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Paula's Choice Resist Super Antioxidant Serum

Resist Super Antioxidant Serum

A hydrating, antioxidant-enriched serum that restores visible radiance for dull, dry skin while fighting against environmental attack and the appearance of sun-damaged skin.
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Paula's Choice Resist Super Antioxidant Serum
Ingredients explained

What-it-does: emollient, solvent

A super commonly used 5 unit long, cyclic structured silicone that is water-thin and does not stay on the skin but evaporates from it (called volatile silicone). Similar to other silicones, it gives skin and hair a silky, smooth feel

It's often combined with the non-volatile (i.e. stays on the skin) dimethicone as the two together form a water-resistant, breathable protective barrier on the skin without a negative tacky feel.

What-it-does: emollient | Irritancy: 0 | Comedogenicity: 1

Probably the most common silicone of all. It is a polymer (created from repeating subunits) molecule and has different molecular weight and thus different viscosity versions from water-light to thick liquid.

As for skincare, it makes the skin silky smooth, creates a subtle gloss and forms a protective barrier (aka occlusive). Also, works well to fill in fine lines and wrinkles and give skin a plump look (of course that is only temporary, but still, it's nice). There are also scar treatment gels out there using dimethicone as their base ingredient. It helps to soften scars and increase their elasticity. 

Also-called: Form of Vitamin C, Ascorbyl Isotetrapalmitate, Ascorbyl Tetraisopalmitate, ATIP | What-it-does: antioxidant, skin brightening

Tetrahexyldecyl Ascorbate is a stable, oil-soluble form of skincare big shot Vitamin C. If you do not know, why Vitamin C is such a big deal in skincare, click here and read all about it. We are massive vitamin C fans and have written about it in excruciating detail.

So now, you know that Vitamin C is great and all, but it's really unstable and gives cosmetics companies many headaches. To solve this problem they came up with vitamin C derivatives, and one of them is Tetrahexyldecyl Ascorbate (let's call it ATIP in short).

Also-called: Syn-Coll | What-it-does: cell-communicating ingredient

A tripeptide (three amino acids attached to each other: Lys-Val-Lys) that's claimed to protect and boost collagen and improve skin texture.

The manufacturer did an in-vivo (made on real people) study with 45 volunteers and found that used twice daily for 84 days 1% and 2.5% Syn-Coll reduces the appearance of wrinkles by 7 and 12% respectively. In another study (also by the manufacturer) with 33 female Chinese volunteers, 77% of the participants felt that Syn-Coll visibly improved the firmness and elasticity of the skin after 4 weeks. What's more, 60% of the participants also noticed a reduction in the look of the pore size also after 4 weeks of treatment. 

Ceramide NP - goodie
Also-called: Ceramide 3 | What-it-does: skin-identical ingredient

One of the many types of ceramides that can be found naturally in the upper layer of the skin. Ceramides make up about 50% of the goopy stuff that's between our skin cells and play a super important role in having a healthy skin barrier and keeping the skin hydrated. It works even better when combined with its pal, Ceramide 1.

We wrote way more about ceramides at ceramide 1, so click here to know more.

We don't have description for this ingredient yet.

Tocopherol - goodie
Also-called: Vitamin E | What-it-does: antioxidant | Irritancy: 0-3 | Comedogenicity: 0-3
  • Primary fat-soluble antioxidant in our skin
  • Significant photoprotection against UVB rays
  • Vit C + Vit E work in synergy and provide great photoprotection
  • Has emollient properties
  • Easy to formulate, stable and relatively inexpensive
Read all the geeky details about Tocopherol here >>

Ubiquinone - goodie
Also-called: Coenzyme Q10 | What-it-does: antioxidant

Thanks to Nivea, Q10 is a pretty well-known ingredient and the fame and Beiersdorf's (the parent company of Nivea) obsession with it are not for no reason. It's an antioxidant found naturally in human cells where it plays a big role in energy production.

In fact, it's so important for energy production that if taken as an oral supplement it has a caffeine-like effect and if taken at night you will probably not sleep very well (so you should take it in the morning). Q10 supplementation is not a bad idea: it not only gives you energy but research also shows that oral Q10 increases the Q10 level of the skin (of course, it decreases with age like pretty much every good thing in the skin) and may help to reduce wrinkles. If you are not for supplements, dietary sources include fish, spinach, and nuts.

