle, popular in sensitive skin formulas.
A form of skincare superstar, vitamin C. If you do not know why vitamin C is such a big deal in skincare, we have a really detailed, geeky description that's good to read. :)
So now you know that because pure vitamin C is such a diva (very unstable and hard to formulate) the cosmetic industry is trying to come up with some derivatives that have the badass anti-aging properties of vitamin C (antioxidant protection + collagen boosting + fading hyperpigmentation) but without the disadvantages. This is a hard task, and there is not yet a derivative that is really proven to be better in every aspect, but Ascorbyl Glucoside is one of the best options when it comes to vitamin C derivatives. Let's see why:
First, it's really stable and easy to formulate, so the problems that come with pure vitamin C are solved here.
Second, in vitro (meaning made in the lab, not on real humans) studies show that ascorbyl glucoside can penetrate the skin. This is kind of important for an anti-aging ingredient to do the job, so this is good news, though in-vivo (made on real humans) studies are still needed.
Third, in-vitro studies show that after ascorbyl glucoside is absorbed into the skin it is converted to pure vitamin C (though the rate of conversion is still a question mark). It also shows all the three anti-aging benefits (antioxidant protection + collagen boosting + fading hyperpigmentation) that pure vitamin C does.
Bottom line: ascorbyl glucoside is one of the best and most promising vitamin C derivatives that shows similar benefits to that of pure vitamin C, but it's less proven (in vivo vs. in vitro studies) and the extent of the benefits are also not the same.
A sugar beet-derived amino acid derivative with nice skin protection and moisturization properties. Betaine's special thing is being an osmolyte, a molecule that helps to control cell-water balance. It is also a natural osmoprotectant, meaning that it attracts water away from the protein surface and thus protects them from denaturation and increases their thermodynamic stability.
It also gives sensorial benefits to the formula and when used in cleansers, it helps to make them milder and gentler.
Ectoin is a surprisingly well-researched, multi-functional active that can do from pollution & light protection to skin hydration, soothing, and barrier repair, several things to your skin.
It is an extremolyte, a small stress-protection molecule that protects microorganisms living under extreme conditions such as salt lakes, hot springs, arctic ice, the deep sea, or deserts. It was discovered in 1985 in a microorganism living in a salt lake in the Egyptian desert.
The key skill of Ectoin is protection that applies also to the skin. Its main mode of action is binding water molecules (aka kosmotropic) and creating hydro complexes. These complexes then surround important biomolecules (e.g. cells, proteins, enzymes) and form a stabilizing hydration shell around them.
This protection mechanism means good things when it comes to our skin: Ectoin has antioxidant, anti-inflammatory, pollution& light protecting, skin hydrating, barrier repairing as well as anti-aging properties.
A placebo-controlled 10-person study examined a four-week treatment with 0.5% Ectoin in the crow's feet area and found a significant anti-wrinkle effect (-19% mean wrinkle depth) in 100% of the participants. Another double-blind, placebo-controlled clinical study with 24 participants used a 2% Ectoin cream twice a day for 4 weeks and found an improvement in all of the measured parameters, such as wrinkle volume, skin scaling, roughness, and elasticity.
Another remarkable property of Ectoin is protecting the epidermal immune cells called Langerhans cells from UV damage. 0.3% and 0.5% Ectoin cream was used twice a day for 14 days on the forearm and then irradiated with 1.5 MED UV (one and a half times the UV dose that causes detectable redness). While the untreated, UV-stressed area showed a 40% decrease in viable Langerhans cells, 0.5% Ectoin showed 100% protection (and 0.3% showed ~95% protection).
The soothing efficacy is also backed up by multiple in-vivo studies. A 20-person study compared 1% Ectoin cream to 0.25% hydrocortisone treatment on surfactant irritated skin and found similar effectiveness in reducing skin redness. Another study with 23 females with sensitive skin found that a 1% Ectoin cream helped to tolerate a 0.5% or 1% retinol treatment much better.
A tiny, 5-person study examined the long-term (7 days) skin hydration effect of 1% Ectoin. During the study, hydration levels increased up to 200% compared to placebo, and even 7 days after stopping the treatment hydration status was largely preserved. Higher concentration (5-7%) Ectoin treatments are also used as OTC medical products for the treatment of eczema or atopic skin.
The anti-pollution magic properties are also well-established and Ectoin is currently the only anti-pollution active ingredient approved for use in medical products (e.g. inhalation solutions) in Europe. Clinical studies showed a reduction of inflammations in human lungs of patients with COPD (a pulmonary disease) and pollution-induced asthma. But coming back to the skin, Ectoin protects both from PMs (Particulate Matters, including ultrafine) as well as PAHs (Polycyclic Aromatic Hydrocarbons) and heavy metals.
If that weren't enough, Ectoin is also shown to protect the skin from blue and visible light, and pigmentation resulting from environmental stress (think UV, pollution, oxidative stress).