Thioctic Acid - goodie
Also-called: Alpha-Lipoic Acid | What-it-does: antioxidant

Alpha-Lipoic Acid (ALA) is a great antioxidant that's also part of the body's natural antioxidant system. It's soluble both in water-rich and lipid-rich environments so it's versatile and can interact with many types of evil oxidants as well as other nice antioxidants. 

ALA seems to be a great choice for topical use as studies show it can penetrate the skin rapidly where it's converted to DHLA (dihydrolipoic acid), an even more potent antioxidant molecule.  A nicely designed (we mean double-blind, placebo-controlled) 12-week study from 2003 confirmed that 5% ALA cream can decrease skin roughness and improve general signs of photoaging statistically significantly.  A slight catch, though, is that burning and warmth in the skin was quite a common side effect, especially in the first 4 weeks. 

Also-called: Vitamin E Acetate | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 0

It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version. 

According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E. 

Also-called: Form of Vitamin C, MAP | What-it-does: skin brightening, antioxidant

A form of skincare superstar, Vitamin C. If you do not know, what the big deal about Vitamin C is, click here and read all about it, we will wait here for you. 

So now you know that pure vitamin C (aka ascorbic acid, AA) is really unstable and hard to formulate so the cosmetics industry is coming up with a bunch of derivatives to solve the problem and Magnesium Ascorbyl Phosphate (or MAP) is one of them.  

Ferulic Acid - goodie

Ferulic Acid (FA) is a goodie that can be found naturally in plant cell walls. There is a lot of it especially in the bran of grasses such as rice, wheat and oats. 

FA - whose main job is to be an antioxidant - owes its fame to a 2005 research that discovered that adding in 0.5% FA to a 15% Vitamin C + 1% Vitamin E solution not only stabilizes the highly unstable, divaish Vit C, but it also doubles the photoprotection abilities of the formula. 

Beta-Glucan - goodie

Beta-Glucan is a nice big molecule composed of many smaller sugar molecules (called polysaccharide). It’s in the cell walls of yeast, some mushrooms, seaweeds, and cereals.

It’s a real goodie no matter if you eat it or put it on your face. Eating it is anti-diabetic, anti-cancer, and even lowers blood cholesterol. 

Also-called: SOD | What-it-does: antioxidant

Superoxide Dismutase - or in short SOD - is the body's smart antioxidant enzyme that protects the cells from highly reactive, cell-damaging superoxide radicals (O2−).

You have probably read the terms "free radicals" and "antioxidants" a thousand times, and you know that free radicals are the evil guys, and antioxidants are the good guys. So superoxide radical is a very common free radical that can cause all kinds of cell damages and superoxide dismutase is an enzyme that catalyzes the conversion of superoxide radicals into molecular oxygen and hydrogen peroxide (btw, this one has to be further converted by other antioxidant enzymes, called catalases).

Also-called: EGCG | What-it-does: antioxidant, soothing

If EGCG does not tell you anything, green tea sure does. We have written about green tea in excruciating details, so if you wanna become an expert in the "green tea in skincare" topic,  click here and read it

So now you know that EGCG is the magic ingredient in green tea. It's the most active polyphenol that green tea owes most of its magic properties to. It's a fantastic antioxidant, anti-inflammatory and anticarcinogenic agent. Be happy, if you spot it on the ingredient list. 

What-it-does: antioxidant

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Also-called: Lutein

We don't have description for this ingredient yet.

Also-called: Soybean Extract | What-it-does: antioxidant, skin brightening, soothing, emollient

When you hear the word Soy, you probably associate it with soy sauce or tofu, not skincare. But as it turns out, the soybean has a bunch of useful active components and soybean extract is an interesting cosmetic ingredient with a wide range of possible effects. 

Its main active components are antioxidant phenolic acids and flavonoids as well as small and large soy proteins. The large proteins give soybean extract nice skin smoothing and softening properties, while the small proteins (soybean trypsin inhibitor (STI) and Bowman-Birk inhibitor (BBI)) are thought to inhibit skin pigmentation and delay hair regrowth.   

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

Also-called: Bearberry, Kinnikinnick | What-it-does: antioxidant, skin brightening

Arctostaphylos Uva-Ursi is a little plant with nice red berries that lives in the North and is also called bearberry or kinnikinnick. According to Wikipedia the uva-ursi part means “grape of the bear”.  

As for skincare bearberry is interesting because it contains the well-known skin lightening agent arbutin. The leaves contain 5-15% percent of it and might be able to help fading brown spots on the skin. Also, kinnikinnick (such a cool name :)) is an antioxidant and has some antibacterial activity

We don't have description for this ingredient yet.

Also-called: Turmeric Root Extract | What-it-does: antioxidant, soothing, skin brightening, perfuming

Turmeric is the yellow spice you probably know from curry and Indian food. It's also a traditional herbal medicine used in Ayurveda for its bunch of anti-something magic abilities including being anti-inflammatory, antimicrobial, antioxidant and anticarcinogenic. 

As for turmeric and skincare, we have good news: studies show that the root extract and its main biologically active component, curcumin can do multiple good things for the skin. Thanks to its anti-inflammatory and antimicrobial activity, it shows some promise for acne-prone skin and a small study from 2013 showed that it might be able to regulate sebum production

What-it-does: emollient

We don't have description for this ingredient yet.

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

You may also want to take a look at...

what‑it‑does emollient | solvent
It's a super commonly used water-thin volatile silicone that gives skin and hair a silky, smooth feel.  [more]
what‑it‑does emollient
irritancy, com. 0, 1
A very common silicone that gives both skin and hair a silky smooth feel. It also forms a protective barrier on the skin and fills in fine lines. Also used for scar treatment. [more]
what‑it‑does antioxidant | skin brightening
A stable, oil-soluble form of Vitamin C, that might have (in-vitro results) all the magic abilities of pure vitamin C (antioxidant, collagen booster, skin brightener). [more]
what‑it‑does cell-communicating ingredient
Syn-Coll - An anti-aging tripeptide that's claimed to protect and boost collagen and improve skin texture. [more]
what‑it‑does skin-identical ingredient
Ceramides make up 50% of the goopy stuff that's between our skin cells and play a super important role in having a healthy skin barrier and keeping the skin hydrated.  [more]
what‑it‑does antioxidant
irritancy, com. 0-3, 0-3
Pure Vitamin E. Great antioxidant that gives significant photoprotection against UVB rays. Works in synergy with Vitamin C. [more]
what‑it‑does antioxidant
Q10 - an antioxidant found naturally in human cells where it plays an important role in energy production. As for skincare, it works as an awesome antioxidant that might also be able to reduce wrinkle depth. [more]
what‑it‑does antioxidant
Alpha-Lipoic Acid (ALA) is a great antioxidant that's also part of the body's natural antioxidant system. It's soluble both in water-rich and lipid-rich environments so it's versatile and can interact with many types of evil oxidants as well as other nice antioxidants. ALA seems to be a great choice for topical use as studies show it can penetrate the skin rapidl [more]
what‑it‑does antioxidant
irritancy, com. 0, 0
A form of vitamin E that works as an antioxidant. Compared to the pure form it's more stable, has longer shelf life, but it's also more poorly absorbed by the skin. [more]
what‑it‑does skin brightening | antioxidant
A form of skincare superstar, Vitamin C - it has proven skin-brightening abilities (in-vivo) and it might be able to boost collagen production as well (in-vitro). [more]
what‑it‑does antioxidant | antimicrobial/antibacterial
A great antioxidant that is most famous for stabilizing the highly unstable Vitamin C. It also doubles the photoprotection abilities of Vit C+E formulas. [more]
what‑it‑does soothing | moisturizer/humectant
A great skin soother and moisturizer, and it even shows promising anti-aging benefits. It‘s also shown to have wound healing properties and is a mild antioxidant. [more]
what‑it‑does antioxidant
Superoxide Dismutase - or in short SOD - is the body's smart antioxidant enzyme that protects the cells from highly reactive, cell-damaging superoxide radicals (O2−). You have probably read the terms "free radicals" [more]
what‑it‑does antioxidant | soothing
The most active polyphenol in green tea. A fantastic antioxidant, anti-inflammatory and anticarcinogenic agent. [more]
what‑it‑does antioxidant
what‑it‑does antioxidant | skin brightening | soothing | emollient
When you hear the word Soy, you probably associate it with soy sauce or tofu, not skincare. But as it turns out, the soybean has a bunch of useful active components and soybean extract is an interesting cosmetic ingredient with a wide range of possible effects. Its main active components are antioxidant phenolic acids and flavonoids  [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does antioxidant | skin brightening
Arctostaphylos Uva-Ursi is a little plant with nice red berries that lives in the North and is also called bearberry or kinnikinnick. According to Wikipedia the uva-ursi part means “grape of the bear”. [more]
what‑it‑does antioxidant | soothing | skin brightening | perfuming
Turmeric Root Extract that has nice anti-inflammatory, antioxidant and skin-brightening properties. [more]
what‑it‑does emollient
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]