All in all, we think Ectoin is one of those under-the-radar actives that deserves more hype than it is currently getting. As an amazing all-around skin protectant, it is a useful addition to any skincare routine.
It's a super small, chemically chopped up version of sodium hyaluronate. Its trade name is miniHA, and its molecular weight is 10 kDa. This counts as really tiny given that "normal" HA has a molecular weight of 0.5-2 million Da.
To be honest, low molecular weight (LMW), and especially this ultra-low molecular weight HA is a controversial ingredient. On the upside, it can penetrate the skin better (though 10kDa still counts as big!) and might be able to moisturize the deeper layers of the skin where normal HA cannot get. Also, according to the manufacturer of miniHA, it has better antioxidant activity than a 1.6MDa version HA and it also has better sun protection and after-sun repair abilities than the higher MW versions. It also works in synergy with higher molecular weight versions, and the combination of 0.1% 1.45MDa-HA + 0.1% 380 kDa-HA + 0.1% miniHA hydrated the skin significantly better than 0.3% 1.45MDa-HA alone.
On the downside, the biological role of LMW-HA in the skin is being a pro-inflammatory signaling agent and there is a study by another manufacturer called Evonik showing that HA versions with smaller than 50kDa molecular weight might be pro-inflammatory when put on the skin. Granted, the study was only done on reconstituted human epidermis, so it might or might not be like this on real human skin.
If you wanna get confused and read much more about hyaluronic acid and what the different molecular weight versions might or might not do, click here and read our excruciatingly long description.
The salt form of one of the main anti-inflammatory ingredients in the licorice plant, monoammonium glycyrrhizinate. It’s a yellowish powder with a nice sweet smell.
It’s used mainly for its soothing and anti-inflammatory properties, but according to manufacturer info, it’s also sebum regulating so it's a perfect ingredient for problem skin products.
Read more about licorice and why it's a skincare superstar here.
We don't have description for this ingredient yet.
Lactobacillus ferment is an interesting probiotic ingredient with some promising properties.
First, according to a 2009 Estee Lauder patent, it’s a DNA repair enzyme and it can help to protect the skin against environmental aggressors.
Second, still according to Estee Lauder research but now from 2012 the ingredient has anti-microbial and anti-inflammatory properties and holds promise in the treatment of acne and rosacea. For the former one 5% was needed to show effectiveness, but for reducing skin sensitivity already 1% showed results.
The anti-acne effect is confirmed also by US manufacturer, Barnet, that says that Lactobacillus ferment is helpful in killing harmful bacteria and creating a healthy balanced microflora. Compared to well-known anti-acne and anti-inflammatory salicylic acid the probiotic worked faster at reducing the size and redness of acne lesions.
It also goes by the trade name Leucidal Liquid SF and can serve in the formula as a natural preservative.
Bottom line: It’s not the most proven ingredient (yet) but definitely a very promising one especially if you have sensitive skin, acne or rosacea.
An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid).
Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier.
Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.
Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation.
If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.
As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily.
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
- Primary fat-soluble antioxidant in our skin
- Significant photoprotection against UVB rays
- Vit C + Vit E work in synergy and provide great photoprotection
- Has emollient properties
- Easy to formulate, stable and relatively inexpensive
A 100% natural and plant-derived moisturizer that mimics the natural carbohydrate fraction found in the upper layer of the skin. Its special magic power is to bind to the skin stronger and longer than other moisturizer ingredients do so it can keep the skin hydrated longer than usual.
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically.
It's not only soothing but it' also skin-softening and protecting and can promote wound healing.
A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments more evenly in makeup products. And that is still not all: it can also boost the antimicrobial activity of preservatives.
We don't have description for this ingredient yet.
Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.
BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.
It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive.
It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol.
The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula.
It's a very alkaline stuff that helps to set the pH of the cosmetic formula to be just right. It's similar to the more often used sodium hydroxide and pretty much the same of what we wrote there applies here too.
A helper ingredient that helps to neutralize the metal ions in the formula (they usually come from water) so it stays nice longer. The special property of this particular ingredient is that it's more effective against more problematic ions, like Cu (copper) and Fe (iron) compared to less problematic ones like Ca (calcium) and Mg (magnesium).
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| what‑it‑does | solvent |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | antioxidant | skin brightening |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | antioxidant | soothing | moisturizer/humectant |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | soothing | moisturizer/humectant |
| what‑it‑does | soothing | preservative |
| what‑it‑does | soothing | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | antioxidant |
| irritancy, com. | 0-3, 0-3 |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | soothing |
| irritancy, com. | 0, 0 |
| what‑it‑does | solvent |
| what‑it‑does | viscosity controlling |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 1 |
| what‑it‑does | moisturizer/humectant | emollient |
| what‑it‑does | emulsifying | surfactant/cleansing |
| irritancy, com. | 0, 0 |
| what‑it‑does | buffering |
| what‑it‑does | antioxidant |
| what‑it‑does | chelating |
| what‑it‑does | emulsifying |